{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:35:04Z","timestamp":1762065304771,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Central serous chorioretinopathy (CSCR) and pachychoroid neovasculopathy (PNV) are among the pachychoroid spectrum diseases (PSDs). Half-fluence photodynamic therapy (hf-PDT) is one of the effective treatment methods for both diseases. The aim of this study was to compare the effect of hf-PDT on the choroidal structure in CSCR and PNV. Methods: This study included 35 patients with chronic CSCR and 18 patients with PNV. The hf-PDT protocol was applied to all eyes. Before and 3 months after hf-PDT, enhanced-depth optical coherence tomography images were analyzed. The total choroidal area (CA), luminal area (LA), and stromal area (SA) were measured using ImageJ software. Results: Compared with baseline values, 3 months after hf-PDT, the mean CA reduced from 1.398 to 1.197 mm2 (p &lt; 0.001) in the CSCR group and the total CA reduced from 1.050 to 1.000 mm2 (p &lt; 0.021) in the PNV group. The mean percentage changes in CA, LA, and SA values were statistically higher in the chronic CSCR group (13.86%, 13.53%, and 14.11%, respectively) than those in the PNV group (4.61%, 4.02%, and 5.74%; p = 0.001, p = 0.002, and p = 0.031, respectively). Conclusion: CSCR and PNV are thought to be PSDs. However, they differ in choroidal morphological response after hf-PDT, which might be a result of the different structural components of the PNV lesions.<\/jats:p>","DOI":"10.3390\/life12091304","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T02:04:32Z","timestamp":1661479472000},"page":"1304","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Comparative Study of Short-Term Vascular and Stromal Alterations of the Choroid Following Half-Fluence Photodynamic Therapy in Pachychoroid Neovasculopathy and Chronic Central Serous Chorioretinopathy"],"prefix":"10.3390","volume":"12","author":[{"given":"\u00d6zge","family":"Yan\u0131k","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Ankara University School of Medicine, 06620 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibel","family":"Demirel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara University School of Medicine, 06620 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"Bat\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara University School of Medicine, 06620 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"\u00d6zmert","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ankara University School of Medicine, 06620 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"ref_1","first-page":"111","article-title":"Pachychoroid diseases of the macula","volume":"3","author":"Mrejen","year":"2014","journal-title":"Med. 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