{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:50Z","timestamp":1787028770754,"version":"build-2736575974"},"reference-count":50,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"GREEN CROSS WellBeing Co., Ltd.","award":["2019 research grant"],"award-info":[{"award-number":["2019 research grant"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Several air pollution components such as sulfur dioxide, ozone, nitrogen dioxide, and diesel exhaust particulate matter (DEPM) have been linked to the development of asthma. In this study, we investigated the therapeutic potential of three lactic acid bacteria species, Lactobacillus plantarum GREEN CROSS Wellbeing (GCWB)1001, Pediococcus acidilactici GCWB1085, and Lactobacillus rhamnosus GCWB1156, in preventing DEPM-exacerbated asthma in mice. BALB\/c mice were first sensitized with ovalbumin (OVA) and were either challenged with OVA or DEPM (DEPM-exacerbated asthma model) by intranasal instillation. All three strains showed no hemolytic activity, suggesting a good safety profile. Oral administration of lactic acid bacteria reduced OVA + DEPM-induced inflammatory infiltration, goblet cell hyperplasia, airway remodeling, and the levels of proinflammatory cytokines and chemokines in bronchoalveolar lavage fluid (BALF). The probiotics also attenuated OVA + DEPM-induced immunoglobulin E (IgE) levels in serum and in BALF, and significantly reduced caspase-3 activity, total collagen level, and matrix metalloproteinase (MMP)-9 activity. In conclusion, lactic acid bacteria such as L. plantarum GCWB1001, P. acidilactici GCWB1085, and L. rhamnosus treatment in mice with asthma showed significant efficacy in preventing lung inflammation exacerbated by DEPM administration.<\/jats:p>","DOI":"10.3390\/life10110260","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T11:43:06Z","timestamp":1603885386000},"page":"260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lactic Acid Bacteria Ameliorate Diesel Exhaust Particulate Matter-Exacerbated Allergic Inflammation in a Murine Model of Asthma"],"prefix":"10.3390","volume":"10","author":[{"given":"Sun Woo","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jung","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyeong Eun","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi Deok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Research, GREEN CROSS Wellbeing Co., Ltd., Seongnam 13595, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Yung","family":"Choi","sequence":"additional","affiliation":[{"name":"Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research, Naju 59338, Jeollanamdo, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Ho","family":"Choi","sequence":"additional","affiliation":[{"name":"Subtropical\/tropical Organism Gene Bank, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Gwon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacokinetics, College of Pharmacy, Gachon University, Incheon 21936, Korea"},{"name":"Department of Pharmaceutical Engineering, International University of Korea, Jinju 52833, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8020-8914","authenticated-orcid":false,"given":"Hye Gwang","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon 34134, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-4181","authenticated-orcid":false,"given":"Yong Pil","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering, International University of Korea, Jinju 52833, Korea"},{"name":"Fisheries Promotion Division, Mokpo City 58613, Jeollanamdo, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MCP.0000000000000441","article-title":"Airway remodeling in asthma: Update on mechanisms and therapeutic approaches","volume":"24","author":"Boulet","year":"2018","journal-title":"Curr. 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