{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:40:20Z","timestamp":1764906020304,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T00:00:00Z","timestamp":1622678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010816","name":"Anhui Science and Technology Department","doi-asserted-by":"publisher","award":["1604a0802075"],"award-info":[{"award-number":["1604a0802075"]}],"id":[{"id":"10.13039\/501100010816","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Gastric cancer (GC) is the fifth most common cancer globally. Secreted frizzled-related proteins (SFRP) are important elements associated with the Wnt signaling pathway, and its dysregulated expression is found in multiple cancers. However, the function of distinct SFRPs in GC remains poorly understood. We investigated the differential expression, prognostic value, and immune cell infiltration of SFRPs in gastric cancer patients from the Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), UALCAN, Kaplan\u2013Meier plotter, cBioPortal, STRING, Gene-MANIA, DAVID, MethSurv, and TIMER databases. We found that the expression levels of SFRP2 and SFRP4 were significantly increased in GC tissues, whereas the SFRP1 and SFRP5 expressions were reduced. SFRP1, SFRP2, and SFRP5 were significantly correlated with the clinical cancer stage in GC patients. Higher expression of SFRPs was associated with short overall survival (OS) in GC patients. Besides, high SFRPs methylation showed favorable OS in GC patients. The functions of SFRPs were primarily related to the Wnt signaling pathway, immune system development, and basal cell carcinoma. The expression of SFRPs was strongly correlated with immune infiltrating cells, including CD4+ T cells and macrophages in GC. Our study indicated that SFRPs could be potential targets of precision therapy and prognostic biomarkers for the survival of GC patients.<\/jats:p>","DOI":"10.3390\/life11060522","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T10:59:51Z","timestamp":1622717991000},"page":"522","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comprehensive Analysis of SFRP Family Members Prognostic Value and Immune Infiltration in Gastric Cancer"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4972-8601","authenticated-orcid":false,"given":"Dehua","family":"Liu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-3164","authenticated-orcid":false,"given":"Chenyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, Chicago, IL 60657, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-4525","authenticated-orcid":false,"given":"Nahyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, Chicago, IL 60657, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandur","family":"Bhan","sequence":"additional","affiliation":[{"name":"Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, Chicago, IL 60657, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Pocholo Whitaker","family":"Tuason","sequence":"additional","affiliation":[{"name":"Internal Medicine, AMITA Health Saint Joseph Hospital Chicago, Chicago, IL 60657, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of the First Clinical Medicine, Anhui Medical University, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaodi","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University, Hefei 230032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9986-5124","authenticated-orcid":false,"given":"Yuting","family":"Huang","sequence":"additional","affiliation":[{"name":"University of Maryland Medical Center Midtown Campus, Baltimore, MD 21201, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce","family":"Cheng","sequence":"additional","affiliation":[{"name":"The University of Arizona College of Medicine, Banner University Medical Center at South Campus, Tucson, AZ 85724, USA"},{"name":"Banner-University Medical Center South, Tucson, AZ 85713, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9462-6335","authenticated-orcid":false,"given":"Kaiguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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