{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:59:02Z","timestamp":1788994742710,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T00:00:00Z","timestamp":1630800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund.","award":["\u00daNKP-20-3-I"],"award-info":[{"award-number":["\u00daNKP-20-3-I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Psoriasis is frequently accompanied by cardiovascular diseases based on the shared immunopathogenic pathway. Authors determined the effect of interleukin (IL)-17 inhibitor therapy on arterial intima-media thickness (IMT) among severe psoriatic patients. Methods: Thirty-one severe psoriatic patients were enrolled. Twenty received secukinumab and 11 received ixekizumab. Before treatment initiation and after 6 months, the carotid-brachial-femoral IMT, the Psoriasis Area Severity Index (PASI), the Dermatology Life Quality of Index (DLQI) and the EuroQol Visual Analogue Scale (EQ VAS) were evaluated. Results: After 6 months, significant ameliorations were observed in PASI (p &lt; 0.001) from 18 to 0, in DLQI (p &lt; 0.001) from 17 to 0, in EQ VAS (p &lt; 0.001) from 60 to 90, in right carotid IMT (p &lt; 0.001) from 1.1 mm to 0.8 mm, in left carotid IMT (p &lt; 0.001) from 1.1 mm to 0.7 mm, in right brachial IMT (p &lt; 0.001) from 0.75 mm to 0.6 mm, in left brachial IMT (p &lt; 0.001) from 0.8 mm to 0.5 mm, in right femoral IMT (p &lt; 0.001) from 0.9 mm to 0.7 mm and in left femoral IMT (p &lt; 0.001) from 0.8 mm to 0.7 mm. Conclusions: By reducing the inflammation of the vascular wall, anti-IL-17 therapy may have a beneficial long-term effect on cardiovascular complications of systemic inflammation.<\/jats:p>","DOI":"10.3390\/life11090919","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T13:15:56Z","timestamp":1630934156000},"page":"919","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of Interleukin-17 Inhibitor Therapy on Arterial Intima-media Thickness among Severe Psoriatic Patients"],"prefix":"10.3390","volume":"11","author":[{"given":"\u00c9va Anna","family":"Piros","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary"},{"name":"R\u00e1cz K\u00e1roly Doctoral School of Clinical Medicine, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1kos","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"R\u00e1cz K\u00e1roly Doctoral School of Clinical Medicine, Semmelweis University, 1085 Budapest, Hungary"},{"name":"Department of Health Economics, Corvinus University, 1093 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9674-620X","authenticated-orcid":false,"given":"Fanni","family":"Rencz","sequence":"additional","affiliation":[{"name":"Department of Health Economics, Corvinus University, 1093 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Brodszky","sequence":"additional","affiliation":[{"name":"Department of Health Economics, Corvinus University, 1093 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kl\u00e1ra","family":"Szalai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mi","family":"Galajda","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1lint","family":"Szilveszter","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edit","family":"D\u00f3sa","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, Department of Interventional Radiology, Semmelweis University, 1122 Budapest, Hungary"},{"name":"Hungarian Vascular Radiology Research Group, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9la","family":"Merkely","sequence":"additional","affiliation":[{"name":"Heart and Vascular Center, MTA-SE Cardiovascular Imaging Research Group, Semmelweis University, 1122 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Holl\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, 1085 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2147\/PTT.S64950","article-title":"Current knowledge on psoriasis and autoimmune diseases","volume":"6","author":"McCormick","year":"2016","journal-title":"Psoriasis Targets Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3389\/fimmu.2018.00579","article-title":"Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences","volume":"9","author":"Boehncke","year":"2018","journal-title":"Front. 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