{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:07:43Z","timestamp":1790636863464,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Idiopathic intracranial hypertension (IIH) incorporates symptoms and signs of increased intracranial pressure (ICP) and is diagnosed by increased lumbar cerebrospinal fluid pressure. However, our knowledge about the characteristics of ICP abnormality, e.g., changes in pulsatile versus static ICP, remains scarce. This study questioned how overnight pulsatile ICP (mean ICP wave amplitude, MWA) associates with static ICP (mean ICP) in IIH patients who were refractory to conservative medical treatment. The material included 80 consecutive IIH patients undergoing ICP monitoring prior to shunt, as part of work-up for failed conservative medical therapy. In this group, the overnight mean ICP was normalized in 52\/80 patients, but with abnormal overnight MWA in 45 of the 52 patients. Even though there was a positive correlation between MWA and mean ICP at group level and within individual ICP recordings, the levels of MWA were abnormal in a high proportion of patients despite normalized mean ICP. Taken together, the present results disclosed lasting abnormal pulsatile ICP despite normalized static ICP in IIH patients refractory to conservative medical therapy, which may reflect the underlying pathophysiology. It is tentatively suggested that abnormal pulsatile ICP in IIH may reflect alterations at the glia\u2013neurovascular interface, resulting in impaired astrocytic pulsation absorber mechanisms.<\/jats:p>","DOI":"10.3390\/life11060537","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T04:22:22Z","timestamp":1623212542000},"page":"537","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Abnormal Intracranial Pulse Pressure Amplitude Despite Normalized Static Intracranial Pressure in Idiopathic Intracranial Hypertension Refractory to Conservative Medical Therapy"],"prefix":"10.3390","volume":"11","author":[{"given":"Per Kristian","family":"Eide","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 0316 Oslo, Norway"},{"name":"Department of Neurosurgery, Oslo University Hospital\u2014Rikshospitalet, 0424 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1136\/jnnp-2017-317440","article-title":"Idiopathic intracranial hypertension: Consensus guidelines on management","volume":"89","author":"Mollan","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S1474-4422(06)70442-2","article-title":"Idiopathic intracranial hypertension","volume":"5","author":"Ball","year":"2006","journal-title":"Lancet Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1155\/2011\/630475","article-title":"Cognitive impairment in patients with Pseudotumor Cerebri Syndrome","volume":"24","author":"Kharkar","year":"2011","journal-title":"Behav. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e004376","DOI":"10.1136\/bmjopen-2013-004376","article-title":"Cognitive function in idiopathic intracranial hypertension: A prospective case-control study","volume":"4","author":"Yri","year":"2014","journal-title":"BMJ Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1212\/WNL.0b013e31829c5c9d","article-title":"Olfactory dysfunction in patients with idiopathic intracranial hypertension","volume":"81","author":"Kunte","year":"2013","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1136\/jnnp-2015-311302","article-title":"Evolving evidence in adult idiopathic intracranial hypertension: Pathophysiology and management","volume":"87","author":"Mollan","year":"2016","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00701-016-3010-2","article-title":"Efficacy, complications and cost of surgical interventions for idiopathic intracranial hypertension: A systematic review of the literature","volume":"159","author":"Kalyvas","year":"2017","journal-title":"Acta Neurochir."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e372","DOI":"10.1111\/j.1467-789X.2010.00799.x","article-title":"Idiopathic intracranial hypertension in the USA: The role of obesity in establishing prevalence and healthcare costs","volume":"12","author":"Friesner","year":"2011","journal-title":"Obes. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s00415-011-6273-9","article-title":"Idiopathic intracranial hypertension is not benign: A long-term outcome study","volume":"259","author":"Yri","year":"2012","journal-title":"J. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1080\/02688690601047312","article-title":"Lumbar cerebrospinal fluid pressure waves versus intracranial pressure waves in idiopathic normal pressure hydrocephalus","volume":"20","author":"Eide","year":"2006","journal-title":"Br. J. Neurosurg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12987-020-00195-3","article-title":"Measuring intracranial pressure by invasive, less invasive or non-invasive means: Limitations and avenues for improvement","volume":"17","author":"Evensen","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.clineuro.2010.10.008","article-title":"Static and pulsatile intracranial pressure in idiopathic intracranial hypertension","volume":"113","author":"Eide","year":"2011","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3171\/2015.11.JNS151529","article-title":"The correlation between pulsatile intracranial pressure and indices of intracranial pressure-volume reserve capacity: Results from ventricular infusion testing","volume":"125","author":"Eide","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Eide, P.K., Pripp, A.H., Ringstad, G., and Valnes, L.M. (2021). Impaired glymphatic function in idiopathic intracranial hypertension. Brain Commun.","DOI":"10.1093\/braincomms\/fcab043"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.121537","article-title":"Brain-wide glymphatic enhancement and clearance in humans assessed with MRI","volume":"3","author":"Ringstad","year":"2018","journal-title":"JCI Insight"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1227\/01.NEU.0000363408.69856.B8","article-title":"Diagnostic intracranial pressure monitoring and surgical management in idiopathic normal pressure hydrocephalus: A 6-year review of 214 patients","volume":"66","author":"Eide","year":"2010","journal-title":"Neurosurgery"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Mestre, H., Tithof, J., Du, T., Song, W., Peng, W., Sweeney, A.M., Olveda, G., Thomas, J.H., Nedergaard, M., and Kelley, D.H. (2018). Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat. Commun., 9.","DOI":"10.1038\/s41467-018-07318-3"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.3171\/2016.4.JNS152862","article-title":"Comparative observational study on the clinical presentation, intracranial volume measurements, and intracranial pressure scores in patients with either Chiari malformation Type I or idiopathic intracranial hypertension","volume":"126","author":"Fric","year":"2017","journal-title":"J. Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/s41433-018-0238-5","article-title":"The expanding burden of idiopathic intracranial hypertension","volume":"33","author":"Mollan","year":"2019","journal-title":"Eye"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1468-1331.2011.03372.x","article-title":"The incidence and prevalence of idiopathic intracranial hypertension in Sheffield, UK","volume":"18","author":"Raoof","year":"2011","journal-title":"Eur. J. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1212\/WNL.33.10.1386","article-title":"Cerebrospinal fluid pressure in normal obese subjects and patients with pseudotumor cerebri","volume":"33","author":"Corbett","year":"1983","journal-title":"Neurology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1179\/016164107X224132","article-title":"Association among intracranial compliance, intracranial pulse pressure amplitude and intracranial pressure in patients with intracranial bleeds","volume":"29","author":"Eide","year":"2007","journal-title":"Neurol. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/nn.4288","article-title":"Pericytes of the neurovascular unit: Key functions and signaling pathways","volume":"19","author":"Sweeney","year":"2016","journal-title":"Nat. Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/bpa.12152","article-title":"The pericyte: A forgotten cell type with important implications for Alzheimer\u2019s disease?","volume":"24","author":"Winkler","year":"2014","journal-title":"Brain Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/glia.20990","article-title":"The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction","volume":"58","author":"Mathiisen","year":"2010","journal-title":"Glia"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1152\/physrev.00011.2013","article-title":"Physiological roles of aquaporin-4 in brain","volume":"93","author":"Nagelhus","year":"2013","journal-title":"Physiol. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3171\/2012.9.JNS121227","article-title":"Impaired pulsation absorber mechanism in idiopathic normal pressure hydrocephalus: Laboratory investigation","volume":"117","author":"Park","year":"2012","journal-title":"J. Neurosurg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.brainres.2018.02.017","article-title":"Cerebral microvascular abnormalities in patients with idiopathic intracranial hypertension","volume":"1686","author":"Eidsvaag","year":"2018","journal-title":"Brain Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/jnen\/nlz063","article-title":"Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension","volume":"78","author":"Hansson","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainres.2016.05.024","article-title":"Cortical astrogliosis and increased perivascular aquaporin-4 in idiopathic intracranial hypertension","volume":"1644","author":"Eide","year":"2016","journal-title":"Brain Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/jnr.24743","article-title":"Increased occurrence of pathological mitochondria in astrocytic perivascular endfoot processes and neurons of idiopathic intracranial hypertension","volume":"99","author":"Eide","year":"2021","journal-title":"J. Neurosci. 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