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It is the major risk factor for neurodegeneration. Neurodegenerative disorders including Alzheimer\u2019s disease (AD) and Parkinson\u2019s disease (PD) are the main causes of dementia in the old population. Gut microbiota is a community of microorganisms colonized in the gastrointestinal (GI) tract. The alteration of gut microbiota has been proved to be associated with aging and aging related neurodegeneration. Drosophila is a powerful tool to study microbiota-mediated physiological and pathological functions. Here, we summarize the recent advances using Drosophila as model organisms to clarify the molecular mechanisms and develop a therapeutic method targeting microbiota in aging and aging-related neurodegenerative disorders.<\/jats:p>","DOI":"10.3390\/life11080855","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"855","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Role of Gut Microbiota in Aging and Aging Related Neurodegenerative Disorders: Insights from Drosophila Model"],"prefix":"10.3390","volume":"11","author":[{"given":"Yan","family":"Kong","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing 210009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baichun","family":"Jiang","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Experimental Teratology, Ministry of Education, Department of Molecular Medicine and Genetics, School of Basic Medical Sciences, Shandong University, Jinan 250012, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The Hallmarks of Aging","volume":"153","author":"Blasco","year":"2013","journal-title":"Cell"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.abb8587","article-title":"Microglia modulate neurodegeneration in Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"370","author":"Bartels","year":"2020","journal-title":"Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1159\/000490615","article-title":"The Gut Microbiota and Healthy Aging: A Mini-Review","volume":"64","author":"Kim","year":"2018","journal-title":"Gerontology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"4250","DOI":"10.1016\/j.febslet.2014.06.041","article-title":"Transient adult microbiota, gut homeostasis and longevity: Novel insights from the Drosophila model","volume":"588","author":"Erkosar","year":"2014","journal-title":"FEBS Lett."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1146\/annurev-genet-112618-043650","article-title":"The Microbiome and Aging","volume":"53","author":"Bana","year":"2019","journal-title":"Annu. 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