{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:43:34Z","timestamp":1760244214935,"version":"build-2065373602"},"reference-count":68,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Since its apomorphic appearance in 2019, severe acute respiratory syndrome Coronavirus type 2 (SARS-CoV-2) nowadays circulates as a plesiomorphic human virus in several synapomorphic variants. The respiratory tract is the most important site of infection, the viral effects in the lungs are well described, and more than half of the patients could develop shortness of breath and dyspnea and require ventilatory support. The physiological sign of this condition is the decrease in the partial pressure of oxygen in the blood, leading to acute hypoxia, which could be a factor in the disease. In severe patients, we recorded several physiological parameters: breath frequency (BF), partial pressure of oxygen in the blood (pO2), partial pressure of carbon dioxide in the blood (pCO2), hemoglobin (Hb), heart rate (HR), and blood pressure in correlation with the olfactory threshold. We found significant correlations between reduced olfactory threshold with pO2 and hemoglobin levels, changes in heart rate, and increased HR and pCO2. These results suggest that COVID-19 causes an impaired sense of smell that decreases in threshold corresponding to the disease severity.<\/jats:p>","DOI":"10.3390\/life12091408","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T01:44:03Z","timestamp":1663033443000},"page":"1408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["COVID-19 Smell Impairment and Crosstalk with Hypoxia Physiology"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5132-0029","authenticated-orcid":false,"given":"Andrea","family":"Mazzatenta","sequence":"first","affiliation":[{"name":"Neurophysiology, Olfaction and Chemoreception Laboratory, Physiology and Physiopathology Section, Neuroscience, Imaging and Clinical Sciences Department, G. d\u2019Annunzio University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Maffei","sequence":"additional","affiliation":[{"name":"Istituto di Neuroscienze, Consiglio Nazionale delle Ricerche, 56124 Pisa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1073-6989","authenticated-orcid":false,"given":"Camillo","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Neurophysiology, Olfaction and Chemoreception Laboratory, Physiology and Physiopathology Section, Neuroscience, Imaging and Clinical Sciences Department, G. d\u2019Annunzio University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4078-3973","authenticated-orcid":false,"given":"Giampiero","family":"Neri","sequence":"additional","affiliation":[{"name":"Neurophysiology, Olfaction and Chemoreception Laboratory, Physiology and Physiopathology Section, Neuroscience, Imaging and Clinical Sciences Department, G. d\u2019Annunzio University of Chieti-Pescara, 66100 Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.3201\/eid2607.200282","article-title":"High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2","volume":"26","author":"Sanche","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1177\/0145561320920762","article-title":"Clinical Presentation of COVID-19: A Systematic Review Focusing on Upper Airway Symptoms","volume":"99","author":"Lovato","year":"2020","journal-title":"Ear Nose Throat J."},{"key":"ref_4","unstructured":"WHO (2020, February 11). WHO Director-General\u2019s Remarks at the Media Briefing on 2019-nCoV on 11 February 2020. Available online: https:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-remarksat-the-media-briefing-on-2019-ncov-on-11-february-2020."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"12658","DOI":"10.1128\/JVI.01542-10","article-title":"Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2","volume":"84","author":"Matsuyama","year":"2010","journal-title":"J. Virol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"4122","DOI":"10.1128\/JVI.02232-10","article-title":"Evidence that TMPRSS2 activates the severe acute respiratory syndrome coronavirus spike protein for membrane fusion and reduces viral control by the humoral immune response","volume":"85","author":"Glowacka","year":"2011","journal-title":"J. Virol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1056\/NEJMoa2001316","article-title":"Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia","volume":"382","author":"Li","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Fagerberg","year":"2015","journal-title":"Science"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41591-020-0868-6","article-title":"SARS-CoV-2 Entry Genes Are Most Highly Expressed in Nasal Goblet and Ciliated Cells within Human Airways","volume":"26","author":"Sungnak","year":"2020","journal-title":"Nat. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"59","DOI":"10.5492\/wjccm.v8.i5.74","article-title":"Diagnosis and treatment of acute pulmonary inflammation in critically ill patients: The role of inflammatory biomarkers","volume":"8","author":"Chalmers","year":"2019","journal-title":"World J. Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s00277-020-04103-5","article-title":"Hematological findings in coronavirus disease 2019: Indications of progression of disease","volume":"99","author":"Liu","year":"2020","journal-title":"Ann. Hematol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa2008975","article-title":"Renin-Angiotensin-Aldosterone System Inhibitors and Risk of COVID-19","volume":"382","author":"Reynolds","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China","volume":"77","author":"Mao","year":"2020","journal-title":"JAMA Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ana.25807","article-title":"COVID-19: A Global Threat to the Nervous System","volume":"88","author":"Koralnik","year":"2020","journal-title":"Ann. Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s15010-015-0720-y","article-title":"Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)","volume":"43","author":"Arabi","year":"2015","journal-title":"Infection"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3988\/jcn.2017.13.3.227","article-title":"Neurological Complications during Treatment of Middle East Respiratory Syndrome","volume":"13","author":"Kim","year":"2017","journal-title":"J. Clin. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3201\/eid1002.030638","article-title":"Possible central nervous system infection by SARS coronavirus","volume":"10","author":"Lau","year":"2004","journal-title":"Emerg. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1001\/archneur.61.11.1669","article-title":"Neuromuscular disorders in severe acute respiratory syndrome","volume":"61","author":"Tsai","year":"2004","journal-title":"Arch. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1086\/444461","article-title":"Detection of severe acute respiratory syndrome coronavirus in the brain: Potential role of the chemokine mig in pathogenesis","volume":"41","author":"Xu","year":"2005","journal-title":"Clin. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3233\/JAD-200581","article-title":"Neurobiology of COVID-19","volume":"76","author":"Fotuhi","year":"2020","journal-title":"J. Alzh. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"295","DOI":"10.4193\/Rhin20.116","article-title":"Presentation of new onset anosmia during the COVID-19 pandemic","volume":"58","author":"Hopkins","year":"2020","journal-title":"Rhinology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S1473-3099(20)30293-0","article-title":"Smell and taste dysfunction in patients with COVID-19","volume":"20","author":"Xydakis","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"589409","DOI":"10.3389\/fmed.2020.589409","article-title":"Smell and Taste in Severe COVID-19: Self-Reported vs. Testing","volume":"7","author":"Mazzatenta","year":"2020","journal-title":"Front. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/jmv.25728","article-title":"The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients","volume":"92","author":"Li","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1126\/science.1683005","article-title":"PreB\u00f6tzinger complex: A brainstem region that may generate respiratory rhythm in mammals","volume":"254","author":"Smith","year":"1991","journal-title":"Science"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.celrep.2012.09.013","article-title":"The H3K27 demethylase JMJD3 is required for maintenance of the embryonic respiratory neuronal network, neonatal breathing, and survival","volume":"2","author":"Burgold","year":"2012","journal-title":"Cell Rep."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1001\/jama.2020.8391","article-title":"Olfactory Dysfunction in COVID-19: Diagnosis and Management","volume":"323","author":"Whitcroft","year":"2020","journal-title":"JAMA"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.2006.115550","article-title":"Novel roles of a local angiotensin-generating system in the carotid body","volume":"575","author":"Leung","year":"2006","journal-title":"J. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1152\/physrev.1994.74.4.829","article-title":"Carotid body chemoreceptors: From natural stimuli to sensory discharges","volume":"74","author":"Gonzalez","year":"1994","journal-title":"Physiol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1089\/ars.2012.4614","article-title":"Angiotensin peptides and nitric oxide in 479 cardiovascular disease","volume":"19","author":"Patel","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"L620","DOI":"10.1152\/ajplung.00309.2020","article-title":"The potential role of the Carotid Body in COVID-19","volume":"319","author":"Porzionato","year":"2020","journal-title":"Am. J. Physiol. Lung. Cell. Mol. Physiol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"103476","DOI":"10.1016\/j.resp.2020.103476","article-title":"Coping with hypoxemia: Could erythropoietin (EPO) be an adjuvant treatment of COVID-19?","volume":"279","author":"Soliz","year":"2020","journal-title":"Resp. Physiol. Neurobiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"108409","DOI":"10.1016\/j.clim.2020.108409","article-title":"Individual risk management strategy and potential therapeutic options for the COVID-19 pandemic","volume":"215","author":"Gasmi","year":"2020","journal-title":"Clin. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1126\/science.1089311","article-title":"Functional adaptation to high altitude hypoxia","volume":"187","author":"Frisancho","year":"1975","journal-title":"Science"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"R806","DOI":"10.1152\/ajpregu.2000.278.4.R806","article-title":"Gender differentiation of the chemoreflex during growth at high altitude: Functional and neurochemical studies","volume":"278","author":"Joseph","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1016\/S0140-6736(03)13591-X","article-title":"High-altitude illness","volume":"361","author":"Basnyat","year":"2003","journal-title":"Lancet"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/5584_2014_70","article-title":"Adaptation of olfactory threshold at high altitude","volume":"837","author":"Ruffini","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"19193","DOI":"10.18632\/oncotarget.8393","article-title":"Olfactory phenotypic expression unveils human aging","volume":"7","author":"Mazzatenta","year":"2016","journal-title":"Oncotarget"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/BF00464640","article-title":"Examination and classification of human olfactory mucosa in patients with clinical olfactory disturbances","volume":"245","author":"Yamagishi","year":"1988","journal-title":"Arch. Otorhinolaryngol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"5932","DOI":"10.1016\/j.cell.2021.10.027","article-title":"Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb","volume":"184","author":"Khan","year":"2021","journal-title":"Cell"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1002\/lary.30078","article-title":"Neuroradiological Basis of COVID-19 Olfactory Dysfunction: A Systematic Review and Meta-Analysis","volume":"132","author":"Tan","year":"2022","journal-title":"Laryngoscope"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S1474-4422(21)00182-4","article-title":"Post-viral effects of COVID-19 in the olfactory system and their implications","volume":"20","author":"Xydakis","year":"2021","journal-title":"Lancet Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mazzatenta, A., Berardi, A., Novarria, G.A., and Neri, G. (2022). Unmasking the \u2018Asymptomatic\u2019 COVID-19: A Nose Question. Life, 12.","DOI":"10.3390\/life12081248"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"346","DOI":"10.18176\/jiaci.0595","article-title":"Smell and taste dysfunction in COVID-19 is associated with younger age in ambulatory settings: A multicenter cross-sectional study","volume":"30","author":"Villarreal","year":"2020","journal-title":"J. Investig. Allergol. Clin. Immunol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/alr.22655","article-title":"Psychophysical tests reveal impaired olfaction but preserved gustation in COVID-19 patients","volume":"10","author":"Hintschich","year":"2020","journal-title":"Int. Forum. Allergy Rhinol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"6284","DOI":"10.1523\/JNEUROSCI.3526-14.2015","article-title":"Odor-taste convergence in the nucleus of the solitary tract of the awake freely licking rat","volume":"35","author":"Escanilla","year":"2015","journal-title":"J. Neurosci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3758\/BF03208363","article-title":"Tests of human olfactory function: Principal components analysis suggests that most measure a common source of variance","volume":"56","author":"Doty","year":"1994","journal-title":"Percept. Psychophys."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"eabo0171","DOI":"10.1126\/sciadv.abo0171","article-title":"Tunneling nanotubes provide a route for SARS-CoV-2 spreading","volume":"8","author":"Pepe","year":"2022","journal-title":"Sci. Adv."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1128\/CMR.00118-13","article-title":"Pathogens penetrating the central nervous system: Infection pathways and the cellular and molecular mechanisms of invasion","volume":"27","author":"Dando","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1113\/JP280769","article-title":"Silent hypoxaemia in COVID-19 patients","volume":"599","author":"Simonson","year":"2021","journal-title":"J. Physiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1164\/rccm.202008-3142ED","article-title":"The Respiratory Drive: An Overlooked Tile of COVID-19 Pathophysiology","volume":"202","author":"Gattinoni","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cphy.c100069","article-title":"Peripheral chemoreceptors: Function and plasticity of the carotid body","volume":"2","author":"Kumar","year":"2012","journal-title":"Compr. Physiol."},{"key":"ref_57","first-page":"28","article-title":"Acute cardiac injury in patients with COVID-19","volume":"10","author":"Kasal","year":"2020","journal-title":"Am. J. Cardiovasc. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/joe.0.1730305","article-title":"Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors","volume":"173","author":"Fung","year":"2002","journal-title":"J. Endocrinol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/alr.22680","article-title":"Prevalence and reversibility of smell dysfunction measured psychophysically in a cohort of COVID-19 patients","volume":"10","author":"Moein","year":"2020","journal-title":"Int. Forum. Allergy Rhinol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/S1474-4422(17)30123-0","article-title":"Olfactory dysfunction in neurodegenerative diseases: Is there a common pathological substrate?","volume":"16","author":"Doty","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.parkreldis.2010.06.012","article-title":"Parkinsonism and neurological mani-festations of influenza throughout the 20th and 21st centuries","volume":"16","author":"Henry","year":"2010","journal-title":"Parkinsonism Relat. Disord."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1152\/japplphysiol.00684.2003","article-title":"Regulation of the angiotensin-converting enzyme activity by a time-course hypoxia in the carotid body","volume":"96","author":"Lam","year":"2004","journal-title":"J. Appl. Physiol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"7264","DOI":"10.1128\/JVI.00737-08","article-title":"Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2","volume":"82","author":"Netland","year":"2008","journal-title":"J. Virol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e645","DOI":"10.1212\/WNL.0000000000011150","article-title":"Teaching NeuroImages: SARS-CoV-2-Related Encephalitis: MRI Pattern of Olfactory Tract Involvement","volume":"96","author":"Casez","year":"2021","journal-title":"Neurology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jamaneurol.2021.0009","article-title":"Absent blood oxygen level-dependent functional magnetic resonance imaging activation of the orbitofrontal cortex in a patient with persistent cacosmia and cacogeusia after COVID-19 infection","volume":"78","author":"Ismail","year":"2021","journal-title":"JAMA Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"bjab006","DOI":"10.1093\/chemse\/bjab006","article-title":"Six-Month Psychophysical Evaluation of Olfactory Dysfunction in Patients with COVID-19","volume":"46","author":"Menegaldo","year":"2021","journal-title":"Chem. Senses"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S1474-4422(17)30125-4","article-title":"Detection of neurodegenerative disease using olfaction","volume":"16","author":"Xydakis","year":"2017","journal-title":"Lancet Neurol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e069503","DOI":"10.1136\/bmj-2021-069503","article-title":"Prognosis and persistence of smell and taste dysfunction in patients with COVID-19: Meta-analysis with parametric cure modelling of recovery curves","volume":"378","author":"Tan","year":"2022","journal-title":"BMJ"}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/9\/1408\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:28:30Z","timestamp":1760142510000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/9\/1408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,9]]},"references-count":68,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["life12091408"],"URL":"https:\/\/doi.org\/10.3390\/life12091408","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2022,9,9]]}}}