{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T18:40:56Z","timestamp":1783795256733,"version":"3.55.0"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Kinesiology &amp; Health Studies at the University of Regina","award":["#IT18480"],"award-info":[{"award-number":["#IT18480"]}]},{"name":"Mitacs Accelerate","award":["#IT18480"],"award-info":[{"award-number":["#IT18480"]}]},{"name":"LLA Technologies Inc.","award":["#IT18480"],"award-info":[{"award-number":["#IT18480"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Current methods to diagnose concussions are subjective and difficult to confirm. A variety of physiological biomarkers have been reported, but with conflicting results. This study assessed heart rate variability (HRV), spontaneous baroreflex sensitivity (BRS), and systolic blood pressure variability (BPV) in concussed athletes. The assessment consisted of a 5-min seated rest followed by a 5-min (0.1 Hz) controlled breathing protocol. Thirty participants completed baseline assessments. The protocol was repeated during the post-injury acute phase (days one to five). Total (p = 0.02) and low-frequency (p = 0.009) BPV spectral power were significantly decreased during the acute phase of concussion. BRS down-sequence (p = 0.036) and up-sequence (p = 0.05) were significantly increased in the acute phase of concussion, with a trend towards an increased BRS pooled (p = 0.06). Significant decreases in HRV were also found. Acute concussion resulted in altered BRS and BPV dynamics compared to baseline. These findings highlight objective physiological parameters that could aid concussion diagnosis and return-to-play protocols.<\/jats:p>","DOI":"10.3390\/life12091400","type":"journal-article","created":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T04:18:32Z","timestamp":1662610712000},"page":"1400","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Alterations in Baroreflex Sensitivity and Blood Pressure Variability Following Sport-Related Concussion"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7481-1832","authenticated-orcid":false,"given":"Chase J.","family":"Ellingson","sequence":"first","affiliation":[{"name":"Faculty of Kinesiology & Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyotpal","family":"Singh","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology & Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody A.","family":"Ellingson","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology & Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-635X","authenticated-orcid":false,"given":"Luke W.","family":"Sirant","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Manitoba, 66 Chancellors Cir, Winnipeg, MB R3T 2N2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory P.","family":"Kr\u00e4tzig","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1845-2668","authenticated-orcid":false,"given":"Kim D.","family":"Dorsch","sequence":"additional","affiliation":[{"name":"Faculty of Kinesiology & Health Studies, University of Regina, 3737 Wascana Parkway, Regina, SK S4S 0A2, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0866-734X","authenticated-orcid":false,"given":"Jaroslaw","family":"Piskorski","sequence":"additional","affiliation":[{"name":"Institute of Physics, University of Zielona G\u00f3ra, Licealna 9, 65-417 Zielona G\u00f3ra, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2480-8031","authenticated-orcid":false,"given":"J. 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Sports Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1249\/MSS.0b013e3182249539","article-title":"Cerebrovascular reactivity impairment after sport-induced concussion","volume":"43","author":"Len","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ijpsycho.2017.11.016","article-title":"An anatomical and physiological basis for the cardiovascular autonomic nervous system consequences of sport-related brain injury","volume":"132","year":"2018","journal-title":"Int. J. Psychophysiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1111\/cpf.12487","article-title":"Heart rate variability and implication for sport concussion","volume":"38","author":"Bishop","year":"2018","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1227\/NEU.0000000000000505","article-title":"The new neurometabolic cascade of concussion","volume":"75","author":"Giza","year":"2014","journal-title":"Neurosurgery"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12178-019-09536-8","article-title":"Concussion Pathophysiology and Injury Biomechanics","volume":"12","author":"Giza","year":"2019","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.spen.2019.03.004","article-title":"Pathophysiology of Concussion","volume":"30","author":"Chancellor","year":"2019","journal-title":"Semin. Pediatr. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1136\/bjsports-2017-097699","article-title":"Consensus statement on concussion in sport-the 5(th) international conference on concussion in sport held in Berlin, October 2016","volume":"51","author":"McCrory","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1002\/hbm.25630","article-title":"Noninvasive magnetic resonance imaging techniques in mild traumatic brain injury research and diagnosis","volume":"42","author":"Lunkova","year":"2021","journal-title":"Hum. Brain Mapp."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mutch, W.A., Ellis, M.J., Graham, M.R., Wourms, V., Raban, R., Fisher, J.A., Mikulis, D., Leiter, J., and Ryner, L. (2014). Brain MRI CO2 stress testing: A pilot study in patients with concussion. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0102181"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"107389","DOI":"10.1016\/j.clineuro.2022.107389","article-title":"What are we measuring? A refined look at the process of disrupted autoregulation and the limitations of cerebral perfusion pressure in preventing secondary injury after traumatic brain injury","volume":"221","author":"Small","year":"2022","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","article-title":"An Overview of Heart Rate Variability Metrics and Norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front. Public Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1080\/02699052.2021.1891459","article-title":"Unclear outcomes of heart rate variability following a concussion: A systematic review","volume":"35","author":"Charron","year":"2021","journal-title":"Brain Inj."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Neary, J.P., Singh, J., Bishop, S.A., Dech, R.T., Butz, M.J.A., and Len, T.K. (2019). An Evidence-Based Objective Study Protocol for Evaluating Cardiovascular and Cerebrovascular Indices Following Concussion: The Neary Protocol. Methods Protoc., 2.","DOI":"10.3390\/mps2010023"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1139\/cjpp-2021-0395","article-title":"Effects of phytocannabinoids on heart rate variability and blood pressure variability in female post-concussion syndrome patients: Case series","volume":"100","author":"Singh","year":"2022","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1249\/MSS.0000000000001833","article-title":"Attenuation of Spontaneous Baroreceptor Sensitivity after Concussion","volume":"51","author":"Hohn","year":"2019","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12471-012-0346-y","article-title":"Baroreflex sensitivity: Mechanisms and measurement","volume":"21","author":"Swenne","year":"2013","journal-title":"Neth. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2170\/physiolsci.RP005506","article-title":"Correlations between the Poincare plot and conventional heart rate variability parameters assessed during paced breathing","volume":"57","author":"Guzik","year":"2007","journal-title":"J. Physiol. Sci."},{"key":"ref_20","first-page":"R1287","article-title":"Uncoupling of the autonomic and cardiovascular systems in acute brain injury","volume":"275","author":"Goldstein","year":"1998","journal-title":"Am. J. Physiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jcrc.2007.04.006","article-title":"Investigation of heart rate and blood pressure variability, baroreflex sensitivity, and approximate entropy in acute brain injury patients","volume":"23","author":"Papaioannou","year":"2008","journal-title":"J. Crit. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"7154120","DOI":"10.1155\/2020\/7154120","article-title":"Causal Link between Ventricular Ectopy and Concussion","volume":"2020","author":"Neary","year":"2020","journal-title":"Case Rep. Med."},{"key":"ref_23","first-page":"1","article-title":"Cardiovascular sequelae of sports-related concussions","volume":"2021","author":"Krzyzaniak","year":"2021","journal-title":"PMR"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/hr.2010.138","article-title":"Asymmetric features of short-term blood pressure variability","volume":"33","author":"Guzik","year":"2010","journal-title":"Hypertens. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1161\/01.HYP.25.6.1276","article-title":"Spectral analysis of blood pressure and heart rate variability in evaluating cardiovascular regulation. A critical appraisal","volume":"25","author":"Parati","year":"1995","journal-title":"Hypertension"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.crphys.2022.06.003","article-title":"The influence of external stressors on physiological testing: Implication for return-to-play protocols","volume":"5","author":"Ellingson","year":"2022","journal-title":"Curr. Res. Physiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1136\/bjsports-2017-097506","article-title":"The Sport Concussion Assessment Tool 5th Edition (SCAT5): Background and rationale","volume":"51","author":"Echemendia","year":"2017","journal-title":"Br. J. Sports Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e07148","DOI":"10.1016\/j.heliyon.2021.e07148","article-title":"The validity and reliability of an open source biosensing board to quantify heart rate variability","volume":"7","author":"Burma","year":"2021","journal-title":"Heliyon"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smrv.2016.02.003","article-title":"Circadian mechanisms of 24-hour blood pressure regulation and patterning","volume":"33","author":"Smolensky","year":"2017","journal-title":"Sleep Med. Rev."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1109\/10.678605","article-title":"Power spectral density of unevenly sampled data by least-square analysis: Performance and application to heart rate signals","volume":"45","author":"Laguna","year":"1998","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3233\/NRE-210243","article-title":"Autonomic dysfunction in adults following mild traumatic brain injury: A systematic review","volume":"50","author":"Mercier","year":"2022","journal-title":"NeuroRehabilitation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1540-8159.2010.02841.x","article-title":"A quantitative systematic review of normal values for short-term heart rate variability in healthy adults","volume":"33","author":"Nunan","year":"2010","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_33","first-page":"1","article-title":"Cardiac cycle timing and contractility following acute sport-related concussion","volume":"2022","author":"Singh","year":"2022","journal-title":"Res. Sports Med."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/9\/1400\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:27:12Z","timestamp":1760142432000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/9\/1400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,8]]},"references-count":33,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["life12091400"],"URL":"https:\/\/doi.org\/10.3390\/life12091400","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,8]]}}}