{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:16:23Z","timestamp":1792448183550,"version":"4.5.0"},"reference-count":153,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T00:00:00Z","timestamp":1639958400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>In the framework of space flight, the risk of radiation carcinogenesis is considered a \u201cred\u201d risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions. The cyclic AMP response element-binding protein (CREB) is overexpressed both in haematological malignancies and solid tumours and its expression and function are modulated following irradiation. The CREB protein is a transcription factor and member of the CREB\/activating transcription factor (ATF) family. As such, it has an essential role in a wide range of cell processes, including cell survival, proliferation, and differentiation. Among the CREB-related nuclear transcription factors, NF-\u03baB and p53 have a relevant role in cell response to ionising radiation. Their expression and function can decide the fate of the cell by choosing between death or survival. The aim of this review was to define the role of the CREB\/ATF family members and the related transcription factors in the response to ionising radiation of human haematological malignancies and solid tumours.<\/jats:p>","DOI":"10.3390\/life11121437","type":"journal-article","created":{"date-parts":[[2021,12,20]],"date-time":"2021-12-20T08:43:32Z","timestamp":1639989812000},"page":"1437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms"],"prefix":"10.3390","volume":"11","author":[{"given":"Gianmarco","family":"Stati","sequence":"first","affiliation":[{"name":"Department of Medicine and Ageing Sciences, G. d\u2019Annunzio University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Passaretta","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences, G. d\u2019Annunzio University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-6093","authenticated-orcid":false,"given":"Florelle","family":"Gindraux","sequence":"additional","affiliation":[{"name":"Laboratoire de Nanom\u00e9decine, Imagerie, Th\u00e9rapeutique EA 4662, Universit\u00e9 Bourgogne Franche-Comt\u00e9, 25030 Besan\u00e7on, France"},{"name":"Service de Chirurgie Orthop\u00e9dique, Traumatologique et Plastique, CHU, 25030 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Centurione","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences, G. d\u2019Annunzio University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Di Pietro","sequence":"additional","affiliation":[{"name":"Department of Medicine and Ageing Sciences, G. d\u2019Annunzio University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,20]]},"reference":[{"key":"ref_1","first-page":"148","article-title":"A commentary on the impact of modelling results to inform mission planning and shield design","volume":"25","author":"Lewis","year":"2020","journal-title":"Life Sci. 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