{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:51:32Z","timestamp":1774633892767,"version":"3.50.1"},"reference-count":76,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Diabetes mellitus (DM) is the most severe metabolic disease that reached the level of a global pandemic and is associated with high cardiovascular morbidity. Statins are the first\u2013line lipid\u2013lowering therapy in diabetic patients with or without a history of atherosclerotic disease. Although well tolerated, chronic treatment may result in side effects that lead to treatment interruption. Mitochondrial dysfunction has emerged as a central pathomechanism in DM\u2013 and statin\u2013induced side effects. Assessment of mitochondrial respiration in peripheral platelets has been increasingly used as a mirror of organ mitochondrial dysfunction. The present study aimed to assess the: (i) changes in mitochondrial respiration elicited by statins in patients with type 2 DM and (ii) the effects of cell\u2013permeable succinate (NV118) on respiratory parameters in platelets harvested from these patients. No significant changes were found in global mitochondrial respiration of intact platelets isolated from diabetic patients treated with either atorvastatin or rosuvastatin. Similarly, no significant changes in mitochondrial respiration of permeabilized platelets were found between diabetic patients treated with atorvastatin and healthy controls. Acute ex vivo administration of NV118 significantly improved respiration in isolated platelets. These results prompt further research on the role of permeable succinate as a therapeutic alternative for improving mitochondrial function in metabolic pathologies and point to the role of peripheral platelets as a potential biomarker of treatment response.<\/jats:p>","DOI":"10.3390\/life11040288","type":"journal-article","created":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T22:09:01Z","timestamp":1616969341000},"page":"288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Improvement of Platelet Respiration by Cell\u2013Permeable Succinate in Diabetic Patients Treated with Statins"],"prefix":"10.3390","volume":"11","author":[{"given":"Vlad Florian","family":"Avram","sequence":"first","affiliation":[{"name":"Department VII Internal Medicine\u2014Diabetes, Nutrition and Metabolic Diseases, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Center for Translational Research and Systems Medicine, \u201dVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca Mihaela","family":"B\u00eena","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Systems Medicine, \u201dVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department III Functional Sciences\u2014Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sima","sequence":"additional","affiliation":[{"name":"Department VII Internal Medicine\u2014Diabetes, Nutrition and Metabolic Diseases, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Maria","family":"Aburel","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Systems Medicine, \u201dVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department III Functional Sciences\u2014Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Sturza","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Systems Medicine, \u201dVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department III Functional Sciences\u2014Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidiu","family":"Burlacu","sequence":"additional","affiliation":[{"name":"Department IX Surgery\u2014Surgical Semiotics I, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Center for Hepato\u2013Biliary and Pancreatic Surgery, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romulus Zorin","family":"Timar","sequence":"additional","affiliation":[{"name":"Department VII Internal Medicine\u2014Diabetes, Nutrition and Metabolic Diseases, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Center for Translational Research and Systems Medicine, \u201dVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danina Mirela","family":"Muntean","sequence":"additional","affiliation":[{"name":"Center for Translational Research and Systems Medicine, \u201dVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"},{"name":"Department III Functional Sciences\u2014Pathophysiology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7901-1826","authenticated-orcid":false,"given":"Eskil","family":"Elm\u00e9r","sequence":"additional","affiliation":[{"name":"Mitochondrial Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, BMC A13, 221 84 Lund, 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