{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:38:48Z","timestamp":1786117128749,"version":"build-2736575974"},"reference-count":38,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Pers. Med.","JPM"],"abstract":"<jats:p>Objectives: To assess whether muscle morphology and metabolism can inform personalised care in ventral hernias and to define which parts of a proposed postoperative remodelling model are supported by direct evidence. Methods: We conducted a structured narrative review of PubMed\/MEDLINE, Scopus and Web of Science from 1 January 2010 through 30 April 2026. Two authors selected 38 publications. Evidence was classified as direct when generated in ventral or incisional hernia cohorts and indirect when drawn from inguinal hernia, transplantation, geriatric, oncological, animal or general muscle studies. No quantitative synthesis was undertaken. Results: Direct studies document lateral muscle displacement, impaired abdominal wall function, inconsistent associations between low muscle mass and clinical outcomes, and CT-derived increases in muscle cross-sectional areas after transversus abdominis release (TAR). The evidence for anterior abdominal wall myosteatosis, biomarker-guided care and the three proposed remodelling trajectories remains largely indirect. In a 37-patient TAR series, the median rectus abdominis cross-sectional area increased by 16.1% (IQR 11.4\u201327.0%); muscle function and metabolic recovery were not measured. Conclusions: Routine CT can yield muscle area, attenuation and intermuscular adipose tissue measures without further imaging. No anterior abdominal wall-specific thresholds or biomarker cut-offs have been validated, so these measures should not determine current treatment in isolation. Prospective studies should test whether combined imaging, functional and clinical phenotyping improves the selection of prehabilitation and follow-up.<\/jats:p>","DOI":"10.3390\/jpm16080419","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:03:27Z","timestamp":1786021407000},"page":"419","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolism, Morphology and Function of the Anterior Abdominal Wall Musculature in Ventral Hernias and After Repair: A Narrative Review and Research Agenda"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1493-0351","authenticated-orcid":false,"given":"Sergey Yu.","family":"Muraviev","sequence":"first","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zakhar A.","family":"Akulov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4792-4353","authenticated-orcid":false,"given":"Maria A.","family":"Sukhanova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava O.","family":"Pilipenko","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1847-711X","authenticated-orcid":false,"given":"Evgeniy A.","family":"Tarabrin","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4335-3987","authenticated-orcid":false,"given":"Zelimkhan G. M.","family":"Berikkhanov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9917-6230","authenticated-orcid":false,"given":"Milena Yu.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey M.","family":"Nikolaev","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7802-4588","authenticated-orcid":false,"given":"Vadim S.","family":"Razumovsky","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav S.","family":"Rakintsev","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksey G.","family":"Kotelnikov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Nourmahal","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey L.","family":"Shestakov","sequence":"additional","affiliation":[{"name":"Sechenov First Moscow State Medical University (Sechenov University), 119048 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e70131","DOI":"10.1111\/wrr.70131","article-title":"Incisional Hernia Development: Wound Healing Gone Wrong?","volume":"34","author":"Abbas","year":"2026","journal-title":"Wound Repair Regen."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.9738\/INTSURG-D-12-00002.1","article-title":"A systematic review of outcomes following repair of complex ventral incisional hernias with biologic mesh","volume":"98","author":"Ferzoco","year":"2013","journal-title":"Int. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Paduraru, D.N., Palcau, A.C., Ion, D., and Seicaru, R. (2025). Multimodal Prehabilitation for Hernia Repair: Linking Metabolic Modulation and Mechanical Methods. Biomedicines, 13.","DOI":"10.3390\/biomedicines13123117"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s00423-025-03706-8","article-title":"Transversalis fascia collagen content and the risk of surgical complications: Results of a prospective study","volume":"410","author":"Morawski","year":"2025","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_5","first-page":"404","article-title":"Extracellular matrix in skeletal muscle injury and atrophy: Mechanisms and therapeutic implications","volume":"52","author":"Ge","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Dawi, J., Misakyan, Y., Gonzalez, E., Kafaja, K., Affa, S., Tumanyan, K., Qumsieh, K., and Venketaraman, V. (2025). ECM Remodeling in Direct Inguinal Hernia: The Role of Aging, Oxidative Stress, and Antioxidants Defenses. Clin. Pract., 15.","DOI":"10.3390\/clinpract15120219"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/jcsm.12948","article-title":"Chest computed tomography-derived muscle mass and quality indicators, in-hospital outcomes, and costs in older inpatients","volume":"13","author":"Shen","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"10416","DOI":"10.4081\/ejtm.2022.10416","article-title":"Exercise-mediated reinnervation of skeletal muscle in elderly people: An update","volume":"32","author":"Coletti","year":"2022","journal-title":"Eur. J. Transl. Myol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s10029-020-02179-6","article-title":"The emerging role of sarcopenia as a prognostic indicator in patients undergoing abdominal wall hernia repairs: A systematic review of the literature","volume":"24","author":"Clark","year":"2020","journal-title":"Hernia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s10029-025-03452-2","article-title":"Prediction of incisional hernia after kidney transplantation: Analysis of wound closure technique and risk factors","volume":"29","author":"Brismar","year":"2025","journal-title":"Hernia"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00384-023-04329-5","article-title":"A systematic review of the association between parastomal hernia and sarcopenia","volume":"38","author":"Schutte","year":"2023","journal-title":"Int. J. Colorectal Dis."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Read, J.W., Ibrahim, N., Jacombs, A.S.W., Elstner, K.E., Saunders, J., and Rodriguez-Acevedo, O. (2022). Imaging Insights Into Abdominal Wall Function. Front. Surg., 9.","DOI":"10.3389\/fsurg.2022.799277"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10029-021-02535-0","article-title":"Changes in the abdominal wall after anterior, posterior, and combined component separation","volume":"26","author":"Daes","year":"2022","journal-title":"Hernia"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10029-026-03630-w","article-title":"Abdominal wall muscle remodeling after open transversus abdominis release: A CT-based analysis","volume":"30","author":"Macret","year":"2026","journal-title":"Hernia"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/SLA.0b013e31825ffd02","article-title":"Reversibility of abdominal wall atrophy and fibrosis after primary or mesh herniorrhaphy","volume":"257","author":"Culbertson","year":"2013","journal-title":"Ann. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s10029-014-1242-8","article-title":"Abdominal muscle function and incisional hernia: A systematic review","volume":"18","author":"Jensen","year":"2014","journal-title":"Hernia"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10029-025-03557-8","article-title":"Abdominal wall function in hernia and diastasis: Systematic review of evaluation methods and clinical relevance","volume":"30","author":"Brucchi","year":"2026","journal-title":"Hernia"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Nessel, R., L\u00f6ffler, T., Rinn, J., L\u00f6sel, P., Voss, S., Heuveline, V., Vollmer, M., G\u00f6rich, J., Ludwig, Y.M., and Al-Hileh, L. (2021). Primary and Recurrent Repair of Incisional Hernia Based on Biomechanical Considerations to Avoid Mesh-Related Complications. Front Surg., 8.","DOI":"10.3389\/fsurg.2021.764470"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"20170954","DOI":"10.1259\/bjr.20170954","article-title":"Use of imaging for pre- and post-operative characterisation of ventral hernia: Systematic review","volume":"91","author":"Halligan","year":"2018","journal-title":"Br. J. Radiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/s10029-021-02499-1","article-title":"A systematic review and meta-analysis of technical aspects and clinical outcomes of botulinum toxin prior to abdominal wall reconstruction","volume":"25","author":"Timmer","year":"2021","journal-title":"Hernia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s10029-020-02333-0","article-title":"Prehabilitation of complex ventral hernia patients with Botulinum: A systematic review of the quantifiable effects of Botulinum","volume":"25","author":"Wegdam","year":"2021","journal-title":"Hernia"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Bracale, U., Peltrini, R., Iacone, B., Martirani, M., Sannino, D., Gargiulo, A., Corcione, F., Serra, R., and Bracale, U.M. (2023). A Systematic Review on the Role of Matrix Metalloproteinases in the Pathogenesis of Inguinal Hernias. Biomolecules, 13.","DOI":"10.3390\/biom13071123"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1007\/s00268-021-06198-x","article-title":"Matrix Metalloproteinases (MMP-2) and Tissue Inhibitors of Metalloproteinases (TIMP-2) in Male Inguinal Hernia Patients at Different Ages","volume":"45","author":"Wang","year":"2021","journal-title":"World J. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e179137","DOI":"10.1172\/JCI179137","article-title":"Estrogen receptor-\u03b1 ablation reverses muscle fibrosis and inguinal hernias","volume":"135","author":"Potluri","year":"2025","journal-title":"J. Clin. Investig."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Pogson-Morowitz, K., Porras Fimbres, D., Barrow, B.E., Oleck, N.C., and Patel, A. (2024). Contemporary Abdominal Wall Reconstruction: Emerging Techniques and Trends. J. Clin. Med., 13.","DOI":"10.3390\/jcm13102876"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1007\/s00464-014-3599-2","article-title":"Endoscopic component separation for ventral hernia causes fewer wound complications compared to open components separation: A systematic review and meta-analysis","volume":"28","author":"Jensen","year":"2014","journal-title":"Surg. Endosc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10029-022-02657-z","article-title":"Outcomes of open transverse abdominis release for ventral hernias: A systematic review, meta-analysis and meta-regression of factors affecting them","volume":"27","author":"Vasavada","year":"2023","journal-title":"Hernia"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/2000656X.2017.1285783","article-title":"Chemical component separation: A systematic review and meta-analysis of botulinum toxin for management of ventral hernia","volume":"51","author":"Weissler","year":"2017","journal-title":"J. Plast. Surg. Hand Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s10029-023-02816-w","article-title":"Systematic review and meta-analysis of the pre-operative application of botulinum toxin for ventral hernia repair","volume":"27","author":"Dias","year":"2023","journal-title":"Hernia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10029-025-03369-w","article-title":"Effectiveness of pre-operative chemical component separation with computed tomography-guided intramuscular injection of OnabotulinumtoxinA in outcomes of large complex incisional ventral abdominal hernia repair: A propensity score-weighted comparative analysis","volume":"29","author":"Jahangiri","year":"2025","journal-title":"Hernia"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.surg.2021.03.027","article-title":"Fascial closure in giant ventral hernias after preoperative botulinum toxin a and progressive pneumoperitoneum: A systematic review and meta-analysis","volume":"170","author":"Yurtkap","year":"2021","journal-title":"Surgery"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Zamkowski, M., Bullock, J., Aim, A., Alhasso, A., Boermeester, M.A., Capoccia Giovannini, S., de Beaux, A., East, B., Hern\u00e1ndez-Granados, P., and Klugar, M. (2025). Patient-Reported Outcomes After Preoperative Botulinum Toxin A Injection Prior to Abdominal Wall Hernia Surgery: An International Survey. J. Abdom. Wall Surg., 4.","DOI":"10.3389\/jaws.2025.15523"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1007\/s00464-025-11921-z","article-title":"The new bridge to hernia surgery: Achieving preoperative weight optimization with GLP-1 receptor agonists for abdominal wall hernia repair","volume":"39","author":"Spurzem","year":"2025","journal-title":"Surg. Endosc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Xu, S., Tu, S., Hao, X., Chen, X., Pan, D., Liao, W., Wu, R., Yang, L., Xia, H., and Wang, S. (2025). Exercise, Nutrition, and Neuromuscular Electrical Stimulation for Sarcopenic Obesity: A Systematic Review and Meta-Analysis of Management in Middle-Aged and Older Adults. Nutrients, 17.","DOI":"10.3390\/nu17091504"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nakashima, Y., Iwaki, D., Kataoka, Y., Ariie, T., Taito, S., Nishikawa, Y., Mio, N., and Mikami, Y. (2023). Efficacy of neuromuscular electrical stimulation for thoracic and abdominal surgery: A systematic review and meta-analysis. PLoS ONE, 18.","DOI":"10.1371\/journal.pone.0294965"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"zrad142","DOI":"10.1093\/bjsopen\/zrad142","article-title":"Safety of core muscle training immediately after abdominal surgery: Systematic review","volume":"7","author":"Perrodin","year":"2023","journal-title":"BJS Open"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Schaaf, S., Schwab, R., G\u00fcsgen, C., Vilz, T.O., and Willms, A. (2021). Recommendations on Postoperative Activities After Abdominal Operations and Incisional Hernia Repair-A National and International Survey. Front. Surg., 8.","DOI":"10.3389\/fsurg.2021.713138"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s10029-021-02377-w","article-title":"Recommendations on postoperative strain and physical labor after abdominal and hernia surgery: An expert survey of attendants of the 41st EHS Annual International Congress of the European Hernia Society","volume":"26","author":"Schaaf","year":"2022","journal-title":"Hernia"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/8\/419\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:10:34Z","timestamp":1786021834000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/16\/8\/419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":38,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["jpm16080419"],"URL":"https:\/\/doi.org\/10.3390\/jpm16080419","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]}}}