{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T20:49:19Z","timestamp":1784321359760,"version":"3.55.0"},"reference-count":54,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic inflammatory disease of the skin whose main symptom is pruritus and may affect all age ranges. Regarding the prevalence, it has been estimated at around 10% of the world population. Many concomitant diseases have been associated with AD, but the causal relationship between AD and psychological impairment has not been clearly established. Scientific literature studying the probable association between male or female sexual dysfunction and dermatological pathology is limited, even more so in AD. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines and the Cochrane Collaboration methodology for systematic reviews. All relevant articles in English were identified through a search from inception to 10 December 2020, including the following databases: Medline (via PubMed), Scopus, Web of Science Core Collection, and SciELO. The results of the search were compiled using the COVIDENCE software for systematic reviews. The methodological quality of the included studies was done using the \u201cQuality Assessment Tool for Observational Cohort and Cross-Sectional Studies\u201d and the \u201cQuality Assessment of Case-Control Studies\u201d developed by the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH). Our search yielded potentially relevant studies. Five studies that evaluated the prevalence of sexual dysfunction in atopic dermatitis were retrieved after applying the selection criteria. The present systematic review achieved data from 8088 patients with atopic dermatitis from four articles. Sample sizes for atopic dermatitis patients ranged from 266 to 3997. We identified one cohort study with four years of follow-up, three studies with a cross-sectional design, and one case-control study. Three studies reported data disaggregated by the severity of atopic dermatitis. Two studies included healthy controls with a total sample size of 1,747,755 subjects. Two studies compared data with other dermatological conditions such as psoriasis. In conclusion, we can establish that unlike other psychological comorbidities such as anxiety and depression, sexual dysfunction is a field scarcely explored in the literature. This sexual dysfunction focuses on the male sex in large population studies and in clinical diagnoses without exploring it through specific and validated questionnaires in this regard. Further studies focused on both genders are needed. It is important to correlate this sexual dysfunction with the severity of the disease, previous treatments, and cardiovascular comorbidities.<\/jats:p>","DOI":"10.3390\/life11121314","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T01:43:22Z","timestamp":1638323002000},"page":"1314","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Sexual Dysfunction and Atopic Dermatitis: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Laura","family":"Linares-Gonzalez","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, 18016 Granada, Spain"},{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Lozano-Lozano","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Gutierrez-Rojas","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Granada, 18011 Granada, Spain"},{"name":"Psychiatry Service, Hospital Cl\u00ednico San Cecilio, 18016 Granada, Spain"},{"name":"CTS-549 Research Group, Institute of Neuroscience, University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5854-3567","authenticated-orcid":false,"given":"Mario","family":"Lozano-Lozano","sequence":"additional","affiliation":[{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), 18012 Granada, Spain"},{"name":"Department of Physical Therapy, Faculty of Health Sciences, University of Granada, 18011 Granada, Spain"},{"name":"Sport and Health Joint University Institute (iMUDS), University of Granada, 18011 Granada, Spain"},{"name":"\u2018Cu\u00eddate\u2019 Support Unit for Oncology Patients, 18011 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Rodenas-Herranz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, 18016 Granada, Spain"},{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-6174","authenticated-orcid":false,"given":"Ricardo","family":"Ruiz-Villaverde","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitario San Cecilio, 18016 Granada, Spain"},{"name":"Biohealth Research Institute in Granada (ibs.GRANADA), 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.det.2017.02.002","article-title":"Public Health Burden and Epidemiology of Atopic Dermatitis","volume":"35","author":"Silverberg","year":"2017","journal-title":"Dermatol. 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