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C. Wong Education Foundation","award":["81974179"],"award-info":[{"award-number":["81974179"]}]},{"name":"K. C. Wong Education Foundation","award":["81801170"],"award-info":[{"award-number":["81801170"]}]},{"name":"K. C. Wong Education Foundation","award":["82071284"],"award-info":[{"award-number":["82071284"]}]},{"name":"K. C. Wong Education Foundation","award":["81870921"],"award-info":[{"award-number":["81870921"]}]},{"name":"K. C. Wong Education Foundation","award":["2019-01-07-00-02-E00064"],"award-info":[{"award-number":["2019-01-07-00-02-E00064"]}]},{"name":"K. C. Wong Education Foundation","award":["20JC1411900"],"award-info":[{"award-number":["20JC1411900"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Stroke is a leading cause of death and long-term disability worldwide. Astrocytes structurally compose tripartite synapses, blood\u2013brain barrier, and the neurovascular unit and perform multiple functions through cell-to-cell signaling of neurons, glial cells, and vasculature. The crosstalk of astrocytes and other cells is complicated and incompletely understood. Here we review the role of astrocytes in response to ischemic stroke, both beneficial and detrimental, from a cell\u2013cell interaction perspective. Reactive astrocytes provide neuroprotection through antioxidation and antiexcitatory effects and metabolic support; they also contribute to neurorestoration involving neurogenesis, synaptogenesis, angiogenesis, and oligodendrogenesis by crosstalk with stem cells and cell lineage. In the meantime, reactive astrocytes also play a vital role in neuroinflammation and brain edema. Glial scar formation in the chronic phase hinders functional recovery. We further discuss astrocyte enriched microRNAs and exosomes in the regulation of ischemic stroke. In addition, the latest notion of reactive astrocyte subsets and astrocytic activity revealed by optogenetics is mentioned. This review discusses the current understanding of the intimate molecular conversation between astrocytes and other cells and outlines its potential implications after ischemic stroke. \u201cNeurocentric\u201d strategies may not be sufficient for neurological protection and recovery; future therapeutic strategies could target reactive astrocytes.<\/jats:p>","DOI":"10.3390\/life12060910","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T11:45:44Z","timestamp":1655466344000},"page":"910","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Crosstalk of Astrocytes and Other Cells during Ischemic Stroke"],"prefix":"10.3390","volume":"12","author":[{"given":"Tingting","family":"He","sequence":"first","affiliation":[{"name":"Department of Neurology, Shanghai Tenth People\u2019s Hospital, Tongji University, Shanghai 200072, China"},{"name":"Neuroscience and Neuroengineering Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Yuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Neuroscience and Neuroengineering Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Neuroscience and Neuroengineering Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"17513","DOI":"10.1073\/pnas.0602841103","article-title":"Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury","volume":"103","author":"Wilhelmsson","year":"2006","journal-title":"Proc. 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