{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T09:32:06Z","timestamp":1780047126247,"version":"3.53.1"},"reference-count":118,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Exposure to ionizing radiation (IR) could affect the human brain and eyes leading to both cognitive and visual impairments. The aim of this paper was to review and analyze the current literature, and to comment on the ensuing findings in the light of our personal contributions in this field. The review was carried out according to the PRISMA guidelines by searching PubMed, Scopus, Embase, PsycINFO and Google Scholar English papers published from January 2000 to January 2020. The results showed that prenatally or childhood-exposed individuals are a particular target group with a higher risk for possible radiation effects and neurodegenerative diseases. In adulthood and medical\/interventional radiologists, the most frequent IR-induced ophthalmic effects include cataracts, glaucoma, optic neuropathy, retinopathy and angiopathy, sometimes associated with specific neurocognitive deficits. According to available information that eye alterations may induce or may be associated with brain dysfunctions and vice versa, we propose to label this relationship \u201ceye-brain axis\u201d, as well as to deepen the diagnosis of eye pathologies as early and easily obtainable markers of possible low dose IR-induced brain damage.<\/jats:p>","DOI":"10.3390\/life10040041","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T13:01:39Z","timestamp":1587042099000},"page":"41","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Radiation-Induced Cerebro-Ophthalmic Effects in Humans"],"prefix":"10.3390","volume":"10","author":[{"given":"Konstantin N.","family":"Loganovsky","sequence":"first","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Marazziti","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale Section of Psychiatry, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavlo A.","family":"Fedirko","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostiantyn V.","family":"Kuts","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina Y.","family":"Antypchuk","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna V.","family":"Perchuk","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetyana F.","family":"Babenko","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetyana K.","family":"Loganovska","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena O.","family":"Kolosynska","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Y.","family":"Kreinis","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina V.","family":"Gresko","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-9674","authenticated-orcid":false,"given":"Sergii V.","family":"Masiuk","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9746-8237","authenticated-orcid":false,"given":"Federico","family":"Mucci","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Clinica e Sperimentale Section of Psychiatry, University of Pisa, Via Roma, 67, I 56100 Pisa, Italy"},{"name":"Dipartimento di Biochimica Biologia Molecolare, University of Siena, 53100 Siena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid L.","family":"Zdorenko","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation 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Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raisa Y.","family":"Dorichevska","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlata L.","family":"Vasilenko","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor I.","family":"Kravchenko","sequence":"additional","affiliation":[{"name":"National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, 53 Illyenko Street, 04050 Kyiv, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya 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Environ. Radioact."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s13246-016-0445-y","article-title":"Reducing absorbed dose to eye lenses in head CT examinations: The effect of bismuth shielding","volume":"39","author":"Ciarmatori","year":"2016","journal-title":"Phys. Eng. Sci. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.exer.2017.09.009","article-title":"Exposing primary rat retina cell cultures to \u03b3-rays: An in vitro model for evaluating radiation responses","volume":"166","author":"Gaddini","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.icrp.2012.02.001","article-title":"ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs\u2014Threshold doses for tissue reactions in a radiation protection context","volume":"41","author":"Stewart","year":"2012","journal-title":"Ann. ICRP"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1093\/jrr\/rru036","article-title":"Emerging issues in radiogenic cataracts and cardiovascular disease","volume":"55","author":"Hamada","year":"2014","journal-title":"J. Radiat. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1161\/CIRCULATIONAHA.117.031251","article-title":"Low-dose exposure to ionizing radiation deregulates the brain-specific microRNA-134 in interventional cardiologists","volume":"136","author":"Borghini","year":"2017","journal-title":"Circulation"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., and PRISMA Group (2009). Preferred reporting items for systematic reviews and meta analyses: The PRISMA statement. PLoS Med., 6.","DOI":"10.1371\/journal.pmed.1000097"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/MPH.0000000000001142","article-title":"Radiation-induced cataracts in children with brain tumors receiving craniospinal irradiation","volume":"40","author":"Whelan","year":"2018","journal-title":"J. Pediatr. Hematol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1093\/rpd\/ncx251","article-title":"Direct measurements of skin, eye lens and thyroid dose during pediatric brain ct examinations","volume":"179","author":"Ploussi","year":"2018","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/0284185118770894","article-title":"Topogram-based tube current modulation of head computed tomography for optimizing image quality while protecting the eye lens with shielding","volume":"60","author":"Lin","year":"2019","journal-title":"Acta Radiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.2214\/AJR.17.18261","article-title":"Lens dose reduction by patient posture modification during neck CT","volume":"210","author":"Mosher","year":"2018","journal-title":"Am. J. Roentgenol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2967\/jnmt.117.192849","article-title":"Corneal dose reduction using a bismuth-coated latex shield over the eyes during brain SPECT\/CT","volume":"45","author":"Matsutomo","year":"2017","journal-title":"J. Nucl. Med. Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1097\/00004032-199505000-00002","article-title":"Prevalence of lens changes in ukrainian children residing around Chernobyl","volume":"68","author":"Day","year":"1995","journal-title":"Health Phys."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1667\/RR0298.1","article-title":"Cataracts among Chernobyl clean-up workers: Implications regarding permissible eye exposures","volume":"167","author":"Worgul","year":"2007","journal-title":"Radiat. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wang, T.V., Chen, J.C., Guo, G.L., Wu, S.F., Hwang, B.F., Chen, J.Y., Lee, Y.M., and Chang, W.P. (1999). Prevalence of lens opacity in population with chronic low-dose gamma-radiation exposure from radioactive apartments in Taiwan. Ocular Radiation Risk Assessment in Populations Exposed to Environmental Radiation Contamination, Springer Science & Business Media.","DOI":"10.1007\/978-94-011-5278-5_21"},{"key":"ref_16","first-page":"155","article-title":"The state of the lens in children residing in the zone of radioactive contamination\u2014Analysis of results of a long-term observation","volume":"2","author":"Fedirko","year":"1998","journal-title":"Ophtalmol. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/bdr2.1551","article-title":"Nuclear radiation and prevalence of structural birth defects among infants born to women from the Marshall Islands","volume":"111","author":"Nembhard","year":"2019","journal-title":"Birth Defects Res."},{"key":"ref_18","unstructured":"Babenko, T.F. (2013). Clinical and Epidemiological Characteristics of the Organ of Vision of Persons Irradiated Prenatally Due to the Chernobyl Catastrophe. [Ph.D. Thesis, National Research Centre for Radiation Medicine of National Academy of Medical sciences of Ukraine]."},{"key":"ref_19","first-page":"407","article-title":"Radiation exposed in utero as result of Chernobyl catastrophe: Prevalence and relative risks of eye illnesses","volume":"108","author":"Fedirko","year":"2011","journal-title":"Probl. Ecol. Med. Genet. Clin. Immunol."},{"key":"ref_20","first-page":"359","article-title":"Prevalence and dose dependence pathology in chidren irradiated antenataly as a result of the Chornobyl accident","volume":"16","author":"Babenko","year":"2011","journal-title":"Probl. Radiat. Med. Radiobiol."},{"key":"ref_21","first-page":"67","article-title":"Clinical features of eye diseases in irradiated in utero due to the Chernobyl disaster","volume":"2","author":"Babenko","year":"2013","journal-title":"Ophthalmology"},{"key":"ref_22","unstructured":"Bazyka, D., Sushko, V., and Chumak, A. (2016). Eye pathology in the exposed prenatally as a result of the Chernobyl Disaster. Health Effects of the Chernobyl Accident\u2014Thirty Years Aftermath, DIA Publishing House."},{"key":"ref_23","first-page":"359","article-title":"Prevalence and dose-related ophthalmologic pathologies in antenatelly exposed childrenas a result od the Chernobyl disaster","volume":"16","author":"Babenko","year":"2011","journal-title":"Probl. Radiat. Med. Radiobiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"467","DOI":"10.33145\/2304-8336-2015-20-467-473","article-title":"Retinal vascular pathology risk development in the irradiated at different ages as a result of Chernobyl NPP accident","volume":"20","author":"Fedirko","year":"2015","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.33145\/2304-8336-2016-21-172-177","article-title":"The risk of macular degeneration development in persons antenatally irradiated as a result of Chernobyl NPP accident","volume":"21","author":"Babenko","year":"2016","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1176\/jnp.2008.20.3.274","article-title":"Disrupted development of the dominant hemisphere following prenatal irradiation","volume":"20","author":"Loganovsky","year":"2008","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_27","first-page":"91","article-title":"Effects of prenatal brain irradiation as a result of the Chernobyl accident","volume":"6","author":"Nyagu","year":"2004","journal-title":"Int. J. Radiat. Med."},{"key":"ref_28","first-page":"130","article-title":"Psychophysiological effects in prenatally irradiated children and adolescents after the Chernobyl NPP accident","volume":"4","author":"Loganovska","year":"2004","journal-title":"Med. Universe"},{"key":"ref_29","unstructured":"Loganovska, T.K. (2005). Mental Disorders in Children Exposed to Prenatal Radiation after the Chernobyl NPP Accident. [Ph.D. Thesis, Research Center for Radiation Medicine of Academy of Medical Sciences of Ukraine]."},{"key":"ref_30","unstructured":"Francesco, C. (2018). Psychophysiology research in the detection of ionizing radiation effects. Advances in Psychobiology, Nova Science Publishers."},{"key":"ref_31","first-page":"69","article-title":"Visual vertex potential and psychopathology of children irradiated in utero","volume":"35","author":"Loganovskaja","year":"2000","journal-title":"Int. J. Psychophysiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Vision Loss Expert Group of the Global Burden of Disease Study. Global causes of blindness and distance vision impairment 1990\u20132020: A systematic review and meta-analysis","volume":"6","author":"Flaxman","year":"2017","journal-title":"Lancet Glob Health"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1136\/bjophthalmol-2011-300539","article-title":"Global estimates of visual impairment: 2010","volume":"96","author":"Pascolini","year":"2012","journal-title":"Br. J. Ophthalmol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0140-6736(05)70803-5","article-title":"Age-related cataract","volume":"365","author":"Asbell","year":"2005","journal-title":"Lancet"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2307\/3580093","article-title":"Lenticular opacities in individuals exposed to ionizing radiation in infancy","volume":"152","author":"Hall","year":"1999","journal-title":"Radiat. Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.icrp.2012.06.018","article-title":"Radiation cataract","volume":"41","author":"Kleiman","year":"2012","journal-title":"Ann. ICRP"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/09553002.2018.1439194","article-title":"Oxidative and nitrative stress-related changes in human lens epithelial cells following exposure to X-rays","volume":"94","author":"Bahia","year":"2018","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_38","first-page":"372","article-title":"Experimental radiation cataract\u2014Its clinical relevance","volume":"59","author":"Merriam","year":"1983","journal-title":"Bull. N. Y. Acad. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/01.HP.0000175442.03596.63","article-title":"A reanalysis of atomic-bomb cataract data, 2000\u20132002: A threshold analysis","volume":"90","author":"Nakashima","year":"2006","journal-title":"Health Phys."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1667\/RR0928.1","article-title":"Postoperative cataract cases among atomic bomb survivors: Radiation dose response and threshold","volume":"168","author":"Neriishi","year":"2007","journal-title":"Radiat. Res."},{"key":"ref_41","unstructured":"Fedirko, P.A. (2016). Specific Radiation Damages of the Eye. Thirty Years of Chernobyl Catastrophe: Radiological and Health Effects: National Report of Ukraine, National Academy of Medical Sciences of Ukraine, National Research Centre for Radiation Medicine."},{"key":"ref_42","first-page":"46","article-title":"Radiation cataracts as a delayed effect of the Chernobyl accident","volume":"2","author":"Fedirko","year":"2000","journal-title":"Data Sci. Res."},{"key":"ref_43","unstructured":"Fedirko, P.A. (1993). Methods of Detecting Lens Radiation Damage: Methodical Recommendations, National Academy of Medical Sciences of Ukraine, National Research Centre for Radiation Medicine."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1667\/rr1122.1","article-title":"Mrad9 and Atm haploinsufficiency enhance spontaneous and x-ray-induced cataractogenesis in Mice","volume":"168","author":"Kleiman","year":"2007","journal-title":"Radiat. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S162","DOI":"10.1016\/j.survophthal.2007.08.012","article-title":"What is the present pathogenetic concept of glaucomatous optic neuropathy?","volume":"52","author":"Flammer","year":"2007","journal-title":"Surv. Ophthalmol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1667\/RR3273.2","article-title":"Glaucoma in atomic bomb survivors","volume":"180","author":"Kiuchi","year":"2013","journal-title":"Radiat. Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-45049-7","article-title":"Association between radiation, glaucoma subtype, and retinal vessel diameter in atomic bomb survivors","volume":"9","author":"Kiuchi","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"332","DOI":"10.33145\/2304-8336-2017-22-332-338","article-title":"Radiation induced violations of blood circulation in the ciliary body and changes of the anterior chamber angle in the pathogenesis of glaucoma in clean up workers of the Chernobyl NPP accident and residents of contaminated areas","volume":"22","author":"Garkava","year":"2017","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_49","first-page":"139","article-title":"The peculiarities of angle of anterior chamber and iris in persons, radiation-exposed as a result of the Chornobyl accident and their significance for choice of open-angle glaucoma treatment","volume":"16","author":"Fedirko","year":"2013","journal-title":"Tavrian Med. Biol. Bull."},{"key":"ref_50","first-page":"194","article-title":"The peculiarities of clinical course and treatment of open-angle glaucoma in persons, radiation-exposed as a result of Chernobyl accident","volume":"15","author":"Fedirko","year":"2012","journal-title":"Tavrian Med. Biol. Bull."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/S0161-6420(01)00797-7","article-title":"Plaque radiotherapy for retinoblastoma: Long-term tumor control and treatment complications in 208 tumors","volume":"108","author":"Shields","year":"2001","journal-title":"Ophthalmology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1001\/archopht.120.7.933","article-title":"Combined plaque radiotherapy and transpupillary thermotherapy for choroidal melanoma: Tumor control and treatment complications in 270 consecutive patients","volume":"120","author":"Shields","year":"2002","journal-title":"Arch. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0167-8140(02)00345-6","article-title":"LINAC based stereotactic radiotherapy of uveal melanoma: 4 years clinical experience","volume":"67","author":"Dieckmann","year":"2003","journal-title":"Radiother. Oncol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0360-3016(99)00057-7","article-title":"Late retinal complications of radiation therapy for nasal and paranasal malignancies: Relationship between irradiated-dose area and severity","volume":"44","author":"Takeda","year":"1999","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mrrev.2019.01.001","article-title":"Glaucomagenesis following ionizing radiation exposure","volume":"779","author":"Hamada","year":"2019","journal-title":"Mutat. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1667\/RR13680.1","article-title":"Cerebrovascular diseases incidence and mortality in an extended Mayak Worker Cohort 1948\u20131982","volume":"182","author":"Azizova","year":"2014","journal-title":"Radiat. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/01.HP.0000282195.34508.b0","article-title":"Late cancer and noncancer risks among Chernobyl emergency workers of Russia","volume":"93","author":"Ivanov","year":"2007","journal-title":"Health Phys."},{"key":"ref_58","first-page":"9","article-title":"Epidemiology of non-cancer diseases among Chernobyl accident recovery operation workers","volume":"3","author":"Buzunov","year":"2001","journal-title":"Int. J. Radiat. Med."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/opo.12297","article-title":"Neurodegeneration beyond the primary visual pathways in a population with a high incidence of normal-pressure glaucoma","volume":"36","author":"Boucard","year":"2016","journal-title":"Ophthalmic Physiol. Opt."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.brainres.2019.05.006","article-title":"Combined machine learning and diffusion tensor imaging reveals altered anatomic fiber connectivity of the brain in primary open-angle glaucoma","volume":"1718","author":"Qu","year":"2019","journal-title":"Brain Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1167\/iovs.17-23597","article-title":"White matter abnormalities and correlation with severity in normal tension glaucoma: A whole brain atlas-based diffusion tensor study","volume":"59","author":"Wang","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep31464","article-title":"Retinal Structures and visual cortex activity are impaired prior to clinical vision loss in glaucoma","volume":"6","author":"Murphy","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/brain\/awy338","article-title":"Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease","volume":"142","author":"You","year":"2019","journal-title":"Brain"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"64","DOI":"10.33145\/2304-8336-2016-21-64-90","article-title":"Ionizing radiation: Brain effects and related neuropsychiatric manifestations","volume":"21","author":"Marazziti","year":"2016","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2481\/dsj.BR-04","article-title":"Do low doses of ionizing radiation affect the human brain?","volume":"8","author":"Loganovsky","year":"2009","journal-title":"Data Sci. J."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/0360-3016(92)90938-E","article-title":"Stereotactic radiotherapy for pediatric and adult brain tumors: Preliminary report","volume":"30","author":"Dunbar","year":"1994","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1207\/S15324826AN0803_1","article-title":"Memory performance used to detect radiation effects on cognitive functioning","volume":"8","author":"Armstrong","year":"2001","journal-title":"Appl. Neuropsychol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0278-2626(03)00269-0","article-title":"The impact of frontal and non-frontal brain tumor lesions on Wisconsin Card Sorting Test performance","volume":"54","author":"Goldstein","year":"2004","journal-title":"Brain Cogn."},{"key":"ref_69","first-page":"82","article-title":"Estimation of the multiple sclerosis risk in population living on contaminated territories after the Chernobyl catastrophe","volume":"18","author":"Kolosynska","year":"2013","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/WNO.0000000000000670","article-title":"Radiation-induced optic neuropathy: Clinical and imaging profile of twelve patients","volume":"39","author":"Archer","year":"2019","journal-title":"J. Neuro Ophthalmol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/08820538.2017.1346133","article-title":"Factors associated with occurrence of radiation-induced optic neuropathy at \u2019safe\u2019 radiation dosage","volume":"33","author":"Tamhankar","year":"2018","journal-title":"Semin. Ophthalmol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ajoc.2016.06.008","article-title":"Radiation optic neuropathy and retinopathy with low dose (20 Gy) radiation treatment","volume":"3","author":"Peeler","year":"2016","journal-title":"Am. J. Ophthalmol. Case Rep."},{"key":"ref_73","unstructured":"Serdiuk, A., Bebeshko, V., and Bazyka, D. (2016). Eye: Clinic, diagnostics, regularities and risks for development of eye pathology in Chernobyl catastrophe sufferers. Health Effects of the Chernobyl Accident\u2013Thirty Years Aftermath, National Academy of Medical Sciences of Ukraine, National Research Centre for Radiation Medicine."},{"key":"ref_74","first-page":"24","article-title":"Patterns of development of retinal vascular pathology at remote time period after radiation exposure","volume":"6","author":"Fedirko","year":"2016","journal-title":"J. Ophthalmol."},{"key":"ref_75","unstructured":"Fedirko, P.A. (2002). Clinical and Epidemiological Study of Occupational Diseases of the Organ of Vision in the victims of the Chernobyl Accident (Patterns of Development, Risks, Prognosis). [Ph.D. Thesis, Institute of Occupational Medicine, Academy of Medical Sciences of Ukraine]."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"481","DOI":"10.33145\/2304-8336-2018-23-481-489","article-title":"Morphometric parameters of retinal macular zone in reconvalescents of acute radiation sickness (in remote period)","volume":"23","author":"Fedirko","year":"2018","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.meddos.2017.07.007","article-title":"Risk of dry eye syndrome in patients treated with whole-brain radiotherapy","volume":"42","author":"Nanda","year":"2017","journal-title":"Med. Dosim."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s11060-016-2071-7","article-title":"Optic toxicity in radiation treatment of meningioma: A retrospective study in 213 patients","volume":"127","author":"Farzin","year":"2016","journal-title":"J. Neurooncol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1080\/09553002.2017.1304669","article-title":"Guidance on radiation dose limits for the lens of the eye: Overview of the recommendations in NCRP Commentary No. 26","volume":"93","author":"Dauer","year":"2017","journal-title":"Int. J. Radiat. Biol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/rpd\/nci725","article-title":"Patient and staff doses in interventional neuroradiology","volume":"117","author":"Bor","year":"2005","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1136\/bmj.328.7439.578","article-title":"Sustainability of medical imaging","volume":"328","author":"Picano","year":"2004","journal-title":"BMJ"},{"key":"ref_82","unstructured":"(2019, December 31). United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), Sources and Effects of Ionizing Radiation, United Nations, New York. Available online: https:\/\/www.unscear.org\/docs\/publications\/2010\/UNSCEAR_2010_Report.pdf."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1136\/neurintsurg-2015-011703","article-title":"The value of protective head cap and glasses in neurointerventional radiology","volume":"8","author":"Korchi","year":"2016","journal-title":"J. Neurointerv. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jcin.2016.11.026","article-title":"Head and neck radiation dose and radiation safety for interventional physicians","volume":"10","author":"Fetterly","year":"2017","journal-title":"JACC Cardiovasc. Interv."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jvir.2016.11.043","article-title":"Radiation cataractogenesis: The progression of our understanding and its clinical consequences","volume":"28","author":"Khan","year":"2017","journal-title":"J. Vasc. Interv. Radiol."},{"key":"ref_86","first-page":"471","article-title":"Evaluation of the current status of the eye lens radiation exposure in an Interventional Radiology department","volume":"109","author":"Pugliese","year":"2018","journal-title":"Med. Lav."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ejmp.2017.11.002","article-title":"Eye lens radiation exposure of the medical staff performing interventional urology procedures with an over-couch X-ray tube","volume":"43","author":"Medici","year":"2017","journal-title":"Phys. Med."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1093\/rpd\/ncs116","article-title":"Eye lens radiation exposure to interventional cardiologists: A retrospective assessment of cumulative doses","volume":"153","author":"Jacob","year":"2013","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"237","DOI":"10.5271\/sjweh.3152","article-title":"Lens opacities among physicians occupationally exposed to ionizing radiation--A pilot study in Finland","volume":"37","author":"Mrena","year":"2011","journal-title":"Scand. J. Work Environ. Health"},{"key":"ref_90","doi-asserted-by":"crossref","unstructured":"Picano, E., Vano, E., Domenici, L., Bottai, M., and Thierry-Chef, I. (2012). Cancer and non-cancer brain and eye effects of chronic low-dose ionizing radiation exposure. BMC Cancer, 12.","DOI":"10.1186\/1471-2407-12-157"},{"key":"ref_91","first-page":"344","article-title":"Eye lens radiation exposure in Greek interventional cardiology article","volume":"175","author":"Thrapsanioti","year":"2017","journal-title":"Radiat. Prot. Dosim."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/ccd.27173","article-title":"Radiation-associated lens changes in the cardiac catheterization laboratory: Results from the IC-CATARACT (CATaracts Attributed to RAdiation in the CaTh lab) study","volume":"91","author":"Karatasakis","year":"2018","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1088\/0952-4746\/36\/3\/561","article-title":"InterCardioRisk: A novel online tool for estimating doses of ionising radiation to occupationally-exposed medical staff and their associated health risks","volume":"36","author":"Grellier","year":"2016","journal-title":"J. Radiol. Prot."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"e003273","DOI":"10.1161\/CIRCINTERVENTIONS.115.003273","article-title":"Occupational health risks in cardiac catheterization laboratory workers","volume":"9","author":"Andreassi","year":"2016","journal-title":"Circ. Cardiovasc. Interv."},{"key":"ref_95","unstructured":"The 2007 Recommendations of the International Commission on Radiological Protection (2007). ICRP publication 103. Ann. ICRP, 37, 1\u2013332."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1177\/0146645314562322","article-title":"Implications in medical imaging of the new ICRP thresholds for tissue reactions","volume":"44","author":"Miller","year":"2015","journal-title":"Ann. ICRP"},{"key":"ref_97","unstructured":"International Atomic Energy Agency (2019, December 31). IAEA Annual Report 2012. Available online: https:\/\/www.iaea.org\/sites\/default\/files\/publications\/reports\/2012\/anrep2012_full.pdf."},{"key":"ref_98","unstructured":"National Council on Radiation Protection and Measurements (2019, December 31). NCRP Annual Report 2011. Available online: http:\/\/ncrponline.org\/wp-content\/themes\/ncrp\/PDFs\/NCRP_2011_Annual_Rpt.pdf."},{"key":"ref_99","unstructured":"United Nations Scientific Committee on the Effects of Atomic Radiation (2019, December 31). Sources and Effects of Ionizing Radiation 2000. Available online: http:\/\/www.unscear.org\/unscear\/en\/publications\/2000_1.html."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"105017","DOI":"10.1088\/1361-6560\/aab955","article-title":"A scalable and deformable stylized model of the adult human eye for radiation dose assessment","volume":"63","author":"Furuta","year":"2018","journal-title":"Phys. Med. Biol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"5008","DOI":"10.1523\/JNEUROSCI.2433-16.2017","article-title":"Selective modulation of the pupil light reflex by microstimulation of prefrontal cortex","volume":"37","author":"Ebitz","year":"2017","journal-title":"J. Neurosci."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neulet.2017.08.073","article-title":"Light deprivation produces distinct morphological orchestrations on RGCs and cortical cells in a depressive-like YFP-H mouse model","volume":"659","author":"Lu","year":"2017","journal-title":"Neurosci. Lett."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuroscience.2016.11.026","article-title":"Alterations of motor cortical microcircuit in a depressive-like mouse model produced by light deprivation","volume":"341","author":"Zhang","year":"2017","journal-title":"Neuroscience"},{"key":"ref_104","first-page":"200","article-title":"Depression and ionizing radiation","volume":"18","author":"Loganovsky","year":"2013","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"373","DOI":"10.33145\/2304-8336-2018-23-373-409","article-title":"Neuropsychobiological mechanisms of affective and cognitive disorders in the Chernobyl clean-up workers taking into account the specific gene polymorphisms","volume":"23","author":"Loganovsky","year":"2018","journal-title":"Probl. Radiac. Med. Radiobiol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e184406","DOI":"10.1001\/jamanetworkopen.2018.4406","article-title":"Association of retinal nerve fiber layer thickness with brain alterations in the visual and limbic networks in elderly adults without dementia","volume":"1","author":"Pelletier","year":"2018","journal-title":"JAMA Netw. Open"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3233\/JAD-160067","article-title":"The association between retinal neuronal layer and brain structure is disrupted in patients with cognitive impairment and Alzheimer\u2019s disease","volume":"54","author":"Liu","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-141239","article-title":"Diffusion tensor imaging reveals visual pathway damage in patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"45","author":"Nishioka","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nicl.2017.01.012","article-title":"Lateralized occipital degeneration in posterior cortical atrophy predicts visual field deficits","volume":"14","author":"Millington","year":"2017","journal-title":"Neuroimage Clin."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1007\/s00429-018-1702-5","article-title":"Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage","volume":"223","author":"Yoshimine","year":"2018","journal-title":"Brain Struct Funct."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1097\/WNR.0000000000001135","article-title":"Microstructural differences in visual white matter tracts in people with aniridia","volume":"29","author":"Burton","year":"2018","journal-title":"Neuroreport"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/bjophthalmol-2014-305809","article-title":"Alteration of the optic radiations using diffusion-tensor MRI in patients with retinitis pigmentosa","volume":"99","author":"Ohno","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e727","DOI":"10.1111\/aos.13797","article-title":"Retinal perfusion changes in radiation retinopathy","volume":"96","author":"Rose","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.lssr.2014.06.003","article-title":"Space radiation risks to the central nervous system","volume":"2","author":"Cucinotta","year":"2014","journal-title":"Life Sci. Space Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.preteyeres.2017.07.001","article-title":"Phosphenes, retinal discrete dark noise, negative afterimages and retinogeniculate projections: A new explanatory framework based on endogenous ocular luminescence","volume":"60","author":"Salari","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_116","first-page":"449","article-title":"Phosphenes in low earth orbit: Survey responses from 59 astronauts","volume":"77","author":"Fuglesang","year":"2006","journal-title":"Aviat. Space Environ. Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jphotobiol.2011.03.011","article-title":"Visible light induced ocular delayed bioluminescence as a possible origin of negative afterimage","volume":"103","author":"Vimal","year":"2011","journal-title":"J. Photoch. Photobio. B"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"075010","DOI":"10.1088\/1367-2630\/10\/7\/075010","article-title":"Heavy ions light flashes and brain functions: Recent observations at accelerators and in spaceflight","volume":"10","author":"Narici","year":"2008","journal-title":"New J. Phys."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/10\/4\/41\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:30:53Z","timestamp":1760362253000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/10\/4\/41"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":118,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["life10040041"],"URL":"https:\/\/doi.org\/10.3390\/life10040041","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,16]]}}}