{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:01:02Z","timestamp":1790218862718,"version":"4.1.0"},"reference-count":88,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Maternal exposure to some dietary and environmental factors during embryonic development can affect offspring\u2019s phenotype and, furthermore, the risk of developing diseases later in life. One potential mechanism responsible for this early programming may be the modification of the epigenome, such as DNA methylation. Methyl-group donors are essential for DNA methylation and are shown to have an important role in fetal development and later health. The main goal of the present review is to summarize the available literature data on the epigenetic effect (DNA methylation) of maternal methyl-group donor availability on reproductivity, perinatal outcome, and later health of the offspring. In our literature search, we found evidence for the association between alterations in DNA methylation patterns caused by different maternal methyl-group donor (folate, choline, methionine, betaine) intake and reproductivity, birth weight, neural tube defect, congenital heart defect, cleft lip and palate, brain development, and the development of obesity and associated non-communicable diseases in later life. We can conclude that maternal methyl-group donor availability could affect offspring\u2019s health via alterations in DNA methylation and may be a major link between early environmental exposure and the development of diseases in the offspring. However, still, further studies are necessary to confirm the associations and causal relationships.<\/jats:p>","DOI":"10.3390\/life12050609","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T22:07:26Z","timestamp":1650406046000},"page":"609","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Epigenetic Effect of Maternal Methyl-Group Donor Intake on Offspring\u2019s Health and Disease"],"prefix":"10.3390","volume":"12","author":[{"given":"Szilvia","family":"Bokor","sequence":"first","affiliation":[{"name":"Department of Paediatrics, University of P\u00e9cs Medical School, H-7624 P\u00e9cs, Hungary"},{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9ka A.","family":"Vass","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynaecology, University of P\u00e9cs Medical School, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Funke","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynaecology, University of P\u00e9cs Medical School, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor","family":"Ertl","sequence":"additional","affiliation":[{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"},{"name":"Department of Obstetrics and Gynaecology, University of P\u00e9cs Medical School, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3675-7019","authenticated-orcid":false,"given":"D\u00e9nes","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University of P\u00e9cs Medical School, H-7624 P\u00e9cs, Hungary"},{"name":"National Laboratory for Human Reproduction, University of P\u00e9cs, H-7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rubini, E., Baijens, I.M.M., Hor\u00e1nszky, A., Schoenmakers, S., Sinclair, K.D., Zana, M., Dinny\u00e9s, A., Steegers-Theunissen, R.P.M., and Rousian, M. 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