{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:12:41Z","timestamp":1760238761821,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T00:00:00Z","timestamp":1655942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Viral infections are a key issue in modern medicine. SARS-CoV-2 infection confirms that we are not sufficiently prepared for these unforeseen infections. The COVID-19 pandemic has cultivated a great sense of fear and distrust in patients. If viral infections, in this case, SARS-CoV-2, overlap with another infection, the symptoms are prolonged and worsened, and complications may occur. Starting from an objective clinical finding of a patient they had in follow-up and treatment, the authors present the problems of the diseases the patient suffered from. These are described as reviews so that readers can get an idea of the clinical methods of expression and the therapeutic possibilities. Therefore, this article describes Lyme disease and post-treatment Lyme disease syndrome, SARS-CoV-2 infection, and multisystem inflammatory syndrome in children (MISC-C), as the patient suffered from an incomplete form of Kawasaki disease. During the treatment for Lyme disease, the patient also contracted the influenza type A virus. Although any of these diseases could have the potential for serious evolution, our patient still went through these infections relatively well. This can be explained by the fact that the patient had a slow immune response to the aforementioned infections, which allowed him to survive these diseases relatively easily, unlike other individuals who have an exaggerated immune response or who suffer from serious immune involvement, e.g., hepatitis B with a fulminant response. The case was presented chronologically, but at the same time, all particular infection manifestations were accurately described. For these reasons, the article is presented in the form of a review, exemplified by the case itself. Of the 52 cases of MISC-C found in the Pediatrics Clinic II of Cluj-Napoca, we present the case of a male patient who presented with Lyme disease, post-treatment Lyme disease syndrome, Kawasaki disease, and MISC-C incomplete form.<\/jats:p>","DOI":"10.3390\/life12070940","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T22:43:00Z","timestamp":1656024180000},"page":"940","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Immune Responses to Some Viral Infections That Have a High Evolutionary Potential\u2014A Case Report with Literature Review"],"prefix":"10.3390","volume":"12","author":[{"given":"Maria Lucia","family":"Sur","sequence":"first","affiliation":[{"name":"Department of Pediatric I, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan-Stefan","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Children\u2019s Emergency Clinical Hospital, 400370 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Children\u2019s Emergency Clinical Hospital, 400370 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7645-0716","authenticated-orcid":false,"given":"Gabriel","family":"Samasca","sequence":"additional","affiliation":[{"name":"Children\u2019s Emergency Clinical Hospital, 400370 Cluj-Napoca, Romania"},{"name":"Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulia","family":"Lupan","sequence":"additional","affiliation":[{"name":"Molecular Biology Department, Babes Bolyai University, 400084 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-539X","authenticated-orcid":false,"given":"Ionel","family":"Armat","sequence":"additional","affiliation":[{"name":"Children\u2019s Emergency Clinical Hospital, 400370 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-0376","authenticated-orcid":false,"given":"Marin","family":"Harabagiu","sequence":"additional","affiliation":[{"name":"Department of Pediatric I, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"},{"name":"Clinical Hospital of Infectious Diseases, 400000 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genel","family":"Sur","sequence":"additional","affiliation":[{"name":"Children\u2019s Emergency Clinical Hospital, 400370 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Calin","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department of Pediatric I, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"ref_1","unstructured":"Sur, G., Delia, S., Sur, L., Sur, D., and Floca, E. (2022, March 08). Disease with a Thousand Faces\u2014A Case Report. Available online: https:\/\/www.omicsonline.org\/scientific-reports\/0975-0851-SR-659.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1097\/INF.0000000000002772","article-title":"Posttreatment Lyme Disease Syndrome-What It Might Be and What It Is Not","volume":"40","author":"Schmid","year":"2021","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s00431-012-1779-4","article-title":"Rational diagnostic strategies for Lyme borreliosis in children and adolescents: Recommendations by the Committee for Infectious Diseases and Vaccinations of the German Academy for Pediatrics and Adolescent Health","volume":"171","author":"Huppertz","year":"2012","journal-title":"Eur. J. Pediatr."},{"key":"ref_4","unstructured":"Epidemiologisches Bulletin, Robert Koch-Institut (2012). Seropr\u00e4valenz der Lyme-Borreliose bei Kindern und Jugend-lichen in Deutschland, Robert Koch-Institut."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1469-0691.2010.03175.x","article-title":"Lyme borreliosis: Clinical case definitions for diagnosis and management in Europe","volume":"17","author":"Stanek","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1001\/jama.2016.2884","article-title":"Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review","volume":"315","author":"Sanchez","year":"2016","journal-title":"JAMA"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s100960050381","article-title":"Incidence of Lyme borreliosis in the W\u00fcrzburg region of Germany","volume":"18","author":"Huppertz","year":"1999","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1056\/NEJM199610243351703","article-title":"Lyme disease in children in southeastern Connecticut. Pediatric Lyme Disease Study Group","volume":"335","author":"Gerber","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1055\/s-0031-1287652","article-title":"Nervous system Lyme disease: Is there a controversy?","volume":"31","author":"Halperin","year":"2011","journal-title":"Semin. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10096-007-0340-2","article-title":"Duration of antibiotic treatment in disseminated Lyme borreliosis: A double-blind, randomized, placebo-controlled, multicenter clinical study","volume":"26","author":"Oksi","year":"2007","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1056\/NEJM200107123450202","article-title":"Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease","volume":"345","author":"Klempner","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1056\/NEJMoa1505425","article-title":"Randomized Trial of Longer-Term Therapy for Symptoms Attributed to Lyme Disease","volume":"374","author":"Berende","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_13","first-page":"w14353","article-title":"Update of the Swiss guidelines on post-treatment Lyme disease syndrome","volume":"146","author":"Nemeth","year":"2016","journal-title":"Swiss Med. Wkly."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1212\/01.WNL.0000071227.23769.9E","article-title":"Study and treatment of post Lyme disease (STOP-LD): A randomized double masked clinical trial","volume":"60","author":"Krupp","year":"2003","journal-title":"Neurology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1542\/peds.112.2.e93","article-title":"Long-term neuropsychologic and health outcomes of children with facial nerve palsy attributable to Lyme disease","volume":"112","author":"Sparrow","year":"2003","journal-title":"Pediatrics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s42399-020-00690-6","article-title":"Emerging Evidence on Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 Infection: A Systematic Review with Meta-analysis","volume":"3","author":"Sood","year":"2021","journal-title":"SN Compr. Clin. Med."},{"key":"ref_17","first-page":"119","article-title":"Multisystem Inflammatory Syndrome in Children Related to SARS-CoV-2","volume":"23","author":"Esposito","year":"2021","journal-title":"Paediatr. Drugs"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1002\/art.41616","article-title":"American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2","volume":"73","author":"Henderson","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1001\/jama.2021.2091","article-title":"Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19","volume":"325","author":"Feldstein","year":"2021","journal-title":"JAMA"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1093\/jpids\/piab007","article-title":"Sixteen Weeks Later: Expanding the Risk Period for Multisystem Inflammatory Syndrome in Children","volume":"10","author":"Cirks","year":"2021","journal-title":"J. Pediatric. Infect. Dis. Soc."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e340","DOI":"10.1097\/INF.0000000000002888","article-title":"A Systematic Review of Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection","volume":"39","author":"Kaushik","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"100527","DOI":"10.1016\/j.eclinm.2020.100527","article-title":"Multisystem inflammatory syndrome in children: A systematic review","volume":"26","author":"Ahmed","year":"2020","journal-title":"EClinicalMedicine"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S2352-4642(20)30215-7","article-title":"Intensive care admissions of children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the UK: A multicentre observational study","volume":"4","author":"Davies","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"n385","DOI":"10.1136\/bmj.n385","article-title":"Acute covid-19 and multisystem inflammatory syndrome in children","volume":"372","author":"Rubens","year":"2021","journal-title":"BMJ"},{"key":"ref_25","unstructured":"(2022, March 12). Multisystem Inflammatory Syndrome in Children (MIS-C) Interim Guidance. Available online: https:\/\/www.aap.org\/en\/pages\/2019-novel-coronavirus-covid-19-infections\/clinical-guidance\/multisystem-inflammatory-syndrome-in-children-mis-c-interim-guidance\/."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.15585\/mmwr.mm6932e2","article-title":"COVID-19-Associated Multisystem Inflammatory Syndrome in Children\u2014United States, March\u2013July 2020","volume":"69","author":"Bryant","year":"2020","journal-title":"MMWR Morb. Mortal Wkly. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00431-020-03766-6","article-title":"Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: A comprehensive review and proposed clinical approach","volume":"180","author":"Sperotto","year":"2021","journal-title":"Eur. J. Pediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S2352-4642(20)30257-1","article-title":"SARS-CoV-2 in cardiac tissue of a child with COVID-19-related multisystem inflammatory syndrome","volume":"4","author":"Dolhnikoff","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/jama.2020.10369","article-title":"Clinical Characteristics of 58 Children with a Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2","volume":"324","author":"Whittaker","year":"2020","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1016\/S2352-4642(20)30272-8","article-title":"Multisystem inflammatory syndrome in children in South Africa","volume":"4","author":"Webb","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/S2352-4642(20)30165-6","article-title":"Gastrointestinal features in children with COVID-19: An observation of varied presentation in eight children","volume":"4","author":"Tullie","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1001\/jamaneurol.2020.2687","article-title":"Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children","volume":"77","author":"Eyre","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/jamaneurol.2021.0504","article-title":"Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome","volume":"78","author":"LaRovere","year":"2021","journal-title":"JAMA Neurol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jaad.2020.10.060","article-title":"Mucocutaneous disease and related clinical characteristics in hospitalized children and adolescents with COVID-19 and multisystem inflammatory syndrome in children","volume":"84","author":"Rekhtman","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem Inflammatory Syndrome in U.S. Children and Adolescents","volume":"383","author":"Feldstein","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJMoa2021756","article-title":"Multisystem Inflammatory Syndrome in Children in New York State","volume":"383","author":"Dufort","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: An observational cohort study","volume":"395","author":"Verdoni","year":"2020","journal-title":"Lancet"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"m2094","DOI":"10.1136\/bmj.m2094","article-title":"Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: Prospective observational study","volume":"369","author":"Toubiana","year":"2020","journal-title":"BMJ"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/annrheumdis-2020-217960","article-title":"Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): A multicentre cohort","volume":"79","author":"Pouletty","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1742-1241.2007.01305.x","article-title":"Assessment of B-type natriuretic peptide in patients with pneumonia","volume":"62","author":"Yetkin","year":"2008","journal-title":"Int. J. Clin. Pract."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1001\/jama.2021.0694","article-title":"Association of Intravenous Immunoglobulins Plus Methylprednisolone vs Immunoglobulins Alone With Course of Fever in Multisystem Inflammatory Syndrome in Children","volume":"325","author":"Ouldali","year":"2021","journal-title":"JAMA"},{"key":"ref_42","unstructured":"(2022, March 12). Paediatric Multisystem Inflammatory Syndrome Temporally Associated with COVID-19 (PIMS)\u2014Guidance for Clinicians|RCPCH. Available online: https:\/\/www.rcpch.ac.uk\/resources\/paediatric-multisystem-inflammatory-syndrome-temporally-associated-covid-19-pims-guidance."},{"key":"ref_43","unstructured":"(2022, March 12). Multisystem Inflammatory Syndrome in Children and Adolescents Temporally Related to COVID-19. Available online: https:\/\/www.who.int\/news-room\/commentaries\/detail\/multisystem-inflammatory-syndrome-in-children-and-adolescents-with-covid-19."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1542\/pir.2016-0182","article-title":"Kawasaki Disease","volume":"39","author":"Son","year":"2018","journal-title":"Pediatr. Rev."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1172\/JCI141113","article-title":"Distinct clinical and immunological features of SARS-CoV-2-induced multisystem inflammatory syndrome in children","volume":"130","author":"Lee","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"564","DOI":"10.3389\/fped.2021.656768","article-title":"Multisystem Inflammatory Syndrome in Children (MIS-C)\u2014A Case Series in December 2020 in Vienna, Austria","volume":"9","author":"Kurz","year":"2021","journal-title":"Front. Pediatr."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13052-021-00980-2","article-title":"Childhood multisystem inflammatory syndrome associated with COVID-19 (MIS-C): A diagnostic and treatment guidance from the Rheumatology Study Group of the Italian Society of Pediatrics","volume":"47","author":"Cattalini","year":"2021","journal-title":"Ital. J. Pediatr."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jpeds.2020.06.045","article-title":"Multisystem Inflammatory Syndrome in Children Associated with Severe Acute Respiratory Syndrome Coronavirus 2 Infection (MIS-C): A Multi-institutional Study from New York City","volume":"224","author":"Kaushik","year":"2020","journal-title":"J. Pediatr."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1182\/blood-2004-11-4211","article-title":"How I treat venous thrombosis in children","volume":"107","year":"2006","journal-title":"Blood"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"101232","DOI":"10.1016\/j.ppedcard.2020.101232","article-title":"COVID-19 associated Multisystem Inflammatory Syndrome in Children (MIS-C) guidelines; a Western New York approach","volume":"62","author":"Hennon","year":"2020","journal-title":"Prog. Pediatr. 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