{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:38:57Z","timestamp":1779212337218,"version":"3.51.4"},"reference-count":44,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Ha\u2019il","award":["RD-21 042"],"award-info":[{"award-number":["RD-21 042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This study investigated the druggability, pharmacokinetics and ethyl acetate extract of Teucrium polium (EA T. polium), from Ha'il, and the protective effect against carbon tetrachloride (CCl4) induced liver cirrhosis in rats. The total antioxidant capacity (TAC) and scavenging activity of the extract were examined. The in vivo protective study was based on the use of an animal model of CCl4-induced liver cirrhosis. Four groups of rats have been used: Group I: control rats; Group II: received CCl4 in olive oil (0.5 mL\/kg); Group III: received the EA T. polium (25 mg\/kg) of pretreatment for seven days by gavage then CCl4 in olive oil by gavage for 15 days. Group IV: received the EA of T. polium for seven days (25 mg\/kg). EA T. polium was found to possess significant antioxidant capacity. CCl4 caused a hepatotoxicity associated increase in both levels of AST and ALT, which were reduced back to normal values following EA T. polium pretreatment. Hepatotoxicity associated structural modifications of liver tissues and increase in thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and carbonyl proteins (CP), associated decreases in several assessed antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). The in vivo findings on the protective effect of T. polium were supported by its druggability, its pharmacokinetic properties and molecular docking assays. These results confirm the modulatory antioxidant and hepatoprotective potential of T. polium in this experimental liver cirrhosis model. T. polium phytochemicals are good candidates for further pharmaceutical explorations and drug design.<\/jats:p>","DOI":"10.3390\/life12071092","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T22:38:50Z","timestamp":1658443130000},"page":"1092","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies"],"prefix":"10.3390","volume":"12","author":[{"given":"Fatma","family":"Rahmouni","sequence":"first","affiliation":[{"name":"Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty of Sfax, University of Sfax, Sfax 3029, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-7744","authenticated-orcid":false,"given":"Riadh","family":"Badraoui","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Ha\u2019il, Ha\u2019il 81451, Saudi Arabia"},{"name":"Section of Histology-Cytology, Medicine Faculty of Tunis, Tunis El Manar University, La Rabta, Tunis 1007, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hmed","family":"Ben-Nasr","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Medicine Faculty of Sfax, University of Sfax, Sfax 3029, Tunisia"},{"name":"Department of Biology, Faculty of Sciences of Gafsa, University of Gafsa, Zarroug, Gafsa 2112, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fevzi","family":"Bardakci","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Ha\u2019il, Ha\u2019il 81451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salem","family":"Elkahoui","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Ha\u2019il, Ha\u2019il 81451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6236-0920","authenticated-orcid":false,"given":"Arif","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Ha\u2019il, Ha\u2019il 81451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3443-386X","authenticated-orcid":false,"given":"Mohd","family":"Saeed","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Ha\u2019il, Ha\u2019il 81451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2309-2601","authenticated-orcid":false,"given":"Mejdi","family":"Snoussi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science, University of Ha\u2019il, Ha\u2019il 81451, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mongi","family":"Saoudi","sequence":"additional","affiliation":[{"name":"Laboratory of Animal Physiology, Sciences Faculty of Sfax, University of Sfax, Sfax 3064, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarek","family":"Rebai","sequence":"additional","affiliation":[{"name":"Laboratory of Histo-Embryology and Cytogenetics, Medicine Faculty of Sfax, University of Sfax, Sfax 3029, Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"104606","DOI":"10.1016\/j.pestbp.2020.104606","article-title":"Pathophysiological impacts of exposure to an endocrine disruptor (tetradifon) on \u03b1\u2013amylase and lipase activities associated metabolic disorders","volume":"167","author":"Badraoui","year":"2020","journal-title":"Pestic Biochem. 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