{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:55:51Z","timestamp":1787972151761,"version":"build-2784847793"},"reference-count":77,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The demographic trend of aging is associated with an increased prevalence of comorbidities among the elderly. Physical, immunological, emotional and cognitive impairment, in the context of the advanced biological age segment, leads to the maintenance and precipitation of cardiovascular diseases. Thus, more and more data are focused on understanding the pathophysiological mechanisms underlying each fragility phenotype and how they potentiate each other. The implications of inflammation, sarcopenia, vitamin D deficiency and albumin, as dimensions inherent in fragility, in the development and setting of chronic coronary syndromes (CCSs) have proven their patent significance but are still open to research. At the same time, the literature speculates on the interdependent relationship between frailty and CCSs, revealing the role of the first one in the development of the second. In this sense, depression, disabilities, polypharmacy and even cognitive disorders in the elderly with ischemic cardiovascular disease mean a gradual and complex progression of frailty. The battery of tests necessary for the evaluation of the elderly with CCSs requires a permanent update, according to the latest guidelines, but also an individualized approach related to the degree of frailty and the conditions imposed by it. By summation, the knowledge of frailty screening methods, through the use of sensitive and individualized tools, is the foundation of secondary prevention and prognosis in the elderly with CCSs. Moreover, a comprehensive geriatric assessment remains the gold standard of the medical approach of these patients. The management of the frail elderly, with CCSs, brings new challenges, also from the perspective of the treatment particularities. Sometimes the risk\u2013benefit balance is difficult to achieve. Therefore, the holistic, individualized and updated approach of these patients remains a desired objective, by understanding and permanently acquiring knowledge on the complexity of the frailty syndrome.<\/jats:p>","DOI":"10.3390\/life12081133","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T03:21:16Z","timestamp":1658978476000},"page":"1133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic Coronary Syndrome in Frail Old Population"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-8534","authenticated-orcid":false,"given":"Adina Carmen","family":"Ilie","sequence":"first","affiliation":[{"name":"Department of Medical Specialties II, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabinne Marie","family":"Taranu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties II, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Stefaniu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties II, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8456-3019","authenticated-orcid":false,"given":"Ioana Alexandra","family":"Sandu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties II, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Iuliana","family":"Pislaru","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties II, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calina Anda","family":"Sandu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties II, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana-Maria","family":"Turcu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties II, Grigore T. 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Med., 10.","DOI":"10.3390\/jcm10081696"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/agm2.12201","article-title":"A relationship among the blood serum levels of interleukin-6, albumin, and 25-hydroxyvitamin D and frailty in elderly patients with chronic coronary syndrome","volume":"5","author":"Dai","year":"2022","journal-title":"Aging Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"489","DOI":"10.14336\/AD.2017.1125","article-title":"Frailty in Older Adults with Cardiovascular Disease: Cause, Effect or Both?","volume":"9","author":"Kleipool","year":"2018","journal-title":"Aging Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"100042","DOI":"10.1016\/j.ahr.2021.100042","article-title":"Hospital readmission and mortality associations to frailty in hospitalized patients with coronary heart disease","volume":"1","author":"Chang","year":"2021","journal-title":"Aging Health Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/eurheartj\/ehz425","article-title":"ESC Scientific Document Group. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes","volume":"41","author":"Knuuti","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.jacc.2017.12.068","article-title":"Coronary Artery Disease in Patients \u2265 80 Years of Age","volume":"71","author":"Madhavan","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"897","DOI":"10.21470\/1678-9741-2019-0484","article-title":"Frailty Significantly Associated with a Risk for Mid-term Outcomes in Elderly Chronic Coronary Syndrome Patients: A Prospective Study","volume":"35","author":"Ozmen","year":"2020","journal-title":"Braz. J. Cardiovasc. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jacc.2021.11.029","article-title":"Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Review","volume":"79","author":"Ijaz","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cger.2010.08.008","article-title":"Frailty defined by deficit accumulation and geriatric medicine defined by Frailty","volume":"27","author":"Rockwood","year":"2011","journal-title":"Clin. Geriatr. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"M146","DOI":"10.1093\/gerona\/56.3.M146","article-title":"Frailty in older adults: Evidence for a phenotype","volume":"56","author":"Fried","year":"2001","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e001314","DOI":"10.1136\/openhrt-2020-001314","article-title":"Prospective cohort study of elderly patients with coronary artery disease: Impact of frailty on quality of life and outcome","volume":"7","author":"Qayyum","year":"2020","journal-title":"Open Heart"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"111302","DOI":"10.1016\/j.exger.2021.111302","article-title":"Benchside to the bedside of frailty and cardiovascular aging: Main shared cellular and molecular mechanisms","volume":"148","author":"Barbalho","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/cvr\/cvz331","article-title":"NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload","volume":"117","author":"Schnelle","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.ijcard.2014.06.046","article-title":"NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats","volume":"175","author":"Bechara","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"670076","DOI":"10.3389\/fphar.2021.670076","article-title":"Coordinated Contribution of NADPH Oxidase- and Mitochondria-Derived Reactive Oxygen Species in Metabolic Syndrome and Its Implication in Renal Dysfunction","volume":"12","author":"Lee","year":"2021","journal-title":"Front. Pharmacol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.21037\/atm-20-5115","article-title":"Ulinastatin alleviates cerebral ischemia-reperfusion injury in rats by activating the Nrf-2\/HO-1 signaling pathway","volume":"8","author":"Cui","year":"2020","journal-title":"Ann. Transl. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.freeradbiomed.2020.11.017","article-title":"Low shear stress induced vascular endothelial cell pyroptosis by TET2\/SDHB\/ROS pathway","volume":"162","author":"Chen","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/eurjhf\/hfr007","article-title":"Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography","volume":"13","author":"Wehr","year":"2011","journal-title":"Eur. J. Heart Fail."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e1184","DOI":"10.1002\/cti2.1184","article-title":"Age-related remodelling of the blood immunological portrait and the local tumor immune response in patients with luminal breast cancer","volume":"9","author":"Berben","year":"2021","journal-title":"Clin. Transl. Immunol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Cho, J., Choi, Y., Sajgalik, P., No, M.H., Lee, S.H., Kim, S., Heo, J.W., Cho, E.J., Chang, E., and Kang, J.H. (2021). Exercise as a therapeutic strategy for sarcopenia in heart failure: Insights into underlying mechanisms. Cells, 9.","DOI":"10.3390\/cells9102284"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Kelley, N., Jeltema, D., Duan, Y., and He, Y. (2019). The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20133328"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00424-021-02515-4","article-title":"The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation","volume":"473","author":"Wang","year":"2021","journal-title":"Pflug. Arch."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1002\/jcp.30285","article-title":"The NLRP3 inflammasome: Multiple activation pathways and its role in primary cells during ventricular remodeling","volume":"236","author":"Yan","year":"2021","journal-title":"J. Cell. Physiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/iid3.388","article-title":"Silenced SOX2-OT alleviates ventricular arrhythmia associated with heart failure by inhibiting NLRP3 expression via regulating miR-2355-3p","volume":"9","author":"Liang","year":"2021","journal-title":"Immun. Inflamm. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.jacc.2017.01.064","article-title":"The aging cardiovascular system: Understanding it at the cellular and clinical levels","volume":"69","author":"Paneni","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111317","DOI":"10.1016\/j.exger.2021.111317","article-title":"Frailty is associated with chronic inflammation and pro-inflammatory monocyte subpopulations","volume":"149","author":"Cybularz","year":"2021","journal-title":"Exp. Gerontol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2016.08.006","article-title":"Inflammation and frailty in the elderly: A systematic review and meta-analysis","volume":"31","author":"Soysal","year":"2016","journal-title":"Ageing Res. Rev."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s12170-011-0186-0","article-title":"Frailty in Patients with Cardiovascular Disease: Why, When, and How to Measure","volume":"5","author":"Afilalo","year":"2011","journal-title":"Curr. Cardiovasc. Risk Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1001\/archinte.162.20.2333","article-title":"Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: Results from the Cardiovascular Health Study","volume":"162","author":"Walston","year":"2002","journal-title":"Arch. Intern. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.2215\/CJN.12131116","article-title":"Factors associated with frailty and its trajectory among patients on hemodialysis","volume":"12","author":"Johansen","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"g3656","DOI":"10.1136\/bmj.g3656","article-title":"Vitamin D and mortality: Meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States","volume":"348","author":"Jorde","year":"2014","journal-title":"BMJ"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1093\/eurheartj\/ehy267","article-title":"The Performance of Non-Invasive Tests to Rule-in and Rule-out Significant Coronary Artery Stenosis in Patients with Stable Angina: A Meta-Analysis Focused on Post-Test Disease Probability","volume":"39","author":"Knuuti","year":"2018","journal-title":"Eur. Heart J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1097\/00007611-198804000-00004","article-title":"Graded Exercise Testing for Diagnosis of Coronary Artery Disease in Elderly Patients","volume":"81","author":"NEWMAN","year":"1988","journal-title":"South. Med. J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1742-1241.2012.02900.x","article-title":"Diagnostic accuracy of exercise stress testing for coronary artery disease: A systematic review and meta-analysis of prospective studies","volume":"66","author":"Banerjee","year":"2012","journal-title":"Int. J. Clin. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0735-1097(00)01214-6","article-title":"Prognostic Value of Exercise Echocardiography in 2632 Patients \u2265 65 Years of Age","volume":"37","author":"Arruda","year":"2001","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/S0002-9149(97)00595-X","article-title":"Safety and Results of Dobutamine Stress Echocardiography in Women versus Men and in Patients Older and Younger than 75 Years of Age","volume":"80","author":"Hiro","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jacc.2004.04.047","article-title":"Anemia Is an Independent Predictor of Mortality after Percutaneous Coronary Intervention","volume":"44","author":"Lee","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_38","first-page":"241","article-title":"Prognostic Role of Stress Cardiac Magnetic Resonance in the Elderly","volume":"73","author":"Bastarrika","year":"2020","journal-title":"Rev. Espa\u00f1ola Cardiol. (Engl. Ed.)"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"P5347","DOI":"10.1093\/eurheartj\/eht310.P5347","article-title":"Coronary CT Angiography: A Useful Diagnostic Modality in the Elderly?","volume":"34","author":"Jordan","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1503\/cmaj.050051","article-title":"A global clinical measure of fitness and frailty in elderly people","volume":"173","author":"Rockwood","year":"2005","journal-title":"CMAJ"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Liguori, I., Russo, G., Bulli, G., Curcio, F., Flocco, V., Galizia, G., Della-Morte, D., Gargiulo, G., Testa, G., and Cacciatore, F. (2020). Validation of \u201c(fr)AGILE\u201d: A quick tool to identify multidimensional frailty in the elderly. BMC Geriatr., 20.","DOI":"10.1186\/s12877-020-01788-1"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1111\/j.1532-5415.2004.52521.x","article-title":"Operationalizing a frailty index from a standardized comprehensive geriatric assessment","volume":"52","author":"Jones","year":"2004","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/ehjacc\/zuab114","article-title":"Clinical Frailty Scale classes are independently associated with 6-month mortality for patients after acute myocardial infarction","volume":"11","author":"Ekerstad","year":"2022","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Dou, Q., Wang, W., Wang, H., Ma, Y., Hai, S., Lin, X., Liu, Y., Zhang, X., Wu, J., and Dong, B. (2019). Prognostic value of frailty in elderly patients with acute coronary syndrome: A systematic review and meta-analysis. BMC Geriatr., 19.","DOI":"10.1186\/s12877-019-1242-8"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.exger.2016.12.021","article-title":"Sex difference in frailty: A systematic review and meta-analysis","volume":"89","author":"Gordon","year":"2017","journal-title":"Exp. Gerontol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1093\/eurheartj\/ehab468","article-title":"Frailty and cardiovascular outcomes in the National Health and Aging Trends Study","volume":"42","author":"Damluji","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"7619438","DOI":"10.1155\/2022\/7619438","article-title":"To Analyze the Influencing Factors of Senile Coronary Heart Disease Patients Complicated with Frailty Syndrome","volume":"2022","author":"Qin","year":"2022","journal-title":"J. Healthc. Eng."},{"key":"ref_48","first-page":"e18","article-title":"Heart disease and stroke statistics\u20142011 update: A report from the American Heart Association","volume":"123","author":"Roger","year":"2011","journal-title":"Circulation"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Lyu, H., Wang, C., Jiang, H., Wang, P., and Cui, J. (2021). Prevalence and determinants of frailty in older adult patients with chronic coronary syndrome: A cross-sectional study. BMC Geriatr., 21.","DOI":"10.1186\/s12877-021-02426-0"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/gerona\/62.7.722","article-title":"Frailty in relation to the accumulation of deficits","volume":"62","author":"Rockwood","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0959259802012236","article-title":"Some mathematical models of frailty and their clinical implications","volume":"12","author":"Rockwood","year":"2002","journal-title":"Rev. Clin. Gerontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2147\/CIA.S308569","article-title":"Impact of the Malnutrition on Mortality in Elderly Patients Undergoing Percutaneous Coronary Intervention","volume":"16","author":"Chen","year":"2021","journal-title":"Clin. Interv. Aging"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijcard.2020.04.043","article-title":"Heart failure, frailty, and pre-frailty: A systematic review and meta-analysis of observational studies","volume":"316","author":"Marengoni","year":"2020","journal-title":"Int. J. Cardiol."},{"key":"ref_54","first-page":"109","article-title":"Stable ischemic heart disease in the older adults","volume":"13","author":"Dai","year":"2016","journal-title":"J. Geriatr. Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4065\/83.10.1146","article-title":"Frailty and its potential relevance to cardiovascular care","volume":"83","author":"Singh","year":"2008","journal-title":"Mayo Clin. Proc."},{"key":"ref_56","unstructured":"Kurdi, H. (2020). Chronic Coronary Syndrome\u2014A New Era for the Diagnosis and Management of Stable Coronary Artery Disease, BCS Editorial."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2147\/CIA.S305006","article-title":"Potentially Inappropriate Medication and Associated Factors Among Older Patients with Chronic Coronary Syndrome at Hospital Discharge in Beijing, China","volume":"16","author":"Zhao","year":"2021","journal-title":"Clin. Interv. Aging"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Alexa, I.D., Prada, G.I., Donca, V.I., Mos, L.M., and Alexa, O. (2013, January 21\u201323). Improving quality of life of elderly people aged 85 and older by improving treatment adherence. Proceedings of the E-Health and Bioengineering Conference (EHB), Iasi, Romania.","DOI":"10.1109\/EHB.2013.6707380"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ijcard.2015.05.045","article-title":"Ischemic heart disease, prescription of optimal medical therapy and geriatric syndromes in community-dwelling older men: A population-based study","volume":"192","author":"Gnjidic","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1136\/hrt.2005.071266","article-title":"Coronary interventions in the elderly","volume":"92","author":"Kaehler","year":"2006","journal-title":"Heart"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1253\/circj.CJ-20-0594","article-title":"Current understanding of the role of frailty in cardiovascular disease","volume":"84","author":"Uchikado","year":"2020","journal-title":"Circ. J."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s11606-011-1821-7","article-title":"Assessing balance and mobility to track illness and recovery in older inpatients","volume":"26","author":"Hubbard","year":"2011","journal-title":"J. Gen. Intern. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.arcmed.2014.01.009","article-title":"Long-term outcomes of dialysis patients after coronary revascularization: A population-based cohort study in Taiwan","volume":"45","author":"Chou","year":"2014","journal-title":"Arch. Med. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/jocs.12665","article-title":"Long-Term Post-CABG Survival: Performance of Clinical Risk Models Versus Actuarial Predictions","volume":"31","author":"Carr","year":"2016","journal-title":"J. Card. Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1016\/j.athoracsur.2018.10.077","article-title":"Incidence, Cost, and Risk Factors for Readmission After Coronary Artery Bypass Grafting","volume":"107","author":"Shah","year":"2019","journal-title":"Ann. Thorac. Surg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.athoracsur.2020.04.142","article-title":"Development of a Risk Score to Predict 90-Day Readmission After Coronary Artery Bypass Graft","volume":"111","author":"Zhang","year":"2021","journal-title":"Ann. Thorac. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1161\/CIRCULATIONAHA.108.841437","article-title":"Frail Patients Are at Increased Risk for Mortality and Prolonged Institutional Care After Cardiac Surgery","volume":"121","author":"Lee","year":"2010","journal-title":"Circulation"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e009882","DOI":"10.1161\/JAHA.118.009882","article-title":"Association of Frailty and Long-Term Survival in Patients Undergoing Coronary Artery Bypass Grafting","volume":"7","author":"Tran","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1016\/j.jtcvs.2014.07.087","article-title":"The Impact of Frailty on Outcomes after Cardiac Surgery: A Systematic Review","volume":"148","author":"Sepehri","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1053\/euhj.1999.1752","article-title":"Coronary angioplasty in octogenarians. Quality of life and costs","volume":"20","author":"Meinertz","year":"1999","journal-title":"Eur. Heart J."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"104544","DOI":"10.1016\/j.archger.2021.104544","article-title":"Frailty as a Predictor of All-Cause Mortality in Elderly Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis","volume":"98","author":"He","year":"2022","journal-title":"Arch. Gerontol. Geriatr."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"e000294","DOI":"10.1136\/openhrt-2015-000294","article-title":"Impact of Frailty on Outcomes after Percutaneous Coronary Intervention: A Prospective Cohort Study","volume":"2","author":"Iqbal","year":"2015","journal-title":"Open Heart"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"771","DOI":"10.2147\/CIA.S252318","article-title":"Percutaneous Coronary Intervention in Elderly Patients with Coronary Chronic Total Occlusions: Current Evidence and Future Perspectives","volume":"15","author":"Guo","year":"2020","journal-title":"Clin. Interv. Aging"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/eurheartj\/ehy394","article-title":"2018 ESC\/EACTS Guidelines on Myocardial Revascularization","volume":"40","author":"Neumann","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/0021-9681(78)90058-9","article-title":"questionnaire for the assessment of leisure time physical activities","volume":"31","author":"Taylor","year":"1978","journal-title":"J. Chronic Dis."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cjco.2021.08.015","article-title":"Management of Frail and Older Homebound Patients With Heart Failure: A Contemporary Virtual Ambulatory Model","volume":"4","author":"Kobulnik","year":"2021","journal-title":"CJC Open"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2102156","DOI":"10.1155\/2019\/2102156","article-title":"Telemedicine and Cardiology in the Elderly in France: Inventory of Experiments","volume":"2019","author":"Zulfiqar","year":"2019","journal-title":"Adv. Prev. 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