{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:43:32Z","timestamp":1788306212601,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>(1) Background: A retrospective clinical study was conducted to compare the effectiveness of different pharmacological and non-pharmacological regimens for treating sudden sensorineural hearing loss (SSNHL). (2) Methods: Adult patients (n = 130) diagnosed with sudden sensorineural hearing loss (SSNHL) and hospitalized between 2015 and 2020 were enrolled in this study. Depending on the treatment regimen applied, patients were divided into five groups. Inclusion criteria were as follows: (i) hearing loss of sudden onset; (ii) hearing loss of at least 30 dB at three consecutive frequencies; (iii) unilateral hearing loss; (iv) age above 18 years. Exclusion criteria were as follows: (i) no follow-up audiogram; (ii) bilateral hearing loss; (iii) recognized alternative diagnosis such as tumor, disorder of inner ear fluids, infection or inflammation, autoimmune disease, malformation, hematological disease, dialysis-dependent renal failure, postdural puncture syndrome, gene-related syndrome, mitochondrial disease; and (iv) age below 18 years. (3) Results: Complete recovery was found in 14% of patients (18\/130) and marked improvement was found in 6% (8\/130), giving an overall success rate of 20%. The best results were obtained in the second group (i.e., patients given intratympanic glucocorticoid + prolonged orally administered glucocorticoid) where the success rate was 28%. In general, the older the patient, the smaller the improvement in hearing, a correlation that was statistically significant. (4) Conclusions: In treating SSNHL, the highest rate of hearing recovery\u201428%\u2014was in the group of patients given intratympanic corticoid plus prolonged treatment with orally administered glucocorticoid.<\/jats:p>","DOI":"10.3390\/life12010096","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T22:03:13Z","timestamp":1641852193000},"page":"96","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss\u2014A Retrospective Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3340-1698","authenticated-orcid":false,"given":"Magdalena B.","family":"Skar\u017cy\u0144ska","sequence":"first","affiliation":[{"name":"Institute of Sensory Organs, Nadarzyn, 05830 Warsaw, Poland"},{"name":"Center of Hearing and Speech Medincus, Nadarzyn, 05830 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ko\u0142odziejak","sequence":"additional","affiliation":[{"name":"World Hearing Center, Department of Teleaudiology and Screening, Institute of Physiology and Pathology of Hearing, Nadarzyn, 05830 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u017cbieta","family":"Gos","sequence":"additional","affiliation":[{"name":"World Hearing Center, Department of Teleaudiology and Screening, Institute of Physiology and Pathology of Hearing, Nadarzyn, 05830 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milaine Dominici","family":"Sanfis","sequence":"additional","affiliation":[{"name":"Child and Adolescent Health Program, Faculty of Medical Sciences, University of Campinas, Campinas 13083970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-1915","authenticated-orcid":false,"given":"Piotr H.","family":"Skar\u017cy\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Sensory Organs, Nadarzyn, 05830 Warsaw, Poland"},{"name":"World Hearing Center, Department of Teleaudiology and Screening, Institute of Physiology and Pathology of Hearing, Nadarzyn, 05830 Warsaw, Poland"},{"name":"Heart Failure and Cardiac Rehabilitation Department, Faculty of Medicine, Medical University of Warsaw, 02091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/00016484409119921","article-title":"Sudden complete or partial loss of function of the octavus-system in apparently normal persons","volume":"32","author":"Kleyn","year":"1944","journal-title":"Acta Oto-Laryngol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1177\/0394632016673845","article-title":"Sudden sensorineural hearing loss: Is there a connection with inner ear electrolytic disorders? 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