{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:21:47Z","timestamp":1787235707439,"version":"build-2736575974"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The chronic, inflammatory skin disorder hidradenitis suppurativa (HS) is associated well documented negative influences on patients\u2019 quality of life (QoL). The aim of this study was to present more robust data on patients\u2019 QoL impairment by demographic data and its correlation with well-known HS risk factors on a cohort of 1795 German patients. The instrument used for measuring QoL in this study was the Dermatology Life Quality Index (DLQI). Overall, patients reported a very large effect of HS on their QoL (mean DLQI: 13.2 \u00b1 8.1 points), and 22% of the analyzed population even reported to consider the effect as extremely large. Women tended to experience significantly higher impairment than men (p &lt; 0.001). QoL impairment correlated positively with pain (r = 0.581, p &lt; 0.001), HS severity (measured by the International Hidradenitis Suppurativa Severity Score System (IHS4)) as well as Hurley. Neck involvement tended to decrease QoL significantly more than any other location (14.7 \u00b1 8.3 points). This study confirms the enormous influence of HS on patients\u2019 QoL in a large cohort. Knowledge of QoL impairment in such patients is crucial for proper understanding and holistic management of this disease.<\/jats:p>","DOI":"10.3390\/life11010034","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T21:21:45Z","timestamp":1610313705000},"page":"34","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Quality-of-Life Impairment among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study of 1795 Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"Piotr K.","family":"Krajewski","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2067-4929","authenticated-orcid":false,"given":"\u0141ukasz","family":"Matusiak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9802-9642","authenticated-orcid":false,"given":"Esther","family":"von Stebut","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, University of Cologne, 50923 Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2957-074X","authenticated-orcid":false,"given":"Michael","family":"Schultheis","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center, Johannes Gutenberg University, 55122 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Kirschner","sequence":"additional","affiliation":[{"name":"Dermatology Outpatient Office Dr. Uwe Kirschner, 55116 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios","family":"Nikolakis","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, 06847 Dessau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-6342","authenticated-orcid":false,"given":"Jacek C.","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/ced.14021","article-title":"The impact of chronic skin disease in adolescence and the need for specialist adolescent services","volume":"45","author":"Howard","year":"2020","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.5664\/jcsm.27992","article-title":"Eczema, sleep, and behavior in children","volume":"6","author":"Camfferman","year":"2010","journal-title":"J. Clin. Sleep Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2147\/CCID.S91263","article-title":"Stigmatization and self-perception in children with atopic dermatitis","volume":"9","author":"Chernyshov","year":"2016","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000501905","article-title":"Risk Factors of Sexual Dysfunction in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study","volume":"236","year":"2020","journal-title":"Dermatology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/00015555-0866","article-title":"Psychophysical aspects of hidradenitis suppurativa","volume":"90","author":"Matusiak","year":"2010","journal-title":"Acta Derm. Venereol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaad.2006.08.061","article-title":"Quality of Life Group of the French Society of Dermatology. Quality of life impairment in hidradenitis suppurativa: A study of 61 cases","volume":"56","author":"Wolkenstein","year":"2007","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jaad.2009.09.021","article-title":"Hidradenitis suppurativa markedly decreases quality of life and professional activity","volume":"62","author":"Matusiak","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2340\/00015555-2967","article-title":"Influence of Itch and Pain on Sleep Quality in Patients with Hidradenitis Suppurativa","volume":"98","author":"Kaaz","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/bjd.18656","article-title":"Pain perception in patients with hidradenitis suppurativa","volume":"182","author":"Nielsen","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000431175","article-title":"Hidradenitis Suppurativa\/Acne Inversa: Criteria for Diagnosis, Severity Assessment, Classification and Disease Evaluation","volume":"231","author":"Zouboulis","year":"2015","journal-title":"Dermatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jaad.2015.07.046","article-title":"Pain management in patients with hidradenitis suppurativa","volume":"73","author":"Horvath","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/bjd.15748","article-title":"Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity","volume":"177","author":"Zouboulis","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1002\/ejp.906","article-title":"Establishment of cutpoints to categorize the severity of chronic pain using composite ratings with Rasch analysis","volume":"21","author":"Chien","year":"2017","journal-title":"Eur. J. Pain"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1111\/jdv.15519","article-title":"Quality of life measurement in hidradenitis suppurativa: Position statement of the European Academy of Dermatology and Venereology task forces on Quality of Life and Patient-Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa","volume":"33","author":"Chernyshov","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/jdv.12106","article-title":"Psoriasis Area Severity Index (PASI) and the Dermatology Life Quality Index (DLQI): The correlation between disease severity and psychological burden in patients treated with biological therapies","volume":"28","author":"Mattei","year":"2014","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Janmohamed, S.R., Gwillim, E.C., Yousaf, M., Patel, K.R., and Silverberg, J.I. (2020). The impact of prurigo nodularis on quality of life: A systematic review and meta-analysis. Arch. Dermatol. Res.","DOI":"10.1007\/s00403-020-02148-0"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/jdv.15223","article-title":"The impact of atopic dermatitis on sexual health","volume":"33","author":"Misery","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/bjd.15750","article-title":"Efficacy and safety of guselkumab in patients with psoriasis who have an inadequate response to ustekinumab: Results of the randomized, double-blind, phase III NAVIGATE trial","volume":"178","author":"Langley","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1080\/09546634.2019.1612836","article-title":"Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: Analysis of pooled data from the randomized trials SOLO 1 and SOLO 2","volume":"31","author":"Cork","year":"2020","journal-title":"J. Dermatolog. Treat"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1177\/1203475416677721","article-title":"Development of a Quality-of-Life Measure for Hidradenitis Suppurativa","volume":"21","author":"Sisic","year":"2017","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1365-2230.1994.tb01167.x","article-title":"Dermatology Life Quality Index (DLQI)\u2014A simple practical measure for routine clinical use","volume":"19","author":"Finlay","year":"1994","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/jid.2012.255","article-title":"Incidence of hidradenitis suppurativa and associated factors: A population-based study of Olmsted County, Minnesota","volume":"133","author":"Vazquez","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Schneider-Burrus, S., Lux, G., Van der Linde, K., Barbus, S., Huss-Marp, J., Tsaousi, A., Wasem, J., Wolff, B., and Sabat, R. (2020). Hidradenitis suppurativa-prevalence analyses of German statutory health insurance data. J. Eur. Acad. Dermatol. Venereol.","DOI":"10.1111\/jdv.16783"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1365-2133.1988.tb03227.x","article-title":"The symptomatology of hidradenitis suppurativa in women","volume":"119","author":"Jemec","year":"1988","journal-title":"Br. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1684\/ejd.2019.3552","article-title":"Assessing the psychological burden of patients with hidradenitis suppurativa","volume":"29","author":"Frings","year":"2019","journal-title":"Eur. J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00403-019-02025-5","article-title":"Factors affecting quality of life in patients with hidradenitis suppurativa","volume":"312","author":"Jorgensen","year":"2020","journal-title":"Arch. Dermatol. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1159\/000453355","article-title":"Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa","volume":"232","author":"Kouris","year":"2016","journal-title":"Dermatology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1365-2133.2001.04137.x","article-title":"Morbidity in patients with hidradenitis suppurativa","volume":"144","author":"Jemec","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1468-3083.2012.04468.x","article-title":"Depression in patients with hidradenitis suppurativa","volume":"27","author":"Onderdijk","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"515","DOI":"10.4103\/0019-5154.190102","article-title":"The Psychosocial Impact of Acne Vulgaris","volume":"61","author":"Hazarika","year":"2016","journal-title":"Indian J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/bjd.14497","article-title":"Alopecia areata and health-related quality of life: A systematic review and meta-analysis","volume":"175","author":"Rencz","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/1346-8138.14502","article-title":"Impact of chronic urticaria on quality of life and work in Japan: Results of a real-world study","volume":"45","author":"Itakura","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1365-2133.2007.08236.x","article-title":"Impact of adalimumab treatment on health-related quality of life and other patient-reported outcomes: Results from a 16-week randomized controlled trial in patients with moderate to severe plaque psoriasis","volume":"158","author":"Revicki","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.anai.2018.07.006","article-title":"Patient burden and quality of life in atopic dermatitis in US adults: A population-based cross-sectional study","volume":"121","author":"Silverberg","year":"2018","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000455236","article-title":"The Burden of Hidradenitis Suppurativa in a Cohort of Patients in Southern Finland: A Pilot Study","volume":"3","author":"Kluger","year":"2017","journal-title":"Skin Appendage Disord."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2340\/00015555-1082","article-title":"Psychosocial impact of hidradenitis suppurativa: A qualitative study","volume":"91","author":"Esmann","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jnr.23831","article-title":"Sex differences in neuroimmunity and pain","volume":"95","author":"Rosen","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2147\/CCID.S151114","article-title":"Vitiligo and social acceptance","volume":"11","author":"Bidaki","year":"2018","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"36","DOI":"10.5114\/pdia.2016.62286","article-title":"How does stigma affect people with psoriasis?","volume":"34","author":"Lakuta","year":"2017","journal-title":"Postepy Dermatol. Alergol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1177\/1203475416685078","article-title":"Atopic Dermatitis, Depression, and Suicidality","volume":"21","author":"Nicholas","year":"2017","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhang, X.J., Wang, A.P., Shi, T.Y., Zhang, J., Xu, H., Wang, D.Q., and Feng, L. (2019). The psychosocial adaptation of patients with skin disease: A scoping review. BMC Public Health, 19.","DOI":"10.1186\/s12889-019-7775-0"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/AJP.0000000000000132","article-title":"Sex differences in psychological response to pain in patients with fibromyalgia syndrome","volume":"31","author":"Racine","year":"2015","journal-title":"Clin. J. Pain."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","article-title":"Hidradenitis suppurativa","volume":"6","author":"Sabat","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1016\/j.lfs.2007.02.007","article-title":"Functional significance of non-neuronal acetylcholine in skin epithelia","volume":"80","author":"Hana","year":"2007","journal-title":"Life Sci."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1139\/cjpp-2013-0050","article-title":"Metabolic inflammation: Role of cytokines in the crosstalk between adipose tissue and liver","volume":"91","author":"Gerner","year":"2013","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Da Silva, N., Augustin, M., Langenbruch, A., Mrowietz, U., Reich, K., Thaci, D., Boehncke, W.H., Kirsten, N., Danckworth, A., and Sommer, R. (2020). Sex-related impairment and patient needs\/benefits in anogenital psoriasis: Difficult-to-communicate topics and their impact on patient-centred care. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0235091"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/1\/34\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:08:23Z","timestamp":1760159303000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/1\/34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["life11010034"],"URL":"https:\/\/doi.org\/10.3390\/life11010034","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,8]]}}}