{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:47:35Z","timestamp":1790815655852,"version":"4.1.0"},"reference-count":56,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>This study aimed to analyse the thickness of the adipose tissue (AT) around the upper airways with anthropometric parameters in the prediction and pathogenesis of OSA and obstruction of the upper airways using artificial intelligence. One hundred patients were enrolled in this prospective investigation, who were divided into control (non-OSA) and mild, moderately severe, and severe OSA according to polysomnography. All participants underwent drug-induced sleep endoscopy, anthropometric measurements, and neck MRI. The statistical analyses were based on artificial intelligence. The midsagittal SAT, the parapharyngeal fat, and the midsagittal tongue fat were significantly correlated with BMI; however, no correlation with AHI was observed. Upper-airway obstruction was correctly categorised in 80% in the case of the soft palate, including parapharyngeal AT, sex, and neck circumference parameters. Oropharyngeal obstruction was correctly predicted in 77% using BMI, parapharyngeal AT, and abdominal circumferences, while tongue-based obstruction was correctly predicted in 79% using BMI. OSA could be predicted with 99% precision using anthropometric parameters and AT values from the MRI. Age, neck circumference, midsagittal and parapharyngeal tongue fat values, and BMI were the most vital parameters in the prediction. Basic anthropometric parameters and AT values based on MRI are helpful in predicting OSA and obstruction location using artificial intelligence.<\/jats:p>","DOI":"10.3390\/life12101543","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T01:43:11Z","timestamp":1665279791000},"page":"1543","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["The Predictive Role of the Upper-Airway Adipose Tissue in the Pathogenesis of Obstructive Sleep Apnoea"],"prefix":"10.3390","volume":"12","author":[{"given":"Vikt\u00f3ria","family":"Moln\u00e1r","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zolt\u00e1n","family":"Lakner","sequence":"additional","affiliation":[{"name":"Szent Istv\u00e1n Campus, Hungarian University of Agriculture and Life Sciences, 2100 G\u00f6d\u00f6ll\u0151, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e1s","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Semmelweis University, 1083 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7001-7647","authenticated-orcid":false,"given":"D\u00e1vid L\u00e1szl\u00f3","family":"T\u00e1rnoki","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5909-3780","authenticated-orcid":false,"given":"\u00c1d\u00e1m Domonkos","family":"T\u00e1rnoki","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kunos","sequence":"additional","affiliation":[{"name":"Institute of Pulmonology, T\u00f6r\u00f6kb\u00e1lint, 2045 T\u00f6r\u00f6kb\u00e1lint, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5407-6540","authenticated-orcid":false,"given":"Zs\u00f3fia","family":"Jokkel","sequence":"additional","affiliation":[{"name":"Medical Imaging Centre, Semmelweis University, 1082 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Tam\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Head and Neck Surgery, Semmelweis University, 1083 Budapest, Hungary"},{"name":"Department of Voice, Speech and Swallowing Therapy, Faculty of Health Sciences, Semmelweis University, 1088 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"15015","DOI":"10.1038\/nrdp.2015.15","article-title":"Obstructive sleep apnoea syndrome","volume":"1","author":"Kohler","year":"2015","journal-title":"Nat. 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