{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:05:49Z","timestamp":1790136349184,"version":"4.0.1"},"reference-count":59,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Oral candidiasis is the most common opportunistic fungal infection caused by commensal Candida species. Since there are various local and systemic predisposing factors for the disease, the treatment also varies from topical to systemic antifungal agents. Nystatin is a common antifungal agent used topically. The aim of this systematic review was to evaluate and compare the efficacy of different antifungal agents and the safety of nystatin in the treatment of oral candidiasis. Three electronic databases were searched for randomized controlled trials comparing nystatin with other anti-fungal therapies or placebo. Clinical and\/or mycological cure was the outcome evaluation. A meta-analysis and descriptive study on the efficacy, treatment protocols, and safety of nystatin was also conducted. The meta-analysis included five studies, which compared the efficacy of nystatin suspensions with photodynamic therapy. A significant difference in the colony-forming units per milliliters (CFU\/mL) of Candida species was observed at 60 days intervals for both palatal mucosa and denture surfaces, with both groups favoring nystatin with low heterogeneity at a 95% confidence interval. Nystatin and photodynamic therapy were found to be equally effective for the clinical remission of denture stomatitis as well as a significant reduction of CFU\/mL of Candida species from dentures and palatal surfaces of the patients.<\/jats:p>","DOI":"10.3390\/life12111677","type":"journal-article","created":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T04:40:36Z","timestamp":1666586436000},"page":"1677","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Nystatin Effectiveness in Oral Candidiasis Treatment: A Systematic Review &amp; Meta-Analysis of Clinical Trials"],"prefix":"10.3390","volume":"12","author":[{"given":"Anamika","family":"Rai","sequence":"first","affiliation":[{"name":"Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-543X","authenticated-orcid":false,"given":"Satya Ranjan","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurav","family":"Panda","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Sokolowski","sequence":"additional","affiliation":[{"name":"Department of Prosthetics, Medical University of Lodz, 251 Pomorska St., 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-2172","authenticated-orcid":false,"given":"Lora","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry & Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupsa","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine & Radiology, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-8515","authenticated-orcid":false,"given":"Barbara","family":"Lapinska","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Medical University of Lodz, 251 Pomorska St, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.abn1890","article-title":"The effects of oral microbiota on health","volume":"376","author":"Tuganbaev","year":"2022","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.tim.2016.12.012","article-title":"Ecology of the Oral Microbiome: Beyond Bacteria","volume":"25","author":"Baker","year":"2017","journal-title":"Trends Microbiol."},{"key":"ref_3","first-page":"52","article-title":"Update on oral candidosis","volume":"99","author":"Arkell","year":"2003","journal-title":"Nurs. 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