{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:14:00Z","timestamp":1783098840877,"version":"3.54.6"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T00:00:00Z","timestamp":1653091200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"LOEWE Center for Cell and Gene Therapy Frankfurt","award":["III L 4-518\/17.004"],"award-info":[{"award-number":["III L 4-518\/17.004"]}]},{"name":"LOEWE Center for Cell and Gene Therapy Frankfurt","award":["DFG SFB 1213"],"award-info":[{"award-number":["DFG SFB 1213"]}]},{"name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","award":["III L 4-518\/17.004"],"award-info":[{"award-number":["III L 4-518\/17.004"]}]},{"name":"Hessisches Ministerium f\u00fcr Wissenschaft und Kunst","award":["DFG SFB 1213"],"award-info":[{"award-number":["DFG SFB 1213"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["III L 4-518\/17.004"],"award-info":[{"award-number":["III L 4-518\/17.004"]}]},{"name":"Deutsche Forschungsgemeinschaft","award":["DFG SFB 1213"],"award-info":[{"award-number":["DFG SFB 1213"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Introduction: Remote pulmonary artery pressure (PAP)-guided heart failure (HF) therapy for NYHA class III patients has been shown to reduce hospitalizations and increase survival. We aimed to assess whether PAP monitoring allows for the increase in HF directed medication in an elderly German cohort of advanced HF patients already receiving clinically optimized HF medication. Methods: We analyzed PAP and HF medication dosage, including diuretics, in 24 patients (mean age, 76 years) using implanted PAP-sensors during the first 12 months of PAP-guided HF care in an interdisciplinary HF unit. Results: During 12 months of PAP-guided HF therapy, PAP decreased significantly (\u25b3PAP systolic\u20136 \u00b1 10, \u25b3PAP diastolic\u20134 \u00b1 7, \u25b3PAP mean\u20134 \u00b1 8 mm Hg, p &lt; 0.01 for all). 16% of patients had an unplanned HF hospitalization. There was no significant change over time with respect to the dosage of RAAS inhibitors (ACE-I\/ARB\/ARNI), Beta blockers, or MRA treatments. In contrast, the dosage of loop diuretics increased significantly (2.1 \u00b1 0.5-fold) over time. In the comparison of a \u201cresponder\u201d (patients with PAP and diuretic dose decline) and \u201cnon-responder\u201d (patients with PAP and diuretic dose increase) group, there were no significant differences between any of the baseline, medication, or HF hospitalization characteristics between the two groups. Conclusions: In elderly patients treated with clinically optimized HF medication, no further evidence-based medication increase could be achieved using PAP-guided HF care. However, by individual adjustment of diuretic dosage, a significant decline in PAP over time occurred, which could not be predicted by any of the baseline characteristics.<\/jats:p>","DOI":"10.3390\/life12050766","type":"journal-article","created":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T09:18:08Z","timestamp":1653124688000},"page":"766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pulmonary Artery Pressure-Guided Telemonitoring Reduced Pulmonary Artery Pressure but Did Not Result in Higher Doses of Guideline-Directed Medical Therapy\u2013Observations from an Advanced Elderly German Heart Failure Cohort"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3419-0282","authenticated-orcid":false,"given":"Ester J.","family":"Herrmann","sequence":"first","affiliation":[{"name":"Department of Medicine I, Cardiology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5773-0731","authenticated-orcid":false,"given":"Badrinarayanan","family":"Raghavan","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Cardiology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Eissing","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Cardiology, University Hospital Frankfurt am Main, 60590 Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Fichtlscherer","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Cardiology, University Hospital Frankfurt am Main, 60590 Frankfurt am Main, Germany"},{"name":"German Center for Cardiovascular Research, DZHK, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian W.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Cardiology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"},{"name":"German Center for Cardiovascular Research, DZHK, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2658-6444","authenticated-orcid":false,"given":"Birgit","family":"Assmus","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Cardiology, University Hospital Giessen and Marburg, 35392 Giessen, Germany"},{"name":"Department of Medicine III, Cardiology, University Hospital Frankfurt am Main, 60590 Frankfurt am Main, Germany"},{"name":"German Center for Cardiovascular Research, DZHK, 10115 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4137\/CMC.S38896","article-title":"Point-of-Care, Ultraportable Echocardiography Predicts Diuretic Response in Patients Admitted with Acute Decompensated Heart Failure","volume":"10","author":"Krishnan","year":"2016","journal-title":"Clin. 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A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)","volume":"41","author":"Davies","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1161\/CIRCULATIONAHA.120.052503","article-title":"Empagliflozin Effects on Pulmonary Artery Pressure in Patients with Heart Failure","volume":"143","author":"Nassif","year":"2021","journal-title":"Circulation"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/5\/766\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:16:11Z","timestamp":1760138171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/5\/766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,21]]},"references-count":32,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["life12050766"],"URL":"https:\/\/doi.org\/10.3390\/life12050766","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,21]]}}}