{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:58:19Z","timestamp":1790614699624,"version":"4.1.0"},"reference-count":155,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Current achievements in medical science and technological advancements in intensive care medicine have allowed better support of critically ill patients in intensive care units (ICUs) and have increased survival probability. Post-intensive care syndrome (PICS) is a relatively new term introduced almost 10 years ago, defined as \u201cnew or worsening impairments in physical, cognitive, or mental health status arising after critical illness and persisting beyond acute care hospitalization\u201d. A significant percentage of critically ill patients suffer from PICS for a prolonged period of time, with physical problems being the most common. The exact prevalence of PICS is unknown, and many risk factors have been described well. Coronavirus disease 2019 (COVID-19) survivors seem to be at especially high risk for developing PICS. The families of ICU survivors can also be affected as a response to the stress suffered during the critical illness of their kin. This separate entity is described as PICS family (PICS-F). A multidisciplinary approach is warranted for the treatment of PICS, involving healthcare professionals, clinicians, and scientists from different areas. Improving outcomes is both challenging and imperative for the critical care community. The review of the relevant literature and the study of the physical, cognitive, and mental sequelae could lead to the prevention and timely management of PICS and the subsequent improvement of the quality of life for ICU survivors.<\/jats:p>","DOI":"10.3390\/life12010107","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T23:17:07Z","timestamp":1642029427000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Post-Intensive Care Syndrome in Survivors from Critical Illness including COVID-19 Patients: A Narrative Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Charikleia S.","family":"Vrettou","sequence":"first","affiliation":[{"name":"First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, \u201cEvangelismos\u201d Hospital, 106 76 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Mantziou","sequence":"additional","affiliation":[{"name":"First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, \u201cEvangelismos\u201d Hospital, 106 76 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-0476","authenticated-orcid":false,"given":"Alice G.","family":"Vassiliou","sequence":"additional","affiliation":[{"name":"First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, \u201cEvangelismos\u201d Hospital, 106 76 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos E.","family":"Orfanos","sequence":"additional","affiliation":[{"name":"First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, \u201cEvangelismos\u201d Hospital, 106 76 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-500X","authenticated-orcid":false,"given":"Anastasia","family":"Kotanidou","sequence":"additional","affiliation":[{"name":"First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, \u201cEvangelismos\u201d Hospital, 106 76 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Dimopoulou","sequence":"additional","affiliation":[{"name":"First Department of Critical Care Medicine & Pulmonary Services, School of Medicine, National and Kapodistrian University of Athens, \u201cEvangelismos\u201d Hospital, 106 76 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S2213-2600(14)70051-7","article-title":"Depression, Post-Traumatic Stress Disorder, and Functional Disability in Survivors of Critical Illness in the BRAIN-ICU Study: A Longitudinal Cohort Study","volume":"2","author":"Jackson","year":"2014","journal-title":"Lancet Respir. 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