{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:59:07Z","timestamp":1780088347855,"version":"3.54.0"},"reference-count":106,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["PID2019-104205GB-C21"],"award-info":[{"award-number":["PID2019-104205GB-C21"]}]},{"name":"Spanish Ministerio de Ciencia, Innovaci\u00f3n y Universidades","award":["PID2019-107442RB-C32"],"award-info":[{"award-number":["PID2019-107442RB-C32"]}]},{"DOI":"10.13039\/501100011033","name":"Spanish State Research Agency","doi-asserted-by":"publisher","award":["MDM-2017-0737"],"award-info":[{"award-number":["MDM-2017-0737"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Hydrogen cyanide, HCN, is considered a fundamental molecule in chemical evolution. The named HCN polymers have been suggested as precursors of important bioorganics. Some novel researches have focused on the role of mineral surfaces in the hydrolysis and\/or polymerization of cyanide species, but until now, their role has been unclear. Understanding the role of minerals in chemical evolution processes is crucial because minerals undoubtedly interacted with the organic molecules formed on the early Earth by different process. Therefore, we simulated the probable interactions between HCN and a serpentinite-hosted alkaline hydrothermal system. We studied the effect of serpentinite during the thermolysis of HCN at basic conditions (i.e., HCN 0.15 M, 50 h, 100 \u00b0C, pH &gt; 10). The HCN-derived thermal polymer and supernatant formed after treatment were analyzed by several complementary analytical techniques. The results obtained suggest that: (I) the mineral surfaces can act as mediators in the mechanisms of organic molecule production such as the polymerization of HCN; (II) the thermal and physicochemical properties of the HCN polymer produced are affected by the presence of the mineral surface; and (III) serpentinite seems to inhibit the formation of bioorganic molecules compared with the control (without mineral).<\/jats:p>","DOI":"10.3390\/life11070661","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T11:36:44Z","timestamp":1625571404000},"page":"661","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A Lizardite\u2013HCN Interaction Leading the Increasing of Molecular Complexity in an Alkaline Hydrothermal Scenario: Implications for Origin of Life Studies"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3087-4457","authenticated-orcid":false,"given":"Sa\u00fal A.","family":"Villafa\u00f1e-Barajas","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias de la Tierra, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8059-1335","authenticated-orcid":false,"given":"Marta","family":"Ruiz-Bermejo","sequence":"additional","affiliation":[{"name":"Departamento de Evoluci\u00f3n Molecular, Centro de Astrobiolog\u00eda (CSIC-INTA), Ctra, Torrej\u00f3n-Ajalvir, km 4, Torrej\u00f3n de Ardoz, 28850 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Rayo-Pizarroso","sequence":"additional","affiliation":[{"name":"Departamento de Evoluci\u00f3n Molecular, Centro de Astrobiolog\u00eda (CSIC-INTA), Ctra, Torrej\u00f3n-Ajalvir, km 4, Torrej\u00f3n de Ardoz, 28850 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santos","family":"G\u00e1lvez-Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Departamento de Evoluci\u00f3n Molecular, Centro de Astrobiolog\u00eda (CSIC-INTA), Ctra, Torrej\u00f3n-Ajalvir, km 4, Torrej\u00f3n de Ardoz, 28850 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4709-4676","authenticated-orcid":false,"given":"Eva","family":"Mateo-Mart\u00ed","sequence":"additional","affiliation":[{"name":"Departamento de Evoluci\u00f3n Molecular, Centro de Astrobiolog\u00eda (CSIC-INTA), Ctra, Torrej\u00f3n-Ajalvir, km 4, Torrej\u00f3n de Ardoz, 28850 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9193-1761","authenticated-orcid":false,"given":"Mar\u00eda","family":"Col\u00edn-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Instituto de Geolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Ciudad Universitaria, Mexico City 04510, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3390\/life3030421","article-title":"Simple Organics and Biomonomers Identified in HCN Polymers: An Overview","volume":"3","author":"Zorzano","year":"2013","journal-title":"Life"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/anie.201506585","article-title":"The Origin of Life-Out of the Blue","volume":"55","author":"Sutherland","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.chempr.2017.03.001","article-title":"Prebiotic Systems Chemistry: Complexity Overcoming Clutter","volume":"2","author":"Islam","year":"2017","journal-title":"Chem"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/nature08013","article-title":"Synthesis of Activated Pyrimidine Ribonucleotides in Prebiotically Plausible Conditions","volume":"459","author":"Powner","year":"2009","journal-title":"Nature"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nchem.1467","article-title":"Prebiotic Synthesis of Simple Sugars by Photoredox Systems Chemistry","volume":"4","author":"Ritson","year":"2012","journal-title":"Nat. Chem."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1002\/anie.201300321","article-title":"Synthesis of Aldehydic Ribonucleotide and Amino Acid Precursors by Photoredox Chemistry","volume":"52","author":"Ritson","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"13531","DOI":"10.1002\/chem.201502345","article-title":"A Prebiotic Synthesis of Pterins","volume":"21","year":"2015","journal-title":"Chem. Eur. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nchem.2202","article-title":"Common Origins of RNA, Protein and Lipid Precursors in a Cyanosulfidic Protometabolism","volume":"7","author":"Patel","year":"2015","journal-title":"Nat. Chem."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"12785","DOI":"10.1002\/chem.201602195","article-title":"The Role of Aqueous Aerosols in the \u201cGlyoxylate Scenario\u201d: An Experimental Approach","volume":"22","year":"2016","journal-title":"Chem. Eur. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5566","DOI":"10.1039\/C8CC01499J","article-title":"Photochemical Reductive Homologation of Hydrogen Cyanide Using Sulfite and Ferrocyanide","volume":"54","author":"Xu","year":"2018","journal-title":"Chem. Commun."},{"key":"ref_11","first-page":"1","article-title":"Prebiotic Chemistry in Neutral\/Reduced-Alkaline Gas-Liquid Interfaces","volume":"9","author":"Espigares","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1021\/acscentsci.9b00520","article-title":"Insights into the Origin of Life: Did It Begin from HCN and H2O?","volume":"5","author":"Das","year":"2019","journal-title":"ACS Cent. Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13563","DOI":"10.1039\/D0CC05752E","article-title":"Photoredox Chemistry in the Synthesis of 2-Aminoazoles Implicated in Prebiotic Nucleic Acid Synthesis","volume":"56","author":"Liu","year":"2020","journal-title":"Chem. Commun."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"16981","DOI":"10.1002\/anie.201908272","article-title":"A Stark Contrast to Modern Earth: Phosphate Mineral Transformation and Nucleoside Phosphorylation in an Iron- and Cyanide-Rich Early Earth Scenario","volume":"58","author":"Burcar","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/251050a0","article-title":"Evolution of Organic Compounds in Volcanic Regions","volume":"251","author":"Mukhin","year":"1974","journal-title":"Nature"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/BF00927931","article-title":"Volcanic Processes and Synthesis of Simple Organic Compounds on Primitive Earth","volume":"7","author":"Mukhin","year":"1976","journal-title":"Orig. Life"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/279051a0","article-title":"Thiocyanate in Red Sea Brine and Its Implications","volume":"279","author":"Dowler","year":"1979","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01582036","article-title":"Archean Geochemistry of Formaldehyde and Cyanide and the Oligomerization of Cyanohydrin","volume":"24","author":"Arrhenius","year":"1994","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF01809851","article-title":"Was Ferrocyanide a Prebiotic Reagent?","volume":"26","author":"Keefe","year":"1996","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Dzombak, D.A., Ghosh, R.S., and Wong-Chong, G.M. (2006). Cyanide in Water and Soil: Chemistry, Risk, and Management, CRC\/Taylor & Francis.","DOI":"10.1201\/9781420032079"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nrmicro1991","article-title":"Hydrothermal Vents and the Origin of Life","volume":"11","author":"Martin","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"599","DOI":"10.18268\/BSGM2016v68n3a13","article-title":"Hydrothermal Vents and Prebiotic Chemistry: A Review","volume":"68","author":"Heredia","year":"2016","journal-title":"Bolet\u00edn Soc. Geol\u00f3gica"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Col\u00edn-Garc\u00eda, M., Villafa\u00f1e-Barajas, S., Camprub\u00ed, A., Ortega-Guti\u00e9rrez, F., Col\u00e1s, V., and Negr\u00f3n-Mendoza, A. (2018). Prebiotic Chemistry in Hydrothermal Vent Systems. Handbook of Astrobiology, CRC Press. [1st ed.].","DOI":"10.1201\/b22230-21"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1089\/ast.2006.6.364","article-title":"Serpentinization and Its Implications for Life on the Early Earth and Mars","volume":"6","author":"Schulte","year":"2006","journal-title":"Astrobiology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1098\/rstb.2011.0129","article-title":"Serpentinite and the Dawn of Life","volume":"366","author":"Sleep","year":"2011","journal-title":"Philos. Trans. R. Soc. B"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2113\/gselements.9.2.129","article-title":"Serpentinites, Hydrogen, and Life","volume":"9","author":"McCollom","year":"2013","journal-title":"Elements"},{"key":"ref_27","first-page":"959","article-title":"Serpentine and Serpentinization: A Link between Planet Formation and Life","volume":"38","year":"2010","journal-title":"Geology"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev-earth-042711-105316","article-title":"Processes on the Young Earth and the Habitats of Early Life","volume":"40","author":"Arndt","year":"2012","journal-title":"Annu. Rev. Earth Planet Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/gbi.12025","article-title":"Did Life Originate from a Global Chemical Reactor?","volume":"11","author":"Anderson","year":"2013","journal-title":"Geobiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2138\/rmg.2013.75.18","article-title":"Serpentinization, Carbon, and Deep Life","volume":"75","author":"Schrenk","year":"2013","journal-title":"Rev. Miner. Geochem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2113\/gselements.9.2.99","article-title":"Serpentinite: What, Why, Where?","volume":"9","author":"Evans","year":"2013","journal-title":"Elements"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1126\/science.1102556","article-title":"A Serpentinite-Hosted Ecosystem: The Lost City Hydrothermal Field","volume":"307","author":"Kelley","year":"2005","journal-title":"Science"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.precamres.2010.08.011","article-title":"Highly Alkaline, High-Temperature Hydrothermal Fluids in the Early Archean Ocean","volume":"182","author":"Shibuya","year":"2010","journal-title":"Precambrian Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Golding, S.D., and Glikson, M. (2011). Earliest Seafloor Hydrothermal Systems on Earth: Comparison with Modern Analogues. Earliest Life on Earth: Habitats, Environments and Methods of Detection, Springer Netherlands.","DOI":"10.1007\/978-90-481-8794-2"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40645-015-0076-z","article-title":"Hydrogen-Rich Hydrothermal Environments in the Hadean Ocean Inferred from Serpentinization of Komatiites at 300 \u00baC and 500 Bar","volume":"2","author":"Shibuya","year":"2015","journal-title":"Prog. Earth Planet. Sci."},{"key":"ref_36","unstructured":"Corliss, J.B., Baross, J.A., and Hoffman, S.E. (1981). An Hypothesis Concerning the Relationships between Submarine Hot Springs and the Origin of Life on Earth. Oceanol. Acta Spec. Issue."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/BF01808177","article-title":"Submarine Hydrothermal Vents and Associated Gradient Environments as Sites for the Origin and Evolution of Life","volume":"15","author":"Baross","year":"1985","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1467-4866-7-7","article-title":"Alkaline Fluid Circulation in Ultramafic Rocks and Formation of Nucleotide Constituents: A Hypothesis","volume":"7","author":"Holm","year":"2006","journal-title":"Geochem. Trans."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1467-4866-10-9","article-title":"Reduction of Nitrogen Compounds in Oceanic Basement and Its Implications for HCN Formation and Abiotic Organic Synthesis","volume":"10","author":"Holm","year":"2009","journal-title":"Geochem. Trans."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Rimmer, P.B., and Shorttle, O. (2019). Origin of Life\u2019s Building Blocks in Carbon-and Nitrogen-Rich Surface Hydrothermal Vents. Life, 9.","DOI":"10.3390\/life9010012"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.gca.2019.06.031","article-title":"Alkaline Lake Settings for Concentrated Prebiotic Cyanide and the Origin of Life","volume":"260","author":"Toner","year":"2019","journal-title":"Geochim. Cosmochim. Acta"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.gca.2016.06.006","article-title":"Thermodynamic Constraints on the Formation of Condensed Carbon from Serpentinization Fluids","volume":"189","author":"Milesi","year":"2016","journal-title":"Geochim. Cosmochim. Acta"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.gca.2015.01.015","article-title":"Formation of CO2, H2 and Condensed Carbon from Siderite Dissolution in the 200\u2013300\u00b0C Range and at 50MPa","volume":"154","author":"Milesi","year":"2015","journal-title":"Geochim. Cosmochim. Acta"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07385-6","article-title":"Abiotic Formation of Condensed Carbonaceous Matter in the Hydrating Oceanic Crust","volume":"9","author":"Sforna","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1089\/ast.2014.1280","article-title":"RNA Oligomerization in Laboratory Analogues of Alkaline Hydrothermal Vent Systems","volume":"15","author":"Burcar","year":"2015","journal-title":"Astrobiology"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Villafa\u00f1e-Barajas, S.A., Ruiz-Bermejo, M., Rayo-Pizarroso, P., and Col\u00edn-Garc\u00eda, M. (2020). Characterization of HCN-Derived Thermal Polymer: Implications for Chemical Evolution. Processes, 8.","DOI":"10.3390\/pr8080968"},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Villafa\u00f1e-Barajas, S.A., Col\u00edn-Garc\u00eda, M., Negr\u00f3n-Mendoza, A., and Ruiz-Bermejo, M. (2020). An Experimental Study of the Thermolysis of Hydrogen Cyanide: The Role of Hydrothermal Systems in Chemical Evolution. Int. J. Astrobiol., 1\u201310.","DOI":"10.1017\/S1473550420000142"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-79112-5","article-title":"A Dual Perspective on the Microwave-Assisted Synthesis of HCN Polymers towards the Chemical Evolution and Design of Functional Materials","volume":"10","author":"Hortal","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_49","first-page":"223","article-title":"Studies in Prebiotic Synthesis. II. Synthesis of Purine Precursors and Amino Acids from Aqueous Hydrogen Cyanide","volume":"30","author":"Sanchez","year":"1967","journal-title":"J. Mol. Biol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"6968","DOI":"10.1021\/ja00775a018","article-title":"Chemical Evolution. IX. Mechanism of the Oligomerization of Hydrogen Cyanide and Its Possible Role in the Origins of Life","volume":"94","author":"Ferris","year":"1972","journal-title":"J. Am. Chem. Soc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3989","DOI":"10.1021\/jo00415a001","article-title":"Chemical Evolution. 31. Mechanism of the Condensation of Cyanide to Hydrogen Cyanide Oligomers","volume":"43","author":"Ferris","year":"1978","journal-title":"J. Org. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1023\/A:1016514305984","article-title":"The Cold Origin of Life: A. Implications Based on the Hydrolytic Stabilities of Hydrogen Cyanide and Formamide","volume":"32","author":"Miyakawa","year":"2002","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.saa.2017.10.003","article-title":"Experimental Conditions Affecting the Kinetics of Aqueous HCN Polymerization as Revealed by UV\u2013Vis Spectroscopy","volume":"191","author":"Moreno","year":"2018","journal-title":"Spectrochim. Acta A"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"17353","DOI":"10.1039\/C8CP01662C","article-title":"Modelling the Kinetics and Structural Property Evolution of a Versatile Reaction: Aqueous HCN Polymerization","volume":"20","year":"2018","journal-title":"Phys. Chem. Chem. Phys."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"109719","DOI":"10.1016\/j.eurpolymj.2020.109719","article-title":"Temperature Effect on Aqueous NH4CN Polymerization: Relationship between Kinetic Behaviour and Structural Properties","volume":"132","author":"Mas","year":"2020","journal-title":"Eur. Polym. J."},{"key":"ref_56","first-page":"317","article-title":"The Effect of Clays on the Oligomerization of HCN","volume":"13","author":"Ferris","year":"1979","journal-title":"J. Mol. Biol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1023\/A:1006752720769","article-title":"Cyanide self-addition, controlled adsorption, and other processes at layered double hydroxides","volume":"31","author":"Boclair","year":"2001","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0969-806X(01)00400-5","article-title":"Radiolysis of HCN in Heterogeneous Phase","volume":"61","author":"Cruz","year":"2001","journal-title":"Radiat. Phys. Chem."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1021\/acs.langmuir.9b01497","article-title":"Deposition of Aminomalononitrile-Based Films: Kinetics, Chemistry, and Morphology","volume":"35","author":"Toh","year":"2019","journal-title":"Langmuir"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"419","DOI":"10.18268\/BSGM2009v61n3a9","article-title":"Petrology and Geochemistry of Tehuitzingo Serpentinites (Acatl\u00e1n Complex, SW Mexico)","volume":"61","author":"Proenza","year":"2009","journal-title":"Bol. Soc. Geol. Mex."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1107\/S0365110X65003493","article-title":"The Crystal Structure of the Serpentine Mineral, Lizardite Mg3Si2O5(OH)4","volume":"19","author":"Rucklidge","year":"1965","journal-title":"Acta Cryst."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"C189","DOI":"10.1107\/S0108767381093902","article-title":"Crystal Structure of Lizardite 1T","volume":"37","author":"Mellini","year":"1981","journal-title":"Acta Cryst. Sect. A Found. Crystallogr."},{"key":"ref_63","first-page":"109","article-title":"Preparation and Characterization of Lizardite","volume":"556\u2013562","author":"Zheng","year":"2014","journal-title":"AMM"},{"key":"ref_64","first-page":"2","article-title":"Serpentinites: Mineral Structure, Properties and Technological Applications","volume":"31","author":"Carmignano","year":"2020","journal-title":"J. Braz. Chem. Soc."},{"key":"ref_65","first-page":"221","article-title":"Handbook of X-Ray Photoelectron Spectroscopy","volume":"40","author":"Chastain","year":"1992","journal-title":"Perkin-Elmer Corp."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF01797455","article-title":"Chemical Evolution: XXI. The Amino Acids Released on Hydrolysis of HCN Oligomers","volume":"3","author":"Ferris","year":"1974","journal-title":"J. Mol. Evol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Rivero Crespo, M.A., Pereira G\u00f3mez, D., Villa Garc\u00eda, M.V., Gallardo Amores, J.M., and S\u00e1nchez Escribano, V. (2019). Characterization of Serpentines from Different Regions by Transmission Electron Microscopy, X-ray Diffraction, BET Specific Surface Area and Vibrational and Electronic Spectroscopy. Fibers, 7.","DOI":"10.3390\/fib7050047"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.polymdegradstab.2014.09.005","article-title":"Further Progress into the Thermal Characterization of HCN Polymers","volume":"110","author":"Minard","year":"2014","journal-title":"Polym. Degrad. Stab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jaap.2017.02.015","article-title":"The Influence of Reaction Conditions in Aqueous HCN Polymerization on the Polymer Thermal Degradation Properties","volume":"124","year":"2017","journal-title":"J. Anal. Appl. Pyrolysis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.polymdegradstab.2011.01.033","article-title":"Thermal Characterization of HCN Polymers by TG\u2013MS, TG, DTA and DSC Methods","volume":"96","year":"2011","journal-title":"Polym. Degrad. Stabil."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/cbdv.201100036","article-title":"New Insights into the Characterization of \u2018Insoluble Black HCN Polymers","volume":"9","author":"Rogero","year":"2012","journal-title":"Chem. Biodivers."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"11437","DOI":"10.1002\/chem.201901911","article-title":"A Comparative Study on HCN Polymers Synthesized by Polymerization of NH4CN or Diaminomaleonitrile in Aqueous Media: New Perspectives for Prebiotic Chemistry and Materials Science","volume":"25","author":"Aguilar","year":"2019","journal-title":"Chem. Eur. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2138\/am.2010.3366","article-title":"Serpentine Minerals Discrimination by Thermal Analysis","volume":"95","author":"Viti","year":"2010","journal-title":"Am. Min."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.rser.2013.11.002","article-title":"Dehydroxylation of Serpentine Minerals: Implications for Mineral Carbonation","volume":"31","author":"Dlugogorski","year":"2014","journal-title":"Renew. Sustain. Energy Rev."},{"key":"ref_75","first-page":"29","article-title":"The Thermophysical Properties of Serpentinite","volume":"47","year":"2008","journal-title":"Metalurgija"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaap.2009.10.002","article-title":"TGA\u2013FT-IR Study of Pyrolysis of Poly (Hydrogen Cyanide) Synthesized from Thermal Decomposition of Formamide. Implications in Cometary Emissions","volume":"87","author":"Cataldo","year":"2010","journal-title":"J. Anal. Appl. Pyrol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1016\/j.enconman.2004.02.003","article-title":"Characterization of Carbonated Serpentine Using XPS and TEM","volume":"45","author":"Schulze","year":"2004","journal-title":"Energ. Convers. Manag."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.icarus.2008.07.008","article-title":"CH4\/N2\/H2 Spark Hydrophilic Tholins: A Systematic Approach to the Characterization of Tholins","volume":"198","year":"2008","journal-title":"Icarus"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.icarus.2009.07.001","article-title":"CH4\/N2\/H2-Spark Hydrophobic Tholins: A Systematic Approach to the Characterisation of Tholins. Part II","volume":"204","year":"2009","journal-title":"Icarus"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1038\/am.2015.122","article-title":"Prebiotic-Chemistry Inspired Polymer Coatings for Biomedical and Material Science Applications","volume":"7","author":"Thissen","year":"2015","journal-title":"NPG Asia Mater."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"129050","DOI":"10.1016\/j.matlet.2020.129050","article-title":"Antioxidant Activity of Films Inspired by Prebiotic Chemistry","volume":"285","author":"Ball","year":"2021","journal-title":"Mater. Lett."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1029\/JB092iB03p02587","article-title":"Measurements of Plume Flow from a Hydrothermal Vent Field","volume":"92","author":"Little","year":"1987","journal-title":"J. Geophys. Res."},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Holm, N.G., and Hennet, R.J.-C. (1992). Hydrothermal systems: Their varieties, dynamics, and suitability for prebiotic chemistry. Marine Hydrothermal Systems and the Origin of Life, Springer.","DOI":"10.1007\/978-94-011-2741-7_2"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"182","DOI":"10.5670\/oceanog.2012.16","article-title":"Diffuse Flow On and Around Hydrothermal Vents at Mid-Ocean Ridges","volume":"25","author":"Bemis","year":"2012","journal-title":"Oceanog"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11084-005-5945-9","article-title":"An Investigation of Prebiotic Purine Synthesis from the Hydrolysis of HCN Polymers","volume":"35","author":"Borquez","year":"2005","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0883-2889(90)90079-V","article-title":"Synthesis of 1-11C-Labeled Fatty Acid from [11C]HCN","volume":"41","author":"Takahashi","year":"1990","journal-title":"Int. J. Rad. Appl. Instr. A"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/cbdv.200790050","article-title":"On a Hypothetical Generational Relationship between HCN and Constituents of the Reductive Citric Acid Cycle","volume":"4","author":"Eschenmoser","year":"2007","journal-title":"Chem. Biodivers."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Thissen, H., Evans, R.A., and Ball, V. (2021). Films and Materials Derived from Aminomalononitrile. Processes, 9.","DOI":"10.3390\/pr9010082"},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-L\u00f3pez, L.A., Col\u00edn-Garc\u00eda, M., Mel\u00e9ndez-L\u00f3pez, A., Cruz-Casta\u00f1eda, J., and Negr\u00f3n-Mendoza, A. (2021). Prebiotic Experi-Ments Simulating Hydrothermal Vents: Influence of Olivine in the Decomposition of Simple Carboxylic Acids. Bol. Soc. Geol\u00f3g. Mex, in press.","DOI":"10.18268\/BSGM2021v73n3a291220"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00239-014-9658-4","article-title":"An Origin-of-Life Reactor to Simulate Alkaline Hydrothermal Vents","volume":"79","author":"Herschy","year":"2014","journal-title":"J. Mol. Evol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/ast.2015.1406","article-title":"The Origin of Life in Alkaline Hydrothermal Vents","volume":"16","author":"Sojo","year":"2016","journal-title":"Astrobiology"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11214-019-0624-8","article-title":"The Emergence of Life","volume":"215","author":"House","year":"2019","journal-title":"Space Sci. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/ast.2019.2045","article-title":"The Hot Spring Hypothesis for an Origin of Life","volume":"20","author":"Damer","year":"2020","journal-title":"Astrobiology"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"105737","DOI":"10.1016\/j.clay.2020.105737","article-title":"On the Why\u2019s and How\u2019s of Clay Minerals\u2019 Importance in Life\u2019s Emergence","volume":"195","author":"Duval","year":"2020","journal-title":"Appl. Clay Sci."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Deamer, D. (2021). Where Did Life Begin? Testing Ideas in Prebiotic Analogue Conditions. Life, 11.","DOI":"10.3390\/life11020134"},{"key":"ref_96","first-page":"4906","article-title":"Stochastic Prebiotic Chemistry within Realistic Geological Systems","volume":"1","author":"Dass","year":"2016","journal-title":"Chem. Sel."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/ast.2014.1198","article-title":"The Production of Methane, Hydrogen, and Organic Compounds in Ultramafic-Hosted Hydrothermal Vents of the Mid-Atlantic Ridge","volume":"15","author":"Konn","year":"2015","journal-title":"Astrobiology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7668","DOI":"10.1073\/pnas.1506295112","article-title":"Pathways for Abiotic Organic Synthesis at Submarine Hydrothermal Fields","volume":"112","author":"McDermott","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ces.2016.12.071","article-title":"Covalent Organic Polymer Modified TiO 2 Nanosheets as Highly Efficient Photocatalysts for Hydrogen Generation","volume":"162","author":"Yang","year":"2017","journal-title":"Chem. Eng. Sci."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"12821","DOI":"10.1016\/j.tet.2007.10.012","article-title":"The Search for the Chemistry of Life\u2019s Origin","volume":"63","author":"Eschenmoser","year":"2007","journal-title":"Tetrahedron"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"9628","DOI":"10.1021\/ja9029818","article-title":"Formation of Protocell-like Vesicles in a Thermal Diffusion Column","volume":"131","author":"Budin","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11084-008-9131-8","article-title":"Stability of Model Membranes in Extreme Environments","volume":"38","author":"Namani","year":"2008","journal-title":"Orig. Life Evol. Biosph."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"12668","DOI":"10.1002\/chem.201702912","article-title":"Orotidine-Containing RNA: Implications for the Hierarchical Selection (Systems Chemistry Emergence) of RNA","volume":"23","author":"Kim","year":"2017","journal-title":"Chem. Eur. J."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"16708","DOI":"10.1002\/chem.201801847","article-title":"Life\u2019s Biological Chemistry: A Destiny or Destination Starting from Prebiotic Chemistry?","volume":"24","author":"Krishnamurthy","year":"2018","journal-title":"Chem. Eur. J."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1021\/acs.chemrev.9b00546","article-title":"Chemistry of Abiotic Nucleotide Synthesis","volume":"120","author":"Yadav","year":"2020","journal-title":"Chem. Rev."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1023\/A:1007090708084","article-title":"Transition metal orotic acid complexes","volume":"25","author":"Maistralis","year":"2000","journal-title":"Transit. Met. Chem."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/7\/661\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:26:50Z","timestamp":1760164010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/7\/661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,6]]},"references-count":106,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["life11070661"],"URL":"https:\/\/doi.org\/10.3390\/life11070661","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,6]]}}}