{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:28:35Z","timestamp":1788395315981,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The clinical course of Crohn\u2019s disease (CD) is often complicated by intestinal strictures, which can be fibrotic, inflammatory, or mixed, therefore leading to stenosis and eventually symptomatic obstruction. We report two cases of subclinical CD diagnosed after fruit pit ingestion, causing bowel obstruction; additionally, we conducted a narrative review of the scientific literature on cases of intestinal obstruction secondary to impacted bezoars due to fruit pits. Symptoms of gastrointestinal bezoars in CD patients are not diagnostic; and the diagnosis should be based on a combined assessment of history, clinical presentation, imaging examination and endoscopy findings. This report corroborates the concept that CD patients are at a greater risk of bowel obstruction with bezoars generally and shows that accidental ingestion of fruit pits may lead to an unusual presentation of the disease. Therapeutic options in this group of patients differ from the usual approaches implemented in other patients with strictures secondary to CD.<\/jats:p>","DOI":"10.3390\/life11121415","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T21:32:40Z","timestamp":1639690360000},"page":"1415","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["An Unusual Presentation of Crohn\u2019s Disease Diagnosed Following Accidental Ingestion of Fruit Pits: Report of Two Cases and Review of the Literature"],"prefix":"10.3390","volume":"11","author":[{"given":"Emanuele","family":"Sinagra","sequence":"first","affiliation":[{"name":"Department of Endoscopy, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario","family":"Raimondo","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore Marco","family":"Iacopinelli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Conoscenti","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Angela","family":"Di Maggio","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Testai","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alloro","sequence":"additional","affiliation":[{"name":"Department of Endoscopy, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Maras\u00e0","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Calandra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Fondazione Istituto G. 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Martino, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4992-9289","authenticated-orcid":false,"given":"Marcello","family":"Maida","sequence":"additional","affiliation":[{"name":"Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, 93100 Caltanissetta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8791-3395","authenticated-orcid":false,"given":"Ilaria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Endoscopy Service, Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, 90127 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goffredo","family":"Arena","sequence":"additional","affiliation":[{"name":"Department of Surgery, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefal\u00f9, Italy"},{"name":"Department of Surgery, McGill University, Montreal, QC H3G 1A4, Canada"},{"name":"Istituto Oncologico del Mediterraneo, 95029 Viagrande, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/ecco-jcc\/jjw055","article-title":"European Crohn\u2019s and Colitis Organisation Topical Review on Prediction, Diagnosis and Management of Fibrostenosing Crohn\u2019s Disease","volume":"10","author":"Rieder","year":"2016","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1590\/S2237-93632012000400011","article-title":"Bezoar by mesalazine tablets: Cause of intestinal obstruction in Crohn\u2019s disease","volume":"32","author":"Carvalho","year":"2012","journal-title":"J. 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