{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:28:48Z","timestamp":1772252928180,"version":"3.50.1"},"reference-count":19,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:00:00Z","timestamp":1639440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Spanish Ministry of Health","award":["PI081919"],"award-info":[{"award-number":["PI081919"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Matrix metalloproteinases (MMPs) have been implicated in the progression of muscular dystrophy, and recent studies have reported the role of MMP-10 in skeletal muscle pathology of young dystrophic mice. Nevertheless, its involvement in dystrophin-deficient hearts remains unexplored. Here, we aimed to investigate the involvement of MMP-10 in the progression of severe muscular dystrophy and to characterize MMP-10 loss in skeletal and cardiac muscles of aged dystrophic mice. We examined the histopathological effect of MMP-10 ablation in aged mdx mice, both in the hind limb muscles and heart tissues. We found that MMP-10 loss compromises survival rates of aged mdx mice, with skeletal and cardiac muscles developing a chronic inflammatory response. Our findings indicate that MMP-10 is implicated in severe muscular dystrophy progression, thus identifying a new area of research that could lead to future therapies for dystrophic muscles.<\/jats:p>","DOI":"10.3390\/life11121398","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T11:11:35Z","timestamp":1639480295000},"page":"1398","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deficiency of MMP-10 Aggravates the Diseased Phenotype of Aged Dystrophic Mice"],"prefix":"10.3390","volume":"11","author":[{"given":"Arantxa","family":"Baraibar-Churio","sequence":"first","affiliation":[{"name":"Regenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-3483","authenticated-orcid":false,"given":"M\u00edriam","family":"Bobadilla","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2495-0786","authenticated-orcid":false,"given":"Florencio J. D.","family":"Machado","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"},{"name":"Laboratory of Atherothrombosis, Program of Cardiovascular Diseases, University of Navarra, 31009 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neira","family":"S\u00e1inz","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"},{"name":"Centre for Nutrition Research, University of Navarra, 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0616-9600","authenticated-orcid":false,"given":"Carmen","family":"Roncal","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"},{"name":"Laboratory of Atherothrombosis, Program of Cardiovascular Diseases, University of Navarra, 31009 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Abizanda","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-8790","authenticated-orcid":false,"given":"Felipe","family":"Pr\u00f3sper","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6300-7670","authenticated-orcid":false,"given":"Josune","family":"Orbe","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"},{"name":"Laboratory of Atherothrombosis, Program of Cardiovascular Diseases, University of Navarra, 31009 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"P\u00e9rez-Ruiz","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Foundation for Applied Medical Research (FIMA), University of Navarra, 31009 Pamplona, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0140-6736(02)07815-7","article-title":"The muscular dystrophies","volume":"359","author":"Emery","year":"2002","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00001573-199705000-00015","article-title":"Dystrophies and heart disease","volume":"12","author":"Cox","year":"1997","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1101\/gad.815400","article-title":"Matrix metalloproteinases: Effectors of development and normal physiology","volume":"14","author":"Vu","year":"2000","journal-title":"Genes Dev."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fcell.2014.00011","article-title":"Therapeutic potential of matrix metalloproteinases in Duchenne muscular dystrophy","volume":"2","author":"Ogura","year":"2014","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/stem.1553","article-title":"MMP-10 Is Required for Efficient Muscle Regeneration in Mouse Models of Injury and Muscular Dystrophy","volume":"32","author":"Bobadilla","year":"2013","journal-title":"Stem Cells"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1089\/scd.2013.0491","article-title":"The CXCR4\/SDF1 Axis Improves Muscle Regeneration Through MMP-10 Activity","volume":"23","author":"Bobadilla","year":"2014","journal-title":"Stem Cells Dev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1096\/fj.14-259689","article-title":"Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia","volume":"29","author":"Orbe","year":"2015","journal-title":"FASEB J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cardfail.2019.02.006","article-title":"The Role of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Duchenne Muscular Dystrophy Cardiomyopathy","volume":"25","author":"Jonathan","year":"2019","journal-title":"J. Card. Fail."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1172\/JCI98215","article-title":"Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart","volume":"128","author":"Fu","year":"2018","journal-title":"J. Clin. Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1161\/CIRCULATIONAHA.119.044557","article-title":"Single-Cell RNA-seq Analysis Reveals a Crucial Role for Collagen Triple Helix Repeat Containing 1 (CTHRC1) Cardiac Fibroblasts after Myocardial Infarction","volume":"142","author":"Romero","year":"2020","journal-title":"Circulation"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1507\/endocrj.EJ13-0270","article-title":"Role of matrix metalloproteinase-10 in the BMP-2 inducing osteoblastic differentiation","volume":"60","author":"Mao","year":"2013","journal-title":"Endocr. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1365-2613.2010.00750.x","article-title":"Increased connective tissue growth factor associated with cardiac fibrosis in the mdx mouse model of dystrophic cardiomyopathy","volume":"92","author":"Au","year":"2011","journal-title":"Int. J. Exp. Pathol."},{"key":"ref_13","first-page":"1","article-title":"Inflammatory predisposition predicts disease phenotypes in muscular dystrophy","volume":"36","author":"Takeda","year":"2016","journal-title":"Inflamm. Regen."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1242\/dmm.042192","article-title":"Skeletal muscle in health and disease","volume":"13","author":"Morgan","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/cphy.c170052","article-title":"Immunobiology of Inherited Muscular Dystrophies","volume":"8","author":"Tidball","year":"2018","journal-title":"Compr. Physiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ncb2015","article-title":"Muscle injury activates resident fibro\/adipogenic progenitors that facilitate myogenesis","volume":"12","author":"Joe","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yjmcc.2015.12.018","article-title":"Matrix metalloproteinases as input and output signals for post-myocardial infarction remodeling","volume":"91","author":"Lindsey","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.matbio.2007.07.001","article-title":"Control of matrix metalloproteinase catalytic activity","volume":"26","author":"Ra","year":"2007","journal-title":"Matrix Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0960-8966(96)00357-4","article-title":"Cardiac and respiratory involvement in advanced stage Duchenne muscular dystrophy","volume":"6","author":"Melacini","year":"1996","journal-title":"Neuromuscul. Disord."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/12\/1398\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:47:56Z","timestamp":1760168876000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/11\/12\/1398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,14]]},"references-count":19,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["life11121398"],"URL":"https:\/\/doi.org\/10.3390\/life11121398","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints202111.0017.v1","asserted-by":"object"}]},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,14]]}}}