{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:21:36Z","timestamp":1790882496102,"version":"4.1.0"},"reference-count":120,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Tanoto Foundation","award":["NRDUKST18101"],"award-info":[{"award-number":["NRDUKST18101"]}]},{"name":"New Century Foundation","award":["NCCRF-YR2014-SEP-SD2"],"award-info":[{"award-number":["NCCRF-YR2014-SEP-SD2"]}]},{"name":"Ling Foundation","award":["NRDUKSN18101"],"award-info":[{"award-number":["NRDUKSN18101"]}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/Fellowship\/0054\/2017"],"award-info":[{"award-number":["NMRC\/Fellowship\/0054\/2017"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC-OFIRG16NOV090"],"award-info":[{"award-number":["NMRC-OFIRG16NOV090"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["TCR\/010-NCC\/2012"],"award-info":[{"award-number":["TCR\/010-NCC\/2012"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC-OFLCG-18May0028"],"award-info":[{"award-number":["NMRC-OFLCG-18May0028"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SHF-Foundation Research Grant","award":["SHF\/FG653P\/2017"],"award-info":[{"award-number":["SHF\/FG653P\/2017"]}]},{"name":"SingHealth Duke-NUS Academic Medical Centre and Oncology ACP Nurturing Clinician Scientist Scheme","award":["08-FY2017\/P1\/14-A28"],"award-info":[{"award-number":["08-FY2017\/P1\/14-A28"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Natural killer\/T-cell lymphoma (NKTCL) is an Epstein\u2013Barr virus-associated non-Hodgkin lymphoma linked to an aggressive clinical course and poor prognosis. Despite an improvement in survival outcomes with the incorporation of novel agents including immune checkpoint inhibitors in the treatment of NKTCL, a significant proportion of patients still relapse or remain refractory to treatment. Several clinical prognostic models have been developed for NKTCL patients treated in the modern era, though the optimal approach to risk stratification remains to be determined. Novel molecular biomarkers derived from multi-omic profiling have recently been developed, with the potential to improve diagnosis, prognostication and treatment of this disease. Notably, a number of potential biomarkers have emerged from a better understanding of the tumor immune microenvironment and inflammatory responses. This includes a recently described 3\u2032UTR structural variant in the PD-L1 gene, which confers susceptibility to checkpoint immunotherapy. In this review, we summarize the biomarker landscape of NKTCL and highlight emerging biomarkers with the potential for clinical implementation.<\/jats:p>","DOI":"10.3390\/life11080838","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T21:27:45Z","timestamp":1629149265000},"page":"838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Towards Next Generation Biomarkers in Natural Killer\/T-Cell Lymphoma"],"prefix":"10.3390","volume":"11","author":[{"given":"Jason Yongsheng","family":"Chan","sequence":"first","affiliation":[{"name":"Division of Medical Oncology, National Cancer Centre Singapore, Singapore 169610, Singapore"},{"name":"SingHealth Duke-NUS Blood Cancer Centre, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3732-8707","authenticated-orcid":false,"given":"Jing Quan","family":"Lim","sequence":"additional","affiliation":[{"name":"Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore"},{"name":"Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-4288","authenticated-orcid":false,"given":"Choon Kiat","family":"Ong","sequence":"additional","affiliation":[{"name":"Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore 169610, Singapore"},{"name":"Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore 169857, Singapore"},{"name":"Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Singapore 138672, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s12185-018-2406-6","article-title":"Novel findings from the Asian Lymphoma Study Group: Focus on T and NK-cell lymphomas","volume":"107","author":"Chan","year":"2018","journal-title":"Int. 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