{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T09:33:14Z","timestamp":1787563994546,"version":"build-2736575974"},"reference-count":25,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Council of Science and Technology Development","award":["310281\/2017\u20132"],"award-info":[{"award-number":["310281\/2017\u20132"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: Photobiomodulation therapy, alone (PBMT) or combined with a static magnetic field (PBMT-sMF), has been demonstrated to be effective in the regeneration of tissues, modulation of inflammatory processes, and improvement in functional capacity. However, the effects of PBMT-sMF on the pulmonary system and COVID-19 patients remain scarce. Therefore, in this case report, we demonstrated the use of PBMT-sMF for peripheral oxygen saturation, pulmonary function, massive lung damage, and fibrosis as a pulmonary complication after COVID-19. Case report: A 53-year-old Mexican man who presented with decreased peripheral oxygen saturation, massive lung damage, and fibrosis after COVID-19 received PBMT-sMF treatment once a day for 45 days. The treatment was irradiated at six sites in the lower thorax and upper abdominal cavity and two sites in the neck area. We observed that the patient was able to leave the oxygen support during the treatment, and increase his peripheral oxygen saturation. In addition, the patient showed improvements in pulmonary severity scores and radiological findings. Finally, the patient presented with normal respiratory mechanics parameters in the medium-term, indicating total pulmonary recovery. Conclusions: The use of PBMT-sMF may potentially lead to safe treatment of and recovery from pulmonary complications after COVID-19, with regard to the structural and functional aspects.<\/jats:p>","DOI":"10.3390\/life11111124","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T09:18:09Z","timestamp":1634894289000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multi-Wavelength Photobiomodulation Therapy Combined with Static Magnetic Field on Long-Term Pulmonary Complication after COVID-19: A Case Report"],"prefix":"10.3390","volume":"11","author":[{"given":"Shaiane Silva","family":"Tomazoni","sequence":"first","affiliation":[{"name":"Physiotherapy Research Group, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Scott","family":"Johnson","sequence":"additional","affiliation":[{"name":"Multi Radiance Medical, Solon, OH 44139, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto Cesar Pinto","family":"Leal-Junior","sequence":"additional","affiliation":[{"name":"Physiotherapy Research Group, Department of Global Public Health and Primary Care, University of Bergen, 5020 Bergen, Norway"},{"name":"Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Post-Graduate Program in Rehabilitation Sciences, Nove de Julho University, S\u00e3o Paulo 01525-000, Brazil"},{"name":"ELJ Consultancy, Avenida Chibar\u00e1s, S\u00e3o Paulo 04076-000, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2021, February 17). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Available online: https:\/\/www.who.int\/docs\/default-source\/coronaviruse\/who-china-joint-mission-on-covid-19-final-report.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review","volume":"324","author":"Wiersinga","year":"2020","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S2213-2600(20)30076-X","article-title":"Pathological findings of COVID-19 associated with acute respiratory distress syndrome","volume":"8","author":"Xu","year":"2020","journal-title":"Lancet Respir Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: A cohort study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bjpt.2018.12.002","article-title":"Clinical and scientific recommendations for the use of photobiomodulation therapy in exercise performance enhancement and post-exercise recovery: Current evidence and future directions","volume":"23","author":"Bjordal","year":"2019","journal-title":"Braz J. Phys. Ther"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1089\/pho.2006.24.158","article-title":"Low-level laser therapy in acute pain: A systematic review of possible mechanisms of action and clinical effects in randomized placebo-controlled trials","volume":"24","author":"Bjordal","year":"2006","journal-title":"Photomed Laser Surg"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s10103-012-1088-1","article-title":"Suppressive effect of low-level laser therapy on tracheal hyperresponsiveness and lung inflammation in rat subjected to intestinal ischemia and reperfusion","volume":"28","author":"Vitoretti","year":"2013","journal-title":"Lasers Med. Sci"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/lsm.20357","article-title":"Low level laser therapy partially restores trachea muscle relaxation response in rats with tumor necrosis factor alpha-mediated smooth airway muscle dysfunction","volume":"38","author":"Aimbire","year":"2006","journal-title":"Lasers Surg Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.resp.2014.01.008","article-title":"Low-level laser therapy inhibits bronchoconstriction, Th2 inflammation and airway remodeling in allergic asthma","volume":"194","author":"Silva","year":"2014","journal-title":"Respir Physiol Neurobiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s10103-019-02885-3","article-title":"Acute effects of photobiomodulation therapy applied to respiratory muscles of chronic obstructive pulmonary disease patients: A double-blind, randomized, placebo-controlled crossover trial","volume":"35","author":"Ferraresi","year":"2020","journal-title":"Lasers Med. Sci"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5978\/islsm.18.137","article-title":"Combined magnetic and pulsed laser fields produce synergistic acceleration of cellular electron transfer","volume":"18","author":"Friedmann","year":"2009","journal-title":"Laser Ther"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10103-017-2368-6","article-title":"Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: A systematic review and meta-analysis","volume":"33","author":"Vanin","year":"2018","journal-title":"Lasers Med. Sci"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s10103-018-2558-x","article-title":"Photobiomodulation therapy (PBMT) on acute pain and inflammation in patients who underwent total hip arthroplasty-a randomized, triple-blind, placebo-controlled clinical trial","volume":"33","author":"Langella","year":"2018","journal-title":"Lasers Med. Sci"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/lsm.23255","article-title":"Photobiomodulation therapy is able to modulate PGE2 levels in patients with chronic non-specific low back pain: A randomized placebo-controlled trial","volume":"53","author":"Tomazoni","year":"2021","journal-title":"Lasers Surg Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.29390\/cjrt-2020-022","article-title":"Adjunct low level laser therapy (LLLT) in a morbidly obese patient with severe COVID-19 pneumonia: A case report","volume":"56","author":"Sigman","year":"2020","journal-title":"Can. J. Respir Ther"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e926779","DOI":"10.12659\/AJCR.926779","article-title":"A 57-Year-Old African American Man with Severe COVID-19 Pneumonia Who Responded to Supportive Photobiomodulation Therapy (PBMT): First Use of PBMT in COVID-19","volume":"21","author":"Sigman","year":"2020","journal-title":"Am. J. Case Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/thoraxjnl-2017-211280","article-title":"Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS","volume":"73","author":"Warren","year":"2018","journal-title":"Thorax"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"E72","DOI":"10.1148\/radiol.2020201160","article-title":"Frequency and Distribution of Chest Radiographic Findings in Patients Positive for COVID-19","volume":"296","author":"Wong","year":"2020","journal-title":"Radiology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.2147\/JIR.S318758","article-title":"Effects of Photobiomodulation Therapy Combined with Static Magnetic Field in Severe COVID-19 Patients Requiring Intubation: A Pragmatic Randomized Placebo-Controlled Trial","volume":"14","author":"Ferlito","year":"2021","journal-title":"J. Inflamm Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111731","DOI":"10.1016\/j.jphotobiol.2019.111731","article-title":"Low-level laser therapy attenuates lung inflammation and airway remodeling in a murine model of idiopathic pulmonary fibrosis: Relevance to cytokines secretion from lung structural cells","volume":"203","author":"Soares","year":"2020","journal-title":"J. Photochem Photobiol B"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jphotobiol.2014.03.021","article-title":"Low level laser therapy reduces acute lung inflammation in a model of pulmonary and extrapulmonary LPS-induced ARDS","volume":"134","author":"Oliveira","year":"2014","journal-title":"J. Photochem Photobiol B"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/jbio.201500113","article-title":"Low level laser therapy reduces acute lung inflammation without impairing lung function","volume":"9","author":"Cury","year":"2016","journal-title":"J. Biophotonics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1365-2567.1999.00870.x","article-title":"Inhibitory effects of endogenous and exogenous interferon-gamma on bronchial hyperresponsiveness, allergic inflammation and T-helper 2 cytokines in Brown-Norway rats","volume":"98","author":"Huang","year":"1999","journal-title":"Immunology"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Tomazoni, S.S., Machado, C.D.S.M., De Marchi, T., Casalechi, H.L., Bjordal, J.M., de Carvalho, P.T.C., and Leal-Junior, E.C.P. (2019). Infrared low-level laser therapy (photobiomodulation therapy) before intense progressive running test of high-level soccer players: Effects on functional, muscle damage, inflammatory, and oxidative stress markers- a randomized controlled trial. Oxid Med. Cell Longev, 6239058.","DOI":"10.1155\/2019\/6239058"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/11\/1124\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:20:57Z","timestamp":1760167257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/11\/1124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":25,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["life11111124"],"URL":"https:\/\/doi.org\/10.3390\/life11111124","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,22]]}}}