{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:33:04Z","timestamp":1791959584243,"version":"4.3.4"},"reference-count":87,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["FK 124483"],"award-info":[{"award-number":["FK 124483"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Comprehensive Development for Implementing Smart Specialization Strategies at the University of P\u00e9cs","award":["EFOP-3.6.1.-16-2016-00004"],"award-info":[{"award-number":["EFOP-3.6.1.-16-2016-00004"]}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"publisher","award":["Janos Bolyai Scholarship"],"award-info":[{"award-number":["Janos Bolyai Scholarship"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Paediatric second-degree burn injuries are a significant source of medical challenges to the population that may cause severe, lifelong complications. Currently, there are dozens of therapeutic modalities and we aimed to summarise their reported outcomes and determine their effectiveness, compared to the widely used silver sulphadiazine (SSD). Methods: We conducted the meta-analysis and systematic review of randomised controlled trials (RCTs), which investigated the performance of dressings in acute paediatric partial-thickness burns. The evaluated endpoints were time until wound closure, grafting and infection rate, number of dressing changes and length of hospitalisation. Results: Twenty-nine RCTs were included in the qualitative and 25 in the quantitative synthesis, but only three trials compared SSD directly to the same intervention (Biobrane). Data analysis showed a tendency for faster healing times and a reduced complication rate linked to biosynthetic, silver foam and amnion membrane dressings. A substantial difference was found between the number of dressing changes associated with less pain, narcosis and treatment duration. Conclusions: Considerable between-study heterogeneity was caused by the unequal depth subcategory ratio and surface area of the injuries; therefore, no significant difference was found in the main outcomes. Further research is necessary to establish the most effective treatment for these burns.<\/jats:p>","DOI":"10.3390\/life12050619","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T21:39:45Z","timestamp":1650749985000},"page":"619","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-3292","authenticated-orcid":false,"given":"Aba","family":"L\u0151rincz","sequence":"first","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of P\u00e9cs, 12 Szigeti Street, H7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-6340","authenticated-orcid":false,"given":"Alex","family":"V\u00e1radi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Institute for Translational Medicine, Medical School, University of P\u00e9cs, 12 Szigeti Street, H7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e9ter","family":"Hegyi","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs, 20 Ifj\u00fas\u00e1g Street, H7624 P\u00e9cs, Hungary"},{"name":"Centre for Translational Medicine, Semmelweis University, 26 \u00dcll\u0151i Street, H1085 Budapest, Hungary"},{"name":"Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, H1124 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Rumbus","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of P\u00e9cs, 12 Szigeti Street, H7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0474-1394","authenticated-orcid":false,"given":"M\u00e1t\u00e9","family":"Tuba","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of P\u00e9cs, 12 Szigeti Street, H7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7748-6729","authenticated-orcid":false,"given":"Anna Gabriella","family":"Lamberti","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of P\u00e9cs, 12 Szigeti Street, H7624 P\u00e9cs, Hungary"},{"name":"Division of Surgery, Traumatology and Otorhinolaryngology, Department of Paediatrics, Clinical Complex, University of P\u00e9cs, 7 J\u00f3zsef Attila Street, H7623 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margit","family":"Varj\u00fa-Solym\u00e1r","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs, 20 Ifj\u00fas\u00e1g Street, H7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"P\u00e1rniczky","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs, 20 Ifj\u00fas\u00e1g Street, H7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3658-8427","authenticated-orcid":false,"given":"B\u00e1lint","family":"Er\u0151ss","sequence":"additional","affiliation":[{"name":"Institute for Translational Medicine, Szent\u00e1gothai Research Centre, Medical School, University of P\u00e9cs, 20 Ifj\u00fas\u00e1g Street, H7624 P\u00e9cs, Hungary"},{"name":"Centre for Translational Medicine, Semmelweis University, 26 \u00dcll\u0151i Street, H1085 Budapest, Hungary"},{"name":"Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, 68 V\u00e1rosmajor Street, H1124 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-0571","authenticated-orcid":false,"given":"Andr\u00e1s","family":"Garami","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of P\u00e9cs, 12 Szigeti Street, H7624 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-5385","authenticated-orcid":false,"given":"Gerg\u0151","family":"J\u00f3zsa","sequence":"additional","affiliation":[{"name":"Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of P\u00e9cs, 12 Szigeti Street, H7624 P\u00e9cs, Hungary"},{"name":"Division of Surgery, Traumatology and Otorhinolaryngology, Department of Paediatrics, Clinical Complex, University of P\u00e9cs, 7 J\u00f3zsef Attila Street, H7623 P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"ref_1","unstructured":"Peden, M., Oyegbite, K., Ozanne-Smith, J., Hyder, A.A., Branche, C., Rahman, F.A.K.M., Rivara, F., and Bartolomeos, K. (2008). World Report on Child Injury Prevention, World Health Organisation. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/43851\/9789241563574_eng.pdf;sequence=1."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.burns.2011.06.005","article-title":"Epidemiology of burns throughout the world. Part I: Distribution and risk factors","volume":"37","author":"Peck","year":"2011","journal-title":"Burns"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.burns.2014.02.011","article-title":"Up-to-date approach to manage keloids and hypertrophic scars: A useful guide","volume":"40","author":"Arno","year":"2014","journal-title":"Burns"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2119\/molmed.2009.00153","article-title":"Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies","volume":"17","author":"Gauglitz","year":"2011","journal-title":"Mol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/2321-3868.118930","article-title":"Pediatric burn rehabilitation: Philosophy and strategies","volume":"1","author":"Ohgi","year":"2013","journal-title":"Burn. Trauma"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1007\/BF01958075","article-title":"The immature skin","volume":"155","author":"Rutter","year":"1996","journal-title":"Eur. J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/s41372-020-0704-3","article-title":"Premature infant skin barrier maturation: Status at full-term corrected age","volume":"41","author":"Visscher","year":"2021","journal-title":"J. Perinatol."},{"key":"ref_8","first-page":"1114","article-title":"Pediatrics","volume":"113","author":"Mancini","year":"2004","journal-title":"Skin"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/01.BCR.0000124821.22553.24","article-title":"Hot Beverage Scalds in Australian Children","volume":"25","author":"Dewar","year":"2004","journal-title":"J. Burn Care Rehabil."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1097\/BCR.0b013e3181f93571","article-title":"A review of the local pathophysiologic bases of burn wound progression","volume":"31","author":"Shupp","year":"2010","journal-title":"J. Burn Care Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1600-0625.2010.01105.x","article-title":"The biology of burn injury","volume":"19","author":"Evers","year":"2010","journal-title":"Exp. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1097\/00001665-200309000-00021","article-title":"Management of Pediatric Burns","volume":"14","author":"Passaretti","year":"2003","journal-title":"J. Craniofacial Surg."},{"key":"ref_13","first-page":"433","article-title":"Pediatric burn injuries","volume":"4","author":"Helvig","year":"1993","journal-title":"AACN Clin. Issues Crit. Care Nurs."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1055\/s-0033-1356650","article-title":"Management of Burn Wounds","volume":"23","author":"Schiestl","year":"2013","journal-title":"Eur. J. Pediatr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1089\/wound.2012.0412","article-title":"Clinical Impact upon Wound Healing and Inflammation in Moist, Wet, and Dry Environments","volume":"2","author":"Junker","year":"2013","journal-title":"Adv. Wound Care"},{"key":"ref_16","first-page":"241","article-title":"Pediatric Burn Treatment Using Tilapia Skin as a Xenograft for Superficial-Partial Thickness Wounds: A Pilot Study","volume":"41","author":"Filho","year":"2020","journal-title":"J. Burn Care Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/01.BCR.0000216741.21433.66","article-title":"Randomized Clinical Study of Hydrofiber Dressing with Silver or Silver Sulfadiazine in the Management of Partial-Thickness Burns","volume":"27","author":"Caruso","year":"2006","journal-title":"J. Burn Care Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00006534-200001000-00010","article-title":"Biobrane versus 1% Silver Sulfadiazine in Second-Degree Pediatric Burns","volume":"105","author":"Barret","year":"2000","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.jpedsurg.2012.03.028","article-title":"Topical silver sulfadiazine vs. collagenase ointment for the treatment of partial thickness burns in children: A prospective randomized trial","volume":"47","author":"Ostlie","year":"2012","journal-title":"J. Pediatr. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/BCR.0b013e31820aad94","article-title":"Comparisons of the Effects of Biological Membrane (Amnion) and Silver Sulfadiazine in the Management of Burn Wounds in Children","volume":"32","author":"Mostaque","year":"2011","journal-title":"J. Burn Care Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1445-1433.2004.03106.x","article-title":"Treatment of partial-thickness burns: A prospective, randomized trial using TranscyteTM","volume":"74","author":"Kumar","year":"2004","journal-title":"ANZ J. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/00024382-200014030-00013","article-title":"Biobrane\u00ae improves wound healing in burned children without increased risk of infection","volume":"14","author":"Lal","year":"2000","journal-title":"Shock"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/00004630-199807000-00002","article-title":"Prospective, Randomized Study of the Efficacy of Mepitel on Children With Partial-Thickness Scalds","volume":"19","author":"Gotschall","year":"1998","journal-title":"J. Burn Care Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0305-4179(98)00095-3","article-title":"A silicone-coated nylon dressing reduces healing time in burned paediatric patients in comparison with standard sulfadiazine treatment: A prospective randomized trial","volume":"24","author":"Bugmann","year":"1998","journal-title":"Burns"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1097\/BCR.0b013e318198a2e8","article-title":"Randomized Clinical Study of SilvaSorb (R) Gel in Comparison to Silvadene (R) Silver Sulfadiazine Cream in the Management of Partial-Thickness Burns","volume":"30","author":"Glat","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_26","unstructured":"Muganza, A., and Cullingworth, L. (2015). A Prospective Single-Centre Randomised Controlled Study to Compare the Time to Healing of Partial Thickness Burn Wounds Treated with Versajet, Biobrane and Acticoat to Conventional Therapy. Glob. J. Med. Res., 14, Available online: https:\/\/medicalresearchjournal.org\/index.php\/GJMR\/article\/view\/865\/775."},{"key":"ref_27","first-page":"720","article-title":"Preliminary effect observation on the application of micro-negative pressure in children with small-area deep partial-thickness burn","volume":"35","author":"Zheng","year":"2019","journal-title":"Zhonghua Shaoshang Zazhi = Chin. J. Burn."},{"key":"ref_28","unstructured":"BMJ (2021, January 12). The PRISMA 2020 Statement: An Updated Guideline for Reporting Systematic Reviews. Available online: https:\/\/www.bmj.com\/content\/bmj\/372\/bmj.n71.full.pdf."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/sja.SJA_559_18","article-title":"The CONSORT statement","volume":"13","author":"Cuschieri","year":"2019","journal-title":"Saudi J. Anaesth."},{"key":"ref_30","unstructured":"(2021, February 15). Cochrane Handbook for Systematic Reviews of Interventions Version 6.2. Available online: www.training.cochrane.org\/handbook."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Wan, X., Wang, W., Liu, J., and Tong, T. (2014). Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-135"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/wrr.12196","article-title":"Nonsilver treatment vs. silver sulfadiazine in treatment of partial-thickness burn wounds in children: A systematic review and meta-analysis","volume":"22","author":"Rashaan","year":"2014","journal-title":"Wound Repair Regen."},{"key":"ref_34","first-page":"A29","article-title":"Treatment of deep second-degree facial burns in pediatric population with recombinant human GM-CSF hydrogel","volume":"19","author":"Jiaao","year":"2011","journal-title":"Wound Repair Regen."},{"key":"ref_35","first-page":"14","article-title":"Efficacy observation on application of negative pressure therapy in the treatment of superficial partial-thickness scald wound in children","volume":"29","author":"Shen","year":"2013","journal-title":"Zhonghua Shaoshang Zazhi = Chin. J. Burn."},{"key":"ref_36","first-page":"Doc53","article-title":"Therapy of acute wounds with water-filtered infrared-A (wIRA)","volume":"2","author":"Hartel","year":"2007","journal-title":"GMS Krankenhhyg. Interdiszip."},{"key":"ref_37","first-page":"32","article-title":"Quality of pediatric second-degree burn wound scars following the application of basic fibroblast growth factor: Results of a randomized, controlled pilot study?","volume":"58","author":"Hayashida","year":"2012","journal-title":"Ostomy Wound Manag."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1007\/s12262-012-0674-6","article-title":"A Comparative Study of Paediatric Thermal Burns Treated with Topical Heparin and without Heparin","volume":"76","author":"Venkatachalapathy","year":"2014","journal-title":"Indian J. Surg."},{"key":"ref_39","first-page":"1974","article-title":"Repair of second degree facial burns in children using recombinant human epidermal growth factor","volume":"11","author":"Liang","year":"2007","journal-title":"J. Clin. Rehabil. Tissue Eng. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.burns.2007.06.007","article-title":"Amnion in the treatment of pediatric partial-thickness facial burns","volume":"34","author":"Branski","year":"2008","journal-title":"Burns"},{"key":"ref_41","first-page":"126","article-title":"The comparison between long-term results of treatment with amnion graft and skin graft in children second degree burn wounds","volume":"29","author":"Omranifard","year":"2011","journal-title":"J. Isfahan Med. Sch."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.burns.2005.04.029","article-title":"Biobrane versus duoderm for the treatment of intermediate thickness burns in children: A prospective, randomized trial","volume":"31","author":"Cassidy","year":"2005","journal-title":"Burns"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.burns.2011.12.020","article-title":"A prospective randomised clinical pilot study to compare the effectiveness of Biobrane\u00ae synthetic wound dressing, with or without autologous cell suspension, to the local standard treatment regimen in paediatric scald injuries","volume":"38","author":"Wood","year":"2012","journal-title":"Burns"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0305-4179(89)90072-7","article-title":"Comparison of E-Z Derm and Jelonet dressings for partial skin thickness burns","volume":"15","author":"Healy","year":"1989","journal-title":"Burns"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1002\/bjs.11993","article-title":"Randomized clinical trial of negative pressure wound therapy as an adjunctive treatment for small-area thermal burns in children","volume":"107","author":"Frear","year":"2020","journal-title":"Br. J. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.burns.2014.11.005","article-title":"Randomized controlled trial of three burns dressings for partial thickness burns in children","volume":"41","author":"Kimble","year":"2015","journal-title":"Burns"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e340","DOI":"10.1097\/BCR.0000000000000273","article-title":"A Randomized Controlled Study of Silver-Based Burns Dressing in a Pediatric Emergency Department","volume":"37","author":"Brown","year":"2016","journal-title":"J. Burn Care Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.burns.2019.04.004","article-title":"Superiority of silver-foam over porcine xenograft dressings for treatment of scalds in children: A prospective randomised controlled trial","volume":"45","author":"Karlsson","year":"2019","journal-title":"Burns"},{"key":"ref_49","first-page":"63","article-title":"Biobrane\u2122 versus acticoat\u2122 for the treatment of mid-dermal pediatric burns: A prospective randomized controlled pilot study","volume":"8","author":"Hyland","year":"2018","journal-title":"Int. J. Burn. Trauma"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.burns.2015.06.019","article-title":"Scar outcome of children with partial thickness burns: A 3 and 6 month follow up","volume":"42","author":"Kimble","year":"2016","journal-title":"Burns"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.burns.2016.09.018","article-title":"Cost-effectiveness of silver dressings for paediatric partial thickness burns: An economic evaluation from a randomized controlled trial","volume":"43","author":"Stockton","year":"2017","journal-title":"Burns"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1097\/00006534-199611000-00001","article-title":"Combined Use of Allograft and Autograft Epidermal Cultures in Therapy of Burns","volume":"98","year":"1996","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/BCR.0b013e3181b487a8","article-title":"Supplementation of Vitamin E, Vitamin C, and Zinc Attenuates Oxidative Stress in Burned Children: A Randomized, Double-Blind, Placebo-Controlled Pilot Study","volume":"30","author":"Barbosa","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0305-4179(83)90121-3","article-title":"Topical silver sulphadiazine: Side effects and urinary excretion","volume":"10","author":"Lockhart","year":"1983","journal-title":"Burns"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/BCR.0b013e3181a28c9b","article-title":"The side effects of silver sulfadiazine","volume":"30","author":"Fuller","year":"2009","journal-title":"J. Burn Care Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.burns.2013.09.016","article-title":"Optimal treatment of partial thickness burns in children: A systematic review","volume":"40","author":"Vloemans","year":"2014","journal-title":"Burns"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.burns.2016.03.012","article-title":"Diagnostic accuracy of laser Doppler imaging in burn depth assessment: Systematic review and meta-analysis","volume":"42","author":"Shin","year":"2016","journal-title":"Burns"},{"key":"ref_58","unstructured":"Oaks, R.J., and Cindass, R. (2021). Silver Sulfadiazine. StatPearls, StatPearls Publishing LLC."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S1015-9584(09)60061-0","article-title":"Meta-analysis of Randomized Controlled Trials on Hydrocolloid Occlusive Dressing Versus Conventional Gauze Dressing in the Healing of Chronic Wounds","volume":"27","author":"Singh","year":"2004","journal-title":"Asian J. Surg."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"51","DOI":"10.12968\/bjon.1995.4.1.51","article-title":"Mepitel","volume":"4","author":"Williams","year":"1995","journal-title":"Br. J. Nurs."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1742-481X.2007.00316.x","article-title":"Comparative evaluation of silver-containing antimicrobial dressings and drugs","volume":"4","author":"Castellano","year":"2007","journal-title":"Int. Wound J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.ajem.2019.04.014","article-title":"A systematic review of foam dressings for partial thickness burns","volume":"37","author":"Chaganti","year":"2019","journal-title":"Am. J. Emerg. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0305-4179(04)90000-9","article-title":"The role of Acticoat\u2122 with nanocrystalline silver in the management of burns","volume":"30","author":"Dunn","year":"2004","journal-title":"Burns"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2174\/187221311795399264","article-title":"Hydrofiber dressing and wound repair: Review of the literature and new patents","volume":"5","author":"Richetta","year":"2011","journal-title":"Recent Pat. Inflamm. Allergy Drug Discov."},{"key":"ref_65","first-page":"21","article-title":"A review of the applications of the hydrofiber dressing with silver (Aquacel Ag\u00ae) in wound care","volume":"6","author":"Barnea","year":"2010","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_66","first-page":"S193","article-title":"Comparison of five different times for change of a silver-containing soft silicone foam dressing in pediatric partial thickness burns","volume":"36","author":"Demircan","year":"2015","journal-title":"J. Burn Care Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.burns.2020.02.007","article-title":"Burn scar outcome at six and 12 months after injury in children with partial thickness scalds: Effects of dressing treatment","volume":"46","author":"Karlsson","year":"2020","journal-title":"Burns"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.12968\/jowc.2017.26.Sup6a.S1","article-title":"Silver-containing foam dressings with Safetac: A review of the scientific and clinical data","volume":"26","author":"Davies","year":"2017","journal-title":"J. Wound Care"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1080\/14712598.2020.1787979","article-title":"Up-to-date role of the dehydrated human amnion\/chorion membrane (AMNIOFIX) for wound healing","volume":"20","author":"Joshi","year":"2020","journal-title":"Expert Opin. Biol. Ther."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15600","DOI":"10.1038\/s41598-019-52150-4","article-title":"Antimicrobial Efficacy Assessment of Human Derived Composite Amnion-Chorion Membrane","volume":"9","author":"Palanker","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_71","first-page":"1955","article-title":"Use of Nile Tilapia (Oreochromisniloticus) skin in the management of skin burns","volume":"67","author":"Osama","year":"2017","journal-title":"J. Pak. Med. Assoc."},{"key":"ref_72","first-page":"1903","article-title":"Burns: Dressings","volume":"2015","author":"Wasiak","year":"2015","journal-title":"BMJ Clin. Evid."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/SAP.0b013e31806bf446","article-title":"A Critical Evaluation of the Use of Biobrane as a Biologic Skin Substitute: A Versatile Tool for the Plastic and Reconstructive Surgeon","volume":"60","author":"Whitaker","year":"2008","journal-title":"Ann. Plast. Surg."},{"key":"ref_74","first-page":"e14","article-title":"The Use of EZ Derm\u00ae in Partial-Thickness Burns: An Institutional Review of 157 Patients","volume":"13","author":"Troy","year":"2013","journal-title":"Eplasty"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1053\/jpsu.2001.25678","article-title":"The use of a bioactive skin substitute decreases length of stay for pediatric burn patients","volume":"36","author":"Lukish","year":"2001","journal-title":"J. Pediatr. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s40258-018-00457-0","article-title":"ReCell\u00ae Spray-On Skin System for Treating Skin Loss, Scarring and Depigmentation after Burn Injury: A NICE Medical Technology Guidance","volume":"17","author":"Peirce","year":"2019","journal-title":"Appl. Health Econ. Health Policy"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.burns.2020.03.002","article-title":"Eschar removal by bromelain based enzymatic debridement (Nexobrid\u00ae) in burns: European consensus guidelines update","volume":"46","author":"Hirche","year":"2020","journal-title":"Burns"},{"key":"ref_78","first-page":"e8","article-title":"Collagenase Promotes the Cellular Responses to Injury and Wound Healing In Vivo","volume":"4","author":"Riley","year":"2005","journal-title":"J. Burn. Wounds"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"e13196","DOI":"10.1111\/dth.13196","article-title":"The effects of epidermal growth factor on early burn-wound progression in rats","volume":"33","author":"Kaya","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/jsre.1994.1036","article-title":"Basic Fibroblast Growth Factor in the Early Human Burn Wound","volume":"56","author":"Gibran","year":"1994","journal-title":"J. Surg. Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.burns.2010.08.016","article-title":"Topically applied rhGM-CSF for the wound healing: A systematic review","volume":"37","author":"Hu","year":"2011","journal-title":"Burns"},{"key":"ref_82","first-page":"1","article-title":"The uses of heparin to treat burn injury","volume":"148","author":"Oremus","year":"2006","journal-title":"\u00c9vid. Rep. Technol. Assess."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.ccc.2016.06.003","article-title":"Vitamin C in Burn Resuscitation","volume":"32","author":"Rizzo","year":"2016","journal-title":"Crit. Care Clin."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"116972","DOI":"10.1016\/j.lfs.2019.116972","article-title":"Vitamin E preconditioning alleviates in vitro thermal stress in cultured human epidermal keratinocytes","volume":"239","author":"Butt","year":"2019","journal-title":"Life Sci."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Lin, P.-H., Sermersheim, M., Li, H., Lee, P.H.U., Steinberg, S.M., and Matthew, S. (2017). Zinc in Wound Healing Modulation. Nutrients, 10.","DOI":"10.3390\/nu10010016"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1742-481X.2006.00266.x","article-title":"Negative-pressure wound therapy: A snapshot of the evidence","volume":"3","author":"Mendonca","year":"2006","journal-title":"Int. Wound J."},{"key":"ref_87","first-page":"Doc08","article-title":"Heat for wounds\u2014Water-filtered infrared-A (wIRA) for wound healing\u2014A review","volume":"14","author":"Hoffmann","year":"2016","journal-title":"Ger. Med. Sci."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/5\/619\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:58:07Z","timestamp":1760137087000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/5\/619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,21]]},"references-count":87,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["life12050619"],"URL":"https:\/\/doi.org\/10.3390\/life12050619","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,21]]}}}