{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T02:48:25Z","timestamp":1784342905145,"version":"3.55.0"},"reference-count":47,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["1801"],"award-info":[{"award-number":["1801"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EYO24972"],"award-info":[{"award-number":["EYO24972"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Oxygen supplementation is necessary to prevent mortality in severely premature infants. However, the supraphysiological concentration of oxygen utilized in these infants simultaneously creates retinovascular growth attenuation and vasoobliteration that induces the retinopathy of prematurity. Here, we report that hyperoxia regulates the cell cycle and retinal endothelial cell proliferation in a previously unknown Myc-dependent manner, which contributes to oxygen-induced retinopathy.<\/jats:p>","DOI":"10.3390\/life11070614","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T11:07:40Z","timestamp":1624619260000},"page":"614","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Hyperoxia Inhibits Proliferation of Retinal Endothelial Cells in a Myc-Dependent Manner"],"prefix":"10.3390","volume":"11","author":[{"given":"Charandeep","family":"Singh","sequence":"first","affiliation":[{"name":"Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Benos","sequence":"additional","affiliation":[{"name":"Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1463-849X","authenticated-orcid":false,"given":"Allison","family":"Grenell","sequence":"additional","affiliation":[{"name":"Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA"},{"name":"Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Rao","sequence":"additional","affiliation":[{"name":"Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA"},{"name":"Department of Ophthalmology and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4845-9094","authenticated-orcid":false,"given":"Bela","family":"Anand-Apte","sequence":"additional","affiliation":[{"name":"Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA"},{"name":"Department of Ophthalmology and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan E.","family":"Sears","sequence":"additional","affiliation":[{"name":"Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH 44195, USA"},{"name":"Cardiovascular and Metabolic Sciences, Cleveland Clinic, Cleveland 44195, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"19898","DOI":"10.1073\/pnas.0805817105","article-title":"Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy","volume":"105","author":"Sears","year":"2008","journal-title":"Proc. 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