{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:13:21Z","timestamp":1792548801554,"version":"4.5.0"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Seoul National University Bundang Hospital research fund","award":["no. 13-2014-003"],"award-info":[{"award-number":["no. 13-2014-003"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Abnormal histone modification by histone deacetylases (HDACs), including HDAC1 and sirtuin 1 (SIRT1), has been reported to play an important role in the pathogenesis of psoriasis by altering cell proliferation, differentiation, and inflammation. However, findings on the expression level of HDACs in psoriatic skin lack consistency. We assessed the expression of HDAC1, SIRT1, p63, and proliferating cell nuclear antigen (PCNA) in skin tissues from 23 patients with psoriasis (15 with plaque psoriasis and eight with guttate psoriasis) and five healthy individuals using immunohistochemistry, and analyzed their associations with clinical phenotypes of the disease. The expression of HDAC1 and keratinocyte proliferative markers, such as p63 and PCNA significantly increased, whereas that of SIRT1 decreased in the basal layer (p &lt; 0.05) of the patients with psoriasis compared to those in healthy controls. Among the patients with psoriasis, expression of HDAC1, p63, and PCNA was significantly higher in plaque psoriasis than in guttate psoriasis. There was no significant differences in the level of SIRT1 between the two clinical phenotypes. The findings of this study suggest that histone modifications are involved in the pathogenesis of psoriasis and may contribute to the formation of clinical phenotypes.<\/jats:p>","DOI":"10.3390\/life10090157","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T09:21:51Z","timestamp":1598001711000},"page":"157","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Histone Deacetylase 1 and Sirtuin 1 Expression in Psoriatic Skin: A Comparison between Guttate and Plaque Psoriasis"],"prefix":"10.3390","volume":"10","author":[{"given":"Young-Ji","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Im","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Young","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon-Hyo","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hye","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Sun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ryung","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2468-485X","authenticated-orcid":false,"given":"Soyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University College of Medicine, Seoul 03080, Korea"},{"name":"Institute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul 03080, Korea"},{"name":"Department of Dermatology, Seoul National University Boramae Hospital, Seoul 07061, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Woong","family":"Youn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung-Chan","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul National University Bundang Hospital, Seongnam 13620, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/nature05663","article-title":"Pathogenesis and therapy of psoriasis","volume":"445","author":"Lowes","year":"2007","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1365-2133.2006.07675.x","article-title":"A classification of psoriasis vulgaris according to phenotype","volume":"156","author":"Griffiths","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2133.2007.08307.x","article-title":"Explaining phenotype heterogeneity in patients with psoriasis","volume":"158","author":"Christophers","year":"2008","journal-title":"Br. J. Dermatol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1365-2133.2012.11038.x","article-title":"A comparison of serum inflammatory cytokines according to phenotype in patients with psoriasis","volume":"167","author":"Choe","year":"2012","journal-title":"Br. J. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature05913","article-title":"Perceptions of epigenetics","volume":"447","author":"Bird","year":"2007","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"J207","DOI":"10.1016\/j.jaut.2009.12.006","article-title":"Epigenetics and autoimmunity","volume":"34","author":"Brooks","year":"2010","journal-title":"J. Autoimmun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1158\/1535-7163.MCT-13-0626","article-title":"Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities","volume":"12","author":"Newbold","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1073\/pnas.052702999","article-title":"The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines","volume":"99","author":"Leoni","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd4360","article-title":"Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders","volume":"13","author":"Falkenberg","year":"2014","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_10","first-page":"399","article-title":"Histone deacetylase inhibitors as potential anti-skin cancer agents","volume":"59","author":"Saunders","year":"1999","journal-title":"Cancer Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/ijc.1602","article-title":"Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis","volume":"97","author":"Kwon","year":"2002","journal-title":"Int. J. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-4632.2006.02962.x","article-title":"Under-expression of VHL and over-expression of HDAC-1, HIF-1alpha, LL-37, and IAP-2 in affected skin biopsies of patients with psoriasis","volume":"46","year":"2007","journal-title":"Int. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1684\/ejd.2011.1383","article-title":"Abnormal histone modifications in PBMCs from patients with psoriasis vulgaris","volume":"21","author":"Zhang","year":"2011","journal-title":"Eur. J. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/bjd.14021","article-title":"Lack of preclinical support for the efficacy of histone deacetylase inhibitors in the treatment of psoriasis","volume":"174","author":"Ekman","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1056\/NEJMra1100831","article-title":"Epstein Lecture: Sirtuins, aging, and medicine","volume":"364","author":"Guarente","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00403-013-1320-2","article-title":"Sirtuins in dermatology: Applications for future research and therapeutics","volume":"305","author":"Serravallo","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jid.2016.11.044","article-title":"SIRT1, a Class III Histone Deacetylase, Regulates LPS-Induced Inflammation in Human Keratinocytes and Mediates the Anti-Inflammatory Effects of Hinokitiol","volume":"137","author":"Lee","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbrc.2012.01.148","article-title":"SIRT1 overexpression decreases cisplatin-induced acetylation of NF-kappaB p65 subunit and cytotoxicity in renal proximal tubule cells","volume":"419","author":"Jung","year":"2012","journal-title":"Biochem. Bioph. Res. Commun."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/jid.2008.179","article-title":"SIRT1 promotes differentiation of normal human keratinocytes","volume":"129","author":"Blander","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1096\/fj.10-172288","article-title":"STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation","volume":"25","author":"Sestito","year":"2011","journal-title":"FASEB J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s11739-016-1482-y","article-title":"SIRT1 activity is decreased in lesional psoriatic skin","volume":"11","author":"Becatti","year":"2016","journal-title":"Intern. Emerg. Med."},{"key":"ref_22","first-page":"157","article-title":"Abnormal expression of SIRTs in psoriasis: Decreased expression of SIRT 1-5 and increased expression of SIRT 6 and 7","volume":"44","author":"Fan","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Becatti, M., Barygina, V., Mannucci, A., Emmi, G., Prisco, D., Lotti, T., Fiorillo, C., and Taddei, N. (2018). Sirt1 Protects against Oxidative Stress-Induced Apoptosis in Fibroblasts from Psoriatic Patients: A New Insight into the Pathogenetic Mechanisms of Psoriasis. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061572"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/ar.22641","article-title":"Quantitative analysis of histological staining and fluorescence using Image","volume":"296","author":"Jensen","year":"2013","journal-title":"Anat. Rec. (Hoboken)"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1111\/j.1600-0846.2012.00616.x","article-title":"Evaluation epidermal p53 immunostaining by digital image analysis","volume":"19","author":"Brianezi","year":"2013","journal-title":"Skin Res. Technol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00403-018-1808-x","article-title":"Treatment preferences and treatment satisfaction among psoriasis patients: A systematic review","volume":"310","author":"Florek","year":"2018","journal-title":"Arch. Dermatol. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1038\/sj.emboj.7600244","article-title":"Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase","volume":"23","author":"Yeung","year":"2004","journal-title":"EMBO J."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Zhu, X., Liu, Q., Wang, M., Liang, M., Yang, X., Xu, X., Zou, H., and Qiu, J. (2011). Activation of Sirt1 by resveratrol inhibits TNF-\u03b1 induced inflammation in fibroblasts. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0027081"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3892\/or.2015.4332","article-title":"Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1","volume":"35","author":"Lee","year":"2016","journal-title":"Oncol. Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2174\/1568010043343859","article-title":"Histone deacetylase inhibitors in psoriasis therapy","volume":"3","author":"McLaughlin","year":"2004","journal-title":"Cur. Drug Targets Inflamm. Allergy"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Krueger, J.G., Su\u00e1rez-Fari\u00f1as, M., Cueto, I., Khacherian, A., Matheson, R., Parish, L.C., Leonardi, C., Shortino, D., Gupta, A., and Haddad, J. (2015). A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis. 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