{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:27:00Z","timestamp":1760239620458,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The follicle-stimulating hormone receptor (FSH-R) expression was always considered human gonad-specific. The receptor has also been newly detected in extragonadal tissues. In this finding, we evaluated FSH-R expression in the human male early genital tract, in testicular tumors, and in sperm from healthy and varicocele patients. In sperm, we also studied the mechanism of FSH-R action. Immunohystochemistry and Western blot analysis showed FSH-R presence in the first pathways of the human genital tract, in embryonal carcinoma, and in sperm, but it was absent in seminoma and in lower varicocele. In sperm, FSH\/FSH-R activity is mediated by G proteins activating the PKA pathway, as we observed by using the H89. It emerged that increasing FSH treatments induced motility, survival, capacitation, and acrosome reaction in both sperm samples. The different FSH-R expression in tumor testicular tissues may be discriminate by tumor histological type. In spermatozoa, FSH-R indicates a direct action of FSH in these cells, which could be beneficial during semen preparation for in vitro fertilization procedures. For instance, FSH positive effects could be relevant in idiopathic infertility and in the clinic surgery of varicocele. In conclusion, FSH-R expression may be considered a molecular marker of testicular disorders.<\/jats:p>","DOI":"10.3390\/life10120336","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:45:03Z","timestamp":1607561103000},"page":"336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["FSH-R Human Early Male Genital Tract, Testicular Tumors and Sperm: Its Involvement in Testicular Disorders"],"prefix":"10.3390","volume":"10","author":[{"given":"Salvatore","family":"Panza","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"},{"name":"Centro Sanitario, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7621-1969","authenticated-orcid":false,"given":"Francesca","family":"Giordano","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"De Rose","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"},{"name":"Centro Sanitario, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Panno","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7079-1037","authenticated-orcid":false,"given":"Francesca","family":"De Amicis","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"},{"name":"Centro Sanitario, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"},{"name":"Centro Sanitario, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8313-2492","authenticated-orcid":false,"given":"Rocco","family":"Malivindi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3971-7378","authenticated-orcid":false,"given":"Vittoria","family":"Rago","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saveria","family":"Aquila","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Health and Nutritional Sciences, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"},{"name":"Centro Sanitario, University of Calabria\u2014Arcavacata di Rende, 87036 Cosenza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1093\/oxfordjournals.humrep.a137513","article-title":"Reevaluation of the roles of luteinizing hormone and follicle-stimulating hormone in the ovulatory process","volume":"6","author":"Chappel","year":"1991","journal-title":"Hum. 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