{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:22:56Z","timestamp":1781839376864,"version":"3.54.5"},"reference-count":15,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T00:00:00Z","timestamp":1625356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Updated data about the prevalence of Helicobacter pylori (H. pylori) and its correlation with histological results are scarce. The aim of our study was to provide current data on the impact of H. pylori in a third-level endoscopy service. We performed a large, retrospective study analyzing the results of all histological samples of gastroscopy from the year 2019. In total, 1512 subjects were included. The prevalence of H. pylori was 16.8%. A significant difference between the prevalence in subjects born in Italy and those from eastern Europe, south America, or Africa was found (p &lt; 0.0001, p = 0.006, and p = 0.0006, respectively). An association was found between H. pylori and active superficial gastritis (p &lt; 0.0001). Current H. pylori and\/or a previous finding of H. pylori was related to antral atrophy (p &lt; 0.0001). Fifteen patients had low-grade dysplasia. There were no statistically significant associations with current or past H. pylori infection. One patient presented gastric cardia adenocarcinoma with regular gastric mucosa. One patient, H. pylori positive, was diagnosed with gastric signet ring cell adenocarcinoma in a setting of diffuse atrophy, without metaplasia.. Our study provides updated, solid (biopsy diagnosis and large population) data on the prevalence of H. pylori infection in a representative region of southern Europe.<\/jats:p>","DOI":"10.3390\/life11070650","type":"journal-article","created":{"date-parts":[[2021,7,4]],"date-time":"2021-07-04T22:34:36Z","timestamp":1625438076000},"page":"650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Retrospective Experience of Helicobacter pylori Histology in a Large Sample of Subjects in Northern Italy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9421-3087","authenticated-orcid":false,"given":"Davide Giuseppe","family":"Ribaldone","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Division of Gastroenterology, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Zurlo","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Division of Gastroenterology, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6070-6716","authenticated-orcid":false,"given":"Sharmila","family":"Fagoonee","sequence":"additional","affiliation":[{"name":"Institute of Biostructure and Bioimaging (CNR), Molecular Biotechnology Center, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-7089","authenticated-orcid":false,"given":"Chiara","family":"Rosso","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Division of Gastroenterology, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7245-4445","authenticated-orcid":false,"given":"Angelo","family":"Armandi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Division of Gastroenterology, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0529-9481","authenticated-orcid":false,"given":"Gian Paolo","family":"Caviglia","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Division of Gastroenterology, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5310-4143","authenticated-orcid":false,"given":"Giorgio Maria","family":"Saracco","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Division of Gastroenterology, University of Torino, 10124 Torino, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3438-0649","authenticated-orcid":false,"given":"Rinaldo","family":"Pellicano","sequence":"additional","affiliation":[{"name":"Department of General and Specialist Medicine, Gastroenterologia-U, Citt\u00e0 della Salute e della Scienza di Torino, C.so Bramante 88, 10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,4]]},"reference":[{"key":"ref_1","first-page":"304","article-title":"A 2016 panorama of Helicobacter pylori infection: Key messages for clinicians","volume":"58","author":"Pellicano","year":"2016","journal-title":"Panminerva Med."},{"key":"ref_2","first-page":"112","article-title":"Helicobacter Pylori: A comprehensive review for primary care providers","volume":"59","author":"Nelson","year":"2021","journal-title":"Rom. J. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1053\/j.gastro.2017.04.022","article-title":"Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis","volume":"153","author":"Hooi","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/apt.13474","article-title":"Review article: The prevalence of Helicobacter pylori and the incidence of gastric cancer across Europe","volume":"43","author":"Roberts","year":"2016","journal-title":"Aliment. Pharmacol. 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