{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T12:24:20Z","timestamp":1784291060183,"version":"3.55.0"},"reference-count":45,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T00:00:00Z","timestamp":1624752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Psoriasis is a chronic, inflammatory skin disease present in about 3% of the world\u2019s population. The clinical symptoms manifest diversely, therefore one can distinguish several subtypes of psoriasis. The majority of patients with psoriasis experience pruritus, which is an unpleasant sensation that decreases patients\u2019 quality of life. The knowledge on pruritus in different subtypes of psoriasis is limited. We have performed a cross-sectional, prospective, and multicenter study to evaluate the relationship between clinical subtypes of psoriasis (large-plaque, nummular, guttate, palmoplantar, inverse, erythrodermic, palmoplantar pustular, generalized pustular psoriasis, and psoriasis of the scalp) and the prevalence, intensity, and clinical manifestation of itch. We introduced a questionnaire assessing various aspects of pruritus to a total of 254 patients. Out of these, 42 were excluded. Pruritus was present in 92.9% of the remaining patients and its prevalence did not depend on the clinical subtype. A correlation between the severity of psoriasis and the intensity of itch was explicitly noticeable in palmoplantar pustular psoriasis and scalp psoriasis (p &lt; 0.05). The itch sensation was individual and differed among subtypes of psoriasis. In conclusion, pruritus is a frequent phenomenon, and its presentation is different in various subtypes of psoriasis.<\/jats:p>","DOI":"10.3390\/life11070623","type":"journal-article","created":{"date-parts":[[2021,6,27]],"date-time":"2021-06-27T22:24:57Z","timestamp":1624832697000},"page":"623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Characteristics of Pruritus in Various Clinical Variants of Psoriasis: Results of the Multinational, Multicenter, Cross-Sectional Study"],"prefix":"10.3390","volume":"11","author":[{"given":"Kamila","family":"Jaworecka","sequence":"first","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3268-012X","authenticated-orcid":false,"given":"Dominika","family":"Kwiatkowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-1222","authenticated-orcid":false,"given":"Luiza","family":"Marek","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 85-094 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4157-5583","authenticated-orcid":false,"given":"Funda","family":"Tamer","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gazi University School of Medicine, 06560 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3714-8434","authenticated-orcid":false,"given":"Aleksandra","family":"Stefaniak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology, Wroclaw Medical University, 50-368 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Szczegielniak","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pediatric Dermatology and Oncology, Lodz Medical University, 91-347 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Chojnacka-Purpurowicz","sequence":"additional","affiliation":[{"name":"Department and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-959 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Mat\u0142awska","sequence":"additional","affiliation":[{"name":"Department and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-959 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayla","family":"Gulekon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Gazi University School of Medicine, 06560 Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0766-6342","authenticated-orcid":false,"given":"Jacek C.","family":"Szepietowski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Allergology, Wroclaw Medical University, 50-368 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Narbutt","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pediatric Dermatology and Oncology, Lodz Medical University, 91-347 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Owczarczyk-Saczonek","sequence":"additional","affiliation":[{"name":"Department and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Faculty of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-959 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5573-1754","authenticated-orcid":false,"given":"Adam","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institute of Medical Sciences, Medical College of Rzeszow University, 35-055 Rzesz\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,27]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Ixekizumab may improve renal function in psoriasis","volume":"7","author":"Amoruso","year":"2021","journal-title":"Healthcare"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.autrev.2014.01.008","article-title":"Diagnosis and classification of psoriasis","volume":"13","author":"Raychaudhuri","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/dth.13170","article-title":"Effectiveness of brodalumab in acrodermatitis continua of Hallopeau: A case report","volume":"33","author":"Passante","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ejp.768","article-title":"Pruritus in psoriasis: An update","volume":"20","author":"Szepietowski","year":"2015","journal-title":"Eur. J. Pain"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Jaworecka, K., Muda-Urban, J., Rzepko, M., and Reich, A. (2021). Molecular Aspects of Pruritus Pathogenesis in Psoriasis. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22020858"},{"key":"ref_6","first-page":"77","article-title":"Itching in psoriasis","volume":"25","author":"Reich","year":"2004","journal-title":"Kosmet. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"851","DOI":"10.17219\/acem\/69804","article-title":"The reliability of three psoriasis assessment tools: Psoriasis area and severity index, body surface area and physician global assessment","volume":"26","author":"Reich","year":"2017","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_8","first-page":"6","article-title":"How to reliably evaluate the severity of psoriasis?","volume":"2","author":"Reich","year":"2016","journal-title":"Forum Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1046\/j.1365-2133.2001.04411.x","article-title":"Oral liarozole in the treatment of palmoplantar pustular psoriasis: A randomized, double-blind, placebo-controlled study","volume":"145","author":"Bhushan","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/1346-8138.14664","article-title":"Adalimumab treatment in Japanese patients with generalized pustular psoriasis: Results of an open-label phase 3 study","volume":"45","author":"Morita","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/bjd.14464","article-title":"Psychometric properties of the Itch Numeric Rating Scale in patients with moderate-to-severe plaque psoriasis","volume":"175","author":"Kimball","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_12","first-page":"91","article-title":"Validity assessment of the 10-Item Pruritus Severity Scale","volume":"4","author":"Reich","year":"2018","journal-title":"Forum Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1087-0024.2004.09113.x","article-title":"10 Years Experience of the Dermatology Life Quality Index (DLQI)","volume":"9","author":"Lewis","year":"2004","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/j.1365-2133.2004.06093.x","article-title":"The Idi Multipurpose Psoriasis Research on Vital Experiences (Improve) Investigators Prevalence of symptoms experienced by patients with different clinical types of psoriasis","volume":"151","author":"Sampogna","year":"2004","journal-title":"Br. J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1600-0625.2007.00544.x","article-title":"Plasma concentration of selected neuropeptides in patients suffering from psoriasis","volume":"16","author":"Reich","year":"2007","journal-title":"Exp. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5021\/ad.2020.32.1.1","article-title":"Characteristics of Pruritus according to Morphological Phenotype of Psoriasis and Association with Neuropeptides and Interleukin-31","volume":"32","author":"Park","year":"2020","journal-title":"Ann. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.5114\/pdia.2014.44010","article-title":"Apprehension of the disease by patients suffering from psoriasis","volume":"5","author":"Reich","year":"2014","journal-title":"Adv. Dermatol. Allergol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1046\/j.1365-2133.2000.03829.x","article-title":"The prevalence and clinical characteristics of pruritus among patients with extensive psoriasis","volume":"143","author":"Yosipovitch","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/ijd.12074","article-title":"Clinical and psychological characteristics of patients with psoriasis reporting various frequencies of pruritus","volume":"53","author":"Janowski","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1468-3083.2008.02591.x","article-title":"Patients\u2019 perspective of pruritus in chronic plaque psoriasis: A questionnaire-based study","volume":"22","author":"Amatya","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/jdv.12761","article-title":"Pruritus and quality of life in moderate-to-severe plaque psoriasis: Post hoc explorative analysis from the PRISTINE study","volume":"29","author":"Mrowietz","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/ajd.12747","article-title":"Itching for answers: Prevalence and severity of pruritus in psoriasis","volume":"59","author":"Dickison","year":"2017","journal-title":"Australas. J. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jaad.2013.09.030","article-title":"Pruritus severity in patients with psoriasis is not correlated with psoriasis disease severity","volume":"70","author":"Roblin","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4103\/0378-6323.55426","article-title":"The relationship between symptoms and patient characteristics among psoriasis patients","volume":"75","author":"Ermertcan","year":"2009","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_25","first-page":"231","article-title":"Prevalence of pruritus in psoriatic skin lesions and its relations to different variables","volume":"24","author":"Singh","year":"2014","journal-title":"J. Pak. Assoc. Dermatol."},{"key":"ref_26","first-page":"221","article-title":"Itching in patients suffering from psoriasis","volume":"10","author":"Szepietowski","year":"2002","journal-title":"Acta Dermatovenerol. Croat. ADC"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1590\/abd1806-4841.20175402","article-title":"The relationship between pruritus and clinical variables in patients with psoriasis","volume":"92","author":"Bahali","year":"2017","journal-title":"An. Bras. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.lpm.2019.02.016","article-title":"Factors predicting pruritus in psoriasis","volume":"48","author":"Mansouri","year":"2019","journal-title":"Presse M\u00e9dicale"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/jdv.15539","article-title":"Pruritus characteristics in a large Italian cohort of psoriatic patients","volume":"33","author":"Damiani","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_30","unstructured":"Bolognia, J.L., Schaffer, J.V., and Cerroni, L. (2018). Dermatology: 2-Volume Set. Dermatology, Elsevier. [4th ed.]."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2147\/CCID.S4465","article-title":"Itch in psoriasis: Epidemiology, clinical aspects and treatment options","volume":"2","author":"Prignano","year":"2009","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bjps.2004.12.017","article-title":"Nerve fibre and sensory end organ density in the epidermis and papillary dermis of the human hand","volume":"58","author":"Kelly","year":"2005","journal-title":"Br. J. Plast. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.jaad.2009.07.003","article-title":"Factors affecting sleep quality in patients with psoriasis","volume":"63","author":"Gowda","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13555-017-0192-3","article-title":"Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review","volume":"7","author":"Jeon","year":"2017","journal-title":"Dermatol. Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","article-title":"Itch: From mechanism to (novel) therapeutic approaches","volume":"142","author":"Yosipovitch","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Komiya, E., Tominaga, M., Kamata, Y., Suga, Y., and Takamori, K. (2020). Molecular and Cellular Mechanisms of Itch in Psoriasis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21218406"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/jdv.15450","article-title":"Itch: An under-recognized problem in psoriasis","volume":"33","author":"Elewski","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2340\/00015555-2047","article-title":"Topical TrkA Kinase Inhibitor CT327 is an Effective, Novel Therapy for the Treatment of Pruritus due to Psoriasis: Results from Experimental Studies, and Efficacy and Safety of CT327 in a Phase 2b Clinical Trial in Patients with Psoriasis","volume":"95","author":"Roblin","year":"2015","journal-title":"Acta Derm. Venereol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jaad.2020.01.056","article-title":"Serlopitant for psoriatic pruritus: A phase 2 randomized, double-blind, placebo-controlled clinical trial","volume":"82","author":"Pariser","year":"2020","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8171373","DOI":"10.1155\/2019\/8171373","article-title":"Relationship between the Degrees of Itch and Serum Lipocalin-2 Levels in Patients with Psoriasis","volume":"2019","author":"Aizawa","year":"2019","journal-title":"J. Immunol. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2133.2011.10347.x","article-title":"Evaluation of epidermal nerve density and opioid receptor levels in psori-atic itch","volume":"165","author":"Taneda","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"564","DOI":"10.2340\/00015555-2595","article-title":"Opioid receptors in psoriatic skin: Relationship with itch","volume":"97","author":"Kupczyk","year":"2017","journal-title":"Acta Derm. Venereol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"12111","DOI":"10.7150\/thno.52135","article-title":"Resolvin D3 controls mouse and human TRPV1-positive neurons and preclinical progression of psoriasis","volume":"10","author":"Lee","year":"2020","journal-title":"Theranostics"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"115247","DOI":"10.1016\/j.taap.2020.115247","article-title":"Thymol activates TRPM8-mediated Ca2+ influx for its antipruritic effects and alleviates inflammatory response in Imiquimod-induced mice","volume":"407","author":"Wang","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"102429","DOI":"10.1016\/j.ceca.2021.102429","article-title":"Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4","volume":"97","author":"Yan","year":"2021","journal-title":"Cell Calcium"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/7\/623\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:25:22Z","timestamp":1760163922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/7\/623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,27]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["life11070623"],"URL":"https:\/\/doi.org\/10.3390\/life11070623","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,27]]}}}