{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:08:29Z","timestamp":1792591709598,"version":"4.5.0"},"reference-count":19,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Biochemical markers of spermatogenesis and fertility assessment are important in the practical management of infertile males and the determination of an individual\u2019s prognosis. We performed an analysis on 100 males with a male infertility factor. The following study inclusion parameters were analyzed: seminogram, FSH, LH, testosterone, estradiol, prolactin, TSH, and inhibin B concentrations. The patients were subsequently treated by reproductive endocrinologists in accordance with AUA\/ASRM and EAU guidelines. The reproductive status was evaluated over a period of 3 years. We found a strong correlation of sperm count with inhibin B (r = 0.74, p &lt; 0.001) and FSH concentration levels (r = \u22120.46, p &lt; 0.001). Among 95 patients at follow-up, pregnancies occurred for 59 of their partners (48 spontaneous, 5 after IVF\u2013ET, and 6 after IUI). Thirty-six patients remained childless despite the therapy. Sperm count and inhibin B level were the best predictors of natural fertilization (ROC AUC: 0.86 and 0.84; cut-off: 2.7 mln\/mL and 45 pg\/mL). Although inhibin B and FSH can be used to evaluate spermatogenesis and fertility, the initial sperm concentration appeared to be the best predictor of success. Pregnancy was achieved in a surprisingly large proportion of patients with a very low concentration of inhibin B and a low initial sperm count. It is noteworthy that 81% of the pregnancies were achieved without medically assisted reproduction.<\/jats:p>","DOI":"10.3390\/life12040511","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:28:39Z","timestamp":1648675719000},"page":"511","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Inhibin-B and FSH Are Good Indicators of Spermatogenesis but Not the Best Indicators of Fertility"],"prefix":"10.3390","volume":"12","author":[{"given":"Katarzyna","family":"Jankowska","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Centre of Postgraduate Medical Education, ul. Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3624-0391","authenticated-orcid":false,"given":"Natalia","family":"Suszczewicz","sequence":"additional","affiliation":[{"name":"Department of Mini-invasive and Endoscopic Gynecology, Military Institute of Medicine, ul. Zegrzy\u0144ska 8, 05-119 Legionowo, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-7427","authenticated-orcid":false,"given":"Micha\u0142","family":"Rabijewski","sequence":"additional","affiliation":[{"name":"Department of Reproductive Health, Centre of Postgraduate Medical Education, ul. \u017belazna 90, 01-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Dudek","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre of Postgraduate Medical Education, ul. Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Zgliczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Centre of Postgraduate Medical Education, ul. Ceg\u0142owska 80, 01-809 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-6734","authenticated-orcid":false,"given":"Rados\u0142aw B.","family":"Maksym","sequence":"additional","affiliation":[{"name":"Department of Reproductive Health, Centre of Postgraduate Medical Education, ul. \u017belazna 90, 01-004 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2021). WHO Laboratory Manual for the Examination and Processing of Human Semen, WHO Press. [6th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/JU.0000000000001521","article-title":"Diagnosis and Treatment of Infertility in Men: AUA\/ASRM Guideline Part I","volume":"205","author":"Schlegel","year":"2021","journal-title":"J. Urol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.fertnstert.2019.03.005","article-title":"Limits of current male fertility testing","volume":"111","author":"Oehninger","year":"2019","journal-title":"Fertil. Steril."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1210\/jcem.83.9.5121","article-title":"Serum inhibin B as a marker of spermatogenesis","volume":"83","author":"Pierik","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-14-0932","article-title":"The serum inhibin B concentration and reference ranges in normozoospermia","volume":"172","author":"Barbotin","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1530\/eje.0.1450561","article-title":"Inhibin B in male reproduction: Pathophysiology and clinical relevance","volume":"145","author":"Meachem","year":"2001","journal-title":"Eur. J. Endocrinol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e23882","DOI":"10.1002\/jcla.23882","article-title":"Clinical application value of Inhibin B alone or in combination with other hormone indicators in subfertile men with different spermatogenesis status: A study of 324 Chinese men","volume":"35","author":"Kong","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1210\/jc.2012-2400","article-title":"Approach to male infertility and induction of spermatogenesis","volume":"98","author":"Anawalt","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2164\/jandrol.106.001545","article-title":"Relationships between serum hormone levels and semen quality among men from an infertility clinic","volume":"28","author":"Meeker","year":"2007","journal-title":"J. Androl."},{"key":"ref_10","first-page":"1321","article-title":"Inhibin-B: A likely candidate for the physiologically important form of inhibin in men","volume":"81","author":"Illingworth","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_11","first-page":"3341","article-title":"Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction","volume":"81","author":"Anawalt","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_12","first-page":"4059","article-title":"Inhibin B as a serum marker of spermatogenesis: Correlation to differences in sperm concentration and follicle-stimulating hormone levels. A study of 349 Danish men","volume":"82","author":"Jensen","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1093\/humrep\/12.11.2376","article-title":"Inhibin B in men with normal and disturbed spermatogenesis","volume":"12","author":"Haidl","year":"1997","journal-title":"Hum. Reprod."},{"key":"ref_14","first-page":"675","article-title":"Longitudinal reproductive hormone profiles in infants: Peak of inhibin B levels in infant boys exceeds levels in adult men","volume":"83","author":"Andersson","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1677\/joe.0.1410131","article-title":"Expression of inhibin subunit mRNAs and inhibin levels in the testes of rats with stage-synchronized spermatogenesis","volume":"141","author":"Klaij","year":"1994","journal-title":"J. Endocrinol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1093\/humrep\/12.1.80","article-title":"Are there any predictive factors for successful testicular sperm recovery in azoospermic patients?","volume":"12","author":"Tournaye","year":"1997","journal-title":"Hum. Reprod."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.21037\/tau-2019-gcmi-09","article-title":"Genetic counselling for infertile men of known and unknown etiology","volume":"10","author":"Hirji","year":"2021","journal-title":"Transl. Androl. Urol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ucl.2020.07.003","article-title":"Personalized Medicine for the Infertile Male","volume":"47","author":"Velez","year":"2020","journal-title":"Urol. Clin. N. Am."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/andr.12597","article-title":"AMH and INSL3 in testicular and extragonadal pathophysiology: What do we know?","volume":"7","author":"Sansone","year":"2019","journal-title":"Andrology"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/4\/511\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:46:45Z","timestamp":1760136405000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/4\/511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,30]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["life12040511"],"URL":"https:\/\/doi.org\/10.3390\/life12040511","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,30]]}}}