{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:23:14Z","timestamp":1778883794222,"version":"3.51.4"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This retrospective study investigated factors influencing the portal vein thrombosis (PVT) volume and recurrence in 52 cirrhosis patients with PVT from November 2008 to September 2018. All patients were treated with danaparoid sodium with or without additional antithrombin III. Blood platelet counts significantly correlated with the PVT volume (r2 = 0.17; P &lt; 0.01). Computed tomography confirmed recurrence as PVT aggravation was reported in 43 patients, with \u226550% PVT volume reduction following anticoagulation therapy. In 43 patients, recurrence significantly correlated with the pretreatment PVT volume (P = 0.019). Factors influencing recurrence included a Child\u2013Pugh score &gt;8 (P = 0.049) and fibrosis index \u22647.0 based on four factors (FIB-4) (P = 0.048). Moreover, the relationship between recurrence and correlating factors showed that 15 patients who received warfarin experienced recurrence more often when Child\u2013Pugh scores were &gt;8 (P = 0.023), regardless of maintenance treatment. For patients who did not receive warfarin, a PVT volume \u22653.0 mL significantly influenced recurrence (P = 0.039). Therefore, the platelet count influences the PVT volume. The pretreatment PVT volume correlated with recurrence after anticoagulation therapy. According to the Kaplan\u2013Meier curve, risk factors for PVT recurrence after anticoagulation therapy included Child\u2013Pugh scores &gt;8 and FIB-4 \u22647.0. Therefore, the FIB-4 is a unique factor that shows trends opposing other liver function markers.<\/jats:p>","DOI":"10.3390\/life10090177","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T11:24:24Z","timestamp":1599218664000},"page":"177","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of Thrombosis Volume, Anticoagulants, and Recurrence Factors in Portal Vein Thrombosis with Cirrhosis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9608-0444","authenticated-orcid":false,"given":"Tsuyoshi","family":"Suda","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Takatori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rika","family":"Horii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouki","family":"Nio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Terashima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriho","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3053-4356","authenticated-orcid":false,"given":"Masaaki","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Shimakami","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuniaki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3602-8086","authenticated-orcid":false,"given":"Tatsuya","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eishiro","family":"Mizukoshi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-7584","authenticated-orcid":false,"given":"Kenichiro","family":"Okumura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Kozaka","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920-8641, 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