{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:47:27Z","timestamp":1762066047974,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:00:00Z","timestamp":1661904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Acute posterior syphilitic placoid chorioretinopathy (ASPPC) is a rare ocular manifestation of syphilis characterized by outer retinal layers involvement and drop in visual acuity. The current work documents outer retinal layer involvement in this pathology and their reconstitution with treatment by means of adaptive optics (AO). Three eyes of two patients together with four controls eyes were included in the study. Patients underwent optical coherence tomography (OCT) and OCT angiography (OCTA) scan centered on fovea, where vessel density (VD) and vessel perfusion (VP) were calculated. AO images centered on fovea were acquired and cone density (CD) and cone spacing (CS) were measured and compared to control group. Multimodal imaging was performed at presentation, at 10 days, and at 2-month follow-up. All eyes improved in visual acuity, with reconstitution in outer retinal layers at 2-month follow-up. Overall choriocapillary layer VD and VP improved. AO imaging was able to identify outer retinal alterations at presentation and at follow-ups, with improvement in tissue architecture. CD and CS was respectively lower and greater than controls at all follow-ups and improved within patients at the 2-month follow-up. In conclusion, AO was able to document outer retinal alterations in ASPPC at presentation and improvement over the follow-up, representing a tool to study photoreceptor layer involvement in this pathology.<\/jats:p>","DOI":"10.3390\/life12091361","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T01:50:51Z","timestamp":1661997051000},"page":"1361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Adaptive Optics Imaging to Analyze the Photoreceptor Layer Reconstitution in Acute Syphilitic Posterior Placoid Chorioretinopathy"],"prefix":"10.3390","volume":"12","author":[{"given":"Fabrizio","family":"Giansanti","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Vannozzi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Govetto","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Asst-Settelaghi, University of Insubria, 21100 Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5896-5313","authenticated-orcid":false,"given":"Angelo Maria","family":"Minnella","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Ophthalmology Unit, Catholic University \u201cSacro Cuore\u201d, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6902-2983","authenticated-orcid":false,"given":"Tomaso","family":"Caporossi","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Ophthalmology Unit, Catholic University \u201cSacro Cuore\u201d, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Savastano","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Ophthalmology Unit, Catholic University \u201cSacro Cuore\u201d, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina","family":"Savastano","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Ophthalmology Unit, Catholic University \u201cSacro Cuore\u201d, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria","family":"Gambini","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Ophthalmology Unit, Catholic University \u201cSacro Cuore\u201d, 00168 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanislao","family":"Rizzo","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCSS, 00168 Rome, Italy"},{"name":"Ophthalmology Unit, Catholic University \u201cSacro Cuore\u201d, 00168 Rome, Italy"},{"name":"Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, 56127 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Virgili","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7578-7563","authenticated-orcid":false,"given":"Daniela","family":"Bacherini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Psychology, Drug Research, and Child Health, Eye Clinic, University of Florence, AOU Careggi, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0161-6420(90)32418-1","article-title":"Acute Syphilitic Posterior Placoid Chorioretinitis","volume":"97","author":"Gass","year":"1990","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"12071","DOI":"10.1038\/s41598-018-30559-7","article-title":"Clinical Manifestations and Ophthalmic Outcomes of Ocular Syphilis at a Time of Re-Emergence of the Systemic Infection","volume":"8","author":"Furtado","year":"2018","journal-title":"Sci. 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Oftalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1097\/IAE.0b013e31825f3851","article-title":"Acute syphilitic posterior placoid chorioretinitis: Report of a case series and comprehensive review of the literature","volume":"32","author":"Eandi","year":"2012","journal-title":"Retina"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/ICB.0000000000000645","article-title":"Multimodal Imaging Adds New Insights into Acute Syphilitic Posterior Placoid Chorioretinitis","volume":"12","author":"Tsui","year":"2018","journal-title":"Retin. Cases Brief Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"100678","DOI":"10.1016\/j.ajoc.2020.100678","article-title":"Wide field swept source OCT angiography in acute syphilitic placoid chorioretinitis","volume":"18","author":"Barikian","year":"2020","journal-title":"Am. J. Ophthalmol. 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Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ajo.2013.10.021","article-title":"Cone abnormalities in Fundus albipunctatus associated with RDH5 mutations assessed using adaptive optics scanning laser ophthalmoscopy","volume":"157","author":"Makiyama","year":"2014","journal-title":"Am. J. Ophthalmol."},{"key":"ref_16","first-page":"e534","article-title":"Assessment of parafoveal cone density in patients taking hydroxychloroquine in the absence of clinically documented retinal toxicity","volume":"93","author":"Flores","year":"2015","journal-title":"Acta Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1364\/JOSAA.24.001358","article-title":"Automated identification of cone photoreceptors in adaptive optics retinal images","volume":"24","author":"Li","year":"2007","journal-title":"J. Opt. Soc. Am. A Opt. Image Sci. Vis."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/ceo.12356","article-title":"Reliability of cone counts using an adaptive optics retinal camera","volume":"42","author":"Flores","year":"2014","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41433-020-01286-z","article-title":"Adaptive optics: Principles and applications in ophthalmology","volume":"35","author":"Akyol","year":"2021","journal-title":"Eye"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.08.002","article-title":"Adaptive optics imaging of the human retina","volume":"68","author":"Burns","year":"2019","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/IAE.0000000000002457","article-title":"Evaluation of Photoreceptors, Retinal Capillary Plexuses, and Choriocapillaris in Patients with Birdshot Chorioretinopathy","volume":"40","author":"Forte","year":"2020","journal-title":"Retina"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40942-016-0035-x","article-title":"Clinical applications of fundus autofluorescence in retinal disease","volume":"2","author":"Yung","year":"2016","journal-title":"Int. J. Retin. Vitr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/ICB.0000000000000542","article-title":"Choroidal blood vessels in retinal pigment epithelial atrophy using optical coherence tomography angiography","volume":"13","author":"Maruko","year":"2019","journal-title":"Retin. 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