{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:52:54Z","timestamp":1787028774632,"version":"build-2736575974"},"reference-count":40,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background. This study aims to determine whether the administration of ferric carboxymaltose (FCM) in patients with acute heart failure (AHF) and iron deficiency (ID) improves morbidity and mortality. Methods. We studied 890 consecutive patients admitted for AHF. Patients were divided into six groups according to reduced left ventricular ejection fraction (HFrEF) or preserved (HFpEF), presence of ID, and administration of FCM. Emergency visits, re-admissions, and all-cause mortality were assessed at 6 months. Results. The overall prevalence of ID was 91.2%. In the HFrEF group, no differences were found in isolated events when patients with untreated vs. treated ID were compared, while differences were found in the combined event rate (p = 0.049). The risk calculation showed an absolute risk reduction (ARR) of 10% and relative risk reduction (RRR) of 18%. In HFpEF there was a positive trend with regard to the combined event (p = 0.107), with an ARR of 9% and an RRR of 15%. The number of patients we needed to treat to prevent a combined event was 10.5 in HFrEF and 10.8 in HFpEF. Conclusions. FCM in AHF reduced the combined event rate of emergency visits, re-admission, and all-cause death at 6 months in HF with left ventricular ejection fraction &lt;50%, and showed a positive trend in HFpEF.<\/jats:p>","DOI":"10.3390\/life12111828","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T02:49:38Z","timestamp":1667962178000},"page":"1828","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Why Iron Deficiency in Acute Heart Failure Should Be Treated: A Real-World Clinical Practice Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9696-2313","authenticated-orcid":false,"given":"Raquel","family":"L\u00f3pez-Vilella","sequence":"first","affiliation":[{"name":"Heart Failure and Transplantation Unit, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Department of Cardiology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3105-9529","authenticated-orcid":false,"given":"V\u00edctor","family":"Donoso Trenado","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplantation Unit, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Department of Cardiology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6219-2816","authenticated-orcid":false,"given":"Pablo","family":"Jover Pastor","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2851-4153","authenticated-orcid":false,"given":"Ignacio","family":"S\u00e1nchez-L\u00e1zaro","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplantation Unit, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Department of Cardiology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-8191","authenticated-orcid":false,"given":"Luis","family":"Mart\u00ednez Dolz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Almenar Bonet","sequence":"additional","affiliation":[{"name":"Heart Failure and Transplantation Unit, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Department of Cardiology, Hospital Universitario y Polit\u00e9cnico La Fe, 46026 Valencia, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ccep.2018.11.001","article-title":"The Many Faces of Heart Failure","volume":"11","author":"Snipelisky","year":"2019","journal-title":"Card. Electrophysiol. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.hfc.2017.02.001","article-title":"Epidemiology, Pathophysiology, and Prognosis of Heart Failure in Older Adults","volume":"13","author":"Dharmarajan","year":"2017","journal-title":"Heart Fail. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/joim.13033","article-title":"Preheart failure comorbidities and impact on prognosis in heart failure patients: A nationwide study","volume":"287","author":"Christiansen","year":"2020","journal-title":"J. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2459\/JCM.0b013e32834058d1","article-title":"Cardiovascular and noncardiovascular comorbidities in patients with chronic heart failure","volume":"12","author":"Metra","year":"2011","journal-title":"J. Cardiovasc. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1056\/NEJMoa0908355","article-title":"Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency","volume":"361","author":"Anker","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/eurheartj\/ehu385","article-title":"Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency","volume":"36","author":"Ponikowski","year":"2015","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ejhf.823","article-title":"Effects of ferric carboxymaltose on hospitalisations and mortality rates in iron-deficient heart failure patients: An individual patient data meta-analysis","volume":"20","author":"Anker","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"ref_9","first-page":"133","article-title":"Impact of intravenous ferric carboxymaltose on heart failure with preserved and reduced ejection fraction","volume":"9","author":"Ezzitouny","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1016\/S0140-6736(20)32339-4","article-title":"Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: A multicentre, double-blind, randomised, controlled trial","volume":"396","author":"Ponikowski","year":"2020","journal-title":"Lancet"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/ejhf.1305","article-title":"Screening, diagnosis and treatment of iron deficiency in chronic heart failure: Putting the 2016 European Society of Cardiology heart failure guidelines into clinical practice","volume":"20","author":"McDonagh","year":"2018","journal-title":"Eur. J. Heart Fail."},{"key":"ref_12","first-page":"1","article-title":"Perfiles anal\u00edticos pre-configurados en insuficiencia cardiaca: Implementaci\u00f3n y uso en el Sistema Nacional de Salud Espa\u00f1ol","volume":"3","author":"Camafort","year":"2022","journal-title":"Adv. Lab. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s13670-021-00370-w","article-title":"Iron Deficiency in Heart Failure: Characteristics and Treatment","volume":"10","author":"Martin","year":"2021","journal-title":"Curr. Geriatr. Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e001012","DOI":"10.1136\/openhrt-2019-001012","article-title":"Iron deficiency in heart failure with preserved ejection fraction: A systematic review and meta-analysis","volume":"6","author":"Beale","year":"2019","journal-title":"Open Heart"},{"key":"ref_15","first-page":"100871","article-title":"Effect of iron supplementation in patients with heart failure and iron deficiency: A systematic review and meta-analysis","volume":"36","author":"Yamani","year":"2021","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_16","first-page":"85","article-title":"Iron replacement therapy in heart failure: A literature review","volume":"73","author":"Ismahel","year":"2021","journal-title":"Egypt. Heart J. EHJ Off. Bull. Egypt. Soc. Cardiol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"709872","DOI":"10.3389\/fcvm.2021.709872","article-title":"Iron Deficiency: A New Target for Patients With Heart Failure","volume":"8","author":"Rizzo","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1001\/jama.2017.5427","article-title":"Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial","volume":"317","author":"Lewis","year":"2017","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.jacc.2017.12.027","article-title":"The Burden of Iron Deficiency in Heart Failure: Therapeutic Approach","volume":"71","author":"Rocha","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Alcaide-Aldeano, A., Garay, A., Alcoberro, L., Jim\u00e9nez-Marrero, S., Yun, S., Tajes, M., Garc\u00eda-Romero, E., D\u00edez-L\u00f3pez, C., Gonz\u00e1lez-Costello, J., and Mateus-Porta, G. (2020). Iron Deficiency: Impact on Functional Capacity and Quality of Life in Heart Failure with Preserved Ejection Fraction. J. Clin. Med., 9.","DOI":"10.3390\/jcm9041199"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Beale, A., Carballo, D., Stirnemann, J., Garin, N., Agoritsas, T., Serratrice, J., Kaye, D., Meyer, P., and Carballo, S. (2019). Iron Deficiency in Acute Decompensated Heart Failure. J. Clin. Med., 8.","DOI":"10.3390\/jcm8101569"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1002\/ehf2.13617","article-title":"Impact of change in iron status over time on clinical outcomes in heart failure according to ejection fraction phenotype","volume":"8","author":"Fitzsimons","year":"2021","journal-title":"ESC Heart Fail."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/eurheartj\/ehs224","article-title":"Iron deficiency and heart failure: Diagnostic dilemmas and therapeutic perspectives","volume":"34","author":"Jankowska","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/ehf2.12250","article-title":"Single-dose intravenous iron in Southeast Asian heart failure patients: A pilot randomized placebo-controlled study (PRACTICE-ASIA-HF)","volume":"5","author":"Yeo","year":"2018","journal-title":"ESC Heart Fail."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.2337\/dc13-0528","article-title":"Iron Status and Survival in Diabetic Patients With Coronary Artery Disease","volume":"36","author":"Ponikowska","year":"2013","journal-title":"Diabetes Care"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e014254","DOI":"10.1161\/JAHA.119.014254","article-title":"Noninvasive Imaging Estimation of Myocardial Iron Repletion Following Administration of Intravenous Iron: The Myocardial-IRON Trial","volume":"9","author":"Cardells","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1002\/ehf2.13053","article-title":"Short-term changes in left and right systolic function following ferric carboxymaltose: A substudy of the Myocardial-IRON trial","volume":"7","author":"Santas","year":"2020","journal-title":"ESC Heart Fail."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1161\/CIRCULATIONAHA.117.027497","article-title":"Effect of Ferric Carboxymaltose on Exercise Capacity in Patients With Chronic Heart Failure and Iron Deficiency","volume":"136","author":"Ponikowski","year":"2017","journal-title":"Circulation"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1093\/eurheartj\/ehab411","article-title":"The effect of intravenous ferric carboxymaltose on cardiac reverse remodelling following cardiac resynchronization therapy\u2014The IRON-CRT trial","volume":"42","author":"Martens","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ihj.2017.10.009","article-title":"Effect of ferric carboxymaltose on hospitalization and mortality outcomes in chronic heart failure: A meta-analysis","volume":"69","author":"Dalal","year":"2017","journal-title":"Indian Heart J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/ehf2.13204","article-title":"Iron deficiency impacts prognosis but less exercise capacity in heart failure with preserved ejection fraction","volume":"8","author":"Henkens","year":"2021","journal-title":"ESC Heart Fail"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4652","DOI":"10.1016\/j.ijcard.2013.07.185","article-title":"Functional iron deficiency and diastolic function in heart failure with preserved ejection fraction","volume":"168","author":"Kasner","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.amjcard.2016.09.017","article-title":"Impact of Iron Deficiency on Response to and Remodeling After Cardiac Resynchronization Therapy","volume":"119","author":"Martens","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/ehf2.12101","article-title":"Left ventricular ejection fraction recovery in patients with heart failure treated with intravenous iron: A pilot study","volume":"3","author":"Monmeneu","year":"2016","journal-title":"ESC Heart Fail."},{"key":"ref_35","first-page":"1299","article-title":"Intravenous iron for heart failure with evidence of iron deficiency: A meta-analysis of randomised trials","volume":"110","author":"Graham","year":"2021","journal-title":"Clin. Res. Cardiol. Off. J. Ger. Card. Soc."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1093\/eurheartj\/ehab234","article-title":"The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: The results of the AFFIRM-AHF study","volume":"42","author":"Jankowska","year":"2021","journal-title":"Eur. Heart J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ijcard.2016.01.187","article-title":"Iron deficiency and functional capacity in patients with advanced heart failure with preserved ejection fraction","volume":"207","author":"Sanchis","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Costello, J., Com\u00edn-Colet, J., Lup\u00f3n, J., Enjuanes, C., de Antonio, M., Fuentes, L., Moliner-Borja, P., Farr\u00e9, N., Zamora, E., and Manito, N. (2018). Importance of iron deficiency in patients with chronic heart failure as a predictor of mortality and hospitalizations: Insights from an observational cohort study. BMC Cardiovasc. Disord., 18.","DOI":"10.1186\/s12872-018-0942-x"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/ejhf.588","article-title":"Iron deficiency and risk of early readmission following hospitalization for acute heart failure. Reply","volume":"18","author":"Nunez","year":"2016","journal-title":"Eur. J. Heart Fail"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/00015385.2017.1351239","article-title":"Impact of iron deficiency on exercise capacity and outcome in heart failure with reduced, mid-range and preserved ejection fraction","volume":"73","author":"Martens","year":"2018","journal-title":"Acta Cardiol."}],"container-title":["Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/11\/1828\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:12:57Z","timestamp":1760145177000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-1729\/12\/11\/1828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,9]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["life12111828"],"URL":"https:\/\/doi.org\/10.3390\/life12111828","relation":{},"ISSN":["2075-1729"],"issn-type":[{"value":"2075-1729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,9]]}}}