{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:31:04Z","timestamp":1790652664193,"version":"4.1.0"},"reference-count":70,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T00:00:00Z","timestamp":1655856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the European Union\u2019s Horizon 2020 research and innovation program","award":["838602"],"award-info":[{"award-number":["838602"]}]},{"name":"the European Union\u2019s Horizon 2020 research and innovation program","award":["ANR-15-IDEX-01"],"award-info":[{"award-number":["ANR-15-IDEX-01"]}]},{"name":"the NeuroMod Institute under the auspices of the IDEX scheme of the French Government","award":["838602"],"award-info":[{"award-number":["838602"]}]},{"name":"the NeuroMod Institute under the auspices of the IDEX scheme of the French Government","award":["ANR-15-IDEX-01"],"award-info":[{"award-number":["ANR-15-IDEX-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The logopenic variant of Primary Progressive Aphasia (lvPPA), a syndromic disorder centered on language impairment, often presents variable underlying neurodegenerative pathologies such as Alzheimer Disease (AD). Actual language assessment tests and lumbar puncture, focused on AD diagnosis, cannot precisely distinguish the symptoms, or predict their progression at onset time. We analyzed acoustic markers, aiming to discriminate lvPPA and AD as well as the influence of AD biomarkers on acoustic profiles at the beginning of the disease. We recruited people with AD (n = 8) and with lvPPA (n = 8), with cerebrospinal fluid biomarker profiles determined by lumbar puncture. The participants performed a sentence repetition task that allows assessing potential lvPPA phonological loop deficits. We found that temporal and prosodic markers significantly differentiate the lvPPA and AD group at an early stage of the disease. Biomarker and acoustic profile comparisons discriminated the two lvPPA subgroups according to their biomarkers. For lvPPA with AD biomarkers, acoustic profile equivalent to an atypical AD form with a specific alteration of the phonological loop is shown. However, lvPPA without AD biomarkers has an acoustic profile approximating the one for DLFT. Therefore, these results allow us to classify lvPPA differentially from AD based on acoustic markers from a sentence repetition task. Furthermore, our results suggest that acoustic analysis would constitute a clinically efficient alternative to refused lumbar punctures. It offers the possibility to facilitate early, specific, and accessible neurodegenerative diagnosis and may ease early care with speech therapy, preventing the progression of symptoms.<\/jats:p>","DOI":"10.3390\/life12070933","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:12:01Z","timestamp":1655871121000},"page":"933","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Logogenic Primary Progressive Aphasia or Alzheimer Disease: Contribution of Acoustic Markers in Early Differential Diagnosis"],"prefix":"10.3390","volume":"12","author":[{"given":"Elo\u00efse","family":"Da Cunha","sequence":"first","affiliation":[{"name":"Speech Therapy Department of Nice, Faculty of medicine, Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Laboratoire CoBTeK (Cognition Behaviour Technology), Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Plonka","sequence":"additional","affiliation":[{"name":"Speech Therapy Department of Nice, Faculty of medicine, Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Laboratoire CoBTeK (Cognition Behaviour Technology), Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Institut NeuroMod, Universit\u00e9 C\u00f4te d\u2019Azur, 06902 Sophia-Antipolis, France"},{"name":"Service Clinique G\u00e9riatrique du Cerveau et du Mouvement, CMRR, Centre Hospitalier Universitaire, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u00e7kin","family":"Arslan","sequence":"additional","affiliation":[{"name":"BCL, CNRS UMR7320, Campus Saint Jean d\u2019Angely\u2014SJA3\/MSHS-SE, Universit\u00e9 C\u00f4te d\u2019Azur, 06300 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Mouton","sequence":"additional","affiliation":[{"name":"Speech Therapy Department of Nice, Faculty of medicine, Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Laboratoire CoBTeK (Cognition Behaviour Technology), Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Service Clinique G\u00e9riatrique du Cerveau et du Mouvement, CMRR, Centre Hospitalier Universitaire, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tess","family":"Meyer","sequence":"additional","affiliation":[{"name":"Speech Therapy Department of Nice, Faculty of medicine, Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0963-1728","authenticated-orcid":false,"given":"Philippe","family":"Robert","sequence":"additional","affiliation":[{"name":"Speech Therapy Department of Nice, Faculty of medicine, Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Laboratoire CoBTeK (Cognition Behaviour Technology), Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Service Clinique G\u00e9riatrique du Cerveau et du Mouvement, CMRR, Centre Hospitalier Universitaire, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Meunier","sequence":"additional","affiliation":[{"name":"BCL, CNRS UMR7320, Campus Saint Jean d\u2019Angely\u2014SJA3\/MSHS-SE, Universit\u00e9 C\u00f4te d\u2019Azur, 06300 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Manera","sequence":"additional","affiliation":[{"name":"Laboratoire CoBTeK (Cognition Behaviour Technology), Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auriane","family":"Gros","sequence":"additional","affiliation":[{"name":"Speech Therapy Department of Nice, Faculty of medicine, Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Laboratoire CoBTeK (Cognition Behaviour Technology), Universit\u00e9 C\u00f4te d\u2019Azur, 06000 Nice, France"},{"name":"Service Clinique G\u00e9riatrique du Cerveau et du Mouvement, CMRR, Centre Hospitalier Universitaire, 06000 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"ref_1","first-page":"87","article-title":"Non-Pharmacological Therapies for Language Deficits in the Agrammatic and Logopenic Variants of Primary Progressive Aphasia: A Literature Review","volume":"11","author":"Routhier","year":"2013","journal-title":"G\u00e9riatrie Psychol. Neuropsychiatr. Vieil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s11910-014-0466-4","article-title":"Pathology in Primary Progressive Aphasia Syndromes","volume":"14","author":"Harris","year":"2014","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cortex.2019.05.007","article-title":"Machine Learning in the Clinical and Language Characterisation of Primary Progressive Aphasia Variants","volume":"119","author":"Cuetos","year":"2019","journal-title":"Cortex"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-022-01007-6","article-title":"The Course of Primary Progressive Aphasia Diagnosis: A Cross-Sectional Study","volume":"14","author":"Mouton","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ana.91","article-title":"Primary Progressive Aphasia","volume":"49","author":"Mesulam","year":"2001","journal-title":"Ann. Neurol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1056\/NEJMra022435","article-title":"Primary Progressive Aphasia\u2014A Language-Based Dementia","volume":"349","author":"Mesulam","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/13554790490960440","article-title":"Primary Progressive Aphasia: A Review","volume":"10","author":"Grossman","year":"2004","journal-title":"Neurocase"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1212\/01.wnl.0000175982.57472.84","article-title":"Natural History of Primary Progressive Aphasia","volume":"65","author":"Rhun","year":"2005","journal-title":"Neurology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"692","DOI":"10.3389\/fneur.2018.00692","article-title":"Clinical, Anatomical, and Pathological Features in the Three Variants of Primary Progressive Aphasia: A Review","volume":"9","author":"Montembeault","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13195-016-0185-y","article-title":"Classification of the Primary Progressive Aphasias: Principles and Review of Progress since 2011","volume":"8","author":"Vandenberghe","year":"2016","journal-title":"Alzheimers Res. Ther."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","article-title":"Classification of Primary Progressive Aphasia and Its Variants","volume":"76","author":"Hillis","year":"2011","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/brain\/awl078","article-title":"Clinicopathological and Imaging Correlates of Progressive Aphasia and Apraxia of Speech","volume":"129","author":"Josephs","year":"2006","journal-title":"Brain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1001\/archneur.1990.00530120075013","article-title":"Primary Progressive Aphasia: Longitudinal Course, Neuropsychological Profile, and Language Features","volume":"47","author":"Weintraub","year":"1990","journal-title":"Arch. Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1590\/S1980-57642013DN70100002","article-title":"Primary Progressive Aphasia: A Dementia of the Language Network","volume":"7","author":"Mesulam","year":"2013","journal-title":"Dement. Neuropsychol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1212\/01.wnl.0000436070.28137.7b","article-title":"Classification and Pathology of Primary Progressive Aphasia","volume":"81","author":"Harris","year":"2013","journal-title":"Neurology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3389\/fneur.2020.00049","article-title":"Primary Progressive Aphasia as a Prodromal State of Dementia with Lewy Bodies: A Case Report","volume":"11","author":"Watanabe","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ana.21388","article-title":"Alzheimer and Frontotemporal Pathology in Subsets of Primary Progressive Aphasia","volume":"63","author":"Mesulam","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1212\/01.wnl.0000320506.79811.da","article-title":"The Logopenic\/Phonological Variant of Primary Progressive Aphasia","volume":"71","author":"Brambati","year":"2008","journal-title":"Neurology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0028-3932(98)00148-1","article-title":"Phonological Loop and Central Executive Functioning in Alzheimer\u2019s Disease","volume":"37","author":"Collette","year":"1999","journal-title":"Neuropsychologia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/ana.10825","article-title":"Cognition and Anatomy in Three Variants of Primary Progressive Aphasia","volume":"55","author":"Dronkers","year":"2004","journal-title":"Ann. Neurol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.neurobiolaging.2017.11.008","article-title":"Neocortical Origin and Progression of Gray Matter Atrophy in Nonamnestic Alzheimer\u2019s Disease","volume":"63","author":"Phillips","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S1474-4422(10)70223-4","article-title":"Revising the Definition of Alzheimer\u2019s Disease: A New Lexicon","volume":"9","author":"Dubois","year":"2010","journal-title":"Lancet Neurol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/ana.24885","article-title":"Typical and Atypical Pathology in Primary Progressive Aphasia Variants","volume":"81","author":"Spinelli","year":"2017","journal-title":"Ann. Neurol."},{"key":"ref_24","first-page":"89","article-title":"Alzheimers Disease: A Brief Review","volume":"1","author":"McGirr","year":"2020","journal-title":"J. Exp. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3389\/fneur.2019.00485","article-title":"Clinical Correlates of Alzheimer\u2019s Disease Cerebrospinal Fluid Analytes in Primary Progressive Aphasia","volume":"10","author":"Norise","year":"2019","journal-title":"Front. Neurol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e042842","DOI":"10.1002\/alz.042842","article-title":"R\u00e9p\u00e9ter s\u2019il Vous Plait: Working Memory Intensive Sentence Repetition Deficits as a Sensitive Neuropsychological Marker of Primary Progressive Aphasia: Neuropsychology\/Neuropsychological Profiles of Dementia: Valid Biomarkers?","volume":"16","author":"Arslan","year":"2020","journal-title":"Alzheimers Dement."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Madhavan, A., Whitwell, J.L., Weigand, S.D., Duffy, J.R., Strand, E.A., Machulda, M.M., Tosakulwong, N., Senjem, M.L., Gunter, J.L., and Lowe, V.J. (2013). FDG PET and MRI in Logopenic Primary Progressive Aphasia versus Dementia of the Alzheimer\u2019s Type. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062471"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.clinph.2020.03.003","article-title":"Early Diagnosis of Alzheimer\u2019s Disease: The Role of Biomarkers Including Advanced EEG Signal Analysis. Report from the IFCN-Sponsored Panel of Experts","volume":"131","author":"Rossini","year":"2020","journal-title":"Clin. Neurophysiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1474-4422(16)00070-3","article-title":"CSF and Blood Biomarkers for the Diagnosis of Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis","volume":"15","author":"Olsson","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_30","first-page":"27","article-title":"Biomarkers in Alzheimer\u2019s Disease","volume":"2","author":"Janeiro","year":"2021","journal-title":"Adv. Lab. Med. Av. En Med. Lab."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s00415-014-7243-9","article-title":"Progranulin-Associated PiB-Negative Logopenic Primary Progressive Aphasia","volume":"261","author":"Josephs","year":"2014","journal-title":"J. Neurol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1007\/s00415-015-7738-z","article-title":"Amyloid and FDG-PET Study of Logopenic Primary Progressive Aphasia: Evidence for the Existence of Two Subtypes","volume":"262","author":"Carreras","year":"2015","journal-title":"J. Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1093\/brain\/awt266","article-title":"Deciphering Logopenic Primary Progressive Aphasia: A Clinical, Imaging and Biomarker Investigation","volume":"136","author":"Teichmann","year":"2013","journal-title":"Brain"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bandl.2015.01.009","article-title":"Clinical and Neuroimaging Biomarkers of Amyloid-Negative Logopenic Primary Progressive Aphasia","volume":"142","author":"Whitwell","year":"2015","journal-title":"Brain Lang."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/alz.12372","article-title":"State-of-the-Art of Lumbar Puncture and Its Place in the Journey of Patients with Alzheimer\u2019s Disease","volume":"18","author":"Hampel","year":"2022","journal-title":"Alzheimers Dement."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e046450","DOI":"10.1002\/alz.046450","article-title":"Barriers to Recruitment for Research Procedures in Studies of Alzheimer\u2019s Disease and Related Disorders","volume":"16","author":"Hofmann","year":"2020","journal-title":"Alzheimers Dement."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1017\/cjn.2021.67","article-title":"Use of Alzheimer\u2019s Disease Cerebrospinal Fluid Biomarkers in A Tertiary Care Memory Clinic","volume":"49","author":"Stiffel","year":"2022","journal-title":"Can. J. Neurol. Sci."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jalz.2008.07.003","article-title":"Status of Computerized Cognitive Testing in Aging: A Systematic Review","volume":"4","author":"Wild","year":"2008","journal-title":"Alzheimers Dement. J. Alzheimers Assoc."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s11357-016-9934-x","article-title":"Computer-Based Tools for Assessing Micro-Longitudinal Patterns of Cognitive Function in Older Adults","volume":"38","author":"Brown","year":"2016","journal-title":"AGE"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Ballard, K.J., Savage, S., Leyton, C.E., Vogel, A.P., Hornberger, M., and Hodges, J.R. (2014). Logopenic and Nonfluent Variants of Primary Progressive Aphasia Are Differentiated by Acoustic Measures of Speech Production. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0089864"},{"key":"ref_41","unstructured":"Ammar, R., and Benayed, Y. (2021, January 13\u201315). Evaluation of Acoustic Features for Early Diagnosis of Alzheimer Disease. Proceedings of the International Conference on Intelligent Systems Design and Applications, Online."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2174\/1567205017666200213094513","article-title":"Automatic Detection of Cognitive Impairments through Acoustic Analysis of Speech","volume":"17","author":"Nagumo","year":"2020","journal-title":"Curr. Alzheimer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3389\/fneur.2018.00975","article-title":"Identification of Mild Cognitive Impairment from Speech in Swedish Using Deep Sequential Neural Networks","volume":"9","author":"Themistocleous","year":"2018","journal-title":"Front. Neurol."},{"key":"ref_44","first-page":"112","article-title":"Automatic Speech Analysis for the Assessment of Patients with Predementia and Alzheimer\u2019s Disease","volume":"1","author":"Satt","year":"2015","journal-title":"Alzheimers Dement. Diagn. Assess. Dis. Monit."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.jvoice.2011.09.007","article-title":"Materials of Acoustic Analysis: Sustained Vowel Versus Sentence","volume":"26","author":"Moon","year":"2012","journal-title":"J. Voice"},{"key":"ref_46","unstructured":"DSM-5 (2022, April 09). Manuel Diagnostique et Statistique des Troubles Mentaux|Livre|9782294739293. Available online: https:\/\/www.elsevier-masson.fr\/dsm-5-manuel-diagnostique-et-statistique-des-troubles-mentaux-9782294739293.html."},{"key":"ref_47","unstructured":"B\u00e9zy, C., Renard, A., and Pariente, J. (2016). GR\u00c9MOTS: \u00c9valuation du Langage Dans les Pathologies Neurod\u00e9g\u00e9n\u00e9ratives, De Boeck Superieur."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1177\/1533317517715905","article-title":"Detection Test for Language Impairments in Adults and the Aged\u2014A New Screening Test for Language Impairment Associated with Neurodegenerative Diseases: Validation and Normative Data","volume":"32","author":"Macoir","year":"2017","journal-title":"Am. J. Alzheimers Dis. Dement."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.pharmthera.2007.06.006","article-title":"The Role of Amyloid Beta Peptide 42 in Alzheimer\u2019s Disease","volume":"116","author":"Findeis","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1177\/0891988720944237","article-title":"AD-Related CSF Biomarkers Across Distinct Levels of Cognitive Impairment: Correlations with Global Cognitive State","volume":"34","author":"Ibarra","year":"2021","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"ref_51","unstructured":"(2022, January 25). Audacity Manual. Available online: https:\/\/manual.audacityteam.org."},{"key":"ref_52","unstructured":"(2022, February 10). Praat: Doing Phonetics by Computer. Available online: https:\/\/www.fon.hum.uva.nl\/praat."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"620251","DOI":"10.3389\/fpsyg.2021.620251","article-title":"Ten Years of Research on Automatic Voice and Speech Analysis of People with Alzheimer\u2019s Disease and Mild Cognitive Impairment: A Systematic Review Article","volume":"12","author":"Llorente","year":"2021","journal-title":"Front. Psychol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/jamia\/ocaa174","article-title":"A Systematic Literature Review of Automatic Alzheimer\u2019s Disease Detection from Speech and Language","volume":"27","author":"Petti","year":"2020","journal-title":"J. Am. Med. Inform. Assoc. JAMIA"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Themistocleous, C., Dimitrios, K., Eckerstr\u00f6m, M., Fraser, K., and Lundholm Fors, K. (2018, January 28\u201330). Effects of Cognitive Impairment on Vowel Duration. Proceedings of the 9th Tutorial & Research Workshop on Experimental Linguistics (ExLing 2018), Paris, France.","DOI":"10.36505\/ExLing-2018\/09\/0027\/000360"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1080\/02699200701617266","article-title":"Voice Onset Time Production in Speakers with Alzheimer\u2019s Disease","volume":"21","author":"Baker","year":"2009","journal-title":"Clin. Linguist. Phon."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuropsychologia.2018.12.018","article-title":"What Happens When Nothing Happens? An Investigation of Pauses as a Compensatory Mechanism in Early Alzheimer\u2019s Disease","volume":"124","author":"Pistono","year":"2019","journal-title":"Neuropsychologia"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1044\/1092-4388(2010\/09-0030)","article-title":"Emotional Prosody Perception and Production in Dementia of the Alzheimer\u2019s Type","volume":"53","author":"Horley","year":"2010","journal-title":"J. Speech Lang. Hear. Res."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1044\/2020_JSLHR-20-00445","article-title":"Speech Metrics and Samples That Differentiate Between Nonfluent\/Agrammatic and Logopenic Variants of Primary Progressive Aphasia","volume":"64","author":"Haley","year":"2021","journal-title":"J. Speech Lang. Hear. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.cortex.2015.07.003","article-title":"Phonological Short-Term Memory in Logopenic Variant Primary Progressive Aphasia and Mild Alzheimer\u2019s Disease","volume":"71","author":"Meyer","year":"2015","journal-title":"Cortex J. Devoted Study Nerv. Syst. Behav."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/acn3.653","article-title":"Validated Automatic Speech Biomarkers in Primary Progressive Aphasia","volume":"6","author":"Nevler","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Cho, S., Cousins, K., Shellikeri, S., Ash, S., Irwin, D., Liberman, M., Grossman, M., and Nevler, N. Lexical and Acoustic Features in Speech Relating to Alzheimer\u2019s Disease Pathology. medRxiv, 2021.","DOI":"10.1101\/2021.09.27.21264148"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ana.25333","article-title":"Prevalence of Amyloid-\u03b2 Pathology in Distinct Variants of Primary Progressive Aphasia","volume":"84","author":"Bergeron","year":"2018","journal-title":"Ann. Neurol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3233\/JAD-180037","article-title":"A Prototype for the Voice Analysis Diagnosis of Alzheimer\u2019s Disease","volume":"64","author":"Carro","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cortex.2020.08.013","article-title":"Reading Prosody in the Non-Fluent and Logopenic Variants of Primary Progressive Aphasia","volume":"132","author":"Pytel","year":"2020","journal-title":"Cortex"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neurol.2013.06.001","article-title":"Aphasia(s) in Alzheimer","volume":"169","author":"Teichmann","year":"2013","journal-title":"Rev. Neurol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"66","DOI":"10.12779\/dnd.2018.17.2.66","article-title":"Early Onset Alzheimer\u2019s Disease Presenting as Logopenic Primary Progressive Aphasia","volume":"17","author":"Oh","year":"2018","journal-title":"Dement. Neurocogn. Disord."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Yunusova, Y., Graham, N.L., Shellikeri, S., Phuong, K., Kulkarni, M., Rochon, E., Tang-Wai, D.F., Chow, T.W., Black, S.E., and Zinman, L.H. (2016). Profiling Speech and Pausing in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). 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