{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:41:12Z","timestamp":1790743272050,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["421887978, 422182557, EXC 2145 SyNergy \u2013 ID 390857198"],"award-info":[{"award-number":["421887978, 422182557, EXC 2145 SyNergy \u2013 ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hirnliga e.V.","award":["Manfred-Strohscheer-Stiftung"],"award-info":[{"award-number":["Manfred-Strohscheer-Stiftung"]}]},{"DOI":"10.13039\/501100008483","name":"NOMIS foundation","doi-asserted-by":"publisher","award":["FTLD project"],"award-info":[{"award-number":["FTLD project"]}],"id":[{"id":"10.13039\/501100008483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [18F]GE-180 is still unclear. We evaluated the impact of rs6971-SNP on in vivo [18F]GE-180 binding in a healthy brain and in pseudo-reference tissue in neuro-oncological and neurodegenerative diseases. Standardized uptake values (SUVs) of [18F]GE-180-PET were assessed using a manually drawn region of interest in the frontoparietal and cerebellar hemispheres. The SUVs were compared between the LABs, MABs and HABs in control, glioma, four-repeat tauopathy (4RT) and Alzheimer\u2019s disease (AD) subjects. Second, the SUVs were compared between the patients and controls within their rs6971-subgroups. After excluding patients with prior therapy, 24 LABs (7 control, 5 glioma, 6 4RT and 6 AD) were analyzed. Age- and sex-matched MABs (n = 38) and HABs (n = 50) were selected. The LABs had lower frontoparietal and cerebellar SUVs when compared with the MABs and HABs, but no significant difference was observed between the MABs and HABs. Within each rs6971 group, no SUV difference between the patients and controls was detected in the pseudo-reference tissues. The rs6971-SNP affects [18F]GE-180 quantification, revealing lower binding in the LABs when compared to the MABs and HABs. The frontoparietal and cerebellar ROIs were successfully validated as pseudo-reference regions.<\/jats:p>","DOI":"10.3390\/life11060484","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T10:30:32Z","timestamp":1622025032000},"page":"484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of TSPO Receptor Polymorphism on [18F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders"],"prefix":"10.3390","volume":"11","author":[{"given":"Franziska J.","family":"Vettermann","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Unterrainer","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-6240","authenticated-orcid":false,"given":"Boris-Stephan","family":"Rauchmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"},{"name":"Department of Psychiatry and Psychotherapy, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Palleis","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endy","family":"Weidinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7358-4495","authenticated-orcid":false,"given":"Leonie","family":"Beyer","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Eckenweber","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Schuster","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Biechele","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Ferschmann","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6050-8071","authenticated-orcid":false,"given":"Vladimir M.","family":"Milenkovic","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-0003","authenticated-orcid":false,"given":"Christian H.","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rupprecht","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Janowitz","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Buerger","sequence":"additional","affiliation":[{"name":"Institute for Stroke and Dementia Research, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Perneczky","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College, London SW7 2AZ, UK"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"},{"name":"Department of Neurology, Hannover Medical School, 30625 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[{"name":"Department of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4869-1627","authenticated-orcid":false,"given":"Christian","family":"Haass","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"},{"name":"Chair of Metabolic Biochemistry, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, 82152 Planegg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg C.","family":"Tonn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital of Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Niyazi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bartenstein","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie L.","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"},{"name":"German Cancer Consortium (DKTK), Partner Site Munich, 81377 Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany"},{"name":"Munich Cluster for Systems Neurology 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