{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:35:55Z","timestamp":1762522555389,"version":"build-2065373602"},"reference-count":90,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,20]],"date-time":"2021-03-20T00:00:00Z","timestamp":1616198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Cryptosporidiosis and giardiasis have been identified as emerging diseases in both developed and developing countries. Wildlife has been highlighted to play a major role in the spread of these diseases to humans. This review aims to highlight the research findings that relate to Cryptosporidium spp. and Giardia spp., with a focus on (1) parasitism of neo-tropical hystricomorphic rodents and marsupials from the genus Didelphis and (2) prevention and treatment strategies for humans and animals for the neo-tropical region. It was found that there are few studies conducted on neo-tropical rodent and marsupial species, but studies that were found illustrated the potential role these animals may play as zoonotic carriers of these two parasites for the neo-tropical region. Thus, it is recommended that further studies be done to assess the threat of protozoan parasites in neo-tropical wildlife to humans and domestic animals, and to further determine the most effective prophylaxis adapted for the unique conditions of the region.<\/jats:p>","DOI":"10.3390\/life11030256","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T22:00:37Z","timestamp":1616364037000},"page":"256","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Giardia and Cryptosporidium in Neo-Tropical Rodents and Marsupials: Is There Any Zoonotic Potential?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-7606","authenticated-orcid":false,"given":"Kegan Romelle","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Food Production (DFP), Faculty of Food and Agriculture (FFA), St. Augustine Campus, University of the West Indies (UWI), St. Augustine, Trinidad and Tobago"},{"name":"Department of Basic Veterinary Sciences (DBVS), Faculty of Medical Sciences (FMS), School of Veterinary Medicine (SVM), Mt. Hope Campus, University of the West Indies (UWI), Mount Hope, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-635X","authenticated-orcid":false,"given":"Laura","family":"Tardieu","sequence":"additional","affiliation":[{"name":"Department of Food Production (DFP), Faculty of Food and Agriculture (FFA), St. Augustine Campus, University of the West Indies (UWI), St. Augustine, Trinidad and Tobago"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12639-020-01205-9","article-title":"Gastrointestinal parasites in the opossum Didelphis aurita: Are they a potential threat to human health?","volume":"44","author":"Fontes","year":"2020","journal-title":"J. Parasit. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3201\/eid1601.081467","article-title":"Public health threat of new, reemerging, and neglected zoonoses in the industrialized world","volume":"16","author":"Cutler","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"ref_3","first-page":"119","article-title":"Molecular epidemiology","volume":"2","author":"Xiao","year":"2008","journal-title":"Cryptosporidium Cryptosporidiosis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1128\/CMR.15.1.145-154.2002","article-title":"Epidemiology and clinical features of Cryptosporidium infection in immunocompromised patients","volume":"15","author":"Hunter","year":"2002","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/pim.12350","article-title":"Cryptosporidium in humans and animals\u2014A one health approach to prophylaxis","volume":"38","author":"Ryan","year":"2018","journal-title":"Parasite Immunol."},{"key":"ref_6","first-page":"1","article-title":"Evaluation of four techniques for diagnosis of Giardia lamblia in children\u2019s stool from Bel\u00e9m city, Para State, Brazil","volume":"34","author":"Machado","year":"2001","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.parint.2007.10.001","article-title":"Occurrence of gastrointestinal protozoa in Didelphis albiventris (opossum) in the central region of Rio Grande do Sul state","volume":"57","author":"Zanette","year":"2008","journal-title":"Parasitol. Int."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/S0020-7519(00)00127-2","article-title":"Giardiasis as a re-emerging infectious disease and its zoonotic potential","volume":"30","author":"Thompson","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/infdis\/156.6.974","article-title":"Experimental human infections with Giardia lamblia","volume":"156","author":"Nash","year":"1987","journal-title":"J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.3389\/fmicb.2015.01208","article-title":"Drug development against the major diarrhea-causing parasites of the small intestine, Cryptosporidium and Giardia","volume":"6","author":"Miyamoto","year":"2015","journal-title":"Front. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Coelho, C.H., Durigan, M., Leal, D.A.G., De Bernardi Schneider, A., Franco, R.M.B., and Singer, S.M. (2017). Giardiasis as a neglected disease in Brazil: Systematic review of 20 years of publications. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0006005"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0140-6736(02)07744-9","article-title":"Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: A follow-up study","volume":"359","author":"Berkman","year":"2002","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1179\/136485908X267876","article-title":"Giardiasis and other intestinal parasitic infections in relation to anthropometric indicators of malnutrition: A large, population-based survey of schoolchildren in Tehran","volume":"102","author":"Nematian","year":"2008","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Al-Mekhlafi, H.M., Al-Maktari, M.T., Jani, R., Ahmed, A., Anuar, T.S., Moktar, N., Mahdy, M.A., Lim, Y.A., Mahmud, R., and Surin, J. (2013). Burden of Giardia duodenalis infection and its adverse effects on growth of schoolchildren in rural Malaysia. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002516"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/cid\/ciu629","article-title":"Irritable bowel syndrome and chronic fatigue 6 years after Giardia infection: A controlled prospective cohort study","volume":"59","author":"Hanevik","year":"2014","journal-title":"Clin. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijppaw.2015.12.001","article-title":"Public health significance of zoonotic Cryptosporidium species in wildlife: Critical insights into better drinking water management","volume":"5","author":"Zahedi","year":"2016","journal-title":"Int. J. Parasitol. Parasites Wildl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"834","DOI":"10.4269\/ajtmh.2011.10-0449","article-title":"Genotypic characterization of Cryptosporidium hominis from water samples in S\u00e3o Paulo, Brazil","volume":"85","author":"Dropa","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/zph.12757","article-title":"Toxoplasma gondii oocysts, Giardia cysts and Cryptosporidium oocysts in outdoor swimming pools in Brazil","volume":"67","author":"Pineda","year":"2020","journal-title":"Zoonoses Public Health"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6603","DOI":"10.1016\/j.watres.2011.10.013","article-title":"Waterborne transmission of protozoan parasites: Review of worldwide outbreaks\u2014An update 2004\u20132010","volume":"45","author":"Baldursson","year":"2011","journal-title":"Water Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0020-7519(00)00135-1","article-title":"Epidemiology of Cryptosporidium: Transmission, detection and identification","volume":"30","author":"Fayer","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0065-308X(08)60116-5","article-title":"Natural history and biology of Cryptosporidium parvum","volume":"40","author":"Tzipori","year":"1998","journal-title":"Adv. Parasitol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.vetpar.2004.09.004","article-title":"Cryptosporidium: A water-borne zoonotic parasite","volume":"126","author":"Fayer","year":"2004","journal-title":"Vet. Parasitol."},{"key":"ref_23","unstructured":"Knox, A.C. (2013). Prevalence and Genotypic Variation of Cryptosporidium spp.. Mesocarnivores, Opossums, and Dairy Calves, Humboldt State University."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.exppara.2009.03.018","article-title":"Molecular epidemiology of cryptosporidiosis: An update","volume":"124","author":"Xiao","year":"2010","journal-title":"Exp. Parasitol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1017\/S0031182014001085","article-title":"Cryptosporidium species in humans and animals: Current understanding and research needs","volume":"141","author":"Ryan","year":"2014","journal-title":"Parasitology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1590\/S0103-84782009005000085","article-title":"Ocorr\u00eancia de Giardia, Cryptosporidium e microspor\u00eddios em animais silvestres em \u00e1rea de desmatamento no Estado de S\u00e3o Paulo, Brasil","volume":"39","author":"Lallo","year":"2009","journal-title":"Ci\u00eancia Rural"},{"key":"ref_27","first-page":"627","article-title":"Cryptosporidiosis in kids of dairy goats","volume":"127","author":"Thamsborg","year":"1990","journal-title":"Vet. Rec."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.vetpar.2012.03.052","article-title":"Therapy and prevention of cryptosporidiosis in animals","volume":"188","author":"Shahiduzzaman","year":"2012","journal-title":"Vet. Parasitol."},{"key":"ref_29","first-page":"1269","article-title":"A review of the importance of cryptosporidiosis in farm animals","volume":"29","author":"Vanopdenbosch","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s40475-015-0056-9","article-title":"Treatment of Cryptosporidium: What we know, gaps, and the way forward","volume":"2","author":"Sparks","year":"2015","journal-title":"Curr. Trop. Med. Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1056\/NEJMra013170","article-title":"Cryptosporidiosis","volume":"346","author":"Chen","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_32","first-page":"3","article-title":"Waterborne transmission of Cryptosporidium and Giardia: Detection, surveillance and implications for public health","volume":"20","author":"Carmena","year":"2010","journal-title":"Curr. Res. Technol. Educ. Top. Appl. Microbiol. Microb. Biotechnol."},{"key":"ref_33","unstructured":"Brown-Uddenberg, R., Garcia, W.G., Baptiste, Q.S., Counand, T., Adogwa, A., and Sampson, T. (2004). The Agouti (Dasyprocta leporina, D. agouti) Booklet and Production Manual, GWG Publications."},{"key":"ref_34","unstructured":"Brown-Uddenberg, R.C. (2001). Conceptualization of an Intensive Production Model for the Agouti (Dasyprocta leporina) a Neo-Tropical Rodent in Trinidad. [Master\u2019s Thesis, University of the West Indies]."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Nogueira-Filho, S.L., Pinheiro, M.S., and Nogueira, S.S. (2013). Confined and semi-confined production systems for capybaras. Capybara, Springer.","DOI":"10.1007\/978-1-4614-4000-0_13"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Jones, K.R., Lall, K.R., and Garcia, G.W. (2019). Endoparasites of selective native non-domesticated mammals in the neo-tropics (new world tropics). Vet. Sci., 6.","DOI":"10.3390\/vetsci6040087"},{"key":"ref_37","first-page":"261","article-title":"Main gastrointestinal protozoa in wild capybara (Hydrochoerus hydrochaeris) in a village in the municipality of Arauca, Colombia","volume":"33","author":"Linda","year":"2015","journal-title":"Zootecnia Trop."},{"key":"ref_38","first-page":"9","article-title":"Parasitos y Enfermedades parasitarias del Chig\u00fcire (Hydrochoerus hydrochaeris), Bolet\u00edn Acad\u00e9mico Ciencias F\u00edsicas","volume":"72","author":"Canizales","year":"2013","journal-title":"Mat. Nat."},{"key":"ref_39","first-page":"96","article-title":"Infec\u00e7\u00e3o por Giardia spp. e Cystoisospora spp. em capivara e cutia no sul do Brasil (Infection by Giardia spp. and Cystoisospora spp. in capybara and agouti in southern Brazil)","volume":"565\u2013566","author":"Reginatto","year":"2008","journal-title":"Cienc. Vet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.vetpar.2007.03.034","article-title":"Natural infection with zoonotic subtype of Cryptosporidium parvum in Capybara (Hydrochoerus hydrochaeris) from Brazil","volume":"147","author":"Meireles","year":"2007","journal-title":"Vet. Parasitol."},{"key":"ref_41","first-page":"128","article-title":"Gastrointestinal parasites of the agouti (Dasyprocta leporina)","volume":"9","author":"Olivieria","year":"2008","journal-title":"Cienc. Anim. Bras."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0304-4017(83)90078-X","article-title":"Giardia infection in animals in Pozna\u0144 Zoo","volume":"13","author":"Peisert","year":"1983","journal-title":"Vet. Parasitol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1365-2672.2010.04764.x","article-title":"Zoonotic cryptosporidiosis in the UK\u2013challenges for control","volume":"109","author":"Chalmers","year":"2010","journal-title":"J. Appl. Microbiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3855\/jidc.360","article-title":"Cryptosporidiosis in developing countries","volume":"1","author":"Snelling","year":"2007","journal-title":"J. Infect. Dev. Ctries."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.exppara.2008.11.005","article-title":"Cryptosporidium in wild placental mammals","volume":"124","author":"Feng","year":"2010","journal-title":"Exp. Parasitol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1590\/S1984-29612010000400002","article-title":"Cryptosporidium infection in Brazil: Implications for veterinary medicine and public health","volume":"19","author":"Meireles","year":"2010","journal-title":"Rev. Bras. Parasitol. Veterin\u00e1ria"},{"key":"ref_47","first-page":"327","article-title":"The effect of water source and soil supplementation on parasite contamination in organic vegetable gardens","volume":"27","author":"Ferreira","year":"2018","journal-title":"Rev. Bras. Parasitol. Veterin\u00e1ria"},{"key":"ref_48","unstructured":"Wilson, D.E., and Reeder, D.M. (2005). Mammal Species of the World: A Taxonomic and Geographic Reference, JHU Press."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2478\/helm-2018-0008","article-title":"Prevalence, Abundance and Intensity of Eggs and Oocysts of Gastrointestinal Parasites in the Opossum Didelphis virginiana Kerr, 1792 in Yucatan, Mexico","volume":"55","author":"Pech","year":"2018","journal-title":"Helminthologia"},{"key":"ref_50","first-page":"538","article-title":"Responses of opussums and raccoons to bobcat and cotote feces","volume":"63","author":"Gipson","year":"2003","journal-title":"West N. Am. Nat."},{"key":"ref_51","unstructured":"Redford, K.H., and Eisenberg, J.F. (1992). Mammals of the Neotropics. The Southern Cone. II. Chile, Argentina, Uruguay, Paraguay, University of Chicago Press."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-3305-5-111","article-title":"Natural infection of Didelphis aurita (Mammalia: Marsupialia) with Leishmania infantum in Brazil","volume":"5","author":"Carreira","year":"2012","journal-title":"Parasites Vectors"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1645\/GE-2711.1","article-title":"Structure of parasite component communities of Didelphid marsupials: Insights from a comparative study","volume":"97","author":"Catzeflis","year":"2011","journal-title":"J. Parasitol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0020-7519(02)00197-2","article-title":"Host adaptation and host\u2013parasite co-evolution in Cryptosporidium: Implications for taxonomy and public health","volume":"32","author":"Xiao","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1590\/S0102-09352004000100005","article-title":"Ocorr\u00eancia de Cryptosporidium spp. em pequenos mam\u00edferos silvestres de tr\u00eas \u00e1reas serranas do Sudeste brasileiro","volume":"56","author":"Franco","year":"2004","journal-title":"Arq. Bras. Med. Veterin\u00e1ria E Zootec."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1590\/S1984-29612013005000018","article-title":"Natural infection by endoparasites among free-living wild animals","volume":"22","author":"Holsback","year":"2013","journal-title":"Rev. Bras. Parasitol. Vet."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1550-7408.2007.00299.x","article-title":"Cryptosporidium fayeri n. sp. (Apicomplexa: Cryptosporidiidae) from the Red Kangaroo (Macropus rufus)","volume":"55","author":"Ryan","year":"2008","journal-title":"J. Eukaryot. Microbiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1645\/GE-1508.1","article-title":"A new species of Cryptosporidium (Apicomplexa: Cryptosporidiidae) from eastern grey kangaroos (Macropus giganteus)","volume":"94","author":"Power","year":"2008","journal-title":"J. Parasitol."},{"key":"ref_59","unstructured":"Da Silva, M.F., Gon\u00e7alves, I.C.M., De Gino, A.M.O., Mil Czewski, V., and Pereira, S.M. (2017). Identifica\u00e7\u00e3o de Parasitos Encontrados em Animais Silvestres de Vida Livre Encaminhados a Uma Cl\u00ednica Veterin\u00e1ria Particular\u2014Resultados Preliminares, Instituto Federal Catarinense."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1590\/S0074-02761995000600002","article-title":"Giardia survey in live-trapped small domestic and wild mammals in four regions in the southwest region of the state of Sao Paulo, Brazil","volume":"90","author":"Sogayar","year":"1995","journal-title":"Mem\u00f3rias Instig. Oswaldo Cruz"},{"key":"ref_61","unstructured":"Yai, L., Bauab, A., Hirschfeld, M., Summa, M., Da Silva, A., and Damaceno, J. (1997). Estudo da Ocorr\u00eancia de Cryptosporidium Parvum em Didelphis sp (Gamb\u00e1) na Grande S\u00e3o Paulo, Instituto Federal Catarinense."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1128\/AEM.01034-07","article-title":"Cryptosporidium genotypes in wildlife from a New York watershed","volume":"73","author":"Feng","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"157","DOI":"10.7589\/0090-3558-24.1.157","article-title":"Experimental Cryptosporidium parvum infections in opossums (Didelphis virginiana)","volume":"24","author":"Lindsay","year":"1988","journal-title":"J. Wildl. Dis."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.ijpara.2008.03.006","article-title":"Molecular characterisation of species and genotypes of Cryptosporidium and Giardia and assessment of zoonotic transmission","volume":"38","author":"Xiao","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1128\/CMR.13.1.35","article-title":"Immune response to Giardia duodenalis","volume":"13","author":"Faubert","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.vetpar.2004.09.002","article-title":"Drinking water treatment processes for removal of Cryptosporidium and Giardia","volume":"126","author":"Betancourt","year":"2004","journal-title":"Vet. Parasitol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/j.1551-8833.2001.tb09356.x","article-title":"Controlling Cryptosporidium oocysts using conventional treatment","volume":"93","author":"Dugan","year":"2001","journal-title":"J. Am. Water Work. Assoc."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1017\/S0031182011000035","article-title":"Treatment and prevention of cryptosporidiosis: What options are there for a country like Zambia?","volume":"138","author":"Kelly","year":"2011","journal-title":"Parasitology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3201\/eid2004.121415","article-title":"Large outbreak of Cryptosporidium hominis infection transmitted through the public water supply, Sweden","volume":"20","author":"Lilja","year":"2014","journal-title":"Emergy Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1128\/AEM.02873-08","article-title":"Propagation of human enteropathogens in constructed horizontal wetlands used for tertiary wastewater treatment","volume":"75","author":"Graczyk","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2166\/wh.2015.131","article-title":"Removal of Cryptosporidium by wastewater treatment processes: A review","volume":"14","author":"Nasser","year":"2016","journal-title":"J. Water Health"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1016\/S0043-1354(00)00188-3","article-title":"Synergy in sequential inactivation of Cryptosporidium parvum with ozone\/free chlorine and ozone\/monochloramine","volume":"34","author":"Rennecker","year":"2000","journal-title":"Water Res."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5387","DOI":"10.1128\/AEM.68.11.5387-5393.2002","article-title":"Efficacy of UV irradiation in inactivating Cryptosporidium parvum oocysts","volume":"68","author":"Morita","year":"2002","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cgh.2005.12.020","article-title":"Effect of nitazoxanide in diarrhea and enteritis caused by Cryptosporidium species","volume":"4","author":"Rossignol","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.exppara.2009.07.005","article-title":"Cryptosporidium and Giardia: Treatment options and prospects for new drugs","volume":"124","author":"Rossignol","year":"2010","journal-title":"Exp. Parasitol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2334-9-195","article-title":"High dose prolonged treatment with nitazoxanide is not effective for cryptosporidiosis in HIV positive Zambian children: A randomised controlled trial","volume":"9","author":"Amadi","year":"2009","journal-title":"BMC Infect. Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/bmt.2010.200","article-title":"Diagnosis and treatment of digestive cryptosporidiosis in allogeneic haematopoietic stem cell transplant recipients: A prospective single centre study","volume":"46","author":"Legrand","year":"2011","journal-title":"Bone Marrow Transpl."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1086\/515352","article-title":"Combination drug therapy for cryptosporidiosis in AIDS","volume":"178","author":"Smith","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1051\/parasite\/2008153275","article-title":"Drug treatment and novel drug target against Cryptosporidium","volume":"15","author":"Gargala","year":"2008","journal-title":"Parasite"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.biotechadv.2015.04.009","article-title":"Drug resistance in Giardia duodenalis","volume":"33","author":"Ansell","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.1128\/AAC.00384-11","article-title":"Impaired parasite attachment as fitness cost of metronidazole resistance in Giardia lamblia","volume":"55","author":"Millman","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1517\/14740338.2.6.529","article-title":"Efficacy of antigiardial drugs","volume":"2","author":"Wright","year":"2003","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.trstmh.2011.11.007","article-title":"Nitazoxanide for the empiric treatment of pediatric infectious diarrhea","volume":"106","author":"Rossignol","year":"2012","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1128\/CMR.14.1.114-128.2001","article-title":"Treatment of giardiasis","volume":"14","author":"Gardner","year":"2001","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"20131671","DOI":"10.1098\/rspb.2013.1671","article-title":"Antagonism between two intestinal parasites in humans: The importance of co-infection for infection risk and recovery dynamics","volume":"280","author":"Blackwell","year":"2013","journal-title":"Proc. R. Soc. B Biol. Sci."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/pmj.2003.014175","article-title":"Resolution of cryptosporidiosis with probiotic treatment","volume":"80","author":"Pickerd","year":"2004","journal-title":"Postgrad. Med. J."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1590\/s2175-97902018000217360","article-title":"Effect of probiotics on giardiasis. Where are we?","volume":"54","author":"Ventura","year":"2018","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1007\/s10620-012-2503-y","article-title":"Probiotic Lactobacillus rhamnosus GG modulates the mucosal immune response in Giardia intestinalis-infected BALB\/c mice","volume":"58","author":"Goyal","year":"2013","journal-title":"Dig. Dis. Sci."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2105\/AJPH.75.12.1433","article-title":"Moist heat inactivation of Cryptosporidium sp.","volume":"75","author":"Anderson","year":"1985","journal-title":"Am. J. Public Health"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1136\/vr.111.18.414","article-title":"Effect of disinfectants on survival of Cryptosporidium oocysts","volume":"111","author":"Campbell","year":"1982","journal-title":"Vet. 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