{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:52Z","timestamp":1787028772443,"version":"build-2736575974"},"reference-count":27,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T00:00:00Z","timestamp":1618185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Preptin is a bone-anabolic pancreatic peptide hormone. Its role in bone metabolism has been studied in rats and in patients with diabetes, but its levels and significance in bone metabolism in hemodialyzed (HD) patients is unknown. Methods: The relationships between preptin and anthropometric and biochemical parameters related to bone metabolism were studied in 73 patients on chronic hemodialysis (48 males, 25 females; mean age of 57 years; HD vintage of 69.7 months). Of these subjects, 36 patients had diabetes or impaired glucose tolerance (DM\/IGT), and 37 patients had normal glucose tolerance (NGT). Dual-energy X-ray absorptiometry of the femoral neck and lumbar spine were also performed. Results: No differences were observed in preptin levels between DM\/IGT and NGT HD patients. Preptin was positively correlated with HD vintage (r = 0.312, p = 0.007). Negative correlations between preptin and bone mineral density (BMD), T-score, and Z-score in the lumbar spine (L2-L4) were observed (r = \u22120.319, p = 0.009; r = \u22120.341, p = 0.005; r = \u22120.375, p = 0.002). Preptin was positively correlated with parathormone (PTH) levels (r = 0.379, p &lt; 0.001) and osteocalcin levels (r = 0.262, p = 0.027). Conclusions: The results indicate that preptin may reflect on bone and mineral metabolism disturbances seen in HD patients. The significant correlation of preptin with PTH and osteocalcin suggests that preptin may be important in indirect measurement of bone turnover in HD patients.<\/jats:p>","DOI":"10.3390\/life11040341","type":"journal-article","created":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T11:05:06Z","timestamp":1618225506000},"page":"341","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Is Preptin a New Bone Metabolism Parameter in Hemodialysis Patients?"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2116-4384","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Ka\u0142u\u017cna","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6237-0814","authenticated-orcid":false,"given":"Krzysztof","family":"Pawlaczyk","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Schwermer","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5123-9228","authenticated-orcid":false,"given":"Krzysztof","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Yusuf Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6085-4855","authenticated-orcid":false,"given":"Magdalena","family":"Czlapka-Matyasik","sequence":"additional","affiliation":[{"name":"Department of Human Nutrition and Dietetics, Poznan University of Life Sciences, 60-624 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Wrotkowska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5377-8834","authenticated-orcid":false,"given":"Katarzyna","family":"Ziemnicka","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Oko","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Transplantology and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6296-7220","authenticated-orcid":false,"given":"Marek","family":"Rucha\u0142a","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Internal Diseases, Poznan University of Medical Sciences, 60-355 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4239\/wjd.v2.i3.41","article-title":"Osteoporosis in diabetes mellitus: Possible cellular and molecular mechanisms","volume":"2","author":"Wongdee","year":"2011","journal-title":"World J. Diabetes"},{"key":"ref_2","first-page":"28","article-title":"Diabetes and end-stage renal disease; a review article on new concepts","volume":"4","author":"Ghaderian","year":"2015","journal-title":"J. Renal. Inj. Prev."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Yavropoulou, M.P., Vaios, V., Pikilidou, M., Chryssogonidis, I., Sachinidou, M., Tournis, S., Makris, K., Kotsa, K., Daniilidis, M., and Haritanti, A. (2016). Bone Quality Assessment as Measured by Trabecular Bone Score in Patients with End-Stage Renal Disease on Dialysis. J. Clin. Densitom.","DOI":"10.1016\/j.jocd.2016.11.002"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1053\/j.ajkd.2013.12.018","article-title":"Bone disease in CKD: A focus on osteoporosis diagnosis and management","volume":"64","author":"Miller","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1042\/bj3600431","article-title":"Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion","volume":"360","author":"Buchanan","year":"2001","journal-title":"Biochem. J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1080\/07853890802244142","article-title":"Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects","volume":"41","author":"Yang","year":"2009","journal-title":"Ann. Med."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Correction for Colaianni (2015). The myokine irisin increases cortical bone mass. Proc. Natl. Acad. Sci. USA, 112, E5763.","DOI":"10.1073\/pnas.1519137112"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1016\/j.bmc.2014.05.026","article-title":"Synthesis of truncated analogues of preptin-(1-16), and investigation of their ability to stimulate osteoblast proliferation","volume":"22","author":"Kowalczyk","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"E117","DOI":"10.1152\/ajpendo.00642.2005","article-title":"Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo","volume":"292","author":"Cornish","year":"2007","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/08977194.2013.770392","article-title":"Effects and differentiation activity of IGF-I, IGF-II, insulin and preptin on human primary bone cells","volume":"31","author":"Bosetti","year":"2013","journal-title":"Growth Factors"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Li, N., Zheng, Y.B., Han, J., Liang, W., Wang, J.Y., Zhou, J.R., Shen, Y., and Zhang, J. (2013). Lower circulating preptin levels in male patients with osteoporosis are correlated with bone mineral density and bone formation. BMC Musculoskelet Disord, 14.","DOI":"10.1186\/1471-2474-14-49"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1053\/ajkd.2000.19812","article-title":"Increased incidence of hip fractures in dialysis patients with low serum parathyroid hormone","volume":"36","author":"Coco","year":"2000","journal-title":"Am. J. Kidney Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/ndt\/gfg116","article-title":"Spectrum of renal bone disease in end-stage renal failure patients not yet on dialysis","volume":"18","author":"Spasovski","year":"2003","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1053\/j.ajkd.2006.03.083","article-title":"Renal osteodystrophy: Alpha-Heremans Schmid glycoprotein\/fetuin-A, matrix GLA protein serum levels, and bone histomorphometry","volume":"48","author":"Coen","year":"2006","journal-title":"Am. J. Kidney Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1139\/apnm-2014-0338","article-title":"Relationships between preptin and osteocalcin in obese, overweight, and normal weight adults","volume":"40","year":"2015","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"ref_17","first-page":"309","article-title":"Assessment of human cartilage glycoprotein 39 (YKL-40), preptin, and nitric oxide in adolescent patients with type 1 diabetes and its relation to cardiorenal affection","volume":"28","author":"Battah","year":"2015","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1477-7827-10-10","article-title":"The relationship between polycystic ovary syndrome, glucose tolerance status and serum preptin level","volume":"10","author":"Bu","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1136\/jim-2019-000985","article-title":"Elevated serum preptin concentrations in patients with diabetic nephropathy","volume":"67","author":"Wang","year":"2019","journal-title":"J. Investig. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"236085","DOI":"10.1155\/2013\/236085","article-title":"Acylated and desacylated ghrelin, preptin, leptin, and nesfatin-1 Peptide changes related to the body mass index","volume":"2013","author":"Ozkan","year":"2013","journal-title":"Int. J. Endocrinol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"9225","DOI":"10.1039\/C6OB01455K","article-title":"Structure activity relationship study on the peptide hormone preptin, a novel bone-anabolic agent for the treatment of osteoporosis","volume":"14","author":"Amso","year":"2016","journal-title":"Org Biomol. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s00774-017-0882-z","article-title":"Investigation of the relation between bone mass density and serum preptin levels in pre- and postmenopausal women","volume":"36","author":"Nourollahi","year":"2018","journal-title":"J. Bone Miner. Metab."},{"key":"ref_23","first-page":"8","article-title":"Osteocalcin in chronic hemodialysis patients as an additional parameter in the diagnosis of advanced secondary hyperparathyroidism","volume":"16","author":"Motz","year":"1989","journal-title":"Acta Med. Austriaca"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1523-1755.2003.00129.x","article-title":"Differences in bone turnover and intact PTH levels between African American and Caucasian patients with end-stage renal disease","volume":"64","author":"Sawaya","year":"2003","journal-title":"Kidney Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s40620-016-0339-9","article-title":"The role of bone biopsy for the diagnosis of renal osteodystrophy: A short overview and future perspectives","volume":"29","author":"Carvalho","year":"2016","journal-title":"J. Nephrol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"219","DOI":"10.5603\/EP.2015.0028","article-title":"Serum parathyroid hormone concentrations measured by chemiluminescence and electrochemiluminescence methods\u2014Are the results comparable in haemodialysis patients with chronic kidney disease?","volume":"66","author":"Kuczera","year":"2015","journal-title":"Endokrynol. Pol."},{"key":"ref_27","first-page":"A10","article-title":"Are preptin and CTRP1 new bone metabolic markers in hemodialysis patients?","volume":"21","author":"Schwermer","year":"2017","journal-title":"Hemodial. Int."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/4\/341\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:59:43Z","timestamp":1760363983000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/4\/341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,12]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["life11040341"],"URL":"https:\/\/doi.org\/10.3390\/life11040341","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,12]]}}}