{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T17:34:04Z","timestamp":1771954444415,"version":"3.50.1"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Center for Research and Publication (CRP), International Islamic University Chittagong","award":["IRG 180111"],"award-info":[{"award-number":["IRG 180111"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Syzygium fruticosum (SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized the S. fruticosum seed\u2019s fundamental importance in traditional medicine by following an integrated approach combining in vivo, in vitro, and in silico studies. The SF was fractionated with different solvents, and the ethyl acetate fraction of SF (EaF-SF) was further studied. Mice treated with EaF-SF (200 and 400 mg\/kg) manifested anxiolysis evidenced by higher exploration in elevated plus maze and hole board tests. Similarly, a dose-dependent drop of immobility time in a forced swimming test ensured significant anti-depressant activity. Moreover, higher dose treatment exposed reduced exploratory behaviour resembling decreased movement and prolonged sleeping latency with a quick onset of sleep during the open field and thiopental-induced sleeping tests, respectively. In parallel, EaF-SF significantly (p &lt; 0.001) and dose-dependently suppressed acetic acid and formalin-induced pain in mice. Also, a noteworthy anti-inflammatory activity and a substantial (p &lt; 0.01) clot lysis activity (thrombolytic) was observed. Gas chromatography-mass spectrometry (GC\u2013MS) analysis resulted in 49 bioactive compounds. Among them, 12 bioactive compounds with Lipinski\u2019s rule and safety confirmation showed strong binding affinity (molecular docking) against the receptors of each model used. To conclude, the S. fruticosum seed is a prospective source of health-promoting effects that can be an excellent candidate for preventing degenerative diseases.<\/jats:p>","DOI":"10.3390\/life11020155","type":"journal-article","created":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T21:35:42Z","timestamp":1613597742000},"page":"155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways"],"prefix":"10.3390","volume":"11","author":[{"given":"Jannatul Nasma Rupa","family":"Moni","sequence":"first","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1330-2169","authenticated-orcid":false,"given":"Md.","family":"Adnan","sequence":"additional","affiliation":[{"name":"Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-7610","authenticated-orcid":false,"given":"Abu Montakim","family":"Tareq","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-0155","authenticated-orcid":false,"given":"Md. Imtiazul","family":"Kabir","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, South Dakota State University, Bookings, SD 57006, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-0245","authenticated-orcid":false,"given":"A.S.M. Ali","family":"Reza","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"},{"name":"Department of Biochemistry &amp; Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-0096","authenticated-orcid":false,"given":"Mst. Samima","family":"Nasrin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"},{"name":"Department of Biochemistry &amp; Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamrul Hasan","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Al Jawad","family":"Sayem","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-8923","authenticated-orcid":false,"given":"Md Atiar","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Biochemistry &amp; Molecular Biology, University of Chittagong, Chittagong 4331, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2690-6559","authenticated-orcid":false,"given":"AHM Khurshid","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seema Binte","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahfuz Ahmed","family":"Sakib","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Kwang","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Ha","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Bio-Health Convergence, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-1822","authenticated-orcid":false,"given":"Raffaele","family":"Capasso","sequence":"additional","affiliation":[{"name":"Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Aluko, R.E. (2012). Functional Foods and Nutraceuticals, Springer.","DOI":"10.1007\/978-1-4614-3480-1"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Pisanello, D. (2014). Chemistry of Foods: EU Legal and Regulatory Approaches, Springer International Publishing.","DOI":"10.1007\/978-3-319-03434-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.toxlet.2004.01.011","article-title":"Special Issue on Nutraceutical and Functional Food Industries: Aspects on Safety and Regulatory Requirements","volume":"150","author":"Bagchi","year":"2004","journal-title":"Toxicol. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Donno, D., Mellano, M.G., Cerutti, A.K., and Beccaro, G.L. (2018). Nutraceuticals in Alternative and Underutilized Fruits as Functional Food Ingredients: Ancient Species for New Health Needs. Alternative and Replacement Foods, Elsevier BV.","DOI":"10.1016\/B978-0-12-811446-9.00009-5"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Makkar, R., Behl, T., Bungau, S., Zengin, G., Mehta, V., Kumar, A., Uddin, S., Ashraf, G.M., Abdel-Daim, M.M., and Arora, S. (2020). Nutraceuticals in Neurological Disorders. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124424"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2015.08.012","article-title":"Neuro-nutraceuticals: The path to brain health via nourishment is not so distant","volume":"89","author":"Williams","year":"2015","journal-title":"Neurochem. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2016.03.016","article-title":"Neuro-nutraceuticals: Further insights into their promise for brain health","volume":"95","author":"Williams","year":"2016","journal-title":"Neurochem. Int."},{"key":"ref_8","first-page":"1","article-title":"Currants and strawberries as bioactive compound sources: Determination of antioxidant profi les with HPLC-DAD\/MS","volume":"86","author":"Donno","year":"2013","journal-title":"J. Appl. Bot. Food Qual."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Cheung, P.C.K., and Mehta, B.M. (2015). Handbook of Food Chemistry, Springer.","DOI":"10.1007\/978-3-642-36605-5"},{"key":"ref_10","first-page":"16","article-title":"Nutritional supplements in psychotic disorders","volume":"45","year":"2017","journal-title":"Actasespanolas Psiquiatr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S2215-0366(14)00051-0","article-title":"Nutritional medicine as mainstream in psychiatry","volume":"2","author":"Sarris","year":"2015","journal-title":"Lancet Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/HRP.0000000000000101","article-title":"Emerging treatments in schizophrenia: Highlights from recent supplementation and prevention trials","volume":"24","author":"Brown","year":"2016","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_13","unstructured":"Elliot, W.R., and Jones, D.L. (1990). Encyclopaedia of Australian Plants Suitable for Cultivation, Lothian Publishing Company Pty Ltd."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.3390\/molecules13102545","article-title":"Evaluation of the Antioxidant Activity of Syzygiumcumini Leaves","volume":"13","author":"Ruan","year":"2008","journal-title":"Molecules"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5138\/ijpm.2010.0975.0185.02019","article-title":"Anti-inflammatory activity of Syzygiumcumini leaves","volume":"2","author":"Jain","year":"2010","journal-title":"Int. J. Phytomedicine"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3329\/bpj.v17i1.22315","article-title":"Antimicrobial, Cytotoxic, Thrombolytic and Antioxidant Activities of Syzygiumfruticosum (Roxb.) DC","volume":"17","author":"Chadni","year":"2015","journal-title":"Bangladesh Pharm. J."},{"key":"ref_17","first-page":"69","article-title":"Antioxidant, free radical scavenging, antibacterial and cytotoxic compound from the leaves of Syzygium fruticosum","volume":"4","author":"Nasrin","year":"2018","journal-title":"Int. J. Pharma Sci. Sci. Res."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Islam, S., Nasrin, S., Khan, M.A., Hossain, A.S.M.S., Islam, F., Khandokhar, P., Mollah, M.N.H., Rashid, M., Sadik, G., and Rahman, A.A. (2013). Evaluation of antioxidant and anticancer properties of the seed extracts of SyzygiumfruticosumRoxb. growing in Rajshahi, Bangladesh. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-142"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1021\/jo00947a041","article-title":"Datiscacin, a novel cytotoxic cucurbitacin 20-acetate from Datisca glomerata","volume":"38","author":"Kupchan","year":"1973","journal-title":"J. Org. Chem."},{"key":"ref_20","unstructured":"(2020, October 17). Guidance on the Operation of the Animals (Scientific Procedures) Act 1986 - GOV.UK, Available online: https:\/\/www.gov.uk\/guidance\/guidance-on-the-operation-of-the-animals-scientific-procedures-act-1986."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Adnan, M., Chy, M., Uddin, N., Kama, A.T.M., Azad, M., Kalam, O., Chowdhury, K.A.A., Kabir, M.S.H., Das Gupta, S., and Chowdhury, M. (2020). Comparative Study of Piper sylvaticumRoxb. Leaves and Stems for Anxiolytic and Antioxidant Properties Through in vivo, in vitro, and in silico Approaches. Biomedicines, 8.","DOI":"10.3390\/biomedicines8040068"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Auniq, R.B.J., Chy, N.U., Adnan, M., Chowdhury, R., Dutta, T., Ibban, S.S., Jahan, I., Tona, M.R., Shima, M., and Sawon, I.H. (2020). Evaluation of anxiolytic, sedative, and antioxidant activities of Vitex peduncularis Wall. leaves and investigation of possible lead compounds through molecular docking study. Adv. Tradit. Med., 1\u201312.","DOI":"10.1007\/s13596-020-00461-7"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Adnan, M., Chy, N.U., Kamal, A.M., Chowdhury, K.A.A., Rahman, A., Reza, A.S.M.A., Moniruzzaman, M., Rony, S.R., Nasrin, M.S., and Azad, O.K. (2020). Intervention in Neuropsychiatric Disorders by Suppressing Inflammatory and Oxidative Stress Signal and Exploration of In Silico Studies for Potential Lead Compounds from Holigarnacaustica (Dennst.) Oken leaves. Biomolecules, 10.","DOI":"10.3390\/biom10040561"},{"key":"ref_24","first-page":"795","article-title":"Antidepressant-like effect of aqueous extract of Channastriatus fillet in mice models of depression","volume":"15","author":"Saleem","year":"2011","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3389\/fphar.2018.00246","article-title":"Antinociceptive and Anxiolytic and Sedative Effects of Methanol Extract of Anisomeles indica: An Experimental Assessment in Mice and Computer Aided Models","volume":"9","author":"Uddin","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jep.2019.01.025","article-title":"Evaluation of anti-nociceptive and anti-inflammatory activities of the methanol extract of Holigarnacaustica (Dennst.) Oken leaves","volume":"236","author":"Adnan","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"170","DOI":"10.5455\/jcmr.20190805024523","article-title":"Assessment of anti-nociceptive and anthelmintic activities of Vitex Peduncularis Wall. leaves and in silico molecular docking, ADME\/T, and PASS prediction studies of its isolated compounds","volume":"10","author":"Auniq","year":"2019","journal-title":"J. Complement. Med. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1515\/jbcpp-2016-0023","article-title":"Anti-inflammatory, anti-diarrheal, thrombolytic and cytotoxic activities of an ornamental medicinal plant: Persicariaorientalis","volume":"28","author":"Ansari","year":"2017","journal-title":"J. Basic Clin. Physiol. Pharmacol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1477-9560-4-14","article-title":"Development of an in vitro model to study clot lysis activity of thrombolytic drugs","volume":"4","author":"Prasad","year":"2006","journal-title":"Thromb. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s13596-019-00395-9","article-title":"Evaluation of anti-nociceptive and anti-inflammatory activities of Piper sylvaticum (Roxb.) stem by experimental and computational approaches","volume":"20","author":"Chy","year":"2020","journal-title":"Adv. Tradit. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1021\/bi500525s","article-title":"Structures of KcsA in Complex with Symmetrical Quaternary Ammonium Compounds Reveal a Hydrophobic Binding Site","volume":"53","author":"Lenaeus","year":"2014","journal-title":"Biochemistry"},{"key":"ref_32","first-page":"334","article-title":"X-ray structures and mechanism of the human serotonin transporter","volume":"532","author":"Coleman","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"28096","DOI":"10.1074\/jbc.M701335200","article-title":"Structural Basis of Enantioselective Inhibition of Cyclooxygenase-1 by S-\u03b1-Substituted Indomethacin Ethanolamides","volume":"282","author":"Harman","year":"2007","journal-title":"J. Biol. Chem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"22152","DOI":"10.1074\/jbc.M110.119867","article-title":"Structural Basis of Fatty Acid Substrate Binding to Cyclooxygenase-2","volume":"285","author":"Vecchio","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"5893","DOI":"10.1021\/jm500378a","article-title":"Discovery and early clinical development of 2-{6-[2-(3, 5-dichloro-4-pyridyl) acetyl]-2, 3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis","volume":"57","author":"Felding","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"21713","DOI":"10.1074\/jbc.272.35.21713","article-title":"Structural Mapping of the Active Site Specificity Determinants of Human Tissue-type Plasminogen Activator","volume":"272","author":"Renatus","year":"1997","journal-title":"J. Biol. Chem."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1107\/S0907444902003451","article-title":"The Protein Data Bank","volume":"58","author":"Berman","year":"2002","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1021\/ci300367a","article-title":"admetSAR: A Comprehensive Source and Free Tool for Assessment of Chemical ADMET Properties","volume":"52","author":"Cheng","year":"2012","journal-title":"J. Chem. Inf. Model."},{"key":"ref_39","first-page":"412","article-title":"A review on the extraction methods use in medicinal plants, principle, strength and limitation","volume":"4","author":"Azwanida","year":"2015","journal-title":"Med. Aromat. Plants"},{"key":"ref_40","first-page":"1","article-title":"Comparative analysis of EPA and DHA in fish oil nutritional capsules by GC-MS","volume":"13","author":"Yi","year":"2014","journal-title":"Lipids Heal. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Adnan, M., Chy, N.U., Kamal, A.M., Azad, O.K., Paul, A., Uddin, S.B., Barlow, J.W., Faruque, M.O., Park, C.H., and Cho, D.H. (2019). Investigation of the Biological Activities and Characterization of Bioactive Constituents of Ophiorrhiza rugosa var. prostrata (D.Don) & Mondal Leaves through In Vivo, In Vitro, and In Silico Approaches. Molecules, 24.","DOI":"10.3390\/molecules24071367"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.2174\/0929867311320100005","article-title":"Ion channels as drug targets in central nervous system disorders","volume":"20","author":"Gunia","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Coutinho, E., and Vincent, A. (2014). Central Nervous System Neuronal Surface Antibodies. Autoantibodies, Elsevier BV.","DOI":"10.1016\/B978-0-444-56378-1.00070-8"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1097\/00000542-199904000-00035","article-title":"Potassium channels basic aspects, functional roles, and medical significance","volume":"90","author":"Yost","year":"1999","journal-title":"J. Am. Soc. Anesthesiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1177\/1087057115601677","article-title":"Neuronal and cardiovascular potassium channels as therapeutic drug targets: Promise and pitfalls","volume":"20","author":"Humphries","year":"2015","journal-title":"J. Biomol. Screen."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1021\/cn5000056","article-title":"Classics in Chemical Neuroscience: Diazepam (Valium)","volume":"5","author":"Calcaterra","year":"2014","journal-title":"ACS Chem. Neurosci."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Adnan, M., Chy, M., Uddin, N., Kamal, A.T.M., Chowdhury, M., Islam, M., Hossain, M., Tareq, A.M., Bhuiyan, M., and Hossain, I. (2020). Unveiling Pharmacological Responses and Potential Targets Insights of Identified Bioactive Constituents of CuscutareflexaRoxb. Leaves through In Vivo and In Silico Approaches. Pharmaceuticals, 13.","DOI":"10.3390\/ph13030050"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: Recent developments and future needs","volume":"23","author":"Cryan","year":"2002","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Amidfar, M., Colic, L., Walter, M., and Kim, Y.-K. (2018). Complex Role of the Serotonin Receptors in Depression: Implications for Treatment. Understanding Depression, Springer International Publishing.","DOI":"10.1007\/978-981-10-6580-4_6"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"123","DOI":"10.12688\/f1000research.9736.1","article-title":"Serotonin receptors in depression: From A to B","volume":"6","author":"Nautiyal","year":"2017","journal-title":"F1000Research"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.lfs.2018.08.050","article-title":"Serotonin receptors in depression and anxiety: Insights from animal studies","volume":"210","author":"Sapa","year":"2018","journal-title":"Life Sci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"7183","DOI":"10.3390\/molecules17067183","article-title":"Comparison of the Chemical Composition and Pharmacological Effects of the Aqueous and Ethanolic Extracts from a Tibetan \u201cSnow Lotus\u201d (Saussurealaniceps) Herb","volume":"17","author":"Yi","year":"2012","journal-title":"Molecules"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jep.2010.01.037","article-title":"Comparison of the anti-inflammatory and anti-nociceptive effects of three medicinal plants known as \u201cSnow Lotus\u201d herb in traditional Uighur and Tibetan medicines","volume":"128","author":"Yi","year":"2010","journal-title":"J. Ethnopharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Dzoyem, J., McGaw, L., Kuete, V., and Bakowsky, U. (2017). Anti-inflammatory and Anti-nociceptive Activities of African Medicinal Spices and Vegetables. Medicinal Spices and Vegetables from Africa, Elsevier BV.","DOI":"10.1016\/B978-0-12-809286-6.00009-1"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1055\/s-0032-1314843","article-title":"Antidepressants and Anti-Inflammatory Drugs Differentially Reduce the Release of NGF and BDNF from Rat Platelets","volume":"46","author":"Hochstrasser","year":"2012","journal-title":"Pharmacopsychiatry"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.2174\/092986712800099794","article-title":"The protective effects of natural products on blood-brain barrier breakdown","volume":"19","author":"Kam","year":"2012","journal-title":"Curr. Med. Chem."},{"key":"ref_57","first-page":"1","article-title":"Natural Sources of Tocotrienols: A Note on Absorption","volume":"3","author":"Adnan","year":"2017","journal-title":"J. Silico Vitr. Pharmacol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2165\/00003495-199600525-00004","article-title":"The Mechanisms of Action of NSAIDs in Analgesia","volume":"52","author":"Cashman","year":"1996","journal-title":"Drugs"},{"key":"ref_59","first-page":"e218","article-title":"Effects of plasmin on von Willebrand factor and platelets: A narrative review","volume":"2","author":"Remijn","year":"2018","journal-title":"TH Open Companion J. Thromb. Haemost."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-016-1461-x","article-title":"Antioxidant, antidiarrheal, hypoglycemic and thrombolytic activities of organic and aqueous extracts of Hopea odorata leaves and in silico PASS prediction of its isolated compounds","volume":"16","author":"Kabir","year":"2016","journal-title":"BMC Complement. Altern. Med."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/2\/155\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:25:19Z","timestamp":1760160319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/2\/155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["life11020155"],"URL":"https:\/\/doi.org\/10.3390\/life11020155","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]}}}