{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:25:27Z","timestamp":1772252727486,"version":"3.50.1"},"reference-count":98,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T00:00:00Z","timestamp":1642032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NKFI, Sz\u00e9chenyi 2020","award":["GINOP-2.2.1-15-2016-00007"],"award-info":[{"award-number":["GINOP-2.2.1-15-2016-00007"]}]},{"name":"Supported by SZTE \u00c1OK-KKA","award":["Het\u00e9nyi G\u00e9za 2021-5S 269 (A202)"],"award-info":[{"award-number":["Het\u00e9nyi G\u00e9za 2021-5S 269 (A202)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>An increasing amount of evidence indicates the critical role of the cutaneous nervous system in the initiation and maintenance of psoriatic skin lesions by neurogenic inflammation. However, molecular mechanisms affecting cutaneous neurons are largely uncharacterized. Therefore, we reanalyzed a psoriatic RNA sequencing dataset from published transcriptome experiments of nearly 300 individuals. Using the Ingenuity Pathway Analysis software, we associated several hundreds of differentially expressed transcripts (DETs) to nervous system development and functions. Since neuronal projections were previously reported to be affected in psoriasis, we performed an in-depth analysis of neurite formation-related process. Our in silico analysis suggests that SEMA-PLXN and ROBO-DCC-UNC5 regulating axonal growth and repulsion are differentially affected in non-lesional and lesional skin samples. We identified opposing expressional alterations in secreted ligands for axonal guidance signaling (RTN4\/NOGOA, NTNs, SEMAs, SLITs) and non-conventional axon guidance regulating ligands, including WNT5A and their receptors, modulating axon formation. These differences in neuritogenesis may explain the abnormal cutaneous nerve filament formation described in psoriatic skin. The processes also influence T-cell activation and infiltration, thus highlighting an additional angle of the crosstalk between the cutaneous nervous system and the immune responses in psoriasis pathogenesis, in addition to the known neurogenic pro-inflammatory mediators.<\/jats:p>","DOI":"10.3390\/life12010111","type":"journal-article","created":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T10:57:37Z","timestamp":1642071457000},"page":"111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Transcriptional Analysis-Based Alterations Affecting Neuritogenesis of the Peripheral Nervous System in Psoriasis"],"prefix":"10.3390","volume":"12","author":[{"given":"D\u00f3ra","family":"Romh\u00e1nyi","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Korn\u00e9lia","family":"Szab\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"},{"name":"Hungarian Centre of Excellence for Molecular Medicine-University of Szeged Skin Research Group (HCEMM-USZ Skin Research Group), University of Szeged, H-6720 Szeged, Hungary"},{"name":"E\u00f6tv\u00f6s Lor\u00e1nd Research Network, MTA-SZTE Dermatological Research Group, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2119-9501","authenticated-orcid":false,"given":"Lajos","family":"Kem\u00e9ny","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"},{"name":"Hungarian Centre of Excellence for Molecular Medicine-University of Szeged Skin Research Group (HCEMM-USZ Skin Research Group), University of Szeged, H-6720 Szeged, Hungary"},{"name":"E\u00f6tv\u00f6s Lor\u00e1nd Research Network, MTA-SZTE Dermatological Research Group, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-2161","authenticated-orcid":false,"given":"Endre","family":"Sebesty\u00e9n","sequence":"additional","affiliation":[{"name":"1st Department of Pathology and Experimental Cancer Research, Semmelweis University, H-1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-0465","authenticated-orcid":false,"given":"Gergely","family":"Groma","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, University of Szeged, H-6720 Szeged, Hungary"},{"name":"E\u00f6tv\u00f6s Lor\u00e1nd Research Network, MTA-SZTE Dermatological Research Group, H-6720 Szeged, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Chiricozzi, A., Romanelli, P., Volpe, E., Borsellino, G., and Romanelli, M. 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