{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:51:21Z","timestamp":1790877081738,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>A preliminary ethnopharmacological survey, achieved in French Polynesia, led to the collection of the most cited plants among 63 species used to treat \u201cinfectious\u201d diseases, with a description of their medicinal uses. Bibliographical investigations and antimicrobial screening permitted the selection of the botanical species Syzygium malaccense (Myrtaceae) for phytochemical analysis. Leaves of Syzygium malaccense were usually used in mixture with rhizomes of Curcuma longa to treat infectious diseases such as cystitis. The methanolic plant extracts were tested in vitro with an agar microdilution method on 33 bacteria strains and 1 yeast to obtain their Minimal Inhibitory Concentration (MIC), and cytotoxicity against HepG2 cells were evaluated. Antimicrobial synergistic effects of methanolic plant extracts from leaves of Syzygium malaccense and rhizomes from Curcuma longa were also evaluated. The bio-guided isolation of leaf extract from Syzygium malaccense led to the identification of seven alkyl-salicylic acids (anacardic acids or ginkgolic acids C15:0, C15:1, C17:0, C17:1, C17:2, C17:3 and C19:1) described for the first time in this species. All compounds were tested against Staphylococcus aureus (18.75 &lt; MIC &lt; 75.0 \u00b5g\/mL), Streptococcus pyogenes (2.34 &lt; MIC &lt; 18.75 \u00b5g\/mL) and Pseudomonas aeruginosa (MIC = 150 \u00b5g\/mL), and their structure\u2013activity relationships were discussed. The methanolic extract and salicylic derivatives from S. malaccense showed an interesting antimicrobial activity against Gram+ bacteria, without toxicity on hepG2 cells at 400 \u03bcg\/mL. Moreover, these antibacterial compounds have already been studied for their anti-inflammatory activity, which supports the therapeutic interest of S. malaccense against infectious diseases.<\/jats:p>","DOI":"10.3390\/life12050733","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T09:27:56Z","timestamp":1652520476000},"page":"733","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antimicrobial Properties of Compounds Isolated from Syzygium malaccense (L.) Merr. and L.M. Perry and Medicinal Plants Used in French Polynesia"],"prefix":"10.3390","volume":"12","author":[{"given":"Camille","family":"Quenon","sequence":"first","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s d\u2019origine v\u00e9g\u00e9tale, Universit\u00e9 de Lille, JUNIA, Universit\u00e9 de Li\u00e8ge, Universit\u00e9 de Picardie Jules Verne, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Hennebelle","sequence":"additional","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s d\u2019origine v\u00e9g\u00e9tale, Universit\u00e9 de Lille, JUNIA, Universit\u00e9 de Li\u00e8ge, Universit\u00e9 de Picardie Jules Verne, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Fran\u00e7ois","family":"Butaud","sequence":"additional","affiliation":[{"name":"Consultant in Forestry and Polynesian Botany, BP 52832, 98716 Pirae, Tahiti, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimana","family":"Ho","sequence":"additional","affiliation":[{"name":"EIO, UMR 241, Universit\u00e9 de la Polyn\u00e9sie Fran\u00e7aise, BP 6570, 98702 Faa\u2019a, Tahiti, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Samaillie","sequence":"additional","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s d\u2019origine v\u00e9g\u00e9tale, Universit\u00e9 de Lille, JUNIA, Universit\u00e9 de Li\u00e8ge, Universit\u00e9 de Picardie Jules Verne, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-6152","authenticated-orcid":false,"given":"Christel","family":"Neut","sequence":"additional","affiliation":[{"name":"Inserm U1286, Laboratoire de Bact\u00e9riologie, CHU Lille, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques, Universit\u00e9 Lille Nord de France, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamatoa","family":"Lehartel","sequence":"additional","affiliation":[{"name":"EIO, UMR 241, Universit\u00e9 de la Polyn\u00e9sie Fran\u00e7aise, BP 6570, 98702 Faa\u2019a, Tahiti, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8618-5530","authenticated-orcid":false,"given":"C\u00e9line","family":"Rivi\u00e8re","sequence":"additional","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s d\u2019origine v\u00e9g\u00e9tale, Universit\u00e9 de Lille, JUNIA, Universit\u00e9 de Li\u00e8ge, Universit\u00e9 de Picardie Jules Verne, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Siah","sequence":"additional","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s d\u2019origine v\u00e9g\u00e9tale, Universit\u00e9 de Lille, JUNIA, Universit\u00e9 de Li\u00e8ge, Universit\u00e9 de Picardie Jules Verne, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Bonneau","sequence":"additional","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s d\u2019origine v\u00e9g\u00e9tale, Universit\u00e9 de Lille, JUNIA, Universit\u00e9 de Li\u00e8ge, Universit\u00e9 de Picardie Jules Verne, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevser","family":"Sahpaz","sequence":"additional","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s d\u2019origine v\u00e9g\u00e9tale, Universit\u00e9 de Lille, JUNIA, Universit\u00e9 de Li\u00e8ge, Universit\u00e9 de Picardie Jules Verne, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Anth\u00e9rieu","sequence":"additional","affiliation":[{"name":"UMR-S1172, Neuroscience & Cognition INSERM, Facult\u00e9 des Sciences Pharmaceutiques et Biologiques, Universit\u00e9 Lille Nord de France, CEDEX, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4245-2833","authenticated-orcid":false,"given":"Nicolas","family":"Lebegue","sequence":"additional","affiliation":[{"name":"ULR 4483-IMPECS-IMPact de l\u2019Environnement Chimique sur la Sant\u00e9 humaine, CHU Lille, Institut Pasteur de Lille, Universit\u00e9 de Lille, 59006 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phila","family":"Raharivelomanana","sequence":"additional","affiliation":[{"name":"EIO, UMR 241, Universit\u00e9 de la Polyn\u00e9sie Fran\u00e7aise, BP 6570, 98702 Faa\u2019a, Tahiti, French Polynesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Roumy","sequence":"additional","affiliation":[{"name":"UMRT 1158 BioEcoAgro, M\u00e9tabolites sp\u00e9cialis\u00e9s 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