{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:44:05Z","timestamp":1761129845748,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Despite the enormous advances in knowledge about the SARS-CoV-2 infection, the optimal treatment for COVID-19 is still not well defined. The use of convalescent plasma seems to be a promising method of treatment but requires further evaluation. Although it is usually mild, in children with underlying chronic diseases, the course of SARS-CoV-2 infection may be very severe. We described a series of 13 pediatric patients (mean age 10.4 years, median 12) treated with convalescent plasma as a method of COVID-19 therapy. Medical history, with particular emphasis on comorbidities, clinical course, laboratory parameters, supportive treatment and virus elimination time, were analyzed. The mean hospitalization time was 22.6 days (median 20). The most common abnormalities included increased levels of C-reactive protein, D-dimer, and lymphopenia. Median time from symptom onset to convalescent plasma transfusion was 10.6 days (median 7 days). Six patients (46.2%) had a viral clearance on RT-PCR method from a nasopharyngeal swab within 3 days of transfusion, while in the remaining patients the mean elimination time was 12.1 days (median 6 days). Clinical improvement was achieved in all patients; no adverse effects were found in any of the cases. Convalescent plasma may be a promising treatment for COVID-19 in children.<\/jats:p>","DOI":"10.3390\/life11030247","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T11:48:22Z","timestamp":1615981702000},"page":"247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effects and Safety of Convalescent Plasma Administration in a Group of Polish Pediatric Patients with COVID-19: A Case Series"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0651-4454","authenticated-orcid":false,"given":"Pawe\u0142","family":"Ma\u0142ecki","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Szpitalna Street 27\/33, 60-572 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Faltin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Szpitalna Street 27\/33, 60-572 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-2560","authenticated-orcid":false,"given":"Anna","family":"Mania","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Szpitalna Street 27\/33, 60-572 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-4649","authenticated-orcid":false,"given":"Katarzyna","family":"Mazur-Melewska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Szpitalna Street 27\/33, 60-572 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Cwali\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Szpitalna Street 27\/33, 60-572 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Zawadzka","sequence":"additional","affiliation":[{"name":"Regional Blood Center, Marcelinska Street 44, 60-354 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicja","family":"Bukowska","sequence":"additional","affiliation":[{"name":"Regional Blood Center, Marcelinska Street 44, 60-354 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Lisowska","sequence":"additional","affiliation":[{"name":"Regional Blood Center, Marcelinska Street 44, 60-354 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Graniczna","sequence":"additional","affiliation":[{"name":"Regional Blood Center, Marcelinska Street 44, 60-354 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Figlerowicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Child Neurology, Poznan University of Medical Sciences, Szpitalna Street 27\/33, 60-572 Pozna\u0144, Greater Poland Voivodeship, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1038\/s41598-021-82862-5","article-title":"Causes of death and comorbidities in hospitalized patients with COVID-19","volume":"11","author":"Elezkurtaj","year":"2021","journal-title":"Sci. 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