{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:55:24Z","timestamp":1787648124227,"version":"build-2736575974"},"reference-count":80,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>The virus causing monkeypox, a rare zoonotic viral disease, belongs to the Poxviridae family and the Orthopoxvirus genus. On 23 July 2022, the World Health Organization (WHO) declared the monkeypox outbreak as a Public Health Emergency of International Concern (PHEIC). From May to July 2022, a multi-country outbreak of monkeypox was reported in both endemic and non-endemic regions. Major goals of managing monkeypox are to identify the suspected cases, detect generic orthopoxvirus DNA at a state or commercial laboratory, and establish the Centers for Disease Control and Prevention real-time polymerase chain reaction testing. Currently, there are no approved treatments for monkeypox virus infection. However, a variety of antiviral medications originally designed for the treatment of smallpox and other viral infections could be considered. Pre-exposure prophylaxis for laboratory and health care employees and post-exposure prophylaxis for individuals with high-risk or intermediate-risk exposures are to be considered. The CDC Emergency Operations Center is available for advice on the appropriate use of medical countermeasures, and can help in obtaining antiviral drugs and vaccines from the National Strategic Stockpile. This review gives an overview of the global scenario, clinical presentation, and management of monkeypox in the light of a global public health emergency.<\/jats:p>","DOI":"10.3390\/life12101590","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T20:53:29Z","timestamp":1665608009000},"page":"1590","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Monkeypox: An Emerging Global Public Health Emergency"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9045-9493","authenticated-orcid":false,"given":"Madhan","family":"Jeyaraman","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr. MGR Educational and Research Institute, Chennai 600095, Tamil Nadu, India"},{"name":"South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethi","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Faculty of Medicine, Sri Lalithambigai Medical College and Hospital, Dr. MGR Educational and Research Institute, Chennai 600095, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-0441","authenticated-orcid":false,"given":"Manjunatha Budihal","family":"Halesh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, SDM Medical College, Dharwad 600095, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-3326","authenticated-orcid":false,"given":"Naveen","family":"Jeyaraman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Atlas Hospitals, Tiruchirappalli 620002, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2445-2883","authenticated-orcid":false,"given":"Arulkumar","family":"Nallakumarasamy","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, All India Institute of Medical Sciences, Bhubaneswar 751019, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manu","family":"Gupta","sequence":"additional","affiliation":[{"name":"Polar Aesthetics Dental & Cosmetic Center, Noida 201301, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5327-3702","authenticated-orcid":false,"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[{"name":"Department of Musculoskeletal Disorders, School of Medicine and Surgery, University of Salerno, 84084 Fisciano, Italy"},{"name":"San Giovanni di Dio e Ruggi D\u2019Aragona Hospital \u201cClinica Ortopedica\u201d Department, Hospital of Salerno, 84124 Salerno, Italy"},{"name":"Centre for Sports and Exercise Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 4DG, UK"},{"name":"School of Pharmacy and Bioengineering, Keele University School of Medicine, Stoke on Trent ST5 5BG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1224-2755","authenticated-orcid":false,"given":"Ashim","family":"Gupta","sequence":"additional","affiliation":[{"name":"South Texas Orthopaedic Research Institute (STORI Inc.), Laredo, TX 78045, USA"},{"name":"BioIntegrate, Lawrenceville, GA 30043, USA"},{"name":"Future Biologics, Lawrenceville, GA 30043, USA"},{"name":"Regenerative Orthopaedics, Noida 201301, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"ref_1","first-page":"e26531","article-title":"Monkeypox: A Comprehensive Review of Transmission, Pathogenesis, and Manifestation","volume":"14","author":"Kaler","year":"2022","journal-title":"Cureus"},{"key":"ref_2","unstructured":"(2022, August 24). 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