{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:43:07Z","timestamp":1760244187900,"version":"build-2065373602"},"reference-count":62,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cDun\u0103rea de Jos\u201d University of Galati","award":["27232142"],"award-info":[{"award-number":["27232142"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Systemic changes often send signals to the skin, and certain neoplastic diseases of the internal organs can also trigger skin manifestations. In this article, the authors make clinical photography presentations of the patients seen at our clinic with dermatologic paraneoplastic syndromes within pharyngeal\u2013esophageal malignancies, describe several paraneoplastic dermatoses, and also review high-quality scientific literature in order to be able to highlight the dermatological signs of pharyngoesophageal malignant tumors. The majority of our patients with paraneoplastic dermatoses, filtering for pharyngoesophageal malignancies, had esophageal neoplasms, out of whom seven were female and two were male, making esophageal cancer more common within the paraneoplastic dermatoses within pharyngoesophageal malignancies. An early recognition of paraneoplastic dermatoses can diagnose neoplasms and sequentially contribute to a better prognosis for the patient. This matter is also useful for front-line medical personnel in order to improve early diagnosis of the underlying malignancy, curative interventions with prompt therapy administration and good prognosis.<\/jats:p>","DOI":"10.3390\/life12111705","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T07:17:48Z","timestamp":1666768668000},"page":"1705","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharyngeal-Esophageal Malignancies with Dermatologic Paraneoplastic Syndrome"],"prefix":"10.3390","volume":"12","author":[{"given":"Ana","family":"Fulga","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Saint Apostle Andrew Emergency County Clinical Hospital, 177 Brailei st, 800578 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doriana","family":"Cristea Ene","sequence":"additional","affiliation":[{"name":"Saint Apostle Andrew Emergency County Clinical Hospital, 177 Brailei st, 800578 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Bujoreanu","family":"Bezman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Saint Apostle Andrew Emergency County Clinical Hospital, 177 Brailei st, 800578 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oana Maria","family":"Dragostin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Saint Apostle Andrew Emergency County Clinical Hospital, 177 Brailei st, 800578 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iuliu","family":"Fulga","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Saint Apostle Andrew Emergency County Clinical Hospital, 177 Brailei st, 800578 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5056-1015","authenticated-orcid":false,"given":"Elena","family":"Stamate","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Cardiology Department, University Emergency Hospital Bucharest, 169 Independence Square st, 050098 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alin Ionut","family":"Piraianu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Saint Apostle Andrew Emergency County Clinical Hospital, 177 Brailei st, 800578 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3029-9245","authenticated-orcid":false,"given":"Florin","family":"Bujoreanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Saint Parascheva Clinical Hospital of Infectious Diseases, 393 Traian st, 800179 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Laurentiu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Dunarea de Jos University of Galati, 35 AI Cuza st, 800010 Galati, Romania"},{"name":"Saint Parascheva Clinical Hospital of Infectious Diseases, 393 Traian st, 800179 Galati, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3747\/co.27.6557","article-title":"Cutaneous Paraneoplastic Syndrome Associated with Anal Squamous Cel Carcinoma: A Rare Presentation of an Uncommon Cancer","volume":"27","author":"Saeed","year":"2020","journal-title":"Curr. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.clindermatol.2010.09.022","article-title":"Cutaneous Paraneoplasia","volume":"29","author":"Carvalho","year":"2011","journal-title":"Clin. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.det.2007.08.002","article-title":"Cutaneous Manifestations of Internal Malignancies: An Overview","volume":"26","author":"Pipkin","year":"2008","journal-title":"Dermatol. Clin."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/00365520701374270","article-title":"Post-Renal Transplantation Leser-Trelat Sign Associated with Carcinoma of the Gallbladder: A Rare Association","volume":"42","author":"Kocygit","year":"2007","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_5","unstructured":"Global Burden of Disease Cancer Collaboration, Fitzmaurice, C., Allen, C., Barber, R.M., Barregard, L., Bhutta, Z.A., Brenner, H., Dicker, D.J., Chimed-Orchir, O., and Dandona, R. (2017). Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life-Years for 32 Cancer Groups, 1990 to 2015: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol., 3, 524\u2013548."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_7","unstructured":"Global Burden of Disease Cancer Collaboration, Fitzmaurice, C., Abate, D., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdel-Rahman, O., Abdelalim, A., Abdoli, A., and Abdollahpour, I. (2019). Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived with Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol., 5, 1749\u20131768."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/S2468-1253(20)30007-8","article-title":"The Global, Regional, and National Burden of Oesophageal Cancer and Its Attributable Risk Factors in 195 Countries and Territories, 1990\u20132017: A Systematic Analysis for the Global Burden of Disease Study 2017","volume":"5","author":"Kamangar","year":"2020","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Laz\u0103r, D.C., Avram, M.F., Faur, A.C., Goldi\u015f, A., Romo\u015fan, I., T\u0103ban, S., and Cornianu, M. (2020). The Impact of Artificial Intelligence in the Endoscopic Assessment of Premalignant and Malignant Esophageal Lesions: Present and Future. Medicina, 56.","DOI":"10.3390\/medicina56070364"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3322\/caac.20005","article-title":"Cutaneous Manifestations of Internal Malignancy","volume":"59","author":"Thiers","year":"2009","journal-title":"CA Cancer J. Clin."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.3748\/wjg.15.4372","article-title":"Paraneoplastic Dermatological Manifestation of Gastrointestinal Malignancies","volume":"15","author":"Dourmishev","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1067\/j.cpsurg.2010.01.003","article-title":"Cutaneous Manifestations of Internal Malignancy","volume":"47","author":"Ehst","year":"2010","journal-title":"Curr. Probl. Surg."},{"key":"ref_13","first-page":"2357","article-title":"Cutaneous Manifestations of Internal Malignant Disease","volume":"33","author":"McLean","year":"1987","journal-title":"Can. Fam. Physician"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/00005792-199107000-00004","article-title":"Bazex Syndrome (Acrokeratosis Paraneoplastica). An Analytic Review","volume":"70","author":"Bolognia","year":"1991","journal-title":"Medicine"},{"key":"ref_15","first-page":"498","article-title":"Skin Manifestations of Systemic Disease","volume":"38","author":"Lee","year":"2009","journal-title":"Aust. Fam. Physician"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.coms.2008.06.008","article-title":"Pemphigus Vulgaris and Paraneoplastic Pemphigus","volume":"20","author":"Edgin","year":"2008","journal-title":"Oral Maxillofac. Surg. Clin. N. Am."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0733-8635(02)00015-3","article-title":"Paraneoplastic Dermatoses","volume":"20","author":"Boyce","year":"2002","journal-title":"Dermatol. Clin."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1046\/j.1365-4362.1997.00190.x","article-title":"Malignancy in Adult Dermatomyositis","volume":"36","author":"Leow","year":"1997","journal-title":"Int. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1046\/j.1365-4362.2002.01648.x","article-title":"Polymyositis and Dermatomyositis Associated with Malignancy: A 30-Year Retrospective Study: Polymyositis and Dermatomyositis with Malignancy","volume":"41","author":"Wakata","year":"2002","journal-title":"Int. J. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1067\/mjd.2000.107488","article-title":"Sensitivity and Specificity of Clinical, Histologic, and Immunologic Features in the Diagnosis of Paraneoplastic Pemphigus","volume":"43","author":"Joly","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1087-0024.2004.00832.x","article-title":"Paraneoplastic Pemphigus","volume":"9","author":"Anhalt","year":"2004","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"ref_22","first-page":"32","article-title":"Leser Trelat Sign Associated with Carcinoma of Gastro-Oesophageal Junction","volume":"20","author":"Tutakne","year":"1983","journal-title":"Indian J. Cancer"},{"key":"ref_23","first-page":"182","article-title":"Syndrome Paraneoplasique a Type d\u2019hyperkeratose Des Extremites. Guerson Apres Le Traitment de l\u2019epithelioma Larynge","volume":"72","author":"Bazex","year":"1965","journal-title":"Bull. Soc. Fr. Dermatol. Syphiligr"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4103\/0378-6323.51249","article-title":"Acrokeratosis Paraneoplastica (Bazex Syndrome)","volume":"75","author":"Ljubenovic","year":"2009","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s40257-016-0235-z","article-title":"Paraneoplastic Pemphigus and Autoimmune Blistering Diseases Associated with Neoplasm: Characteristics, Diagnosis, Associated Neoplasms, Proposed Pathogenesis, Treatment","volume":"18","author":"Kartan","year":"2017","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0030-4220(93)90095-L","article-title":"Paraneoplastic Pemphigus. A Distinct Autoimmune Vesiculobullous Disorder Associated with Neoplasia","volume":"75","author":"Helm","year":"1993","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-4362.2001.01169.x","article-title":"Paraneoplastic Pemphigus","volume":"40","author":"Jih","year":"2001","journal-title":"Int. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1346-8138.2012.01655.x","article-title":"Retrospective Analysis of 12 Korean Patients with Paraneoplastic Pemphigus","volume":"39","author":"Choi","year":"2012","journal-title":"J. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e477","DOI":"10.1097\/MJT.0000000000000569","article-title":"Bullous Reactions Associated with COX-2 Inhibitors","volume":"24","author":"Tatu","year":"2017","journal-title":"Am. J. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.jaad.2010.10.006","article-title":"Erythema Gyratum Repens","volume":"64","year":"2011","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1046\/j.1365-4362.2002.01482.x","article-title":"Dermatomyositis: Cutaneous Manifestations of Its Variants","volume":"41","author":"Dourmishev","year":"2002","journal-title":"Int. J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/00002281-200311000-00006","article-title":"Skin Involvement in Dermatomyositis","volume":"15","author":"Dugan","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"key":"ref_33","first-page":"2035","article-title":"Ueber Ein Die Krebskrankheit Bein Menschen Haufig Begleitendes, Noch Wenig Gekanntes Symtom","volume":"51","author":"Leser","year":"1901","journal-title":"Munch. Med. Wochenschr."},{"key":"ref_34","first-page":"258","article-title":"Sign of Leser-Trelat with a Metastatic Mucinous Adenorcarcinoma","volume":"47","author":"Swartz","year":"1991","journal-title":"Cutis"},{"key":"ref_35","first-page":"664","article-title":"The Sign of Leser-Tr\u00e9lat Associated with Carcinoma of the Stomach","volume":"83","author":"Kameya","year":"1988","journal-title":"Am. J. Gastroenterol."},{"key":"ref_36","first-page":"255","article-title":"The Sign of Leser-Tr\u00e9lat Associated with Adenocarcinoma of the Rectum","volume":"51","author":"Cohn","year":"1993","journal-title":"Cutis"},{"key":"ref_37","first-page":"27","article-title":"Multimple Seborrheic Keratoses Associated with Rectal Adenocarcinoma","volume":"6","author":"Dourmishev","year":"2004","journal-title":"CEEDVA"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/j.1365-2133.1975.tb03107.x","article-title":"Seborrheic Keratoses and Carcinoma of the Large Bowel. Three Cases Exhibiting the Sign of Leser-Trelat","volume":"92","author":"Liddell","year":"1975","journal-title":"Br. J. Dermatol."},{"key":"ref_39","first-page":"875","article-title":"Leser-Trelat Sign in Adenocarcinoma of the Signoid Colon-a Rare Clinical Picture","volume":"62","author":"Hodak","year":"1987","journal-title":"Z. Hautkrankh."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0190-9622(88)70141-3","article-title":"Linear Seborrheic Keratoses Associated with Underlying Malignancy","volume":"18","author":"Heng","year":"1988","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1468-3083.1992.tb00703.x","article-title":"The Sign of Leser-Trelat: Fact or Myth?","volume":"1","author":"Brauer","year":"1992","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_42","first-page":"251","article-title":"Sign of Leser-Tr\u00e9lat Associated with Adenocarcinoma of the Rectum","volume":"11","author":"Ginarte","year":"2001","journal-title":"Eur. J. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1111\/j.1572-0241.2001.03807.x","article-title":"The Leser-Trelat Sign in Association with Carcinoma of the Ampulla of Vater","volume":"96","author":"Klimopoulos","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02787475","article-title":"Pancreatic Carcinoma Associated with the Leser-Tr\u00e9lat Sign","volume":"22","author":"Ohashi","year":"1997","journal-title":"Int. J. Pancreatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1093\/annonc\/mdw183","article-title":"Cervical Esophageal Cancer: A Gap in Cancer Knowledge","volume":"27","author":"Hoeben","year":"2016","journal-title":"Ann. Oncol."},{"key":"ref_46","unstructured":"SEER (2022, August 19). Surveillance, Epidemiology, and End Results Program, Available online: https:\/\/seer.cancer.gov."},{"key":"ref_47","unstructured":"(2022, August 19). National Oesophago-Gastric Cancer Audit. 2010 Annual Report. Available online: https:\/\/www.nogca.org.uk\/reports\/2010-annual-report\/."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/ajg.2016.20","article-title":"Development of the Northwestern Esophageal Quality of Life Scale: A Hybrid Measure for Use across Esophageal Conditions","volume":"111","author":"Bedell","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"710245","DOI":"10.3389\/fonc.2021.710245","article-title":"Cancer of Pharyngoesophageal Junction: A Different Subtype from Hypopharyngeal and Cervical Esophageal Cancer?","volume":"11","author":"Li","year":"2021","journal-title":"Front. Oncol."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Didona, D., Fania, L., Didona, B., Eming, R., Hertl, M., and Di Zenzo, G. (2020). Paraneoplastic Dermatoses: A Brief General Review and an Extensive Analysis of Paraneoplastic Pemphigus and Paraneoplastic Dermatomyositis. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21062178"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1136\/pgmj.46.541.678","article-title":"Cutaneous Manifestations of Visceral Malignancy","volume":"46","author":"Sneddon","year":"1970","journal-title":"Postgrad. Med. J."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0190-9622(93)70001-A","article-title":"Cutaneous Markers of Internal Malignancy. I. Malignant Involvement of the Skin and the Genodermatoses","volume":"28","author":"Poole","year":"1993","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1590\/S0365-05962010000500026","article-title":"Cutanous Manifestations of internal Malignancies in a Tertiary Health Care Hospital of a Developing Country","volume":"85","author":"Ramos","year":"2010","journal-title":"An. Bras. Dermatol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/S0365-05962013000100001","article-title":"Paraneoplastic Cutaneous Manifestations: Concepts and Updates","volume":"88","author":"Mesquita","year":"2013","journal-title":"An. Bras. Dermatol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"53","DOI":"10.2169\/internalmedicine1962.30.53","article-title":"A Case of Hepatocellular Carcinoma with the Sign of Leser-Trelat: A Possible Role of a Cutenous Marker for Internal Malignancy","volume":"30","author":"Tajima","year":"1991","journal-title":"JPN J. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.clindermatol.2004.06.011","article-title":"Life-Threatening Paraneoplastic Cutaneous Syndromes","volume":"23","author":"Stone","year":"2005","journal-title":"Clin. Dermatol."},{"key":"ref_57","first-page":"197","article-title":"Erythema Gyratum Repens as the Initial Manifestation of Lung Cancer","volume":"18","author":"Martins","year":"2008","journal-title":"Eur. J. Dermatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/1203475417711114","article-title":"Pityriasis Folliculorum of the Back Thoracic Area: Pityrosporum, Keratin Plugs, or Demodex Involved?","volume":"21","author":"Tatu","year":"2017","journal-title":"J. Cutan. Med. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0190-9622(00)90112-9","article-title":"Coexistence of Acanthosis Nigricans and the Sign of Leser-Tr\u00e9lat in a Patient with Gastric Adenocarcinoma: A Case Report and Literature Review","volume":"42","author":"Yeh","year":"2000","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"103676","DOI":"10.1016\/j.critrevonc.2022.103676","article-title":"Paraneoplastic syndromes review: The great forgotten ones","volume":"174","author":"Vivero","year":"2022","journal-title":"Crit. Rev. Oncol.\/Hematol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1442-2050.2007.00632.x","article-title":"Concurrent Chemoradiation for Patients with Squamous Cell Carcinoma of the Cervical Esophagus","volume":"20","author":"Uno","year":"2007","journal-title":"Dis. Esophagus"},{"key":"ref_62","first-page":"33","article-title":"Pharyngo-Espophageal Junction Neoplasia\u2014Therapeutic Management","volume":"107","author":"Bertesteanu","year":"2012","journal-title":"Rev. Chir."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/11\/1705\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:03:10Z","timestamp":1760144590000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/11\/1705"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,26]]},"references-count":62,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["life12111705"],"URL":"https:\/\/doi.org\/10.3390\/life12111705","relation":{},"ISSN":["2075-1729"],"issn-type":[{"type":"electronic","value":"2075-1729"}],"subject":[],"published":{"date-parts":[[2022,10,26]]}}}