{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T03:54:59Z","timestamp":1762055699317,"version":"build-2065373602"},"reference-count":60,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>We aimed to evaluate the effect of a combination of natural products on parameters related to inflammation, endothelial dysfunction, and oxidative stress in a cohort of familial Mediterranean fever (FMF) patients with Serum Amyloid A amyloidosis, in a non-randomized, 24-week open-label interventional study. Morinda citrifolia (anti-atherosclerotic-AAL), omega-3 (anti-inflammatory-AIC), and extract with Alaskan blueberry (antioxidant-AOL) were given to patients with FMF-related biopsy-proven AA amyloidosis. Patients were &gt;18 years and had proteinuria (&gt;3500 mg\/day) but a normal estimated glomerular filtration rate (eGFR). Arterial flow-mediated dilatation (FMD), carotid intima media thickness (CIMT), and serum biomarkers asymmetric dimethylarginine (ADMA), high sensitivity C-reactive protein (hs-CRP), pentraxin (PTX3), malondialdehyde (MDA), Cu\/Zn-superoxide dismutase (Cu\/Zn-SOD), and glutathione peroxidase (GSH-Px) were studied at baseline and after 24 weeks of treatment. A total of 67 FMF-related amyloidosis patients (52 male (77.6%); median age 36 years (range 21\u201366)) were enrolled. At the end of a 24-week treatment period with AAL, AIC, and AOL combination therapy, ADMA, MDA, PTX3, hsCRP, cholesterol, and proteinuria were significantly decreased compared to baseline, while CuZn-SOD, GSH-Px, and FMD levels were significantly increased. Changes in inflammatory markers PTX3, and hsCRP were negatively correlated with FMD change, and positively correlated with decreases in proteinuria, ADMA, MDA, cholesterol, and CIMT. Treatment with AAL, AIC and AOL combination for 24 weeks were significantly associated with reduction in inflammatory markers, improved endothelial functions, and oxidative state. Efficient control of these three mechanisms can have long term cardiovascular and renal benefits for patients with AA amyloidosis.<\/jats:p>","DOI":"10.3390\/life12060896","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T03:01:22Z","timestamp":1655348482000},"page":"896","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti-Inflammatory, Antioxidant, and Anti-Atherosclerotic Effects of Natural Supplements on Patients with FMF-Related AA Amyloidosis: A Non-Randomized 24-Week Open-Label Interventional Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Micol","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Rheumatology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada"},{"name":"Canadian Behcet and Autoinflammatory Disease Center (CAN BE AID), Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8732-247X","authenticated-orcid":false,"given":"Facundo","family":"Garcia-Bournissen","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Clinical Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada"},{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Piskin","sequence":"additional","affiliation":[{"name":"Canadian Behcet and Autoinflammatory Disease Center (CAN BE AID), Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada"},{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulkumen","family":"Rodoplu","sequence":"additional","affiliation":[{"name":"Emergency Medicine Association of Turkey of All, 35220 Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizzy","family":"Piskin","sequence":"additional","affiliation":[{"name":"Robarts Research Institute, University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelbaset","family":"Elzagallaai","sequence":"additional","affiliation":[{"name":"Schulich School of Medicine & Dentistry, Physiology and Pharmacology, University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tunc","family":"Tuncer","sequence":"additional","affiliation":[{"name":"Unit of Biochemistry, Epigenetic Health Solutions, 06810 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siren","family":"Sezer","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Faculty of Medicine, Atilim University, 06830 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-5976","authenticated-orcid":false,"given":"Didar","family":"Ucuncuoglu","sequence":"additional","affiliation":[{"name":"Department of Food Engineering, Faculty of Engineering, Cankiri Karatekin University, 18100 Cankiri, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-1374","authenticated-orcid":false,"given":"Tevfik","family":"Honca","sequence":"additional","affiliation":[{"name":"Unit of Biochemistry, Gur Life Hospital, 26320 Eskisehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-9334","authenticated-orcid":false,"given":"Dimitri","family":"Poddighe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Nazarbayev University School of Medicine, Nur-Sultan 010000, Kazakhstan"},{"name":"Clinical Academic Department of Pediatrics, National Research Center of Maternal and Child Health, University Medical Center, Nur-Sultan 010000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izzet","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Lokman Hekim University, 06510 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8785-4820","authenticated-orcid":false,"given":"Peter","family":"Stenvinkel","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine M99, Karolinska Institute, Karolinska University Hospital, 17164 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-2582","authenticated-orcid":false,"given":"Mahmut","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Unit of Nephrology, Center for Epigenetic Health Solutions, 06810 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-1789","authenticated-orcid":false,"given":"Erkan","family":"Demirkaya","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Division of Paediatric Rheumatology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada"},{"name":"Canadian Behcet and Autoinflammatory Disease Center (CAN BE AID), Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 5W9, Canada"},{"name":"Department of Epidemiology and Biostatistics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1196\/annals.1423.022","article-title":"Genetics and New Treatment Modalities for Familial Mediterranean Fever","volume":"1110","author":"Bhat","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Siligato, R., Gembillo, G., Calabrese, V., Conti, G., and Santoro, D. (2021). Amyloidosis and Glomerular Diseases in Familial Mediterranean Fever. Medicina, 57.","DOI":"10.3390\/medicina57101049"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.4314\/ahs.v11i3.70063","article-title":"Increased oxidative stress in patients with familial Mediterranean fever during attack period","volume":"11","author":"Ediz","year":"2011","journal-title":"Afr. Health Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.freeradbiomed.2004.10.026","article-title":"Oxidative stress status in familial Mediterranean fever with or without proteinuria","volume":"38","author":"Gurbuz","year":"2005","journal-title":"Free Radic. Biol. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3109\/s10165-011-0517-5","article-title":"Acute phase response and oxidative stress status in familial Mediterranean fever (FMF)","volume":"22","author":"Guzel","year":"2012","journal-title":"Mod. Rheumatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1136\/jcp.49.6.453","article-title":"Evidence of oxidative stress in erythrocyte phospholipid composition in the pathogenesis of familial Mediterranean fever (periodical disease)","volume":"49","author":"Karaguezyan","year":"1996","journal-title":"J. Clin. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.freeradbiomed.2007.09.020","article-title":"Oxidative DNA damage in polymorphonuclear leukocytes of patients with familial Mediterranean fever","volume":"44","author":"Kirkali","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1089\/ars.2021.0027","article-title":"Oxidative Stress and Endothelial Dysfunction in Sepsis and Acute Inflammation","volume":"35","author":"Joffre","year":"2021","journal-title":"Antioxid. Redox Signal."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/JPER.17-0638","article-title":"The evaluation of salivary oxidative stress in patients with familial Mediterranean fever and chronic periodontitis","volume":"89","author":"Dogru","year":"2018","journal-title":"J. Periodontol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/rheumatology\/kep131","article-title":"Intima-media thickening in patients with familial Mediterranean fever","volume":"48","author":"Ugurlu","year":"2009","journal-title":"Rheumatology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1093\/rheumatology\/keu231","article-title":"Endothelial function in patients with familial Mediterranean fever-related amyloidosis and association with cardiovascular events","volume":"53","author":"Yilmaz","year":"2014","journal-title":"Rheumatology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1007\/s10067-016-3532-2","article-title":"Evaluation of endothelial dysfunction in patients with familial Mediterranean fever: The relationship between the levels of asymmetric dimethylarginine and endocan with carotid intima\u2013media thickness and endothelium-dependent vasodilation","volume":"36","author":"Ozalper","year":"2017","journal-title":"Clin. Rheumatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00296-008-0605-9","article-title":"Evaluation of intima media thickness of the common and internal carotid arteries with inflammatory markers in familial Mediterranean fever as possible predictors for atherosclerosis","volume":"28","author":"Bilginer","year":"2008","journal-title":"Rheumatol. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3720","DOI":"10.1182\/blood-2010-07-273417","article-title":"Interleukin-1 in the pathogenesis and treatment of inflammatory diseases","volume":"117","author":"Dinarello","year":"2011","journal-title":"Blood"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1161\/CIRCIMAGING.113.001193","article-title":"Increased Benefit of Interleukin-1 Inhibition on Vascular Function, Myocardial Deformation, and Twisting in Patients With Coronary Artery Disease and Coexisting Rheumatoid Arthritis","volume":"7","author":"Ikonomidis","year":"2014","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1258\/acb.2011.011225","article-title":"Amyloidosis","volume":"49","author":"Pinney","year":"2012","journal-title":"Ann. Clin. Biochem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/annrheumdis-2012-202932","article-title":"Mortality risk factors associated with familial Mediterranean fever among a cohort of 1.25 million adolescents","volume":"73","author":"Twig","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"18374","DOI":"10.1038\/s41598-020-75433-7","article-title":"Cardiovascular disease risk assessment in patients with familial Mediterranean fever related renal amyloidosis","volume":"10","author":"Romano","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/ptr.4595","article-title":"Anticancer Activity of Morinda citrifolia (Noni) Fruit: A Review","volume":"26","author":"Brown","year":"2012","journal-title":"Phytother. Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.4239\/wjd.v5.i2.176","article-title":"Phytotherapy in diabetes: Review on potential mechanistic perspectives","volume":"5","author":"Schaalan","year":"2014","journal-title":"World J. Diabetes"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2174\/157339907781368968","article-title":"Omega-3 Fatty Acids for Nutrition and Medicine: Considering Microalgae Oil as a Vegetarian Source of EPA and DHA","volume":"3","author":"Krupanidhi","year":"2007","journal-title":"Curr. Diabetes Rev."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6896","DOI":"10.1021\/jf0511300","article-title":"Antioxidant Properties of Prepared Blueberry (Vaccinium myrtillus) Extracts","volume":"53","author":"Faria","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"9172","DOI":"10.1021\/acs.jafc.8b03201","article-title":"Prevention of Atherosclerosis by Berries: The Case of Blueberries","volume":"66","author":"Wu","year":"2018","journal-title":"J. Agric. Food Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"9018","DOI":"10.1038\/s41598-020-65528-6","article-title":"The Effect of Corrected Inflammation, Oxidative Stress and Endothelial Dysfunction on Fmd Levels in Patients with Selected Chronic Diseases: A Quasi-Experimental Study","volume":"10","author":"Yilmaz","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Arici, Z., Romano, M., Piskin, D., Guzel, F., Sahin, S., Berard, R., Yilmaz, M., and Demirkaya, E. (2021). Evaluation of E148Q and Concomitant AA Amyloidosis in Patients with Familial Mediterranean Fever. J. Clin. Med., 10.","DOI":"10.3390\/jcm10163511"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3899\/jrheum.141249","article-title":"Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry","volume":"43","author":"Demirkaya","year":"2015","journal-title":"J. Rheumatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2105\/AJPH.94.3.361","article-title":"Improving the Reporting Quality of Nonrandomized Evaluations of Behavioral and Public Health Interventions: The TREND Statement","volume":"94","author":"Lyles","year":"2004","journal-title":"Am. J. Public Health"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jclinepi.2017.02.020","article-title":"Quasi-experimental study designs series\u2014paper 1: Introduction: Two historical lineages","volume":"89","author":"Rockers","year":"2017","journal-title":"J. Clin. Epidemiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0140-6736(92)93147-F","article-title":"Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis","volume":"340","author":"Celermajer","year":"1992","journal-title":"Lancet"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0378-4347(96)00531-2","article-title":"Determination of N(G),N(G)-dimethylarginine in human plasma by high-performance liquid chromatography","volume":"692","author":"Chen","year":"1997","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0009-9120(00)00199-5","article-title":"Oxidative stress and nitric oxide related parameters in type II diabetes mellitus: Effects of glycemic control","volume":"34","author":"Orhan","year":"2001","journal-title":"Clin. Biochem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"21340","DOI":"10.1016\/S0021-9258(19)30085-7","article-title":"Hyperglycemia can cause membrane lipid peroxidation and osmotic fragility in human red blood cells","volume":"264","author":"Jain","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1056\/NEJM200205023461819","article-title":"Hereditary periodic fever","volume":"346","author":"Hull","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41581-020-00345-8","article-title":"Food as medicine: Targeting the uraemic phenotype in chronic kidney disease","volume":"17","author":"Mafra","year":"2020","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1136\/annrheumdis-2012-202708","article-title":"Results from a multicentre international registry of familial Mediterranean fever: Impact of environment on the expression of a monogenic disease in children","volume":"73","author":"Ozen","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e161","DOI":"10.1016\/j.atherosclerosis.2007.06.014","article-title":"Impaired coronary microvascular function in familial Mediterranean fever","volume":"195","author":"Caliskan","year":"2007","journal-title":"Atherosclerosis"},{"key":"ref_37","first-page":"2024","article-title":"Increased asymmetric dimethylarginine levels in young men with familial Mediterranean fever (FMF): Is it early evidence of interaction between inflammation and endothelial dysfunction in FMF?","volume":"35","author":"Terekeci","year":"2008","journal-title":"J. Rheumatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10067-007-0764-1","article-title":"The evaluation of carotid intima-media thickness in children with familial Mediterranean fever","volume":"27","author":"Peru","year":"2007","journal-title":"Clin. Rheumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.gene.2017.10.068","article-title":"Genotype-phenotype correlation in FMF patients: A \u201cnon classic\u201d recessive autosomal or \u201catypical\u201d dominant autosomal inheritance?","volume":"641","author":"Procopio","year":"2018","journal-title":"Gene"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/s10067-006-0529-2","article-title":"Early ultrasonographic markers of atherosclerosis in patients with familial Mediterranean fever","volume":"26","author":"Sari","year":"2007","journal-title":"Clin. Rheumatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1177\/1358836X0501000114","article-title":"ADMA and oxidative stress may relate to the progression of renal disease: Rationale and design of the VIVALDI study","volume":"10","author":"Schwedhelm","year":"2005","journal-title":"Vasc. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jdiacomp.2017.12.006","article-title":"Relation of asymmetrical dimethylarginine levels with renal outcomes in hypertensive patients with and without type 2 diabetes mellitus","volume":"32","author":"Triches","year":"2017","journal-title":"J. Diabetes Its Complicat."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1124\/jpet.120.000212","article-title":"Specific Lowering of Asymmetric Dimethylarginine by Pharmacological Dimethylarginine Dimethylaminohydrolase Improves Endothelial Function, Reduces Blood Pressure and Ischemia-Reperfusion Injury","volume":"376","author":"Lee","year":"2020","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/j.ekir.2021.04.023","article-title":"Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2","volume":"6","author":"Stenvinkel","year":"2021","journal-title":"Kidney Int. Rep."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"d4044","DOI":"10.1136\/bmj.d4044","article-title":"Effectiveness and cost effectiveness of cardiovascular disease prevention in whole populations: Modelling study","volume":"343","author":"Barton","year":"2011","journal-title":"BMJ"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/art.24458","article-title":"Familial Mediterranean Fever in the World","volume":"61","author":"Touitou","year":"2009","journal-title":"Arthritis Care Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1681\/ASN.2007040461","article-title":"ADMA Levels Correlate with Proteinuria, Secondary Amyloidosis, and Endothelial Dysfunction","volume":"19","author":"Yilmaz","year":"2008","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_48","first-page":"41","article-title":"Chitotriosidase as a novel biomarker of early atherosclerosis in hemodialysis patients","volume":"21","author":"Yilmaz","year":"2016","journal-title":"Hemodial. Int."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Kocyigit, I., Yilmaz, M.I., Gungor, O., Eroglu, E., Unal, A., Orscelik, O., Tokgoz, B., Sipahioglu, M., Sen, A., and Carrero, J.J. (2016). Vasopressin-related copeptin is a novel predictor of early endothelial dysfunction in patients with adult polycystic kidney disease. BMC Nephrol., 17.","DOI":"10.1186\/s12882-016-0406-4"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00223-016-0136-4","article-title":"Osteoprotegerin in Chronic Kidney Disease: Associations with Vascular Damage and Cardiovascular Events","volume":"99","author":"Yilmaz","year":"2016","journal-title":"Calcif. Tissue Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/01.STR.29.2.439","article-title":"Potential of carotid ultrasonography in the diagnosis of coronary artery disease: A comparison with exercise test and variance ECG","volume":"29","author":"Nowak","year":"1998","journal-title":"Stroke"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1046\/j.1523-1755.1999.00422.x","article-title":"Strong association between malnutrition, inflammation, and atherosclerosis in chronic renal failure","volume":"55","author":"Stenvinkel","year":"1999","journal-title":"Kidney Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrrev.2003.11.001","article-title":"Oxidative DNA damage and disease: Induction, repair and significance","volume":"567","author":"Evans","year":"2004","journal-title":"Mutat. Res. Mutat. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1006\/bbrc.1996.5997","article-title":"Oxidative Stress Is Found in Amyloid Deposits in Systemic Amyloidosis","volume":"232","author":"Ando","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s004390050623","article-title":"Familial Mediterranean fever: Clastogenic plasma factors correlated with increased O2(-)\u2014Production by neu-trophils","volume":"101","author":"Sarkisian","year":"1997","journal-title":"Hum. Genet."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ki.1994.1","article-title":"Renal antioxidant enzymes: Their regulation and function","volume":"45","author":"Ichikawa","year":"1994","journal-title":"Kidney Int."},{"key":"ref_57","first-page":"9","article-title":"Prevalence of ischemic heart disease in patients with familial Mediterranean fever","volume":"3","author":"Langevitz","year":"2001","journal-title":"Isr. Med Assoc. J. IMAJ"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00210-009-0464-2","article-title":"Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes","volume":"380","author":"Pantaler","year":"2009","journal-title":"Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00232-011-9342-1","article-title":"Colchicine Modulates Oxidative Stress in Serum and Leucocytes from Remission Patients with Family Mediterranean Fever Through Regulation of Ca2+ Release and the Antioxidant System","volume":"240","author":"Demirkan","year":"2011","journal-title":"J. Membr. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0300-483X(02)00199-3","article-title":"Anti-\/pro-oxidant effects of phenolic compounds in cells: Are colchicine metabolites chain-breaking antioxi-dants?","volume":"177","author":"Modriansky","year":"2002","journal-title":"Toxicology"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/6\/896\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:32:15Z","timestamp":1760139135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/6\/896"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":60,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["life12060896"],"URL":"https:\/\/doi.org\/10.3390\/life12060896","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2022,6,15]]}}}